Attaining professional success and finding personal happiness in academic medicine is not an easy path, yet both are critical if the future is to be brighter through better science, better clinical care, better training, better responsiveness to communities, and better stewardship and leadership in the health professions. This concise, easy to read title consists of "mini" chapters intended as a resource to assist early- and middle-career physicians, clinicians, and scientists in understanding the unique mission of academic medicine and building creative, effective, and inspiring careers in academic health organizations. Organized in eight sections, the Guide covers such areas as finding your path in academic medicine, getting established at an institution, approaching work with colleagues, writing and reviewing manuscripts, conducting empirical research, developing administrative skills, advancing your academic career, and balancing your professional and personal life. Each chapter includes pointers and valuable career and "best practices" strategies in relation to the topic area. An exciting addition to the professional development literature, Achievement and Fulfillment in Academic Medicine: A Comprehensive Guide is an indispensable resource for anyone seeking to achieve a fulfilling career in academic medicine.

The book aims to provide a comprehensive overview of assessments and interventions applied in young children with, or at high risk, for developmental motor disorders. It provides an evidence-based practical guide for health professionals working in the field of early detection and early intervention (e.g., paediatricians and paediatric physiotherapists). Parts I & II provide an overview of the clinical picture of early detection and early intervention and the neurodevelopmental mechanisms occurring in early life are discussed, including vulnerability and plasticity. In Parts III & IV basic principles and features governing typical and atypical motor development are explained, covering not only motor development but also sensory and cognitive development. Part V summarises the methods available for assessments, including information on technical details of the tools and psychometric properties. Finally, Part VI discusses early intervention, including evidence on effectiveness, together with the application of equipment in young children with developmental motor disorders. Special attention is paid to the family and environmental adaptations.

Simple Medicine chronicles the change in primary care medicine over the past 50 years. Despite all the new medical technology, studies, medications, specialization, and computers, medical care is fractured. The physician-to-physician relationships have decayed. The federal government and insurance companies are dictating what they think is appropriate medical care. Too many patients are over medicated and not receiving the standard of care that is warranted in 2021. In Simple Medicine, the most common medical conditions, complaints, screening, medications, and medical testing are described in layman terms and very easy to understand, helping patients take control of their own health care and challenge their doctor to do the right thing.

Describes best practices in Ventricular Tachycardia and Fibrillation Ablation based on a consensus of the world's leading experts, based on the annual 'Venice Arrythmias' meeting. Catheter ablation of atrial fibrillation has become a widespread, yet controversial, treatment modality in electrophysiology laboratories. Presents a comprehensive and up-to-date overview of all the most important and debated aspects of atrial fibrillation ablation. Covers all key topics, from pre- and intra-procedural management to best techniques and outcomes for patients with and without structural HD to Indications for VT/VF ablation and hybrid therapy to future tools and treatment options.

The increase in environmentally induced diseases and the loosening of regulation and safety measures have inspired a massive challenge to established ways of looking at health and the environment. Communities with disease clusters, women facing a growing breast cancer incidence rate, and people of color concerned about the asthma epidemic have become critical of biomedical models that emphasize the role of genetic makeup and individual lifestyle practices. Likewise, scientists have lost patience with their colleagues' and government's failure to adequately address environmental health issues and to safeguard research from corporate manipulation.

Focusing specifically on breast cancer, asthma, and Gulf War-related health conditions-"contested illnesses" that have generated intense debate in the medical and political communities-Phil Brown shows how these concerns have launched an environmental health movement that has revolutionized scientific thinking and policy. Before the last three decades of widespread activism regarding toxic exposures, people had little opportunity to get information. Few sympathetic professionals were available, the scientific knowledge base was weak, government agencies were largely unprepared, laypeople were not considered bearers of useful knowledge, and ordinary people lacked their own resources for discovery and action.

Brown argues that organized social movements are crucial in recognizing and acting to combat environmental diseases. His book draws on environmental and medical sociology, environmental justice, environmental health science, and social movement studies to show how citizen-science alliances have fought to overturn dominant epidemiological paradigms. His probing look at the ways scientific findings are made available to the public and the changing nature of policy offers a new perspective on health and the environment and the relationship among people, knowledge, power, and authority.

