Incorporates mixed-effects modeling techniques for more powerful and efficient methods
This book presents current and effective nonparametric regression techniques for longitudinal data analysis and systematically investigates the incorporation of mixed-effects modeling techniques into various nonparametric regression models. The authors emphasize modeling ideas and inference methodologies, although some theoretical results for the justification of the proposed methods are presented.
With its logical structure and organization, beginning with basic principles, the text develops the foundation needed to master advanced principles and applications. Following a brief overview, data examples from biomedical research studies are presented and point to the need for nonparametric regression analysis approaches. Next, the authors review mixed-effects models and nonparametric regression models, which are the two key building blocks of the proposed modeling techniques.
The core section of the book consists of four chapters dedicated to the major nonparametric regression methods: local polynomial, regression spline, smoothing spline, and penalized spline. The next two chapters extend these modeling techniques to semiparametric and time varying coefficient models for longitudinal data analysis. The final chapter examines discrete longitudinal data modeling and analysis.
Each chapter concludes with a summary that highlights key points and also provides bibliographic notes that point to additional sources for further study. Examples of data analysis from biomedical research are used to illustrate the methodologies contained throughout the book. Technical proofs are presented in separate appendices.
With its focus on solving problems, this is an excellent textbook for upper-level undergraduate and graduate courses in longitudinal data analysis. It is also recommended as a reference for biostatisticians and other theoretical and applied research statisticians with an interest in longitudinal data analysis. Not only do readers gain an understanding of the principles of various nonparametric regression methods, but they also gain a practical understanding of how to use the methods to tackle real-world problems.

This book provides a state-of-the-art, comprehensive overview of the diagnosis and treatment of sleep disorders. It details evidence-based practice recommendations using parameters primarily developed by the American Academy of Sleep Medicine. The book offers a thorough and extensive board review for specialization in sleep medicine and supports primary care clinicians in appropriately using sleep diagnostic testing results in clinical practice.

Translational Research and Clinical Practice offers a clear and comprehensive introduction to evidence-based medicine. The use of medical literature has always been an integral tool for patient care, yet recently the modern processes of question formulation, literature search, and study evaluation have changed with the advent of the internet and technology. The physician must be able to find empirical evidence from the appropriate study using a searchable question and then determine its impact on patient care. The book provides the general framework for such medical decision making; it covers all kinds of cases and strategies, including questions of diagnosis, therapy, prognosis, differential diagnosis, clinical presentation, and causality.
The tested material and approaches in this book are based on a course developed and taught by the author at Temple University School of Medicine. Organized for ease of use, accessibly written, and replete with clinically germane examples, Translational Research and Clinical Practice is a concise guide for medical students and clinicians seeking to effectively interpret and apply medical evidence in daily practice.

USMLE Step 2 Clinical Skills Triage is the indispensable preparation book for the Step 2 Clinical Skills exam, presenting 40 high-yield patient-encounter cases that simulate the examination experience. Cases are organized for straightforward learning: a sample dialogue that mimics actual doctor-patient communication is followed by guidelines on performing the physical exam, ending the case, writing the patient note, and outlining the differential diagnosis. Comprehensive yet succinct, the cases address almost all possible exam scenarios, including telephone cases and "difficult patient" encounters. Each case contains detailed and relevant information on presenting complaints and conditions, with pertinent points highlighted and boxed for easy review. Written by the author of the popular USMLE Step 3 Triage, this book is optimal for either individual or group study and for any student interested in reviewing how to practice applying medical knowledge and patient-centered skills.

Step 2 Clinical Knowledge is one of the hardest exams you'll take in your medical training, and it's very important to do well Preparation is the key that separates successful candidates from the rest.
USMLE Step 2 Triage provides a thorough yet high-yield review for the exam, covering a gamut of frequently tested specialties and subspecialties with emphasis on pertinent principles of clinical science and patient-centered skills. Consistently organized, each topic is structured to provide the material in a manageable format, divided into several sections: "Symptoms," "Diagnosis," "Treatment," and "Take Home Points." USMLE Step 2 Triage is geared to facilitate the most comprehensive and efficient preparation for the exam; it is packed with tables and figures, and features 100 full color images. Written by the author of the popular USMLE Step 3 Triage and the USMLE Step 2 Clinical Skills Triage, this book will help deliver the best results for any student studying for the Step 2 Clinical Knowledge exam.

