This is the first comprehensive volume to be published on the subject of electrical trauma in humans. Many of the world's leading experts describe the basic mechanisms of tissue injury in victims of electrical trauma, the complex and varied manifestations of electrical trauma, and state-of-the-art clinical treatment protocols. Promising new therapies still in the research stage are also discussed and assessed. The volume describes the basic physiochemical mechanisms responsible for tissue damage and explains the complex and variable ways in which electrical trauma manifests itself. An understanding of these underlying processes provides the basis for a rational and consistent approach to treatment which is highlighted in this volume. Electrical Trauma serves as a new and important source of information from a variety of perspectives that contributes to the understanding of the electrical injury problem. It is suitable for clinicians in plastic surgery, intensive care and burn units and for those with an academic and research interest in the mechanisms and causes of electrical trauma.

It is thirty years since the technique of high-yield preparation of isolated hepatocytes, by collagenase perfusion of the liver, was published. The original method described by Berry and Friend has undergone many minor modifications by other workers, and the two-step procedure introduced by Seglen in 1976 has become the most frequent way to prepare hepatocyte suspensions. An important development introduced by Bissell in 1973 was the use of the cells as the first step in monolayer culture. The availability of the isolated hepatocyte preparation as cells in suspension or culture has undoubtedly facilitated research on the liver. This was emphasised in our book, published (with Dr. Greg Barritt) in 1990, which described in detail methods of preparation and the properties of the isolated hepatocytes. It also discussed the usefulness of the preparation for the study of intermediary and xenobiotic metabolism, calcium ion transport, and the growth and differentiation of hepatocytes in culture. The book also touched briefly on a range of specialised techniques, including peri fusion, subcellular fractionation, transplantation, cryopreservation and measurement of intracellular pH. Although standard procedures for the manipulation of hepatocytes have not changed a great deal in ten years, they have undoubtedly been refined. This applies particularly to hepatocyte culture techniques, cryopreservation, and even to preparation of hepatocyte suspensions, where it is now feasible to use purified enzymes. There is also much more emphasis on the use and study of human hepatocytes, particularly in the field of pharmacology and therapeutics.

Molecular farming has been hailed as the "third wave" of genetically-modified organisms produced through biotechnology for the bio-based economy of the future. Unlike products of the first wave, such as herbicide resistant crop plants, which were perceived to benefit only the farmers who used them and the agrochemical companies who developed them, products of molecular farming are designed specifically for the benefit of the consumer. Such products could be purified from food or non-food organisms for a range of applications in industry, as well as animal and human health. Alternatively, the products of this technology could be consumed more directly in some edible format, such as milk, eggs, fruits or vegetables. There is a rapidly-growing interest Qn the part of the public as well as in the medical community in the role food plays in health, especially in the immunophysiological impact of food over and above the role of basic nutrition.

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Thyroid Disease: A Case-Based and Practical Guide for Primary Care, by Dr. Emanuel Brams, is a supremely readable cased-based approach to understanding the myriad of disorders that encompass thyroid disease. Using cases derived from his busy practice, Dr. Brams gives us the history and physical examination details of each case, along with test results. Then, through a series of questions similar to that which any good clinician asks while caring for a patient, Dr. Brams explains an optimal approach to diagnosis, treatment, and follow-up of thyroid disease, with an emphasis on the practical and common issues that primary care physicians see in their offices. This is an important book for primary care physicians because thyroid disease is common in the population we take care of and accounts for 3-5% of primary care visits. It is often cited as an area that primary care phy- cians find confusing. Dr. Brams clarifies thyroid disease and, through his generous sharing of cases, allows us to join him in making clear diagnoses as well as share in the ambiguity and decisions about approach when the diagnoses and course of treatment are not clear. In this way, the book is honest, and deals directly with the issues of thyroid disease as they are seen by us as physicians, not as we sometimes may wish they were seen if patients presented with the clarity of walking textbooks. Dr.

