The Boron '97 meeting was a great success in summarising all recent developments in basic and applied research on boron's function, especially in plants. New techniques have since been developed and new insight has been gained into the role of boron in plant and animal metabolism. Nevertheless, there were still lots of open questions. The aim of the present workshop held in Bonn as a satellite meeting to the International Plant Nutrition Colloquium was thus to gather all actual information which has been gained since the Boron '97 meeting and to compile knowledge, both from animal and plant sciences. Furthermore, applied aspects had to be addressed too, as there is an increasing awareness of boron deficiencies even in crops such as wheat, which have formerly not been considered as responsive to boron application. Genetic differences in boron demand and efficiency within one species are a further important topic which has gained importance since the 1997 meeting. More in-depth knowledge on the mechanisms of boron efficiency are required as an increased efficiency will be one major possibility to maintain and improve crop yields for resource-poor farmers. Nevertheless, it has also clearly been shown that an adequate supply of boron is needed to obtain high yields of crops with a high quality, and that a sustainable agriculture has to provide an adequate boron supply to compensate for inevitable losses through leaching (especially in the humid tropics and temperate regions) and for the boron removal by the crop.

The availability of analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) sold over-the-counter (OTC) to the public without prescription has become an issue of major concern in recent years. The problem has been highlighted in the UK, USA and other countries because of the continuing high rates of cases of poisoning and the influence of switching from prescription-only status for many NSAIDs to OTC sale brought about, in a large part, by governments and health maintenance organisations (especially in the USA) anxious to save on costs of these drugs. Concern in the UK about poisoning from paracetamol and the appreciable morbidity and mortality from aspirin was such that a major review was initiated in 1996 by the UK government's Medicines Control Agency (MCA). Doubtless, many other governments have also undertaken reviews of the safety issues concerning OTC analgesics and NSAIDs. In the UK the situation has culminated in the decision announced in August 1997, as this book was going to press, that the number of tablets/capsules of the solid dosage forms of paracetamol and aspirin would be limited for sale OTe. This decision was essentially based on the need to limit the unit quantity of these drugs so as to reduce the likelihood of poisoning with paracetamol and the development of gastrointestinal and other more serious side-effects from aspirin. Time. will tell whether these new regulations will influence the occurrence of these adverse events.

Every cell and organism faces the problem of spaces, made up of the two leaflets of the lipid generating a confined space in which metabolic bilayer. The importance of traffic and signaling across membranes is reflected by the estimate and anabolic reactions take place and at the same time allowing entry and exit of metabo that 20% of all genes in the human genome encode membrane proteins. A failure of any of lites, ions, proteins, and signals across its bor der. Evolution has solved the problem by these proteins may have dramatic con se generating lipid membranes that contain trans quences for ceH function. In recent years much porters, ion channels, and receptors. In eukary attention has been paid to diseases resulting otic cells, this problem is exacerbated by the from nonfunctional ion channels ("chan presence of multiple organelles, which are con nelopathies"). Not surprisingly, many of these fined spaces in their own right. Even the lipid diseases affect the excitability of cells. membrane consists of two relatively separate Transporter diseases (perhaps coined "carrier vi PREFACE diseases") are more related to metabolic dis Each chapter is concluded by a summary, and eases, Transporters are frequently found at the most chapters also contain an overview of the beginning or the end of metabolic pathways clinical features of a particular transporter and as a result can have similar effects to disease. a missing enzyme."

The administration of intravenous fluids is one of the most common and important therapeutic practices in the treatment of surgical, medical and critically ill patients. The international literature accordingly contains a vast number of works on fluid management, yet there is still confusion as to the best options in the various situations encountered in clinical practice. The purpose of this volume is to help the decision-making process by comparing different solution properties describing their indications, mechanisms of action and side-effects according to physiologic body water distribution, electrolytic and acid-base balance, and to clarify which products available on the market represent the best choice in different circumstances. The book opens by discussing in detail the concepts central to a sound understanding of abnormalities in fluid and electrolyte homeostasis and the effect of intravenous fluid administration. In the second part of the monograph, these concepts are used to explain the advantages and disadvantages of solutions available on the market in different clinical settings. Body Fluid Management: From Physiology to Therapy will serve as an invaluable decision-making guide, including for those who are not experts in the subject.