The book aims to review knowledge on the disorders of eating behaviour and body composition in some of the non-primate higher animals and to relate these to similar conditions in humans. With advances in understanding the nature of these disorders and their biological basis, it seems timely to assess what cross-species comparisons can tell us about the general underlying factors at work. This may also help to delineate what may be a general biological basis that humans share with their higher animal comrade species and what may distinguish human from non-human, particularly in a cultural context. This could help in combating better the problems of these conditions in the animal species as well as in man and in suggesting well-based preventive measures. As far as people are concerned the last two decades of the 20th century have shown a significant increase in obesity in the richer countries, particularly the USA (Table 1). Possibly associated with the obesity boom, there is an increasing awareness of other disorders of eating behaviour and body composition. These range from anorexia nervosa, at the other end of body composition to obesity, to others, such as bulimia, with more variable effects on body composition.

Few clinical disciplines have been transformed so dramatically by advancements in science and technology as gastrointestinal surgery. To begin with, modern ph- macology has virtually eliminated some kinds of surgery altogether. If one were to take a peek at a typical operating room schedule in a busy hospital of the 1960s, gastrectomies of one kind or another would have constituted a large block of the major surgeries. The advent of effective H2-histamine receptor antagonists and, more ] + recently, the H, K -ATPase (proton pump) inhibitors led to a precipitous decline in those procedures such that they are rarely performed today. Exciting new approaches to treating inflammatory bowel diseases and their complications-such as fistulas- with anticytokine therapy may one day have a similarly profound effect on surgery for this condition as well. Beyond pharmaceutics, advances in imaging techniques have greatly facilitated the identification and characterization of pathology in the gastrointestinal tract in a way that would have been unimaginable only a few years ago. Just to visualize the pancreas in some way was a horrendous task until abdominal ultrasound, magnetic resonance imaging, or computer tomography made it simple. The fact that the gut is a hollow organ that can be accessed through the mouth, anus, or even through the wall of the abdomen has been fully exploited with fiberoptic endoscopes that can bend around corners with ease and permit surgery to be conducted through them.

Now for the first time, a new diagnosis and treatment guide with even more focus on the most commonly encountered disorders than ever before. All major internal medicine diseases and disorders are covered in this new succinct evidence-based guide to treatment and diagnosis in internal medicine. Organized by body system, and focused on critical core topics, the Mayo Clinic Internal Medicine Concise Textbook is replete with summary tables, algorithms, and summary points. Easy-access to tables of current medications, indications and side-effects saves time and improves treatment outcomes. In addition, special sections provide expert guidance on preparation for the USMLE Step 2 Clinical Knowledge and Clinical Skills examinations.

The seventh edition of this BMA award-winning pocket guide provides essential information for doctors based on the comprehensive Kumar & Clark's Clinical Medicine - the highly respected, gold-standard textbook on the treatment and management of medical conditions. Essentials is intended as an easy-to-access revision reference that provides important information for doctors on the ward, including normal values, medical emergencies, useful websites, abbreviations and a dictionary of terms. This best-selling book has been fully updated and is accessible, coherent and concise, making it an essential companion for medical students, doctors and health professionals in the UK and around the world. Small and compact - can be taken anywhere Clearly laid out, logical and easy to follow Emergency guide for quick reference Illustrations and tables to enhance understanding New section on COVID-19 New chapter on Elderly Medicine and Frailty Winner of the Internal Medicine category at the 2018 BMA Medical Book Awards Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. New co-editor Euan Sandilands New chapter on Elderly Medicine and Frailty

Oxidative stress and inflammation are among the most important factors of disease. Chronic infections, obesity, alcohol and tobacco usage, radiation, environmental pollutants, and high-calorie diets have been recognized as major risk factors for a variety of chronic diseases from cancer to metabolic diseases. All these risk factors are linked to chronic diseases through inflammation. While short-term, acute inflammation generated by the immune system serves a therapeutic role, chronic low-level inflammation that may persist "silently" for decades is responsible for chronic diseases. Inflammation, Lifestyle, and Chronic Diseases: The Silent Link describes the role of dysregulated inflammation in persistent and recurring diseases. It investigates links to lifestyle and presents research on how the suppression of proinflammatory pathways may provide opportunities for both prevention and treatment of chronic diseases. The book covers neurodegenerative diseases, pulmonary diseases, asthma, rheumatic and arthritic diseases, skin disease, heart disease, chronic wounds, infectious disease, neuropsychiatric disorders such as depression, gastrointestinal diseases, insulin resistance, and cancer, many of which are also diseases of old age. For each chronic disease, contributors review the clinical and scientific literature and examine current and potential therapies, including conventional pharmacotherapies as well as natural products. Noting that the long-term use of steroids and nonsteroidal anti-inflammatory drugs (NSAIDs) can cause adverse side effects, many of the chapters address the role of dietary agents such as fruits, vegetables, legumes, pulses, nuts, and spices as ideal anti-inflammatory agents that can be consumed regularly. The book also suggests directions for further research. Clinical and science researchers, students, and health professionals interested in the link between inflammation, lifestyle, and chronic diseases will find this an informative resource.

