I wrote this book urged by the overwhelming desire that arises towards the end of life to recapitulate the past. My goal was to summarize my experience of practicing science at the end of the 20th and early 21st centuries in Argentina, a country located far away from the world's leading scientific centers. In the book, I summarize the intricacies of the pineal gland ("the stone of madness") as historical, mystical and medical entity and its entry in contemporary medicine with the description of melatonin. I also reflect on how being associated with an unexplored subject at the beginning of his scientific career impacts the life of a scientist throughout their entire life. Today we know that in humans pineal melatonin is released every day late in the evening, and there is evidence that it is the trigger for the sleep process. But the most exciting aspect of melatonin is that it is a substance that is present in all living creatures, from unicellular organisms to plants and higher mammals, a fact that evinces its importance for life. Further, the neuroprotective action of melatonin promises to be crucial for the control of neurodegenerative diseases we face as a pandemic in this century. The discoverer of melatonin, Aaron Lerner, based its name on melano, the Greek word for black, because of its effect on the pigment cells of the skin. As in "La vie en rose", the immortal Edith Piaf song written in 1946, my lifelong work with melatonin could well be called "Ma vie en noir".

The increasing cost of research means that scientists are in more urgent need of optimal design theory to increase the efficiency of parameter estimators and the statistical power of their tests.

The objectives of a good design are to provide interpretable and accurate inference at minimal costs. Optimal design theory can help to identify a design with maximum power and maximum information for a statistical model and, at the same time, enable researchers to check on the model assumptions.

This Book: Introduces optimal experimental design in an accessible format.Provides guidelines for practitioners to increase the efficiency of their designs, and demonstrates how optimal designs can reduce a study's costs.Discusses the merits of optimal designs and compares them with commonly used designs.Takes the reader from simple linear regression models to advanced designs for multiple linear regression and nonlinear models in a systematic manner.Illustrates design techniques with practical examples from social and biomedical research to enhance the reader's understanding.

Researchers and students studying social, behavioural and biomedical sciences will find this book useful for understanding design issues and in putting optimal design ideas to practice.

A practical approach to the recognition and management of all aspects of migraine Migraine, characterized by periodic bursts of severe debilitating headache, is increasingly recognized as being not only a disease in its own right, but as a disorder that co-occurs with other disorders. Comorbidity in Migraine presents a clinically-oriented, comprehensive treatment approach to migraine. The international collection of authors cover: * Migraine and Psychiatric Disorders * Migraine and Vascular disorders * Migraine and Epilepsy * Migraine and other Pain Disorders * Migraine and Medication Overuse Case vignettes and management algorithms enhance the clinical utility of the book.Comorbidity in Migraine enhances your ability to treat your migraine patients effectively to improve their quality of life. Titles of Related Interest Pediatric Headaches in Clinical Practice Hershey, Powers, Winner, Kabbouche (eds); ISBN 978-0-470-51273-9 Handbook of Epilepsy Treatment, 3e Shorvon; ISBN 978-1-4051-9818-9 Neurology: A Queen Square Textbook Clarke, Howard, Rossor, Shorvon (eds); ISBN 978-1-4051-3443-9

This comprehensive book thoroughly addresses all aspects of health care transition of adolescents and young adults with chronic illness or disability; and includes the framework, tools and case-based examples needed to develop and evaluate a Health Care Transition (HCT) planning program that can be implemented regardless of a patient's disease or disability. Health Care Transition: Building a Program for Adolescents and Young Adults with Chronic Illness and Disability is a uniquely inclusive resource, incorporating youth/young adult, caregiver, and pediatric and adult provider voices and perspectives. Part I of the book opens by defining Health Care Transition, describing the urgent need for comprehensive transition planning, barriers to HCT and then offering a framework for developing and evaluating health care transition programs. Part II focuses on the anatomic and neuro-chemical changes that occur in the brain during adolescence and young adulthood, and how they affect function and behavior. Part III covers the perspectives of important participants in the HCT transition process - youth and young adults, caregivers, and both pediatric and adult providers. Each chapter in Part IV addresses a unique aspect of developing HCT programs. Part V explores various examples of successful transition from the perspective of five key participants in the transition process - patients, caregivers, pediatric providers, adult providers and third party payers. Related financial matters are covered in part VI, while Part VII explores special issues such as HCT and the medical home, international perspectives, and potential legal issues. Models of HCT programs are presented in Part VIII, utilizing an example case study. Representing perspectives from over 75 authors and more than 100 medical centers in North America and Europe, Health Care Transition: Building a Program for Adolescents and Young Adults with Chronic Illness and Disability is an ideal resource for any clinician, policy maker, caregiver, or hospitalist working with youth in transition.