Asian Americans are the fastest growing minority group in the United States. When Asian immigrants arrive in the United States, they regularly encounter a vast number of difficulties integrating themselves into their new culture. In Handbook of Mental Health and Acculturation in Asian American Families, distinguished researchers and clinicians discuss the process of acculturation for individuals and their families, addressing the mental health needs of Asian Americans and thoroughly examining the acculturative process, its common stressors, and characteristics associated with resiliency. This first-of-its-kind, multi-dimensional title synthesizes current acculturation research, while presenting those concepts within a clinical framework. In addition to providing an in-depth look at both past and present research and offering directions for future topics to explore, the book also offers a range of practical tools such as research scales to measure levels of acculturation, interview techniques, and clinical approaches for special populations including children, the elderly, and their families. Thought-provoking and informative, Handbook of Mental Health and Acculturation in Asian American Families will enhance the understanding of the clinical and sociocultural problems Asian Americans face, providing clinicians with all the necessary insights to better care for their patients.

Books such as this one are deceptively difficult to create. The general subject is neither happy, nor easy, nor most anyone's idea of fun. M- practice litigation, however, has become a central fact of existence in the practice of medicine today. This tsunami of lawsuits has led to a high volume of irreconcilable rhetoric and ultimately threatens the stability of the entire health care system. Our goal has been to provide a source of reliable information on a subject of importance to all who provide me- cal care in the United States. The book is divided into four sections. Part I gives an overview of insurance in general and discusses the organization of professional - ability insurance companies in particular. Part II focuses on the litigation process itself with views from the defense and plaintiff bar, and the physician as both expert and defendant. Part III looks at malpractice litigation from the viewpoint of the practicing physician. Some of the chapters are broadly relevant to all doctors-the rise of e-medicine, and the importance of effective communication, for example. The other ch- ters are constructed around individual medical specialties, but discuss issues that are of potential interest to all. Part IV looks ahead. "The Case for Legal Reform" presents changes in medical-legal jurisprudence that can be of immediate benefit. The final two chapters take a broader perspective on aspects of our entire health care system and its interface with law and public policy.

In the modern practice of medicine, new challenges complicate the ethical care of patients. Today's times require a contemporary take on the concept of medical ethics. The idea for this textbook was born out of a need for a teaching resource that merges medical ethics theory with the practical needs of modern clinical medicine. In Evidence-Based Medical Ethics: Cases for Practice-Based Learning, the authors address what has been missing in existing text books and ethics courses to date - clear-cut ethical and legal guidelines that provide a method for the reader to learn how to systematically manage dilemmas seen in the everyday practice of medicine. The reader is guided through several "typical" patient scenarios and prompted by various questions that should be entertained by the treating health care provider. Then, relevant evidence-based medicine, legal precedent, and the ethical theory that applies to the situation are revealed. Often, finding the "best" ethical solution for each problem is automatic, as the solution often becomes self-evident during information-gathering. This general method is reinforced throughout the text with multiple different cases, using a practice-based approach by building on the reader's developing skills. Additionally, we have sought to emphasize a culturally competent manner in resolving these dilemmas, respectfully addressing issues of age, gender, and culture whenever possible. The main goal of Evidence-Based Medical Ethics: Cases for Practice-Bases Learning is to assist the reader in adapting a patient-centered and evidence-based approach to dilemmas faced in their future practice of medicine.

Individuals responses to their chronic illness or disability (CID) vary widely. Some are positive and productive, some negative and self-defeating, and some have elements of both. "Coping with Chronic Illness and Disability" synthesizes the growing literature on these coping styles and strategies by analyzing how individuals with CID face challenges, find and use their strengths, and alter their environment to fit their life-changing realities.

The book s first section provides readers with the major theories and conceptual perspectives on coping, with special emphasis on social aspects and models of coping with different types of CID. In Part Two, an array of specific medical conditions is covered. Each chapter supplies a clinical description, current empirical findings on coping, effective medical, physical, and psychological interventions, employment issues, and social concerns. This book includes: Up-to-date information on coping with high-profile conditions, such as cancer, heart disease, diabetes, arthritis, spinal cord injuries, and traumatic brain injury, in-depth coverage of HIV/AIDS, chronic pain, and severe mental illness, coverage of therapeutic modalities adopted for treatment of people with CID, review of the current state of coping theory and research, appendix of instruments frequently used in assessment of coping.