This practical, engaging book provides concise, real life-tested guidance to healthcare teams concerned with widely reported and incentivized hospital quality and safety metrics, offering both a conceptual approach and specific advice and frameworks for reviewing quality and safety numerator events, from the perspective and experience of clinicians and administrators working within the Ochsner Health System. The text opens with the rationale for closely managing widely (including publicly) reported hospital patient quality and safety measures. Attention is given to the financial implications of quality performance, with respect to both penalties and payment incentives used by payer organizations. It then reviews the major public ratings and their relevant methodologies, including CMS, AHRQ and NSHN. In addition, it addresses ratings by proprietary organizations that have a large member clientele, such as Vizient, USNews, Leapfrog, Healthgrades, CareChex and others. Each metric - for example, the AHRQ Patient Safety Indicators (PSIs), and other metrics such as readmission rate, risk adjusted complications, hospital-acquired conditions and mortality - is addressed in a stand-alone chapter. For each, the importance, approach to review, opportunity for optimization, and engagement of healthcare staff are reviewed and discussed. Overall, this book forefronts the benefits of a collaborative approach within a health system. The concurrent review process, multidisciplinary collaboration among quality improvement, clinical documentation, coding and medical staff personnel are all emphasized. Also described in detail is the approach to and specific opportunities for medical staff education and engagement. Additional key topics include Engagement of the Medical Staff and House Staff (i.e., residents and other trainees), Futile Care, Surgical Quality Improvement (NSQIP), Nursing Provider Partnership, and Translation of Data Review to Successful Performance Improvement. Specialty chapters on pediatric, neurologic and transplant quality metrics are also included.

Authored by leading international researchers, this monograph introduces and reviews developed tomograhic methods for discovering 2D and 3D structures of the ionosphere, and discusses the experimental implementation of these methods. The detailed derivations and explanations make this book an excellent starting point for non-specialists.

RevMED 300 SBAs in Clinical Specialties is a book of 300 single best answer questions covering a range of topics in paediatrics, obstetrics and gynaecology and psychiatry. These topics are the focus of 4th or 5th Year examinations in most medical school curriculums and have usually been separated from topics in general medicine and surgery.Question books are an exceptionally useful resource for medical students preparing for their clinical exams. RevMED 300 SBAs in Clinical Specialties is written by students who have recently sat clinical examinations at medical school and is designed to be student-friendly with detailed explanations and flow charts summarising the most up-to-date guidelines. The questions have been edited by teaching fellows and registrars to ensure the topics covered provide students with a functional understanding of important concepts with the hope of aiding their future careers.

Knowledge Translation in Health Care is a practical introduction to knowledge translation for everyone working and learning within health policy and funding agencies, and as researchers, clinicians and trainees. Using everyday examples, it explains how to use research findings to improve health care in real life. This new second edition defines the principles and practice of knowledge translation and outlines strategies for successful knowledge translation in practice and policy making. It includes relevant real world examples and cases of knowledge translation in action that are accessible and relevant for all stakeholders including clinicians, health policy makers, administrators, managers, researchers, clinicians and trainees. From an international expert editor and contributor team, and fully revised to reflect current practice and latest developments within the field, Knowledge Translation in Health Care is the practical guide for all health policy makers and researchers, clinicians, trainee clinicians, medical students and other healthcare professionals seeking to improve healthcare practice.

