This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in liver, lung and heart regeneration. All chapters are contributed by pre-eminent scientists in the field and covers such topics as cell therapy in the treatment of cirrhosis and other liver, heart and lung diseases, characteristics of hepatic progenitor cells, future directions of the discussed therapies and much more. Liver, Lung and Heart Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

This updated volume explores a wide variety of clinical applications of PCR such as detecting DNA methylation, detection of viruses and protozoa in infectious diseases, estimation of gene copy number aberrations, primer extension coupled with mass spectroscopy, and high throughput NGS techniques. The application of PCR has shown incredible value in the study of genomics and transcriptomics, not only for discovery but also for routine clinical applications, and it forms the cornerstone of personalized medicine. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, Clinical Applications of PCR, Third Edition serves as an ideal guide for researchers aiming to understand the principles behind each application and for their implementation in the laboratory.

Das Buch versammelt die Ergebnisse des ersten internationalen Lehrgangs "Klinisches Risikomanagement". Klinisches Risikomanagement ist ein nicht mehr weg zu denkender Bestandteil der Ablaufe im Krankenhaus. Litigationen und Haftpflichtfalle im Zusammenhang mit Schadensfallen bei der Behandlung von Patienten steigen kontinuierlich an. Doch nicht nur Risiken in einem immer rascher werdenden Behandlungsprozess selbst sind ein Problem, auch andere, teilweise durch externe Einflusse verursachte Risiken fur die Gesundheitsversorgung existieren. Die mittel- und langfristige Verfugbarkeit und Bindung von Mitarbeitern in einer uberalterten Gesellschaft, und auch der Umgang mit Katastrophen, oder wie in jungster Zeit gesehen auch Cyberattacken stellen grosse Probleme fur die Gesundheitsversorgung dar. Als gemeinsames Projekt von Krankenhausern in Slowenien, Steiermark und Karnten gestartet, geben die Beitrage einen umfassenden Einblick in verschiedenste praktische Anwendungsgebiete des klinischen Risikomanagements.

Integrated Care in Psychiatry: Redefining the Role of Mental Health Professionals in the Medical Setting is a landmark title in the field, offering a clear, detailed, and cohesive call by leading experts for coordinated care for patients with concurrent psychiatric and medical conditions. The renowned editors and authors argue that what is slowly occurring, and greatly needed at a faster pace, is nothing less than a sea change in the way that psychiatric care will be delivered. The current, mostly segregated, medical and psychiatric model of care has led to the development of competing medical and psychiatric subcultures that have resulted in a lack of dialog among health providers, administrators, and payers - and thus in less than optimal patient outcomes. To remedy this problem, the book offers a practical, insightful road map to achieving the central tenet of health reform - truly coordinated, patient-centered care where the care experience for the patient, the medical care itself, and the cost outcomes improve as the system changes from fee-for-service to population-based health. An invaluable reference for all clinicians, policy makers, payers, administrators, and others interested in the debate surrounding healthcare systems, Integrated Care in Psychiatry: Redefining the Role of Mental Health Professionals in the Medical Setting is a major contribution to the literature and a gold standard resource.

Diagnosing and managing type 2 diabetes presents an enormous challenge to the primary care provider confronted with multiple emerging scientific insights, therapeutic strategies and risk reduction principles. In Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome: The Primary Care Guide to Diagnosis and Management, Second Edition, Ronald A. Codario, M.D., FACP -- a well-known and highly respected authority on diabetes -- details the state-of-the-art in diagnosing, managing and attenuating risks in patients with this disease. Utilizing his extensive experience in private practice, medical education and clinical research for over 35 years, Dr. Codario explains in simple clinical terms, the current understanding of the pathophysiology of diabetes, the latest clinical trials, developing controversies, updates on new medications and an expanded section on Special Populations. With his unique, multiple board certifications in clinical hypertension, vascular medicine, internal medicine, vascular ultrasound and clinical lipidology, Dr. Codario provides practical guidelines for treatment with insulin and oral agents, lipid and hypertension control and comprehensive risk reduction strategies. Extensively reviewed are the metabolic syndrome, the role of exercise and nutrition, and key issues associated with herb and nutriceutical use. Illustrative case studies in diabetes management, an outstanding bibliography of suggested readings, and extensive chapter subheadings for quick reference make this book a practical, easy-to-read guide for dealing with this killer disease. Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome: The Primary Care Guide to Diagnosis and Management, Second Edition is the direct result of many years of listening, teaching, lecturing and empathizing with fellow primary care providers and their patients in the ongoing fight against diabetes. Like the internationally acclaimed first edition, this is a must read and invaluable guide for all primary care providers, students, caregivers and patients battling the ravages of this ever increasing epidemic.

