The increasing cost of research means that scientists are in more urgent need of optimal design theory to increase the efficiency of parameter estimators and the statistical power of their tests.

The objectives of a good design are to provide interpretable and accurate inference at minimal costs. Optimal design theory can help to identify a design with maximum power and maximum information for a statistical model and, at the same time, enable researchers to check on the model assumptions.

This Book: Introduces optimal experimental design in an accessible format.Provides guidelines for practitioners to increase the efficiency of their designs, and demonstrates how optimal designs can reduce a study's costs.Discusses the merits of optimal designs and compares them with commonly used designs.Takes the reader from simple linear regression models to advanced designs for multiple linear regression and nonlinear models in a systematic manner.Illustrates design techniques with practical examples from social and biomedical research to enhance the reader's understanding.

Researchers and students studying social, behavioural and biomedical sciences will find this book useful for understanding design issues and in putting optimal design ideas to practice.

This comprehensive volume captures the latest scientific evidence, technological advances, treatments and impact of biotechnology in hyperbaric oxygen therapy. Divided into three distinct sections, the book begins with basic aspects that include history, equipment, safety and diagnostic approaches; this is followed by clinical applications for hyperbaric oxygen therapy in various modalities; the last section provides an overview of hyperbaric medicine as a specialty with best practices from around the world. Integration of multidisciplinary approaches to complex disorders are also covered. Updated and significantly expanded from previous editions, Textbook of Hyperbaric Medicine, 6th Edition will continue to be the definitive guide to this burgeoning field for students, trainees, physicians and specialists.

This book presents an authoritative overview of the emerging field of person-centered psychiatry. This perspective, articulating science and humanism, arose within the World Psychiatric Association and aims to shift the focus of psychiatry from organ and disease to the whole person within their individual context. It is part of a broader person-centered perspective in medicine that is being advanced by the International College of Person-Centered Medicine through the annual Geneva Conferences held since 2008 in collaboration with the World Medical Association, the World Health Organization, the International Council of Nurses, the International Federation of Social Workers, and the International Alliance of Patients' Organizations, among 30 other international health institutions. In this book, experts in the field cover all aspects of person-centered psychiatry, the conceptual keystones of which include ethical commitment; a holistic approach; a relationship focus; cultural sensitivity; individualized care; establishment of common ground among clinicians, patients, and families for joint diagnostic understanding and shared clinical decision-making; people-centered organization of services; and person-centered health education and research.

This book is designed to present a comprehensive, state-of the-art approach to assessing and managing bariatric surgery and psychosocial care. Unlike any other text, this book focuses on developing a biopsychosocial understanding of patients' obesity journey and psychosocial factors contributing to their obesity and its management from an integrated perspective. Psychiatric Care in Severe Obesity takes a 360 approach by covering the disease's prevalence and relationship to psychiatric illness and social factors, including genetics, neurohormonal pathways and development factors for obesity. This book presents evidence and strategies for assessing psychiatric issues in severe obesity and uses common psychiatric presentations to feature the impact on bariatric surgery and key assessment features for weight loss. Concluding chapters focus on evidence-based psychosocial treatments for supporting patients with weight loss and bariatric surgery and includes educational tools and checklists for assessment, treatment, and care. Experts on non-pharmacological interventions such as mindfulness, cognitive-behavioral therapy and nutrition education describe treatment approaches in each modality, concluding with pharmacological approaches for psychiatric conditions and eating pathology. Additional tools in the appendices support clinicians, making this the ultimate guide for managing psychiatric illness in patients suffering from severe obesity. As obesity continues to grow in prevalence as a medically recognized epidemic, Psychiatric Care in Severe Obesity serves a vital resource to medical students, psychiatrists, psychologists, bariatric surgeons, primary care physicians, dietitians, mental health nurses, social workers, and all medical professionals working with severely obese patients.

A comprehensive guide to the theory, research and practice of violence risk management The Wiley Handbook of What Works in Violence Risk Management: Theory, Research and Practice offers a comprehensive guide to the theory, research and practice of violence risk management. With contributions from a panel of noted international experts, the book explores the most recent advances to the theoretical understanding, assessment and management of violent behavior. Designed to be an accessible resource, the highly readable chapters address common issues associated with violent behavior such as alcohol misuse and the less common issues for example offenders with intellectual disabilities. Written for both those new to the field and professionals with years of experience, the book offers a wide-ranging review of who commit acts of violence, their prevalence in society and the most recent explanations for their behavior. The contributors explore various assessment approaches and highlight specialized risk assessment instruments. The Handbook provides the latest evidence on effective treatment and risk management and includes a number of well-established and effective treatment interventions for violent offenders. This important book: Contains an authoritative and comprehensive guide to the topic Includes contributions from an international panel of experts Offers information on violence risk formulation Reveals the most recent techniques in violence risk assessment Explains what works in violence intervention Reviews specialty clinical assessments Written for clinicians and other professionals in the field of violence prevention and assessment, The Wiley Handbook of What Works in Violence Risk Management is unique in its approach because it offers a comprehensive review of the topic rather than like other books on the market that take a narrower view.