In this issue of Medical Clinics, Guest Editor Jeffrey Callen brings his considerable expertise to the topic of Dermatology. Top experts in the field cover key topics such as alopecia, psoriasis, Cutaneous manifestations of diabetes, Diagnosis and management of cellulitis, and more. Provides in-depth, clinical reviews in Dermatology, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews. Contains more than 10 relevant, practice-oriented topics including Recognition and management of Severe Cutaneous Adverse Drug Reactions (including DRESS, SJS and TEN); Diagnosis and management of eczemas including atopic, hand dermatitis and contact dermatitis; Recognition, staging and management of melanoma; Diagnosis and management of leg ulcers; Approach to the patient with pruritus; and more.

This volume features the results of a meeting held at the National Institutes of Health to advance the goals of having the menstrual cycle accepted and understood as a marker of general health in adolescent girls and defining a related research agenda.
Specific topics covered in the volume include: (1) normal processes of the adolescent menstrual cycle, including menarche, the psychology of puberty, and cultural perceptions and practices surrounding menarche; (2) disease processes and the adolescent menstrual cycle, including genetic mechanisms of amenorrhea, Turner syndrome, FMR1 premutation, galactosemia, disorders of sexual differentiation, congenital adrenal hyperplasia, chronic disease, chemotherapy, autoimmune oophoritis, premature ovarian failure, and polycystic ovary syndrome; (3) bridging normal and abnormal processes, including amenorrhea, dysmenorrhea, adolescent antecedents to adult reproductive disorders, bone health, and HRT in the adolescent; (4) modern dilemmas and the adolescent menstrual cycle, including developmental delay, obesity, exercise-induced amenorrhea, eating disorders, stress-induced amenorrhea, and amenorrhea induced by medications; (5) the synthesis of the volume consisting of a contribution on the transition to adulthood.
NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.
ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Pleasevisit www.nyas.org/membership/main.asp for more information about becoming a member.

The ECG is a fundamental diagnostic tool in cardiology, allowing accurate diagnosis and monitoring of acute and chronic ischemic heart disease. In this most comprehensive book of its kind, internationally renowned authors correlate electrocardiographic recordings with anatomical patterns of myocardial ischemia to improve the diagnosis and management of patients with ischemic heart disease.
The book is structured in two sections. Part One covers electrocardiographic patterns of ischemia, injury and infarction.
* Each chapter discusses a different ECG abnormality in turn, clearly explaining the ischemic insults and electrophysiological mechanisms underlying each pattern to promote rapid and accurate interpretation of the ECG in the clinical setting.
* ECG abnormalities are correlated with myocardial anatomy and coronary angiography to produce a series of practical diagnostic algorithms that allow the clinician to identify not only the occluded artery but the precise location of the occlusion within the artery, facilitating appropriate therapeutic decisions.
* The authors also propose a new classification of Q-wave myocardial infarctions based on imaging correlations with advanced techniques such as contrast-enhanced cardiac magnetic resonance.
Part Two of the book covers the ECG in clinical practice. Each chapter focuses on a different clinical syndrome, describing the role of the ECG in a global approach to the diagnosis, prognosis and risk stratification of patients with acute and chronic ischemic heart disease and guiding clinical decision-making.
Extensively referenced and illustrated throughout, this book is highly recommended for any clinician involved inthe diagnosis and management of ischemic heart disease.

Wilson Disease: Pathogenesis, Molecular Mechanisms, Diagnosis, Treatment and Monitoring translates both clinical and experimental findings into a comprehensive approach for anyone involved in research and patient care. While the clinical variability of Wilson Disease poses a challenge from a diagnostic approach, the book uses the translational impact of new research findings to relate to new treatment concepts. Comprehensive chapters include common knowledge, guideline consensus statements, and discussions of clinical evidence. This is a must-have reference for researchers and clinicians in translational research.

Schock, Lungenversagen, Multiorganversagen: Bei zahlreichen intensivmedizinischen Krankheitsbildern sind extrakorporale organunterstutzende Verfahren lebensnotwendig. Oft handelt es sich um hochkomplexe Systeme, fur deren Implantation, Bedienung und UEberwachung ein fundiertes Fachwissen benoetigt wird. Wenn Sie sich dieses aneignen moechten, dann greifen Sie zu diesem Manual. Lernen Sie Schritt fur Schritt, beginnend mit Begriffserklarungen und der Nomenklatur, die verschiedenen Verfahren zur Herz-Kreislauf- und Lungenunterstutzung kennen: V-A ECMO, V-AV ECMO, V-V ECMO, ECCO2 R, periphere ventrikulare Assist Devices (PVADs) sowie extrakorporale Reanimation (eCPR). Die zahlreichen, exzellenten Abbildungen und UEbersichten, gepaart mit Inhalten, die sich auf das Wesentliche konzentrieren, erleichtern das Verstehen und Merken der komplexen Zusammenhange. Aus der Praxis fur die Praxis geschrieben - fur alle, die arztlich oder pflegerisch auf einer Intensivstation tatig sind.