Histopathologists all over the world have to report cytopathology during the course of their work and it is then that they find themselves facing diagnostic dilemmas. This practical, well-illustrated book, explicitly dedicated to this readership will serve their needs and meets their requirements in daily practice.

Handbook of Food Fortification and Health: From Concepts to Public Health Applications Volume 2 represents a multidisciplinary approach to food fortification. This book aims to disseminate important material pertaining to the fortification of foods from strategic initiatives to public health applications. Optimal nutritional intake is an essential component of health and wellbeing. Unfortunately situations arise on a local or national scale when nutrient supply or intake is deemed to be suboptimal. As a consequence, ill health occurs affecting individual organs or causing premature death. In terms of public health, malnutrition due to micronutrient deficiency can be quite profound imposing economic and social burdens on individuals and whole communities. This comprehensive text examines the broad spectrum of food fortification in all its manifestations. Coverage includes sections on definitions of fortifications, fortified foods, beverages and nutrients, fortifications with micronutrients, biofortification, impact on individuals, public health concepts and issues, and selective methods and food chemistry. Handbook of Food Fortification and Health: From Concepts to Public Health Applications Volume 2 is an indispensable text designed for nutritionists, dietitians, clinicians and health related professionals.

Since their first application in 1982, Totally Implantable Venous Access Devices (TIVADs) have become increasingly important in the clinical practice, as more intensive chemotherapy and parenteral treatments have come into use. At this time, there is objective evidence that TIVADs are a safe, effective strategy for long-term venous access; they play a significant role throughout the management of the oncology patient, as they are needed in the initial phases for active treatments as well as in the last stages for palliative measures, making possible repeated administration of chemotherapeutic vesicant agents, nutrients, antibiotics, analgesics, and blood products. According to a number of prospective studies, use of TIVADs is associated with a significant complication rate (10% to 25% of all patients). Evidence-based data support that most complications are directly related to inappropriate technique of placement and/or nursing care, sometimes leading to TIVAD loss, significant morbidity, increased duration of hospitalization, and additional medical cost. A group of world-renowned experts - both in the clinical and research fields - contributed to this volume, whose aim is to provide clinicians, nurses and medical students with a multidisciplinary, full update on these devices, as long term central venous access can no be longer considered a routine matter, and serious complications can be maintained at a very low level only if strict adherence to a well-defined protocol of surgical technique and of catheter care is maintained.

The science and applied approaches of enzyme inhibition in drug discovery and development

Offering a unique approach that includes both the pharmacologic and pharmaco-kinetic aspects of enzyme inhibition, "Enzyme Inhibition in Drug Discovery and Development" examines the scientific concepts and experimental approaches related to enzyme inhibition as applied in drug discovery and drug development.

With chapters written by over fifty leading experts in their fields, "Enzyme Inhibition in Drug Discovery and Development" fosters a cross-fertilization of pharmacology, drug metabolism, pharmacokinetics, and toxicology by understanding the "good" inhibitions--desirable pharmacological effects--and "bad" inhibitions--drug-drug interactions and toxicity. The book discusses:

The drug discovery process, including drug discovery strategy, medicinal chemistry, analytical chemistry, drug metabolism, pharmacokinetics, and safety biomarker assessment

The manipulations of drug metabolizing enzymes and transporters as well as the negative consequences, such as drug-drug interactions

The inhibition of several major drug target pathways, such as the GPCR pathway, the NFkB pathway, and the ion channel pathway

Through this focused, single-source reference on the fundamentals of drug discovery and development, researchers in drug metabolism and pharmacokinetics (DMPK) will learn and appreciate target biology in drug discovery; discovery biologists and medicinal chemists will also broaden their understanding of DMPK.