This book presents an authoritative overview of the emerging field of person-centered psychiatry. This perspective, articulating science and humanism, arose within the World Psychiatric Association and aims to shift the focus of psychiatry from organ and disease to the whole person within their individual context. It is part of a broader person-centered perspective in medicine that is being advanced by the International College of Person-Centered Medicine through the annual Geneva Conferences held since 2008 in collaboration with the World Medical Association, the World Health Organization, the International Council of Nurses, the International Federation of Social Workers, and the International Alliance of Patients' Organizations, among 30 other international health institutions. In this book, experts in the field cover all aspects of person-centered psychiatry, the conceptual keystones of which include ethical commitment; a holistic approach; a relationship focus; cultural sensitivity; individualized care; establishment of common ground among clinicians, patients, and families for joint diagnostic understanding and shared clinical decision-making; people-centered organization of services; and person-centered health education and research.

This book is designed to present a comprehensive, state-of the-art approach to assessing and managing bariatric surgery and psychosocial care. Unlike any other text, this book focuses on developing a biopsychosocial understanding of patients' obesity journey and psychosocial factors contributing to their obesity and its management from an integrated perspective. Psychiatric Care in Severe Obesity takes a 360 approach by covering the disease's prevalence and relationship to psychiatric illness and social factors, including genetics, neurohormonal pathways and development factors for obesity. This book presents evidence and strategies for assessing psychiatric issues in severe obesity and uses common psychiatric presentations to feature the impact on bariatric surgery and key assessment features for weight loss. Concluding chapters focus on evidence-based psychosocial treatments for supporting patients with weight loss and bariatric surgery and includes educational tools and checklists for assessment, treatment, and care. Experts on non-pharmacological interventions such as mindfulness, cognitive-behavioral therapy and nutrition education describe treatment approaches in each modality, concluding with pharmacological approaches for psychiatric conditions and eating pathology. Additional tools in the appendices support clinicians, making this the ultimate guide for managing psychiatric illness in patients suffering from severe obesity. As obesity continues to grow in prevalence as a medically recognized epidemic, Psychiatric Care in Severe Obesity serves a vital resource to medical students, psychiatrists, psychologists, bariatric surgeons, primary care physicians, dietitians, mental health nurses, social workers, and all medical professionals working with severely obese patients.

the Atlas of AIDS Co-infection illustrates imaging features and clinical outcomes of AIDS related diseases. The common/uncommon opportunistic infections and malignancies are well covered, including bacterial (e.g. Staphylococcus, Rhodococcus equi), fungal (e.g. Penicillium marneffei, Pneumocystis pneumonia, Pulmonary aspergillosis, Mucormycosis) and mycobacterial infections (Mycobacterium tuberculosis, Non-tuberculous Mycobacteria), lymphoma, as well as AIDS related disease in children with AIDS. Excellent photographs (X-ray and CT imaging) reveal the common imaging features of different diseases in different stages of treatment. Co-infections are common in the late stage of AIDS, consistent with considerable overlap of CT findings that are displayed in one single section and some of the cases in several sections. At last, there are excellent descriptions of differential diagnosis based on the same appearance (e.g. diffuse pulmonary miliary nodules, mediastinal and abdominal lymphadenopathy). Learning variety of different imaging will enrich the radiologists experience and knowledge about AIDS-related diseases, and also help clinicians making timely diagnosis and appropriate optimal treatment. It belongs in the library of each Radiologist, HIV expert and all of who care about Infectious Diseases.