Selected as a Doody's Core Title for 2022! Designed for busy clinicians struggling to fit the critical issue of nutrition into their routine patient encounters, Nutrition in Clinical Practice translates the robust evidence base underlying nutrition in health and disease into actionable, evidence-based clinical guidance on a comprehensive array of nutrition topics. Authoritative, thoroughly referenced, and fully updated, the revised 4th edition covers the full scope of nutrition applications in clinical practice, spanning health promotion, risk factor modification, prevention, chronic disease management, and weight control - with a special emphasis on providing concisely summarized action steps within the clinical workflow. Edited by Dr. David L. Katz (a world-renowned expert in nutrition, preventive medicine, and lifestyle medicine) along with Drs. Kofi D. Essel, Rachel S.C. Friedman, Shivam Joshi, Joshua Levitt, and Ming-Chin Yeh, Nutrition in Clinical Practice is a must-have resource for practicing clinicians who want to provide well-informed, compassionate, and effective nutritional counseling to patients. Features short, easily digestible chapters with updated references. Includes comprehensive updates throughout, as well as a newly expanded section on Contemporary Topics in Nutrition. Covers key topics such as the ketogenic diet, intermittent fasting, ultraprocessed food, and strength of evidence assessment in nutrition. Provides data from recent nutritional studies, helpful nutrition data tables, clinically relevant formulas, and patient-specific meal planners. Addresses special topics such as pregnancy and lactation, pediatric nutrition, athletic performance and sports nutrition, health effects of specific foods, plant-based diets, and many more. Features expert contributions from authors with diverse expertise and practical experience in medical education, clinical practice, and preventive medicine. , Enrich Your eBook Reading Experience Read directly on your preferred device(s), such as computer, tablet, or smartphone. Easily convert to audiobook, powering your content with natural language text-to-speech. ,

An Updated Reference on Human Exposure to Environmental Toxicants and A Study of Their Impact on Public Health With the 4th edition of Environmental Toxicants: Human Exposures and Their Health Effects, readers have access to up-to-date information on the study and science of environmental toxicology and public health worldwide. Practitioners and professionals can use this resource to understand newly discovered information on the adverse health effects of toxins and pollutants in air, water, and occupational and environmental environments on large human populations. The 4th edition of this book is updated to reflect new knowledge and research on: Performing risk assessments on exposed individuals Assessing the effects of toxicants and substances on large populations for health and medical professionals Patterns of human exposure to select chemical toxicants World Trade Center dust, agents for chemical terrorism, and nanoparticles For health professionals, including health authorities, public health officials, physicians, and industrial managers, who are seeking new research and techniques for managing environmental substances, this invaluable reference will guide you through in a thorough, easy- to-read manner.

Evidence-based medicine (EBM) has become a required element of clinical practice, but it is critical for the healthcare community to understand the ongoing controversy surrounding EBM. Seeking to address questions raised by critics, The Philosophy of Evidence-based Medicine challenges the over dependency of EBM on randomized controlled trials. This book also explores EBM methodology and its relationship with other approaches used in medicine.

The field of medical education and training has undergone dramatic changes within the past few years, and continues to evolve. Modernising Medical Careers, changes in the statutory role of the Postgraduate Medical Education and Training Board, and the Good Doctors, Safer Patients report from Liam Donaldson, Chief Medical Officer, are just some of the factors affecting the way doctors are now learning. In this book, Yvonne Carter and Neil Jackson, experienced medical educators of both undergraduates and postgraduates who have demonstrated a long standing commitment to multi-professional education and training, bring together a prestigious team of contributors with a wide variety of experience across diverse academic, service and lay backgrounds, to provide a comprehensive, up to date review of medical education and training.
With the demands on young doctors increasing, along with higher patient expectations, the need for ongoing education and training within the medical profession has never been higher. This book offers theoretical and practical guidance for those planning, delivering, and receiving education and training in ever-changing healthcare environments. Themes covered include assessment, professionalism and medical regulation, educational standards, patients' expectations, Continuing Professional Development, leadership and management, the European Working Time Directive, Fitness to Practice, interprofessional learning, the development of the NHS workforce, equality and diversity, and ethical and legal issues. Medical education needs to be a lifelong process, and this book integrates both undergraduate and postgraduate issues throughout, to encourage continued learning.
This book will help ensure that future generations of doctors are trained to meet the changing needs of our population.

This book provides a comprehensive and up-to-date coverage of the relationship between drug metabolism enzymes and transporters on drug toxicity, along with methods to investigate their role on adverse drug reactions. Unites both the metabolism and transporter components of drug toxicity two aspects not normally connected and the latter often neglected Familiarizes readers with the mechanism and species differences in drug metabolizing enzymes and transporters Discusses promising approaches to accurately predict human drug toxicity via the incorporation of human drug metabolism in toxicity evaluation