Combine a working knowledge of epidemiology to your health and medical skills Every day, health promotion and disease prevention professionals interact with epidemiologists during the course of their practices. Investigations into the causes, distribution, and control of disease provide practitioners in the public and allied health fields with findings essential to dealing with patients and clients. This ongoing collaboration makes the need for communication through a common body of knowledge a matter of life--and death. Epidemiology for Health Promotion and Disease Prevention Professionals presents you and your students with practical applications that incorporate up-to-date epidemiological findings into health promotion and disease prevention concepts. The book establishes an operational understanding not only for students in the public health, nursing, medicine, and environmental health fields, but also for future and current health and patient educators, fitness and exercise science specialists, and athletic and personal trainers. This comprehensive textbook includes a step-by-step guide to the epidemiological process, including surveillance and investigation, how studies and trials are conducted (and categorized), and how findings are used to plan, implement, and evaluate health promotion and disease prevention programs. Epidemiology for Health Promotion and Disease Prevention Professionals includes: problem-solving strategies for investigations and studies links to supplemental Web sites chapter-ending knowledge tests that target health improvement and disease prevention Epidemiology for Health Promotion and Disease Prevention Professionals provides students in the health, medical, and fitness fields with the working knowledge of epidemiology they will need as professionals and provides professionals with an understanding essential to their practices.

Das vorliegende Buch entstand im Nachgang zur 1. LAGO-Tagung (Landesarbeitsgemeinschaft Onkologische Versorgung Land Brandenburg e. V.), Onkologie im Land Brandenburg (Febr. 2000). Dieser Tagungsband soll dazu dienen, zentrale Aspekte aus dem Bereich der letzten Lebensphase krebskranker Menschen anzusprechen. Hierbei spielen die medizinische Behandlung und die pflegerische Betreuung eine ebenso groAe Rolle wie die psychosoziale Betreuung der Betroffenen und auch ihrer AngehArigen. Es geht um den menschlichen Umgang mit einer tAdlichen Krankheit, um LebensqualitAt und MenschenwA1/4rde. Das Buch beinhaltet Themen wie "Medizin und Sterben," die "Pflege von Sterbenden" sowie die "Bedeutung der Kommunikation im Betreuungsteam und mit Sterbenden." Weiterhin stehen VortrAge zur "Netzwerkarbeit" im Zentrum, die sich mit dem Sterben und dem Tod von Menschen beschAftigt, die eigentlich erst am Anfang ihres Lebens stehen - von Kindern. Ferner werden Aspekte der Trauerarbeit und TrauerbewAltigung aufgezeigt. Die Auseinandersetzung mit diesem Thema und der Austausch von Erfahrungen sollen dazu beitragen, die Belange von betroffenen Patienten und deren AngehArigen zu verdeutlichen und weiterhin zu verbessern sowie das Wissen um die letzte Lebensphase eines jeden Menschen zu vertiefen.

Targeting the practical needs of clinical teachers who do not have extensive time to undergo additional training, this book provides an accessible, on-the-spot resource to bolster teaching skills and optimize the education of trainees. A massive transformation takes place every summer in the United States: thousands of trainees in graduate medical education are appointed as attending physicians responsible for effectively teaching the next generation of medical students and residents. This handbook includes only the most relevant topics for new clinical teachers, and covers the basics of clinical teaching, teaching in specific situations, teaching different audiences, and best practices for handling challenging situations. The format is conducive to "just in time" learning, perfect for quick reference before meeting with learners or engaging in specific teaching situations, such as in an ambulatory clinic or at the bedside. Key points are emphasized with frequent use of tables and boxed practical content. Applicable to all teaching attendings regardless of specialty, the Handbook of Clinical Teaching is a valuable aid for individuals who wish to improve their teaching, and serves as a practical guide for faculty development in clinical teaching.

