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Mechanisms of Drug Interactions (Paperback, Softcover reprint of the original 1st ed. 1996)
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Mechanisms of Drug Interactions (Paperback, Softcover reprint of the original 1st ed. 1996)
Series: Handbook of Experimental Pharmacology, 122
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Over the years a number of excellent books have classified and
detailed drug drug interactions into their respective categories,
e.g. interactions at plasma protein binding sites; those altering
intestinal absorption or bioavailability; those involving hepatic
metabolising enzymes; those involving competition or antagonism for
receptor sites, and drug interactions modifying excretory
mechanisms. Such books have presented extensive tables of
interactions and their management. Although of considerable value
to clinicians, such publica tions have not, however, been so
expressive about the individual mechanisms that underlie these
interactions. It is within this sphere of "mechanisms" that this
present volume specialises. It deals with mechanisms of in vitro
and in vivo, drug-drug, drug food and drug-herbals interactions and
those that cause drugs to interfere with diagnostic laboratory
tests. We believe that an explanation of the mechanisms of such
interactions will enable practitioners to understand more fully the
nature of the interactions and thus enable them to manage better
their clinical outcome. If mechanisms of interactions are better
understood, then it may be pos sible for the researcher to develop
meaningful animal/biochemical/tissue cul ture or physicochemical
models to which new molecules could be exposed during their
development stages. The present position, which largely relies on
patients experiencing adverse interactions before they can be
established or documented, can hardly be regarded as satisfactory.
This present volume is classified into two major parts; firstly,
pharmacoki netic drug interactions and, secondly, pharmacodynamic
drug interactions."
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