This updated second edition of Molecular Typing in Bacterial Infections, presented in two volumes, covers both common and neglected bacterial pathogenic agents, highlighting the most effective methods for their identification and classification in the light of their specific epidemiology. New chapters have been included to add new species, as well as another view of how bacterial typing can be used. These books are valuable resources for the molecular typing of infectious disease agents encountered in both research and hospital clinical laboratory settings, as well as in culture collections and in the industry. Each of the 21 chapters provides an overview of specific molecular approaches to efficiently detect and type different bacterial pathogens. The chapters are grouped in five parts, covering respiratory and urogenital pathogens (Volume I), and gastrointestinal and healthcare-associated pathogens, as well as a new group of vector-borne and Biosafety level 3 pathogens including a description of typing methods used in the traditional microbiology laboratory in comparison to molecular methods of epidemiology (Volume II). Comprehensive and updated, Molecular Typing in Bacterial Infections provides state-of-the-art methods for accurate diagnosis and for the correct classification of different types which will prove to be critical in unravelling the transmission routes of human pathogens.

This volume represents a substantially revised and updated 2nd edition of a reference handbook on major structural components of soft connective tissues and a whole slew of heritable diseases of soft connective tissues. The number of clearly identifiable and distinct disorders has grown somewhat since the 1st edition in 2014, e.g., Ehlers-Danlos syndrome has now 13 entities. A brand new syndrome, Meester Loeys syndrome carrying the name of Bart Loeys was added as a companion to Loeys-Dietz syndrome. Numerous variations of cutis laxa and joint mobility disorders have been discovered taking advantage of recent advancements in genetic analysis. We have acquired better understanding of pathogenesis and biochemical changes in some other, more established entities, such as Marfan and collagen VI myopathies where better management and possible treatment are on the horizon. Even in the case of connective tissue diseases in domestic animals some progress has been made. All these updates were contributed by a group of distinguished and preeminent physicians and scientists, all of them not just working in the field but making new discoveries described by them. Readers will notice that seemingly there is an overlap among many of these disorders. And indeed, many of them, if not most are interconnected because of the prominent roles of TGF , of fibrillin microfibrils and collagen fibril assembly (and other molecules) playing in connective tissues physiology, and by extension in pathogenesis of many disorders described in the book. What I found particularly helpful that author(s) of each chapter bring their own perspective even when described closely related mechanism of the disease. These observations should help with diagnosis and management of such cases. The first chapters are more general, concentrating more on the physiology, structure and biochemistry of normal soft tissues. That should help in better understanding of the pathophysiology. Last but not least, the chapters are very readable, more like detective stories than dry description of genetic/biochemical defects. I do hope that basic scientists and clinicians with similar and diverse interests alike will appreciate this volume and will be inspired by it to develop their research in the field.

Endemic fluorosis is caused by excessive intake of fluorine in drinking water, air, food, tea and other media in a specific natural environment for a long time, which involves at least 25 countries, such as China, India, Vietnam, Iran, Egypt, Mexico, Argentina and influences more than 200 million of population. China and India are the countries with the most extensive endemic fluorosis and the most serious damages. There are three main intake sources of endemic fluorosis, e.g., drinking water, coal-burning pollution and drinking tea. Coal-burning type of endemic fluorosis was established in Guizhou Province of China in 1970's. The residents in the areas used indoor stoves with no flue to burn coals with high content of fluoride to bake grains in the autumn and heat in the winter. This results in excessive intake of fluorine and then leads chronic poisoning. It has been confirmed that 13 provinces of China with 34.3 million of population are influenced by this type of fluorosis with severe injuries to most organs of human body. The content of this book covers the epidemiology, pathological changes, molecular pathogenesis and clinical treatments of the disease. This book is a suitable reference for the researchers and graduate students in this field, which is helpful to improve the understanding of this disease and to take preventive measures.

Here are 101* of the best ideas to make the most effective use of your time on the ward. Over 250 contributors, including students, doctors, nurses, pharmacists, and therapists from 18 countries, help make you the finest doctor you can be

Pocket-sized for 'dipping into' during a spare moment or a couple of hours on the ward, this short guide is ideal for medical students on rotation or junior doctors who wish to boost learning and motivation.