There is now a substantial body of psychological knowledge, based on research and clinical experience, which supports and guides best practice in dealing with health- and illness-related behaviour. Peter Salmon offers a strong conceptual framework which unifies this knowledge within clinical contexts and problems. Based on the author's special interests in acute physical illness and surgery, this text shows how the beliefs, emotions and behaviour of individuals (both lay people and health professionals) can have a profound effect on the processes of understanding, communication and coping in the course of diagnosis and treatment. Peter Salmon, a senior figure in clinical health psychology, has extensive experience of training medical and health care professionals, and of dealing with patients and families. His book offers
* A focus on acute illness and surgery, in contrast to the many other books which deal with chronic illness and health promotion
* An introduction to psychological concepts and models, situated within the clinical reality of presentation, diagnosis, communication, treatment, and the patient-professional relationship
* Guidance on evaluation of research and clinical practice which will help to inform a better understanding of behaviour and relationships in acute illness and surgery and wider medical contexts.
Students and professionals in clinical health psychology, health care and medicine should read this book for an accessible, authoritative account of how psychological knowledge can help them, why people feel and behave as they do, and which medical situations can be enlightened and facilitated by the integration of psychological principles intotherapeutic practice. This book appears in The Wiley Series in Clinical Psychology Series Editor: J. Mark G. Williams University of Wales, Bangor, UK

This groundbreaking volume is the first to analyze how and to what extent bioethics considerations influence today's judges. Previous books have attended to the law that governs bioethics problems, but this is the first to examine when and how bioethical issues impact judicial reasoning and decision-making. The volume examines the cutting-edge of the relationship of bioethics to law, and explores how law receives, assesses, and uses bioethics.

Global Health Lecture Notes: Issues, Challenges and Global Action provides a thorough introduction to a wide range of important global health issues and explores the resources and skills needed for this rapidly expanding area. Global Health is a growing area that reflects the increasing interconnectedness of health and its determinants. Major socio-economic, environmental and technological changes have produced new challenges, and exacerbated existing health inequalities experienced in both developed and developing countries. This textbook focuses on managing and preventing these challenges, as well as analysing critical links between health, disease, and socio-economic development through a multi-disciplinary approach. Featuring learning objectives and discussion points, Global Health Lecture Notes is an indispensable resource for global health students, faculty and practitioners who are looking to build on their understanding of global health issues.

In Vivo Models of Inflammation (Volume 1 and Volume 2) provides the biomedical researcher in both the pharmaceutical industry and academia with a description of the state of the art animal model systems used to emulate diseases with components of inflammation. This second edition acts as a complement to the first edition by describing and updating the standard models that are most utilized for specific disease areas. In addition, new models are included exploring emerging areas of inflammation research. The format is designed with the laboratory in mind: Both volumes provide detailed descriptions of the methodologies and uses of the most significant models. This includes current information regarding agents that demonstrate efficacy, those that do not and those that can be used as standard controls. The focus remains on those models that serve as pre-clinical correlates to human disease as well as those that represent components of the inflammatory response. Pioneering ideas and provocative comments about future directions are meant to challenge the status quo and stimulate new thinking. Therefore, new approaches to the development of future models in selected therapeutic areas have been highlighted. The focus on novel technologies that are vital for innovative in vivo research has been expanded to include chapters on the use of transgenic and gene transfer technologies, nanotechnology, and stem cells. This up-to-date reference manual helps to select the best animal model for a specific question. At the same time, this set of books continues to acknowledge the solemn responsibility in vivo research carries with it and extends the coverage of animal respect and welfare when used in experimental settings. Chapters describing current regulations in the United States, United Kingdom, and Japan address these concerns. Thus, the ultimate aim of this set of books is to provide current best practices for obtaining the maximum informat

The new edition of this best-selling title from the popular 100 cases series explores common scenarios that will be encountered by the medical student and junior doctor when working in the community setting, and which are likely to feature in qualifying examinations. The book covers a comprehensive range of presentations from tiredness to tremor. Comprehensive answers highlight key take home points from each case and provide practical advice on how to deal with the challenges that occur in general practice at all levels.

Written for students and clinicians who are new to Chronic Fatigue Syndrome (CFS), this work aims to demystify the illness and its management by offering a detailed exploration of the role of the occupational therapist in facilitating the CFS patient's recovery. It provides an in-depth overview of information on aetiology, treatment and evidence-based management of CFS, with specific emphasis on occupational therapy intervention. Recognizing that working with people with CFS involves all aspects of the occupational therapy process, the book demonstrates how many of the skills gained in occupational therapy training and in other areas of clinical practice can be transferred to the management of CFS. Case vignettes and more in-depth studies are used throughout to illustrate the syndrome and its management and a full glossary of terms is also included.