This comprehensive book thoroughly addresses all aspects of health care transition of adolescents and young adults with chronic illness or disability; and includes the framework, tools and case-based examples needed to develop and evaluate a Health Care Transition (HCT) planning program that can be implemented regardless of a patient's disease or disability. Health Care Transition: Building a Program for Adolescents and Young Adults with Chronic Illness and Disability is a uniquely inclusive resource, incorporating youth/young adult, caregiver, and pediatric and adult provider voices and perspectives. Part I of the book opens by defining Health Care Transition, describing the urgent need for comprehensive transition planning, barriers to HCT and then offering a framework for developing and evaluating health care transition programs. Part II focuses on the anatomic and neuro-chemical changes that occur in the brain during adolescence and young adulthood, and how they affect function and behavior. Part III covers the perspectives of important participants in the HCT transition process - youth and young adults, caregivers, and both pediatric and adult providers. Each chapter in Part IV addresses a unique aspect of developing HCT programs. Part V explores various examples of successful transition from the perspective of five key participants in the transition process - patients, caregivers, pediatric providers, adult providers and third party payers. Related financial matters are covered in part VI, while Part VII explores special issues such as HCT and the medical home, international perspectives, and potential legal issues. Models of HCT programs are presented in Part VIII, utilizing an example case study. Representing perspectives from over 75 authors and more than 100 medical centers in North America and Europe, Health Care Transition: Building a Program for Adolescents and Young Adults with Chronic Illness and Disability is an ideal resource for any clinician, policy maker, caregiver, or hospitalist working with youth in transition.

A considerable number of journal publications using a range of qualitative synthesis approaches has been published. Mary Dixon-Woods and colleagues (Mary Dixon-Woods, Booth, & Sutton, 2007) identified 42 qualitative evidence synthesis papers published in health care literature between 1990 and 2004. An ongoing update by Hannes and Macaitis (2010)identified around 100 additional qualitative or mixed methods syntheses. Yet these generally lack a clear, detailed description of what was done and why (Greenhalgh et al, 2007; McInnes & Wimpenny, 2008). Choices are most commonly influenced by what others have successfully used in the past or by a particular school of thought (Atkins et al, 2008; Britten et al, 2002). This is a substantive limitation. This book brings balance to the options available to researchers, including approaches that have not had a substantial uptake among researchers. It provides arguments for when and why researchers or other parties of interest should opt for a certain approach to synthesis, which challenges they might face in adopting it and what the potential strengths and weaknesses are compared with other approaches. This book acts as a resource for readers who would otherwise have to piece together the methodology from a range of journal articles. In addition, it should stimulate further development and documentation of synthesis methodology in a field that is characterized by diversity.

The Yearbook compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

The need has never been more crucial for community health providers, programs, and organizations to have access to training in addressing the unique behavioral health challenges facing our veterans, active duty military, and their families. Handbook of Military Social Work is edited by renowned leaders in the field, with contributions from social work professionals drawing from their wealth of experience working with veterans, active duty military, and their families. Handbook of Military Social Work considers: * Military culture and diversity * Women in the military * Posttraumatic stress disorder in veterans * Traumatic brain injury in the military * Suicide in the military * Homelessness among veterans * Cycles of deployment and family well-being * Grief, loss, and bereavement in military families * Interventions for military children and youth Offering thoughtful advice covering the spectrum of issues encountered by mental health professionals working with individuals and families, Handbook of Military Social Work will contribute to the improvement of efforts to help our military personnel, veterans, and their families deal with the challenges they face.

the Atlas of AIDS Co-infection illustrates imaging features and clinical outcomes of AIDS related diseases. The common/uncommon opportunistic infections and malignancies are well covered, including bacterial (e.g. Staphylococcus, Rhodococcus equi), fungal (e.g. Penicillium marneffei, Pneumocystis pneumonia, Pulmonary aspergillosis, Mucormycosis) and mycobacterial infections (Mycobacterium tuberculosis, Non-tuberculous Mycobacteria), lymphoma, as well as AIDS related disease in children with AIDS. Excellent photographs (X-ray and CT imaging) reveal the common imaging features of different diseases in different stages of treatment. Co-infections are common in the late stage of AIDS, consistent with considerable overlap of CT findings that are displayed in one single section and some of the cases in several sections. At last, there are excellent descriptions of differential diagnosis based on the same appearance (e.g. diffuse pulmonary miliary nodules, mediastinal and abdominal lymphadenopathy). Learning variety of different imaging will enrich the radiologists experience and knowledge about AIDS-related diseases, and also help clinicians making timely diagnosis and appropriate optimal treatment. It belongs in the library of each Radiologist, HIV expert and all of who care about Infectious Diseases.