to Medical Manipulation John K. Paterson, MB. BS. MRCGP currently Vice-President and Han. Secretary of the British Association of Manipulative Medicine and member of the Scientific Advisory Committee of the International Federation of Manual Medicine and Loic Burn, BA. MRCS. LRCP. DPhysMed currently President of the British Association of Manipulative Medicine. Han. Secretary of the Scientific Section of the British League against Rheumatism and member of Council of the Back Pain Association ~~ M.TP PRESS LIM.ITED ~ a member of the KLUWER ACADEMIC PUBLISHERS GROUP LA CASTER I BOSTON I THE HAG E / DORDRECHT Published in the UK and Europe by MTP Press Limited Falcon House Lancaster, England British Library Cataloguing in Publication Data Paterson, John K. An introduction to medical manipulation. 1. Manipulation (Therapeutics) I. Title II. Burn, Loic 615.8'2 RM724 Published in the USA by MTPPress A division of Kluwer Boston Inc 190 Old Derby Street Hingham, MA 02043, USA Library of Congress Cataloging in Publication Data Paterson, John K., 1921- An introduction to medical manipulation. Bibliography: p. Includes index.

One of the most important developments in diagnostic imaging over the last decade has been magnetic resonance imaging (MRI). Its ability to differentiate between tissues and give patholog ical information about diseases has led to earlier treatment, thus increasing the likelihood of recovery. The images produced using this technique give superb anatomical detail in any plane and are obtained without the use of ionising radiation. The increased use of MRI has presented radiographers with a number of challenges, and because we are no longer dealing with ionising radiation understanding the subject can some times be confusing. We hope that this text will help radiographers and student radiographers to further their knowledge and unravel the mysteries of MRI. Philip T. English Christine Moore Contents 1 Basic Principles . . . . . . . . . 1 History ..... . 1 Atomic Theory . . 1 Magnetic Theory . 2 Resonance 4 Relaxation. . . . . 5 2 Instrumentation........ 9 The Magnet .. 9 Shim Coils ........... . 12 Gradient Coils ......... . 13 RF Transmitter/Receiver Coils. 14 The Computer . . . . . . . . . 18 3 Pulse Sequences. . . . . . . . . 19 Saturation Recovery (Partial Saturation) 19 Spin Echo (SE) . . . . . . . . . . . . . 20 Multiple Spin Echo. . . . . . . . . . . 22 Fast Spin Echo (FSE) or Turbo Spin Echo (TSE). 23 Inversion Recovery (IR) . . . . . . . . . . . . . 26 Gradient Echo .................. . 28 Magnetisation Transfer Contrast Imaging (MTC) 34 4 Image Production. . . . . . . .

Infectious diseases are transmitted through various different mechanisms including person to person interactions, by insect vectors and via vertical transmission from a parent to an unborn offspring. The population dynamics of such disease transmission can be very complicated and the development of rational strategies for controlling and preventing the spread of these diseases requires careful modeling and analysis. The book describes current methods for formulating models and analyzing the dynamics of the propagation of diseases which include vertical transmission as one of the mechanisms for their spread. Generic models that describe broad classes of diseases as well as models that are tailored to the dynamics of a specific infection are formulated and analyzed. The effects of incubation periods, maturation delays, and age-structure, interactions between disease transmission and demographic changes, population crowding, spatial spread, chaotic dynamic behavior, seasonal periodicities and discrete time interval events are studied within the context of specific disease transmission models. No previous background in disease transmission modeling and analysis is assumedand the required biological concepts and mathematical methods are gradually introduced within the context of specific disease transmission models. Graphs are widely used to illustrate and explain the modeling assumptions and results. REMARKS: NOTE: the authors have supplied variants on the promotion text that are more suitable for promotionin different fields (by virtue of different emphasis in the content). They are not enclosed, but in the mathematics editorial.

An invaluable self-assessment tool for emergency medicine trainees in Australasia.

"Emergency Medicine MCQs" is an essential resource for Australasia's emergency medicine trainees.

A practical self-assessment tool, the book assists trainees as they expand and refine their knowledge of emergency medicine, and will ultimately help them pass the Australasian Emergency Medicine Fellowship examination (FACEM).

The multiple-choice questions in "Emergency Medicine MCQs" cover both the core and non-core areas in the Australasian Emergency Medicine Fellowship.? Using this text, trainees can revise alone or with their peers to identify the areas in which they need further development.

The curriculum is divided into three main areas where trainees require expert level of knowledge, high level of knowledge and general level of knowledge. It covers important clinical problems encountered in everyday emergency medicine practice - from cardiovascular emergencies through to obstetric and gynaecology emergencies, disaster management and toxicology.

As well as being ideal for emergency medicine trainees qualifying through AECM, the book is a useful resource for GPs taking the GEM qualification through ACEM and JMOs 'on call'.

Plus, this emergency medicine text is accompanied by an app - a separate product containing 180 randomised multiple-choice questions on all the topics within the book.