The editors skillful balance between theoretical and practical material will help rehabilitation specialists (particularly psychologists, counselors, social workers, and health-care providers) develop new insights into promoting successful coping, and discern new means of changing its less effective forms. Students in the helping professions, as well as individuals experiencing CID, may also find this multifaceted book useful for understanding some of the psychosocial dynamics of living with CID."

Metabolome analysis is now recognized as a crucial component of functional genomic and systems biology investigations. Innovative approaches to the study of metabolic regulation in microbial, plant and animal systems are increasingly facilitating the emergence of systems approaches in biology. This book highlights analytical and bioinformatics strategies now available for investigating metabolic networks in microbial, plant and animal systems.

The contributing authors are world leaders in this field and they present an unambiguous case for pursuing metabolome analysis as a means to attain a systems level understanding of complex biological systems.

A practical, clinically-oriented handbook of iron overload disorders giving a compact guide to normal iron metabolism, iron-related pathobiology, and the diagnosis and management of heritable and acquired iron overload disorders. Many of these disorders were discovered and characterized only in the last decade, and are unmentioned or inadequately described in most texts. Written by clinicians for clinicians, this handbook summarizes information on diverse iron overload conditions, including their history, signs, symptoms, and physical examination findings, genetics, genotype-phenotype correlations, pathophysiology, differential diagnosis and treatment. Most physicians, regardless of specialty, encounter patients with systemic or organ-specific iron overload conditions. This book contains essential information for practising adult and pediatric medical specialists in the fields of hematology, gastroenterology, hepatology, rheumatology, endocrinology, diabetology, neurology, oncology, dermatology, and internal medicine. Pathologists, pharmacologists, geneticists, genetic counselors, and epidemiologists will also find substantial, up-to-date sections in this handbook that are pertinent to their respective fields of interest.

"This is a book of byzantine proportions: a treasure trove for anyone with even the slightest initial interest in biomedical ethics. Indeed this book demonstrates that biomedical ethics is a microcosm of culture broadly conceived.

"Principles of Health Care Ethics" is unique. There is no other source-book that provides such diversity within the field. Here you can explore Eastern as well as Western approaches; examine the value of scientific studies in ethics, or of bizarre thought experiments. You can read about specific issues arising in clinical care, or gaze into a future when drugs might be widely used not only to treat disease but also to enhance health and abilities. There are twenty chapters on political and social issues and almost as many on the ethics of medical research and new technologies.

The first edition of "Principles of Health Care Ethics" was a constant companion for me, although one that was rather too frequently 'borrowed'. This second edition is even more exciting. A book of reference; and also a book to explore."
--Tony Hope, Professor of Medical Ethics, University of Oxford

The topics discussed in this book are relevant to everyone working in, or associated with, medicine and health care, whether student, practitioner, teacher of researcher, but its appeal will also extend to those in the fields of philosophy, medical law, sociology and theology, and the general reader concerned about the many moral problems that arise in medical practice.

The Electronic Medical Record (EMR) - is the essential underpinning of any significant healthcare reform and is the more comprehensive record than the Electronic Health Record (EHR). This book clarifies the Crucial Decisions that result in successful EMR adoption and avoidance of expensive EMR mistakes. It provides timely insight in leveraging ARRA/HiTech, Meaningful Use, Stark Safe Harbor, CPOE and PQRI incentives and understanding current HITSP, HL7, ASTM, ELINCS and other interoperability standards.

This book provides practical guidance on: Evaluating EMR ease-of-useDetermining In-office vs. Web-based vs. Blended EMR deploymentDeciding which user-interface approach to adoptUnderstanding structured vs. unstructured charting approachesAssessing EMR developer stabilityObtaining legal advice about RFIs, RFPs and contract negotiations

"The federal government has set aside significant incentives for physicians to adopt and implement electronic medical record systems. As providers across the country seek out various health IT tools and capabilities, this book serves as a remarkably useful, step-by-step guide for successfully deploying an EMR system. This kind of information will be imperative as we bring our health system into the 21st century."
--Newt Gingrich, Founder of The Center for Health Transformation, Former Speaker of the House, USA

Also endorsed by: Rep. Rush Holt (D NJ), Richard Dick, Ph.D. & Radu Kramer, M.D.