Mittlerweile gibt es eine Vielzahl korperorientierter Verfahren, die Entspannung und Wohlbefinden versprechen. Der Band liefert dazu eine Ubersicht und zeigt auf, welche Verfahren wann therapeutisch eingesetzt werden konnen. Welche Auswirkung zum Beispiel Autogenes Training auf den Blutdruck hat, ob Atemtherapie bei Angstzustanden hilft oder wie Musiktherapie psychotherapeutisch eingesetzt werden kann, auf diese und andere Fragen liefern anerkannte Experten ausgearbeitete Antworten. Wissen, das Arzte an ihre Patienten weitergeben konnen."

Based on the Association of Anaesthetists of Great Britain & Ireland's (AAGBI) continuing education lecture series, this clinically-oriented book covers the latest developments in research and the clinical application of anesthesia and pain control. * Reviews latest developments in research and practice * Clinically-oriented but rooted in basic science * Concise and informative articles on key topics * Road-tested through CPD roadshows * Designed specifically for continuing medical education

Drei erfahrene Experten formulieren hier ein klar verstandliches Gesamt-Konzept fur das Unternehmen Arztpraxis. Dabei betonen sie die Wechselwirkungen und das sinnvolle Zusammenspiel aller Aspekte, die einen langfristigen Erfolg ermoglichen und begrunden: Betriebswirtschaft, Kooperationsformen, Steuer-, Vertragsarzt-, Arbeits- und Haftungsrecht, Marketing, Mitarbeiterfuhrung, Praxisorganisation und Altersvorsorge. So ist zum Beispiel die enge Verbindung von Praxis- und Privatbereich von existenzieller Bedeutung fur niedergelassene Arzte. Einsteiger wie Arzte, die bereits in eigener Praxis tatig sind, werden hier optimal informiert. "

A virtualist is a doctor who specializes in virtual medicine. She uses tools like VR headsets, spatial acoustics, haptic feedback, and even olfactory mimicry to induce reactions in patients' bodies that help treat a variety of physiological and psychological conditions, from chronic pain, to compulsive behavior, without the use of pharmaceuticals or surgical techniques. Virtualists don't exist yet, but after reading VRx they just might. In recent years, scientists have established that people's perceptions - their subjective experiences of the world - influence how their bodies work. We typically have little control over our perceptions, particularly when we are sick. But what could we do if we did? In VRx Brennan Spiegel introduces readers to a new kind of medicine, called virtual therapeutics, answering exactly this question, using technology that is already available. It works through two basic but powerful psychological concepts: embodied cognition, the idea that thought processes involve the whole body, not just the brain; and presence, the ability of virtual reality to trick your body into thinking it's somewhere that it isn't, or can do something that it can't usually do. VRx takes readers on a mindbending journey through the ways in which these deep connections between our minds and our bodies are being put to good use. We learn about the woman who endures an exceptionally painful labor by completing breathing exercises on a digital beach, the schizophrenic patient who literally confronts the demon inside his head, the burn victims who are able to manage their pain better after traversing snowy virtual landscapes, and the doctor who confronted his own fear of mortality by watching himself die. Brimming with extraordinary stories of the power of virtual therapeutics to treat both physical and psychological conditions, VRx offers nothing short of a completely new way of healing.

In addition to performing its prime function as a vehicle for scientific communications of varied colora- tions, Molecular and Cellular Biochemistry is again focusing on two subjects which it treats in depth. One of these is a book issue dealing with the transglutaminase reaction. The other is this issue that deals with induction and modulation of enzymes. This is a very broad subject that calls for broader coverage than could be included in one book issue. However, I have elected to include only certain contributions that serve as general examples of the principles involved. There are six articles on enzyme regulation in hepatocyte culture. These include arginase and argino-succi- nate synthetase, y-glutamyl transferase and plasminogen activitor. Other regulatory enzymes that are discussed are protein kinases, 2,3-bisphosphoglycerate synthetases, carbamoyl phosphate synthetase, heme oxygenase, cytochrome P-450, tyrosine hydroxylase, fatty acid synthetase, acetyl eoA carboxylase, among others. Also included is the regulation of several enzyme messengers RNAs. As in the past, subscribers to the journal will receive this double volume as a continuation of regular issues of the journal Molecular and Cellular Biochemistry. This double volume will also be available separately in the form of a book issue to interested readers through Martinus Nijhoff Publishers. v.A. Najjar Part I Molecular and Cellular Biochemistry 53;54,11-21 (1983). (c) 1983, Martinus 1\ ij hoff Publishers. Boston. Printed in The Netherlands.