This practical, engaging book provides concise, real life-tested guidance to healthcare teams concerned with widely reported and incentivized hospital quality and safety metrics, offering both a conceptual approach and specific advice and frameworks for reviewing quality and safety numerator events, from the perspective and experience of clinicians and administrators working within the Ochsner Health System. The text opens with the rationale for closely managing widely (including publicly) reported hospital patient quality and safety measures. Attention is given to the financial implications of quality performance, with respect to both penalties and payment incentives used by payer organizations. It then reviews the major public ratings and their relevant methodologies, including CMS, AHRQ and NSHN. In addition, it addresses ratings by proprietary organizations that have a large member clientele, such as Vizient, USNews, Leapfrog, Healthgrades, CareChex and others. Each metric - for example, the AHRQ Patient Safety Indicators (PSIs), and other metrics such as readmission rate, risk adjusted complications, hospital-acquired conditions and mortality - is addressed in a stand-alone chapter. For each, the importance, approach to review, opportunity for optimization, and engagement of healthcare staff are reviewed and discussed. Overall, this book forefronts the benefits of a collaborative approach within a health system. The concurrent review process, multidisciplinary collaboration among quality improvement, clinical documentation, coding and medical staff personnel are all emphasized. Also described in detail is the approach to and specific opportunities for medical staff education and engagement. Additional key topics include Engagement of the Medical Staff and House Staff (i.e., residents and other trainees), Futile Care, Surgical Quality Improvement (NSQIP), Nursing Provider Partnership, and Translation of Data Review to Successful Performance Improvement. Specialty chapters on pediatric, neurologic and transplant quality metrics are also included.

Advances in Clinical Chemistry, Volume 78, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry, and is the benchmark for novel analytical approaches in the clinical laboratory.

Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses.

Advances in Clinical Chemistry, Volume 76, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians, and research scientists. The serial discusses the latest and most up-to-date technologies related to the field of clinical chemistry and is the benchmark for novel analytical approaches in the clinical laboratory.

Every clinical laboratory devotes considerable resources to Quality Control. Recently, the advent of concepts such as Analytical Goals, Biological Variation, Six Sigma and Risk Management has generated a renewed interest in the way to perform QC.However, laboratory QC practices remain highly non-standardized and a lot of QC questions are left unanswered. The objective of this book is to propose a roadmap for the application of an integrated QC protocol that ensures the safety of patient results in the everyday lab routine.

Die Erstellung eines medizinisches Gutachtens erfordert ein enormes Fachwissen von den einzelnen Fachdisziplinen. Das Standardwerk für ärztliche Gutachter erscheint nun in der 8., komplett aktualisierten Auflage und gilt als unverzichtbares Nachschlagewerk: -       Anordnung der medizinischen Kapitel nach Organsystemen -       Konsequente Strukturierung nach Epidemiologie, Kernsymptomenm Ätiopathogenese, Therapie option und Prognose -       Angaben zur Evidenz und Leistungsfähigkeit von Menschen gemäß der ICF -       Umfangreiches Stichwortverzeichnis zum Nachschlagen Es bietet Ärzten als Gutachter, Sachverständige und Berater der sozialrechtlichen Institutionen, Gerichte und Versicherungen gutachtliches Wissen und umfassende Übersicht über die rechtlichen Voraussetzungen und das Fachwissen aller medizinischen Fachgebiete – von der Frage der Berentung wegen Erwerbsminderung und den Berufskrankheiten über die Arzthaftung bis zur Frage der Schuldfähigkeit.

The Update compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Targeting the practical needs of clinical teachers who do not have extensive time to undergo additional training, this book provides an accessible, on-the-spot resource to bolster teaching skills and optimize the education of trainees. A massive transformation takes place every summer in the United States: thousands of trainees in graduate medical education are appointed as attending physicians responsible for effectively teaching the next generation of medical students and residents. This handbook includes only the most relevant topics for new clinical teachers, and covers the basics of clinical teaching, teaching in specific situations, teaching different audiences, and best practices for handling challenging situations. The format is conducive to "just in time" learning, perfect for quick reference before meeting with learners or engaging in specific teaching situations, such as in an ambulatory clinic or at the bedside. Key points are emphasized with frequent use of tables and boxed practical content. Applicable to all teaching attendings regardless of specialty, the Handbook of Clinical Teaching is a valuable aid for individuals who wish to improve their teaching, and serves as a practical guide for faculty development in clinical teaching.

This textbook consists of ten chapters, and is a must-read to all medical and health professionals, who already have basic knowledge of how to analyze their clinical data, but still, wonder, after having done so, why procedures were performed the way they were. The book is also a must-read to those who tend to submerge in the flood of novel statistical methodologies, as communicated in current clinical reports, and scientific meetings. In the past few years, the HOW-SO of current statistical tests has been made much more simple than it was in the past, thanks to the abundance of statistical software programs of an excellent quality. However, the WHY-SO may have been somewhat under-emphasized. For example, why do statistical tests constantly use unfamiliar terms, like probability distributions, hypothesis testing, randomness, normality, scientific rigor, and why are Gaussian curves so hard, and do they make non-mathematicians getting lost all the time? The book will cover the WHY-SOs.