"The development and application of bioinformatics tools to basic and translational cancer research is, in fact, a rapidly expanding field that deserves a timely review. Therefore, a publication of this type is needed. The editors have done an excellent job in recruiting well-established scientists to author the various chapters of the book."
--Dieter Naf, Jackson Laboratory, USA

Cancer bioinformatics is now emerging as a new interdisciplinary field, which is facilitating an unprecedented synthesis of knowledge arising from the life and clinical sciences.

This groundbreaking title provides a comprehensive and up-to-date account of the enormous range of bioinformatics for cancer therapy development from the laboratory to clinical trials. It functions as a guide to integrated data exploitation and synergistic knowledge discovery, and support the consolidation of the interdisciplinary research community involved.

The Handbook of Speech Production is the first reference work to provide an overview of this burgeoning area of study. Twenty-four chapters written by an international team of authors examine issues in speech planning, motor control, the physical aspects of speech production, and external factors that impact speech production. Contributions bring together behavioral, clinical, computational, developmental, and neuropsychological perspectives on speech production to create a rich and truly interdisciplinary resource Offers a novel and timely contribution to the literature and showcases a broad spectrum of research in speech production, methodological advances, and modeling Coverage of planning, motor control, articulatory coordination, the speech mechanism, and the effect of language on production processes

Kidney stones affect nearly 3 million people every year and the management of these stones can often be complicated. This issue of the Urologic Clinics covers all of the current treatments for kidney stones from medicine to surgery. There are also articles on pathology, imaging, and diet and alternative therapies.

In October of 2011, CLSI published a new guideline EP23A on "Laboratory Quality Control Based on Risk Management.? In March, 2012, CMS announced its intention to incorporate key concepts from EP23A into its Interpretative Guidelines and QC policy for "Individualized Quality Control Plans.? Thus begins a new era of Quality Control in the Age of Risk Management. This issue is intended to help laboratories with the transition between traditional QC practices and the new risk management approach. Laboratories face a steep learning curve to apply risk analysis for identifying and prioritizing failure-modes, developing and implementing control mechanisms to detect those failure-modes, and assessing the acceptability of the residual risks that exist after implementation of a QC Plan. One of the main benefits of the new risk analysis based QC Plans should be an integration of all the control mechanisms that are needed to monitor the total testing process, including pre-analytic, analytic, and post-analytic controls.? One of the main risks of the new approach is an expectation that Statistical QC is no longer important, even though SQC still remains the most useful and flexible approach for monitoring the quality of the analytic process. The key to the future is the successful integration of all these control mechanisms to provide a cost-effective quality system that monitors all phases of the total testing process. This issue should help laboratories understand the evolution of QC practices to include risk management, but also to recognize the need to maintain traditional techniques such as Statistical QC, especially during the transition to well-designed and carefully-validated QC Plans. Risk analysis may be risky business unless laboratories proceed carefully and cautiously.

This new volume of "Methods in Enzymology" continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in biomineralization science, and includes sections on such topics as determining solution chemistry, structure and nucleation; probing structure and dynamics at surfaces; and interfaces mapping biomineral and morphology and ultrastructure.
Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization scienceContains sections on such topics as and includes sections on such topics as determining solution chemistry, structure and nucleation; probing structure and dynamics at surfaces; and interfaces mapping biomineral and morphology and ultrastructure

This authoritative reference surveys mind-body healing concepts and psychosomatic medicine in diverse countries and regions of the world. It provides practical insights on the Western division between medical and mental healing and useful information concerning recent efforts to bridge that enduring divide, particularly in the use of ancient and indigenous healing knowledge in psychosomatic practice. Coverage compares and contrasts current applications of psychosomatic medicine and/or consultation-liaison psychiatry as conducted in such representative countries as France, Britain, China, India, Argentina, Canada, and the United States. And the book predicts how this synthesis of traditions and advances will progress as it: Traces the history and development of psychosomatic medicine. Reviews contributions of traditional healing methods to psychosomatic medicine. Analyzes national styles of psychosomatic medicine as practiced in specific countries. Compares the status of psychosomatic medicine / consultation-liaison psychiatry in various countries. Considers the future of psychosomatic medicine as the field, and the world, evolves. Global Psychosomatic Medicine and Consultation-Liaison Psychiatry expands the knowledge base for psychiatrists, primary care physicians, psychiatric and primary care residents, medical students, behavioral medicine specialists, and others who are interested global and regional perspective on providing biopsychosocial care. It is also relevant for advanced students in health psychology and behavioral medicine, and for professionals in related health fields.