Clinical practice guidelines were initially developed within the context of evidence-based medicine with the goal of putting medical research findings into practice. However, physicians do not always follow them, even when they seem to apply to the particular patient they have to treat. This phenomenon, known as clinical inertia, represents a significant obstacle to the efficiency of care and a major public health problem, the extent of which is demonstrated in this book. An analysis of its causes shows that it stems from a discrepancy between the objective, essentially statistical nature of evidence-based medicine on the one hand and the physician's own complex, subjective view (referred to here as "medical reason") on the other. This book proposes a critique of medical reason that may help to reconcile the principles of evidence-based medicine and individual practice. The author is a diabetologist and Professor of Endocrinology, Diabetology and Metabolic Diseases at Paris 13 University. He has authored several books, including one to be published by Springer (Philosophy and Medicine series) under the title: The Mental Mechanisms of Patient Adherence to Long Term Therapies, Mind and Care. , Diabetology and Metabolic Diseases at the Paris 13-University. He has also published Pourquoi Se soigne-t-on, Enquete sur la rationalite morale de l'observance (2007), Clinique de l'Observance, L'Exemple des diabetes (2006), and Une theorie du soin, Souci et amour face a la maladie (2010). An English adaptation of the first book is published by Springer (Philosophy and Medicine) under the title: The Mental Mechanisms of Patient Adherence to Long Term Therapies, Mind and Care.

Iron is one of the most frequently purchased over-the-counter supplements, second only to vitamin C and calcium. The danger is that, once absorbed, iron can only be excreted in minute amounts of less than one milligram a day (or by heavy blood loss), and excess iron collects in a person's vital organs, thus, setting the disease process under way. As organs literally rust away, patients can experience early death by heart attack, arthritis, liver, pancreatic and colon cancer, increased infections, cirrhosis, diabetes, neurological problems, loss of hearing, tinnitus, depression, impotence, and infertility. Scientists have now discovered a connection to iron impropriety and Alzheimer's, early onset Parkinson's, Huntington's, attention deficit disorder, and epilepsy. EXPOSING THE HIDDEN DANGERS OF IRON is an excellent introduction for medical professionals to the intricacies of iron in the various body systems. Containing a practical guide to diagnosis, it also includes such subjects as the treatment and management of iron-loading conditions, excellent reference charts, a large glossary of terms, additional resources, contact and treatment centers, and a complete bibliography. Cutting edge scientific findings are summarized, complete with endnotes and references, about the devastation of excess iron on the liver, pancreas, gallbladder, spleen, adrenals, kidneys, bone marrow, arteries, heart, pituitary, joints, lungs, hearing, skin, vision, and the brain.

Dementia is a brain disorder that seriously affects a person's ability to carry out daily activities. The most common form of dementia among older people is Alzheimer's disease (AD), which involves the parts of the brain that control thought, memory, and language. Age is the most important known risk factor for AD. The number of people with the disease doubles every 5 years beyond age 65. AD is a slow disease, starting with mild memory problems and ending with severe brain damage. The course the disease takes and how fast changes occur vary from person to person. On average, AD patients live from 8 to 10 years after they are diagnosed, though the disease can last for as many as 20 years. Current research is aimed at understanding why AD occurs and who is at greatest risk of developing it, improving the accuracy of diagnosis and the ability to identify those at risk, discovering, developing, and testing new treatments, and discovering treatments for behavioural problems in patients with AD. This new book gathers state-of-the-art research from leading scientists throughout the world which offers important information on understanding the underlying causes and discovering the most effective treatments for Alzheimer's Disease.