*There are actually 100 ideas. Now it's your turn to develop tip 101 Submit your ideas to www.101things.org

Part of the highly popular and respected Pocket Notebook series,Pocket Primary Care, 3rd Edition, puts answers to common diagnostic questions in the outpatient setting at your fingertips in seconds. Dr. Curtis R. Chong and his team of expert contributors provide current evidence-based practices, accepted best practices, and real-world guidance on all major subspecialties, including appropriate workups and when to refer. This practical, high-yield reference mirrors the thought process of primary care clinicians in day-to-day practice, all in an easy-to-use, loose-leaf format that's ideal for physicians, students, residents, nurses, and PAs-anyone who sees patients in today's busy ambulatory settings. Contains fully updated information throughout, including the latest clinical guidelines and new therapeutic recommendations. Features bulleted lists, tables, diagrams, and algorithms that provide focused information on everything you need to know in order to make an accurate diagnosis and develop a treatment plan. Includes a new chapter on COVID-19. Covers all diseases and conditions commonly seen in the clinic or ambulatory setting, including topics such as routine screenings, health literacy, disease screening, psychiatry, women's health, men's health, and geriatrics. Provides references to landmark papers that help residents and students confidently answer questions during rounds.

This book assesses the most appropriate forms of aerosol therapy for critically ill patients. Aerosol therapy is applied for the treatment of several pulmonary diseases in addition to some promising applications intended for systemic absorption. Nowadays, aerosol delivery to clinically stable patients in the outpatient settings is done easily with a lot of focus on patient counseling and enhancement of lung deposition. A lot of guidelines are available for several diseases and it could offer adequate guidance to the therapists concerning escalation or de-escalation of therapy to enhance treatment efficiency and safety. However, in critically ill patients aerosol delivery is mostly done by the choice of the respiratory therapist only according to his knowledge. The book describes the type of patients requiring aerosol therapy, different aerosol generators available for the treatment of critically ill patients, mechanisms of aerosol lung deposition, and factors affecting aerosol deposition. It also discusses the special needs of neonates and infants, transitioning aerosol from hospital to home, and the methods of aerosol delivery to different patient e.g. nasal delivery patients, ventilated patients, etc. Moreover, it reviews methods of detecting such aerosol delivery to the lung. At the end, it discusses the suggested monitoring plans and weaning protocols to ensure high efficacy and safety of the ventilatory support in such patients. Given its scope, the book can serve as guidelines or specific recommendations to maximize clinical benefits of medicated aerosols in critically ill patients and it represents a valuable resource for intensivists, pulmonologists and healthcare professionals working at ICUs.

This is the second edition of the book originally published under the title Medical Emergencies Caused by Aquatic Animals: A Zoological and Clinical Guide. Including updated chapters, new content and additional references, it discusses follow-up with patients, describes diseases that are not emergencies and explains procedures that can take place at health stations and outpatient centers, focusing on clinical and biological aspects relevant to researchers and practitioners alike. The chapter on Invertebrate Aquatic Animals presents facts and advances that were left out of the first edition. In addition, it includes improved images. The subtopic on Cnidaria presents recent data on outbreaks and new species identification in unprecedented areas, with a timely discussion on first aid treatment. The chapter on Injuries by Vertebrate Aquatic Animals has been improved, based on continued work with bathers and fishermen. Featuring numerous images and representative clinical cases, it explores the most significant injuries caused by fish around the globe. The chapter on Ingestion of Aquatic Venomous Animals: Toxinology, Clinical Aspects, and Treatment discusses outbreaks of intoxication diseases from eating fish and seafood, drawing on reliable records of serial cases of Haff's syndrome, scombroidism and ciguatera. Further, it examines the indiscriminate consumption of aquatic animals, which the author argues present the same (or even greater) risks of poisoning and infections as terrestrial animals. Lastly, since there is a general lack of awareness of the risk of infections in aquatic environments, the chapter on Bacterial and Fungal Infections in Aquatic Environments describes the symptoms and treatments and highlights preventive measures.

This book highlights the nano-antioxidants and their potential therapeutic applications. The chapters start with basic information on free radicals and antioxidants, through natural antioxidants, mechanisms of their action, ending with the use of nano-antioxidants particularly its potential therapeutic applications. Nano-antioxidant therapy has a promising future that has to be explored. It is a bridge topic to connect the already existing literature with potential therapeutic highlights. This book is designated for students and researchers interested in Biochemistry, Chemistry, Physics, Food Science and nutrition, Pharmaceutical Science and Medicine. It would also be interesting to global audiences from human and animal nutrition to food preservation and packaging.