This new edition is a practical guide to patient examination and diagnosis for medical students. Beginning with an introduction to history taking and general physical examination, the following sections discuss patient examination in different systemic regions. The text covers anatomy and physiology to give students a better understanding of each system and describes symptoms and history of common clinical disorders before explaining examination techniques. The third edition has been fully revised to provide the latest information and guidance, and is further enhanced by clinical photographs, diagrams and tables. Key points Practical guide to patient examination and diagnosis for medical students Fully revised, third edition Covers all key systemic regions Previous edition (9789386150417) published in 2016

This comprehensive volume captures the latest scientific evidence, technological advances, treatments and impact of biotechnology in hyperbaric oxygen therapy. Divided into three distinct sections, the book begins with basic aspects that include history, equipment, safety and diagnostic approaches; this is followed by clinical applications for hyperbaric oxygen therapy in various modalities; the last section provides an overview of hyperbaric medicine as a specialty with best practices from around the world. Integration of multidisciplinary approaches to complex disorders are also covered. Updated and significantly expanded from previous editions, Textbook of Hyperbaric Medicine, 6th Edition will continue to be the definitive guide to this burgeoning field for students, trainees, physicians and specialists.

This is a reproduction of a book published before 1923. This book may have occasional imperfections such as missing or blurred pages, poor pictures, errant marks, etc. that were either part of the original artifact, or were introduced by the scanning process. We believe this work is culturally important, and despite the imperfections, have elected to bring it back into print as part of our continuing commitment to the preservation of printed works worldwide. We appreciate your understanding of the imperfections in the preservation process, and hope you enjoy this valuable book. ++++ The below data was compiled from various identification fields in the bibliographic record of this title. This data is provided as an additional tool in helping to ensure edition identification: ++++ Paracelsus-Handschriften; Volume 1 Of Versuch Einer Kritik Der Echtheit Der Paracelsischen Schriften; Karl Sudhoff Karl Sudhoff G. Riemer, 1894

Health systems need to set priorities fairly. In one way or another, part of this important task will fall to physicians. How do they make judgments about resource stewardship, and how should they do so? How can they make such decisions in a manner that is compatible with their clinical duties to patients? In this book, philosophers, bioethicists, physicians, lawyers and health policy experts make the case that priority setting and rationing contribute significantly to the possibility of affordable and fair healthcare and that clinicians play an indispensable role in that process. The book depicts the results of a survey of European physicians about their experiences with rationing and other cost containment strategies, and their perception of scarcity and fairness in their health care systems. Responding to and complementing these findings, commentators discuss why resource allocation and bedside rationing is necessary and justifiable. The book explores how bedside rationing relates to clinical judgments about medical necessity and medical indications, marginal benefits, weak evidence based medicine, off-label use. The book highlights how comparative studies of health care systems can advance more effective and fair bedside rationing through learning from one another. From a practical standpoint, the book offers a number of strategies for health care systems and clinicians to work in tandem to allocate and ration resources as fairly as possible: how to foster more attention to fairness when rationing at the bedside, how to avoid exacerbating health disparities when allocating resources, how to teach about bedside rationing to students, how to discuss rationing more explicitly in the public arena and in the doctor's office.

Clinical Acupuncture and Ancient Chinese Medicine weaves together historical perspectives, ancient wisdom, and modern medicine to provide a holistic, effective, and rewarding way to understand and apply acupuncture in clinical practice. Methodology for memorizing the function of acupuncture meridians and points is supplemented by nearly 600 high-quality images that illustrate point locations and needle insertion techniques. Algorithms for making diagnostic formulations, developing treatment strategies, and implementing effective therapeutic interventions are emphasized. Chapters also cover published outcomes data, the critical role of human psychology and spirituality in healing, and adjunctive therapies to acupuncture such as medicinal herbs and cupping. Authored by Dr. Jingduan Yang and Dr. Daniel A. Monti, two internationally known leaders and teachers of Chinese Medicine and Integrative Health, Clinical Acupuncture and Ancient Chinese Medicine is an ideal resource for a diverse range of health care practitioners and trainees including physicians, chiropractors, and licensed acupuncturists.

The Update compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.