During the last decade it has become evident that the brain is an
important target for hormones. Although it has been discovered only
recently that the brain contains numerous peptide hormones, the
role of pituitary and hypo thalamic hormones in brain activity has
been the subject of basic studies for quite some time. Peptide
hormones are involved in mental performance. pain perception, food
and water metabolism. sleep. sexual behaviour and nursing
behaviour, and disturbances in the hormonal climate of the brain
may be associated with psychopathology. cognitive disturbances and.
possibly. addic tion. The clinical influence of neurohypophysial
hormones and their frag ments is studied today on learning and
memory. on inadequate behaviour and addiction, in Parkinson's
disease. Lesch-Nyhan syndrome. depression and schizophrenia.
Fragments of adrenocorticotrophin have been shown to affect
motivation, concentration and attention. and neuropeptides derived
from -lipotrophin are probably involved in psychopathology.
Thyrotrophin releasing hormone has been implicated in depression.
and lutein-releasing hormone in sexual disturbances. In spite of
the impressive experimental data; clinical results to date have
been controversial and. to some extent. anecdotal. In some cases
they have been exciting. and in others disappointing. It was
against this background that the International Health Foundation
decided to organize and sponsor their workshop on 'The brain as an
endo crine target organ in health and disease' at which the papers
appearing in this book were presented."
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