The Year Book of Medicine brings you abstracts of the articles that reported the year's breakthrough developments in medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed Sections are included on Rheumatology, Infectious Disease, Hematology and Oncology, Kidney, Water, and Electrolytes, Pulmonary Disease, Heart and Cardiovascular Disease, The Digestive System, and Endocrinology, Diabetes, and Metabolism.

This textbook covers all the essential elements of pharmacokinetics, from basics to applications. It describes authoritative equations and methods on pharmacokinetic evaluation procedures with their importance. Each chapter of the book is supplemented with numerous illustrations and figures for easy understanding of the subject. The book presents mathematical techniques, step- by-step descriptive equations, and applicable statistical analysis methods for the easy understanding of the topic. Further, it covers the preclinical applications and methods of pharmacokinetic aspects. The book also contains mathematical problems and questions related to pharmacokinetics for students. Special emphasis is on recent pharmacokinetic methods and their applications for managing clinical data and biostatistical approaches based on the current literature. This book is primarily meant for researchers and students from academic institutions and to R&D professionals.

Prepare for success in today's fast-paced, collaborative healthcare environment! Offering expert perspectives from a variety of primary care and nurse practitioners, Primary Care: A Collaborative Practice, 5th Edition helps you diagnose, treat, and manage hundreds of adult disorders. Care recommendations indicate when to consult with physicians or specialists, and when to refer patients to an emergency facility. This edition includes six new chapters, a fresh new design, the latest evidence-based guidelines, and a new emphasis on clinical reasoning. Combining academic and clinical expertise, an author team led by Terry Mahan Buttaro shows NPs how to provide effective, truly interdisciplinary health care. UNIQUE! A collaborative perspective promotes seamless continuity of care, with chapters written by NPs, physicians, PAs, and other primary care providers. Comprehensive, evidence-based content covers every major disorder of adults seen in the outpatient office setting, reflects today's best practices, and includes the knowledge you need for the NP/DNP level of practice. A consistent format in each chapter is used to describe disorders, facilitating easier learning and quick clinical reference. Diagnostics and Differential Diagnosis boxes provide a quick reference for diagnosing disorders and making care management decisions. Complementary and alternative therapies are addressed where supported by solid research evidence. Referral icons highlight situations calling for specialist referral or emergency referral. NEW chapters cover topics including transitional care, risk management, LGBTQ patient care, bullous pemphigoid, pulmonary embolism, and dysphagia. NEW! An emphasis on clinical reasoning helps you develop skills in diagnosis and treatment, with coverage moving away from pathophysiology and toward diagnostic reasoning and disease management - including pharmacologic management. NEW focus on interdisciplinary care underscores the importance of interprofessional education and practice, and includes Interdisciplinary Management features. UPDATED chapters reflect the latest literature and evidence-based treatment guidelines, including new content on the Affordable Care Act as well as new coverage of patient satisfaction metrics, quality metrics, value-based purchasing, pharmacogenetics/genomics, and teen pregnancy and abnormal pregnancy. NEW quick-reference features make it easier to locate important information, through colorful section tabs, bulleted summaries, additional algorithms, a more logical table of contents, an Index to Standardized Treatment Guidelines, and a Reference to Common Laboratory Values.

This issue examines PET-MRI with evolving but potentially competing technologies. The guest editors have put together an extremely timely issue as practicing radiologists are increasingly curious about the role of diffusion weighted imaging with MRI as a competing or a complementary technique to PET.

This issue of Critical Care Nursing Clinics, Guest Edited by Stephen D. Krau, PhD, RN, CNE, from Vanderbilt University, will focus on Summer Trauma. Article topics will include Tick bites, Rabies, Snake bites, West Nile Virus, Spider bites, Allergic Reactions to Bee and Wasp Stings, Heat Exhaustation and Stroke, Near Drowning, and Musculoskeletal Injuries.

This issue of Medical Clinics covers the latest updates in immunotherapeutics by the wolrd-leading experts on the topic. Immunotherapuetic treatments are discussed in inefctious diseases, rheumatologic and neurologic disorders, renal diseases, diabetes and more. Emerging immunotherapies are also covered in depth.