Just Enough Physiology takes the reader on a guided tour of cardiopulmonary physiology. You'll discover how the heart, lungs, and circulation work in extreme environments so that you're better equipped to understand how they function-or malfunction-at the bedside, in the operating room, or in the intensive care unit. Just Enough Physiology also shows the field through the eyes of some of its most colorful pioneers. While the stories are fascinating in their own right, they also reinforce the foundational principles of physiology and reveal how those discoveries were made-sometimes at great risk, and often against stiff resistance. Written as bite-sized topics, Just Enough Physiology caters to the way people learn, study, and remember. Every subject can be read and mastered in one brief sitting. Like the brain teasers that are included at the end of each chapter, Just Enough Physiology emphasizes the logic, and not just the details, behind physiology. Just Enough Physiology will prepare all students and physicians-in-training for board exams while also teaching them how to think like a physiologist.

All practitioners and pharmacists interested in treatment with herbal remedies should have this book at their disposal. It is the definitive practice-oriented introduction - now in its fifth edition - to phytotherapy. Methodically classified by organic systems and fields of application, the text provides a quick insight into dosage, form of application and effects of the most important herbal remedies. Only those herbal remedies that are of pharmacological and clinical efficiency have been considered. The authors are highly experienced in the field of postgraduate medical education, and, with this work, present an indispensable reference book for the medical practice.

Interest in policy influences on health care is high, and will remain high as long as health care costs continue to rise and health care reform remains a hot topic in the news. There are inevitable and frequent points of interface between health care public policy and the health professions; in their daily work, clinicians see the problems with the health care system but often feel powerless and unsure how to advocate for system changes. Clinicians and Health Care Advocacy is written by clinicians for clinicians and focuses on how policy works and what individual professionals can do to affect policy. It looks at the facts and processes in an accessible way that employs case-based examples of clinician adavocacy to illustrate its points. The book is nonpartisan and will stay neutral on preferences for one public policy solution versus another (single payer vs. market reform, for example). Instead, it encourages a model of clinicians as responsible for healing not only the individual patient but also the larger health care system in which they work.

This is the first comprehensive volume to be published on the subject of electrical trauma in humans. Many of the world's leading experts describe the basic mechanisms of tissue injury in victims of electrical trauma, the complex and varied manifestations of electrical trauma, and state-of-the-art clinical treatment protocols. Promising new therapies still in the research stage are also discussed and assessed. The volume describes the basic physiochemical mechanisms responsible for tissue damage and explains the complex and variable ways in which electrical trauma manifests itself. An understanding of these underlying processes provides the basis for a rational and consistent approach to treatment which is highlighted in this volume. Electrical Trauma serves as a new and important source of information from a variety of perspectives that contributes to the understanding of the electrical injury problem. It is suitable for clinicians in plastic surgery, intensive care and burn units and for those with an academic and research interest in the mechanisms and causes of electrical trauma.

It is thirty years since the technique of high-yield preparation of isolated hepatocytes, by collagenase perfusion of the liver, was published. The original method described by Berry and Friend has undergone many minor modifications by other workers, and the two-step procedure introduced by Seglen in 1976 has become the most frequent way to prepare hepatocyte suspensions. An important development introduced by Bissell in 1973 was the use of the cells as the first step in monolayer culture. The availability of the isolated hepatocyte preparation as cells in suspension or culture has undoubtedly facilitated research on the liver. This was emphasised in our book, published (with Dr. Greg Barritt) in 1990, which described in detail methods of preparation and the properties of the isolated hepatocytes. It also discussed the usefulness of the preparation for the study of intermediary and xenobiotic metabolism, calcium ion transport, and the growth and differentiation of hepatocytes in culture. The book also touched briefly on a range of specialised techniques, including peri fusion, subcellular fractionation, transplantation, cryopreservation and measurement of intracellular pH. Although standard procedures for the manipulation of hepatocytes have not changed a great deal in ten years, they have undoubtedly been refined. This applies particularly to hepatocyte culture techniques, cryopreservation, and even to preparation of hepatocyte suspensions, where it is now feasible to use purified enzymes. There is also much more emphasis on the use and study of human hepatocytes, particularly in the field of pharmacology and therapeutics.

Molecular farming has been hailed as the "third wave" of genetically-modified organisms produced through biotechnology for the bio-based economy of the future. Unlike products of the first wave, such as herbicide resistant crop plants, which were perceived to benefit only the farmers who used them and the agrochemical companies who developed them, products of molecular farming are designed specifically for the benefit of the consumer. Such products could be purified from food or non-food organisms for a range of applications in industry, as well as animal and human health. Alternatively, the products of this technology could be consumed more directly in some edible format, such as milk, eggs, fruits or vegetables. There is a rapidly-growing interest Qn the part of the public as well as in the medical community in the role food plays in health, especially in the immunophysiological impact of food over and above the role of basic nutrition.

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