Palliative Care ist eine Antwort auf grundlegende Fragen der modernen Medizin: Wie weit wollen, sollen oder mMedizin: Wie weit wollen, sollen oder mussen wir Leben erhalten, verlangern und verbessern, wenn es von unheilbarer Krankheit, Alter oder Sterben begrenzt wird? Was wird fur ein der menschlichen Wurde und Freiheit gerecht werdendes Leben und Sterben gefordert? Ist alles medizinisch Machbare zu tun, oder widerspricht dies persoenlichen und gesellschaftlichen Vorstellungen von einem guten Leben und Sterben? Und dort, wo die heutige Medizin an ihre Grenzen stoesst, wie gehen wir mit dem Leiden und Sterben um? Welche Bedurfnisse stehen in diesen Situationen im Vordergrund? Wie kann ihnen fur moeglichst alle entsprochen werden? Was ist wesentlich in der Beziehung, in Haltung und Verhalten zueinander zwischen jenen, die unheilbar krank sind, die gehen mussen, vielleicht wollen, und jenen, die sie in dieser Situation betreuen und begleiten? Das Buch "Ethik in der Palliative Care" gibt Antworten auf diese Fragen, indem es umfassend die historischen, medizinischen, ethischen und theologischen Hintergrunde von Palliative Care beschreibt und ihren Stellenwert im Schweizer Gesundheitssystem dokumentiert.

Research evidence on bully-victim problems has accumulated rapidly in recent years. From this, there is little doubt that prolonged involvement in bullying, as a perpetrator, victim, or, not uncommonly, as both a perpetrator and target of bullying, conveys risk for many aspects of development. As in many emerging areas of psychological science, diverse research efforts evolved more or less independently, producing a very large and rich body of knowledge, but making it difficult to gain a comprehensive, integrated view of the overall evidence base. Preventing and Treating Bullying and Victimization looks across the sometimes disparate perspectives from school, clinical, and developmental researchers and professionals with an eye towards describing and integrating current knowledge into a guide for evidence-based practices and further research. The authors offer new directions for understanding this complex problem and for enhancing intervention approaches. This edited book will be comprised of three sections: Theoretical Perspectives, Assessment and Intervention, and Recommendations for Policy, Practice, and Research. It will be of interest to a number of professions and disciplines including clinical, developmental, counseling, and school psychologists, social workers, school administrators and educators, and public officials involved in setting policies.

People with intellectual disability often have health needs that go unrecognised and untreated; this may be because of difficulties in communication, diagnostic overshadowing, discrimination or indifference. There is concern that public health measures aimed at reducing the main health killers in the population will not address these issues for people with intellectual disability and may preferentially widen the inequality that already exists. This book is a comprehensive and systematic review of physical and mental health co-morbidities in people with intellectual disability. Such an evidence base is vital in shaping public health policy, healthcare commissioning and the development of more effective healthcare systems, as well as supporting better understanding and practice at an individual clinical level. This is essential reading for policy makers and commissioners of services, as well as individual practitioners across mainstream and specialist health and social care, in considering not only service developments but practice at the coalface.

This book explores ethnographic studies of diagnostic work in diverse settings. Switching attention from product ('diagnosis') to process ('diagnosing'), it reveals the importance of collaborative, socio-material, technologically augmented practices, exploring the potential of the multi-disciplinary studies presented to inform innovation.

In comments that were unfortunately prescient, Dr. Doroghazi said in the first edition "the author feels we are currently experiencing a real estate bubble." And in anticipation of the credit crisis, he said "banks are far too lenient in their lending practices...the problem is that bankers are often not lending their own money considering that a significant percentages of mortgages are sold to Fannie Mae (FNM) and Freddie Mac (FRE), the problem is now actually everyone s." This new and expanded edition provides commonsense advice that all investors, physicians and non-physicians will find profitable in these difficult times. Learn about the power of thrift, the magnificence of compound interest, the malevolence of debt and the perniciousness of fees. See how to pay off the mortgage by age 45, fund your children 's education and retire at a reasonable age rather than continue to work because you must.