This issue of Medical Clinics covers the current best practices surrounding the management of patients with acute and chronic headache pain. Guest edited by Steven Waldman, MD, JD, the topics covered will include concerning factors in the diagnosis of headache pain, imaging techniques, tension headaches, migraine headaches, cluster headaches, postdural puncture headaches and more.

This open access book is a systematic update of the philosophical and scientific foundations of the biopsychosocial model of health, disease and healthcare. First proposed by George Engel 40 years ago, the Biopsychosocial Model is much cited in healthcare settings worldwide, but has been increasingly criticised for being vague, lacking in content, and in need of reworking in the light of recent developments. The book confronts the rapid changes to psychological science, neuroscience, healthcare, and philosophy that have occurred since the model was first proposed and addresses key issues such as the model's scientific basis, clinical utility, and philosophical coherence. The authors conceptualise biology and the psychosocial as in the same ontological space, interlinked by systems of communication-based regulatory control which constitute a new kind of causation. These are distinguished from physical and chemical laws, most clearly because they can break down, thus providing the basis for difference between health and disease. This work offers an urgent update to the model's scientific and philosophical foundations, providing a new and coherent account of causal interactions between the biological, the psychological and social.

This issue of Medical Clinics covers the important advances and current best practices surrounding the management of patients with diabetic chronic kidney disease. Guest edited by Mark Williams of the Joslin Diabetes Clinic, the topics covered will include proteonomics, diabetes and hypertension, obesity, genetic predispositions, pancreas transplantation, fibrotic therapies, and more.

This year book brings you abstracts of the articles that reported the year's breakthrough developments in medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to practice.

Obesity has become a worldwide epidemic that is also driving the marked increase in Type 2 diabetes across the globe.? While it is easily recognizable clinically, and readily measurable in the United States, a feature that is not well recognized is the central adiposity that may be the only or primary feature in South East Asian communities.? Thus it is imperative for clinicians to be brought up do date in order for preventative or therapeutic modalities are introduced early in the disease process.
This issue of Medical Clinics of North America covers numerous clinical aspects of obesity including metabolic syndrome, insulin resistance, the link with cardiovascular disease, dyslipidemia, and hypertension.? Several treatment modalities are covered including diet, exercise, cognitive and behavioral approaches, medications, and surgery.

An invaluable self-assessment tool for emergency medicine trainees in Australasia.

"Emergency Medicine MCQs" is an essential resource for Australasia's emergency medicine trainees.

A practical self-assessment tool, the book assists trainees as they expand and refine their knowledge of emergency medicine, and will ultimately help them pass the Australasian Emergency Medicine Fellowship examination (FACEM).

The multiple-choice questions in "Emergency Medicine MCQs" cover both the core and non-core areas in the Australasian Emergency Medicine Fellowship.? Using this text, trainees can revise alone or with their peers to identify the areas in which they need further development.

The curriculum is divided into three main areas where trainees require expert level of knowledge, high level of knowledge and general level of knowledge. It covers important clinical problems encountered in everyday emergency medicine practice - from cardiovascular emergencies through to obstetric and gynaecology emergencies, disaster management and toxicology.

As well as being ideal for emergency medicine trainees qualifying through AECM, the book is a useful resource for GPs taking the GEM qualification through ACEM and JMOs 'on call'.

Plus, this emergency medicine text is accompanied by an app - a separate product containing 180 randomised multiple-choice questions on all the topics within the book.

When Dr. Ellen Einterz first arrives in the town of Kolofata in Cameroon, the situation is dire: patients are exploited by healthcare workers, unsterilized needles are reused, and only the wealthy can afford care. In Life and Death in Kolofata: An American Doctor in Africa, Einterz tells her remarkable story of delivering healthcare for 24 years in one of the poorest countries in the world, revealing both touching stories of those she is able to help and the terrible suffering of people born in extreme poverty. In one case, a 6-year-old burn victim suffers after an oil tanker tips and catches fire; in another story, Dr. Einterz delivers a child in the front yard of her home. In addition to struggling to cure diseases and injuries and combat malnutrition, Einterz faced another kind of danger: the terrorist organization Boko Haram had successively kidnapped politicians from Cameroon and foreigners, and they had set their sights on Americans in particular. It would only be a matter of time before they would come for her. Tragic, heartwarming, and at times even humorous, Life and Death in Kolofata illustrates daily life for the people of Cameroon and their doctor, documenting both the incredible human suffering in the world and the difference that can be made by those willing to help.

Advances in Clinical Chemistry, Volume 88, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.