Prepare for success in today's fast-paced, collaborative healthcare environment! Offering expert perspectives from a variety of primary care and nurse practitioners, Primary Care: A Collaborative Practice, 5th Edition helps you diagnose, treat, and manage hundreds of adult disorders. Care recommendations indicate when to consult with physicians or specialists, and when to refer patients to an emergency facility. This edition includes six new chapters, a fresh new design, the latest evidence-based guidelines, and a new emphasis on clinical reasoning. Combining academic and clinical expertise, an author team led by Terry Mahan Buttaro shows NPs how to provide effective, truly interdisciplinary health care. UNIQUE! A collaborative perspective promotes seamless continuity of care, with chapters written by NPs, physicians, PAs, and other primary care providers. Comprehensive, evidence-based content covers every major disorder of adults seen in the outpatient office setting, reflects today's best practices, and includes the knowledge you need for the NP/DNP level of practice. A consistent format in each chapter is used to describe disorders, facilitating easier learning and quick clinical reference. Diagnostics and Differential Diagnosis boxes provide a quick reference for diagnosing disorders and making care management decisions. Complementary and alternative therapies are addressed where supported by solid research evidence. Referral icons highlight situations calling for specialist referral or emergency referral. NEW chapters cover topics including transitional care, risk management, LGBTQ patient care, bullous pemphigoid, pulmonary embolism, and dysphagia. NEW! An emphasis on clinical reasoning helps you develop skills in diagnosis and treatment, with coverage moving away from pathophysiology and toward diagnostic reasoning and disease management - including pharmacologic management. NEW focus on interdisciplinary care underscores the importance of interprofessional education and practice, and includes Interdisciplinary Management features. UPDATED chapters reflect the latest literature and evidence-based treatment guidelines, including new content on the Affordable Care Act as well as new coverage of patient satisfaction metrics, quality metrics, value-based purchasing, pharmacogenetics/genomics, and teen pregnancy and abnormal pregnancy. NEW quick-reference features make it easier to locate important information, through colorful section tabs, bulleted summaries, additional algorithms, a more logical table of contents, an Index to Standardized Treatment Guidelines, and a Reference to Common Laboratory Values.

Getting involved in medical and biomedical research through necessity or personal choice can be a testing experience. Each step of the process throws up its own challenges, from liaising with supervisors, to the lack of opportunities to promote completed research. This brand new How to provides a complete guide to the process: from the planning stages, to execution, write-up, preparation for the viva examination, and how to maximise the impact of your research. It ensures you get the most out of the experience, both in terms of personal development and academic achievement, and even provides guidance on what to do when things don't quite go to plan. An ideal companion, written by an experienced postgraduate tutor, this concise and user-friendly manual is full of practical exercises, key points, and hints and tips, which will give you the edge when dealing with the more elusive realities of medical and healthcare research.

The continued high mortality (up to 70 %) in patients with necro- tizing pancreatitis and diffuse peritonitis has led to the develop- ment of various surgical strategies within the past few decades. Up to the present decisions about the management of these disea- ses have been rather difficult because of the individual courses differ considerably, even being incomparable. Today, as a result of our in creased knowledge of the pathophysiology, the impro- ved imaging procedures, and the standaridized intensive care, the rend is moving toward delayed surgical intervention. The goals in the surgical treatment of necrotizing pancreatitis and diffuse peritonitis are still surgical removal of the focus of infection, elimination of endotoxins by lavage, and optimal drainage of the peritoneal cavity. Depending on the patient's general condition this cannot always be achieved in the first surgi- cal intervention. A number of surgical methods have therefore been developed, such as postoperative dorsoventral lavage, step- by-step lavage therapy, postoperative closed continuous perito- neal lavage, and open treatment (laparostomy). The last-mentioned method ist not new; it was first described by KOR'J;E in 1894 for the treatment of necrotizing pancreatitis. However, due to the progress in intensive care medicine (long- term respiratory therapy, hemofiltration, etc.) in the last few years this method of management has become successful and gai- ned in recognition.

This volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today. Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication. Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems. This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology.

This 2006 book is a how-to guide for medical students moving from the classroom to the clinical/hospital setting; a particularly stressful transition in a student-physician's career. This handbook is made up of short, easily digestible passages that advise students on everything from reading an EKG or chest x-ray to tips on dealing with difficult residents and what to wear on wards. Passages are peppered with light-hearted anecdotes to bolster the spirits of students intimidated and overwhelmed by their responsibility as fledgling doctors. The handbook has been developed by Dr Richard Loftus, who wrote the first version of this guide after his 3rd year at University of California, San Francisco (UCSF). It contains appendices of useful information, including a PDF file of full size forms that can be accessed from our website.

A considerable number of journal publications using a range of qualitative synthesis approaches has been published. Mary Dixon-Woods and colleagues (Mary Dixon-Woods, Booth, & Sutton, 2007) identified 42 qualitative evidence synthesis papers published in health care literature between 1990 and 2004. An ongoing update by Hannes and Macaitis (2010)identified around 100 additional qualitative or mixed methods syntheses. Yet these generally lack a clear, detailed description of what was done and why (Greenhalgh et al, 2007; McInnes & Wimpenny, 2008). Choices are most commonly influenced by what others have successfully used in the past or by a particular school of thought (Atkins et al, 2008; Britten et al, 2002). This is a substantive limitation. This book brings balance to the options available to researchers, including approaches that have not had a substantial uptake among researchers. It provides arguments for when and why researchers or other parties of interest should opt for a certain approach to synthesis, which challenges they might face in adopting it and what the potential strengths and weaknesses are compared with other approaches. This book acts as a resource for readers who would otherwise have to piece together the methodology from a range of journal articles. In addition, it should stimulate further development and documentation of synthesis methodology in a field that is characterized by diversity.

This is an admirably concise and clear guide to fundamental concepts in physiology relevant to clinical practice. It covers all the body systems in an accessible style of presentation. Bulleted checklists and boxed information provide an easy overview and summary of the essentials. By concentrating on the core knowledge of physiology, it will serve as a useful revision aid for all doctors striving to achieve postgraduate qualification, and for anyone needing to refresh their knowledge base in the key elements of clinical physiology. The author's own experience as an examiner at all levels has been distilled here for the benefit of postgraduate trainees and medical and nursing students.

Selected as a Doody's Core Title for 2022! Concise, portable, and user-friendly, The Washington Manual (TM) Infectious Diseases Subspecialty Consult, Third Edition, provides essential information needed to evaluate patients on a subspecialty consult service. This edition offers state-of-the-art content on the diagnosis, investigation, and treatment of a wide variety of infectious diseases, including coverage of new and emerging pathogens, rapid molecular diagnostics for infectious diseases, and new therapeutic and preventive strategies. Ideal for trainees and practicing physicians who need quick access to current scientific and clinical information in this rapidly changing area, the manual is also useful as a first-line resource for internists and other primary care providers. Content has been thoroughly revised from cover to cover, including two new chapters: Antimicrobial Stewardship and Arboviruses and Hemorrhagic Fevers. A highly templated, bulleted format ensures you can find what you need quickly and easily. Comprehensive coverage includes fever of unknown origin, sexually transmitted infections, opportunistic infections associated with HIV, zoonotic and tickborne infections, protozoal infections, infection prevention, and much more. Text has been organized by organ system to facilitate generating a useful differential diagnosis based on a patient's presentation. Written by faculty and fellows from the Infectious Diseases Division of Internal Medicine at the Washington University School of Medicine in St. Louis. Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech.

This pocket introduction for first year clinical students starting clinical training on the ward provides basic information about how to talk to patients, take a medical history and how to start a clinical examination. The result of many years of clinical teaching experience at the University of Cambridge, this second edition is clearly thought out. With those first clinical encounters in mind, the text has been simplified to allow easy distinction of basic essential information from more detailed discussion. New clinical terms and issues have been included and the text further enlivened by clear line illustrations.

People with somatoform disorder (which used to be known as hysteria) present with a range of symptoms that typically last for years and can't be traced to a specific physical cause. Such symptoms may include frequent headaches; back pain; abdominal cramping and pelvic pain; pain in the joints, legs and arms; chest or abdominal pain, and gastrointestinal problems. This book is an in-depth, clinically orientated review of the somatoform disorders and related clinical presentations (such as chronic fatigue syndrome) and how they present in a medico-legal setting. It is aimed at both clinicians and lawyers who deal with injury claims where these disorders impact much more frequently than is generally recognised.