This issue of Medical Clinics of North America, guest edited by Dr. Lia Logio, is devoted to Common Symptoms in Outpatient Practice. Articles in this issue include: Evaluating and managing the patient with back pain, Update on Indigestion, Approach to the patient with a cough, Diagnosis and Management of Headaches, Current Approach to Constipation, Managing the Forgetful Patient: Best Practice for Cognitive Impairment, Evidence-based Approach to Palpitations, Solving the Problem of Insomnia: Current Practice, Approach to Knee Pain: Diagnosis and Treatment, Approach to Fatigue: Best Practice, Best Practices in the Management of Overweight and Obesity, Best Practice in Approaching Patients with Weight Loss, Common Complaints of the Hands and Feet, A Symptom-Directed Paradigm for the Evaluation and Management of Upper Respiratory Tract Infections, and more.

Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students.

This issue of Medical Clinics, guest edited by Dr. Robert A. Smith and Dr. Kevin Oeffinger, is devoted to Cancer Screening and Prevention. Articles in this important issue cover the development of cancer screening guidelines, implementing cancer screening in the clinical setting, and screening for colorectal, lung, cervical, prostate, skin, and ovarian cancer.

The Comprehensive Textbook of Healthcare Simulation is a cohesive, single-source reference on all aspects of simulation in medical education and evaluation. It covers the use of simulation in training in each specialty and is aimed at healthcare educators and administrators who are developing their own simulation centers or programs and professional organizations looking to incorporate the technology into their credentialing process. For those already involved in simulation, the book will serve as a state-of-the-art reference that helps them increase their knowledge base, expand their simulation program's capabilities, and attract new, additional target learners. Features: * Written and edited by pioneers and experts in healthcare simulation * Personal memoirs from simulation pioneers * Each medical specialty covered * Guidance on teaching in the simulated environment * Up-to-date information on current techniques and technologies * Tips from "insiders" on funding, development, accreditation, and marketing of simulation centers * Floor plans of simulation centers from across the United States * Comprehensive glossary of terminology

The role of reactive oxygen species and other free radicals in normal and disease processes has become a major area of interest in the medical scientific community. In the past 30 years, this area of study has advanced from outright rejection, to general acceptance, to intense study. While there is still some dispute as to the exact role of these highly reactive molecules in pathology, it is clear that they are present in and influence many biological processes. This book provides an overview of the possible biological effects of reactive oxygen species and other free radicals with an emphasis on pathology. The various types of free radicals that may affect the body are discussed along with the potential sources of free radicals, both internal and external to the body. The extensive defenses the body raises against the effects of these molecules in the form of enzymatic and non-enzymatic antioxidants is reviewed. A variety of conditions in which free radicals have been proposed to play a role are discussed. These include the physiological effects of oxygen stress in aging, exercise, and pregnancy. Pathologic conditions discussed include cancer, liver cirrhosis, respiratory problems, and others.

Now in full-colour, this eagerly-anticipated second edition continues to be the most comprehensive resource available on non-invasive ventilation (NIV), both in the hospital and at home. Reflecting a global perspective with expert contributors from more than 15 countries, the book: * provides clinical examples of NIV in practice with insightful vignettes * covers home- and intensive care-based ventilation * details NIV use in acute and chronic respiratory failure, plus paediatric and other specialty applications. Disease-specific sections provide best practice in the science, diagnostics and management of conditions such as COPD, cardiac failure, neuromuscular disease and obesity, while features such as 'Common Clinical Questions & Answers', abundant tables and illustrations, chapter summaries and new clinical vignettes showcase the realities of NIV in practice. This is essential reading for pulmonologists, critical care physicians and intensive care medicine specialists.

This issue of Child and Adolescent Psychiatric Clinics, guest edited by Drs Jessica Jeffrey, Eugene Grudnikoff, Barry Sarvet and Rajeev Krishna, will cover key topics of importance surrounding Measurement-Based Care in Child and Adolescent Psychiatry. This issue is one of four selected each year by our series Consulting Editor, Dr. Todd Peters. Topics discussed in this issue include but are not limited to: Evidence for the use of MBC in clinical practice; Validated Measures in Child Psychiatry and How to Use Them; Integrating MBC into Trainee Education; MBC In the Treatment of Depression; MBC in the Treatment of Anxiety; MBC in the Treatment of ADHD and disruptive behavior disorders; MBC in the Treatment of Substance Use Disorders; Implementing MBC in Various Practice Settings; Use of MBC Data to track Clinic Performance and Quality Outcomes; Use of MBC Data in Population Health Management; HIT resources to support MBC, among others.