This textbook is an essential revision aid for trainees preparing for Membership of the Royal College of Physicians (MRCP) examinations. Divided into 30 sections, the book begins with discussion on common symptoms and presentations, then emergency presentations. The following sections provide in depth coverage of the diagnosis and management of diseases and disorders in different body systems. The text concludes with chapters on geriatric medicine, genetics, epidemiology, clinical pharmacology, and ECG Interpretation. Treatment protocols are current and inline with the latest international guidelines. Each chapter is highly illustrated with images and figures, as well as teaching notes and easy-to-memorise lists to assist revision. Topics frequently encountered in examinations and key points are also highlighted. Key points Practical revision aid for trainees preparing for MRCP examinations Treatment protocols inline with current international guidelines Chapters highly illustrated with images and figures, and teaching notes to assist revision Highlights topics frequently encountered in examinations

This very important work laid the foundation for my subsequent dissertation and for my research work and publications on colorectal cancer. For the first time, several authors systematically summarized one disease exclusively as to its origins, pathology, diagnostics and therapy. This novel concept made a lasting impression on me in my scientific work. Manfred Georg Krukemeyer, MD, Department of Surgical Research, Westphalian Wilhelm University, Munster"

Administrators and faculty in medical, nursing and health science programs are witnessing a substantial increase in the number of students with disabilities entering their programs. Concurrently, the benefits of diversity in healthcare are becoming increasingly apparent and important. Provider-patient concordance is a known mechanism for reducing health care disparities. By developing a workforce that mirrors the patient population, we can appropriately inform disability care, reducing health care disparities while embracing the tenets of the Americans With Disabilities Act (ADA), namely equal opportunity, full participation, independent living, and economic self-sufficiency for qualified individuals with disabilities. One in five individuals will experience disability at some point in their lives, making this the largest minority in the US. A commitment to disability inclusion for qualified students should be a high-level goal of nursing, medical, and other health science programs. To support this goal, leaders in these areas must develop robust programs and an understanding of the best practices for inclusion. This first-of-its-kind title is designed to help deans, program directors, faculty, student affairs personnel and disability resource professionals thoughtfully plan for the growing population of health-care professionals with disabilities. The content helps stakeholders contextualize disability inclusion in health-care education as a function of social justice and a mechanism of reducing health care disparities for patients. It offers pragmatic advice, grounded in research, best practice, and case law to address the highly nuanced approach to determining and implementing accommodations in a high-stakes clinical environment. Disability as Diversity connects the moving parts necessary to ensure equal access for qualified students and provides a blueprint for crafting policy, proactive messaging, improving climate, adhering to accreditation standards, addressing licensing and board exams, responding to student failure, all while remaining compliant with the Americans with Disabilities Act (ADA), and applicable Federal regulations. This text provides educators with the perspectives and skills they need to bring disability inclusion to the forefront of health education.

Patients with chronic pain present a unique set of challenges to the primary care clinician. In Chronic Pain: A Primary Care Guide to Practical Management, Second Edition, leading pain specialist Dawn A. Marcus, MD, again offers practical, clear, and succinct evidence-based approaches to the diagnosis and treatment of the myriad painful conditions clinicians see in their offices every day, such as headache, back pain, arthritis, fibromyalgia, and abdominal pain. Sections addressing pain management in children, pregnant women, and seniors are also included. This new edition is designed to provide a pragmatic approach to assessing and treating the complex issues and characteristics of chronic pain patients. New chapters expand upon the evidence-based recommendations and practical office tools previously provided, with the addition of new chapters addressing risk management; pain syndromes in the shoulder, upper extremity, and lower extremity; and cancer and end-of-life pain. Chronic Pain: A Primary Care Guide to Practical Management, Second Edition provides strategies and techniques that are designed to improve the confidence with which the primary care physician can approach patients with complex pain complaints, reduce staff stress, and improve patient success.