Implementing safety practices in healthcare saves lives and improves the quality of care: it is therefore vital to apply good clinical practices, such as the WHO surgical checklist, to adopt the most appropriate measures for the prevention of assistance-related risks, and to identify the potential ones using tools such as reporting & learning systems. The culture of safety in the care environment and of human factors influencing it should be developed from the beginning of medical studies and in the first years of professional practice, in order to have the maximum impact on clinicians' and nurses' behavior. Medical errors tend to vary with the level of proficiency and experience, and this must be taken into account in adverse events prevention. Human factors assume a decisive importance in resilient organizations, and an understanding of risk control and containment is fundamental for all medical and surgical specialties. This open access book offers recommendations and examples of how to improve patient safety by changing practices, introducing organizational and technological innovations, and creating effective, patient-centered, timely, efficient, and equitable care systems, in order to spread the quality and patient safety culture among the new generation of healthcare professionals, and is intended for residents and young professionals in different clinical specialties.

The fifth edition of Lachman's Case Studies in Anatomy is a thoroughly revised edition of a popular collection of 50 anatomical cases. Each chapter starts with a clinical case presentation, followed by diagnosis and therapy and then an extensive discussion of the anatomy that is relevant to the case. The patient presentations provide the history and physical examination findings in a format consistent with that which the student will utilize in clinical training. Diagnostic and therapeutic procedures that are discussed have been brought up-to-date and are consistent with current medical practice. Cases represent clinical encounters required in clerkship curricula. This should allow students to draw from this book throughout their four years in medical school. The scope of the book has been expanded to include embryological development by including three new cases of developmental abnormalities. Many new figures and have included many diagnostic images including radiographs, CT scans, MRIs and ultrasounds. To help the reader feel confident that the major anatomical points have been mastered, review questions and answers have been added at the end of each unit.

Angesichts des harten Wettbewerbs wird in Zukunft voraussichtlich ein Drittel aller Krankenhauser schlieen mussen. Allein verstarkte marktwirtschaftliche Optimierung - inklusive des dazugehorigen Marketings - sichert Krankenhausern das Uberleben. Das Buch gibt Antworten auf Fragen wie: Welche Bedurfnisse haben die verschiedenen Anspruchsgruppen? Welche zusatzlichen Leistungen konnen angeboten werden? Leser finden das Handwerkszeug fur die Realisierung einer gelungenen Marktprasenz - von der Analyse, uber die Konzeption bis zur Umsetzung.

This book provides an overview of multiple facets of ageing and its evolving dynamics in various Indian states. It elaborates on key dimensions like health, dependence and disability, as well as living arrangements for the elderly. Drawing on information from National Sample Surveys to offer readers a broader and richer understanding of the evolving demographic reality in India, the book addresses a range of detailed policies and programmes for the elderly in India. Given its scope, the book is essential reading for students and researchers in the fields of sociology, demography, economics and development studies. It also offers a valuable reference guide for anyone engaged in planning and policy formulation for social security, welfare of the aged or mainstreaming ageing concerns.

Excel on your rotation, impress on the wards, and score your highest on the Neurology shelf exam! First Aid for the Neurology Clerkship covers all the key principles and clinically relevant information that neurology clerks are expected to learn. The content organization is mirrored directly after standard clerkship objectives and the Neurology shelf exam blueprint. This high-yield resource focuses on clinical scenarios, with details explaining how to understand the disease process and differentiate it from other disorders. The pharmacology content emphasizes medications specifically targeting neurologic diagnoses, as well as recreational drugs. First Aid for the Neurology Clerkship features: The latest clinical research and perspectives Images, diagrams, and charts Tips on how to succeed on rotations and on the shelf exam Mnemonics, ward tips, and integrated mini-cases Summary boxes highlighting high-yield information needed for exam success

How do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: state-dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted. While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows. This is the eighth volume in the Masterclass in Neuroendocrinology series* - now a co-publication between Springer Nature and the INF (International Neuroendocrine Federation). *Volumes 1-7 published by Wiley