Essentials of Palliative Care is a to-the-point, clinically oriented resource for all members of the multidisciplinary palliative care team and trainees. It covers practical clinical topics, including assessment of the patient and pain and symptom management, and practical non-medical topics central to providing effective palliative care, including psychological management, guidance on how to help patients and their families through the many healthcare decision points they face, and sensitivity to the goals and culture of the patient. Review questions, with detailed answers, provide a convenient way for readers to test their knowledge.

Features:

. Concise, comprehensive, clinically focused

. Multiple choice review questions, with detailed answers

. Expert contributors from leading institutions

. Coordination of care by palliative care team a major focus

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Consumer interest in diet and nutritional supplements is increasing dramatically. Patients and members of the public are seeking advice from health professionals, nutritionists and food scientists. This book is designed to meet the needs of those professionals who are called upon to advise patients and the general public. It provides also a valuable text for those who are researchers or decision makers in the food and pharmaceutical industries. The text presents a thorough account of this topical subject and enables the reader to appreciate the functions of nutrients in health and common disease states, to understand the current debates over the roles of nutrients and supplements in the diet, and to answer those questions frequently asked by patients and consumers.

The Boron '97 meeting was a great success in summarising all recent developments in basic and applied research on boron's function, especially in plants. New techniques have since been developed and new insight has been gained into the role of boron in plant and animal metabolism. Nevertheless, there were still lots of open questions. The aim of the present workshop held in Bonn as a satellite meeting to the International Plant Nutrition Colloquium was thus to gather all actual information which has been gained since the Boron '97 meeting and to compile knowledge, both from animal and plant sciences. Furthermore, applied aspects had to be addressed too, as there is an increasing awareness of boron deficiencies even in crops such as wheat, which have formerly not been considered as responsive to boron application. Genetic differences in boron demand and efficiency within one species are a further important topic which has gained importance since the 1997 meeting. More in-depth knowledge on the mechanisms of boron efficiency are required as an increased efficiency will be one major possibility to maintain and improve crop yields for resource-poor farmers. Nevertheless, it has also clearly been shown that an adequate supply of boron is needed to obtain high yields of crops with a high quality, and that a sustainable agriculture has to provide an adequate boron supply to compensate for inevitable losses through leaching (especially in the humid tropics and temperate regions) and for the boron removal by the crop.

Every cell and organism faces the problem of spaces, made up of the two leaflets of the lipid generating a confined space in which metabolic bilayer. The importance of traffic and signaling across membranes is reflected by the estimate and anabolic reactions take place and at the same time allowing entry and exit of metabo that 20% of all genes in the human genome encode membrane proteins. A failure of any of lites, ions, proteins, and signals across its bor der. Evolution has solved the problem by these proteins may have dramatic con se generating lipid membranes that contain trans quences for ceH function. In recent years much porters, ion channels, and receptors. In eukary attention has been paid to diseases resulting otic cells, this problem is exacerbated by the from nonfunctional ion channels ("chan presence of multiple organelles, which are con nelopathies"). Not surprisingly, many of these fined spaces in their own right. Even the lipid diseases affect the excitability of cells. membrane consists of two relatively separate Transporter diseases (perhaps coined "carrier vi PREFACE diseases") are more related to metabolic dis Each chapter is concluded by a summary, and eases, Transporters are frequently found at the most chapters also contain an overview of the beginning or the end of metabolic pathways clinical features of a particular transporter and as a result can have similar effects to disease. a missing enzyme."

The administration of intravenous fluids is one of the most common and important therapeutic practices in the treatment of surgical, medical and critically ill patients. The international literature accordingly contains a vast number of works on fluid management, yet there is still confusion as to the best options in the various situations encountered in clinical practice. The purpose of this volume is to help the decision-making process by comparing different solution properties describing their indications, mechanisms of action and side-effects according to physiologic body water distribution, electrolytic and acid-base balance, and to clarify which products available on the market represent the best choice in different circumstances. The book opens by discussing in detail the concepts central to a sound understanding of abnormalities in fluid and electrolyte homeostasis and the effect of intravenous fluid administration. In the second part of the monograph, these concepts are used to explain the advantages and disadvantages of solutions available on the market in different clinical settings. Body Fluid Management: From Physiology to Therapy will serve as an invaluable decision-making guide, including for those who are not experts in the subject.

The third edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers.
Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical ResearchAddresses the vast opportunities for translation of basic science observations to the bedside through clinical researchDelves into data management and addresses how to collect data and use it for discoveryContains valuable, up-to-date information on how to obtain funding from the federal government

to Medical Manipulation John K. Paterson, MB. BS. MRCGP currently Vice-President and Han. Secretary of the British Association of Manipulative Medicine and member of the Scientific Advisory Committee of the International Federation of Manual Medicine and Loic Burn, BA. MRCS. LRCP. DPhysMed currently President of the British Association of Manipulative Medicine. Han. Secretary of the Scientific Section of the British League against Rheumatism and member of Council of the Back Pain Association ~~ M.TP PRESS LIM.ITED ~ a member of the KLUWER ACADEMIC PUBLISHERS GROUP LA CASTER I BOSTON I THE HAG E / DORDRECHT Published in the UK and Europe by MTP Press Limited Falcon House Lancaster, England British Library Cataloguing in Publication Data Paterson, John K. An introduction to medical manipulation. 1. Manipulation (Therapeutics) I. Title II. Burn, Loic 615.8'2 RM724 Published in the USA by MTPPress A division of Kluwer Boston Inc 190 Old Derby Street Hingham, MA 02043, USA Library of Congress Cataloging in Publication Data Paterson, John K., 1921- An introduction to medical manipulation. Bibliography: p. Includes index.

For over half a century Davidson's Principles and Practice of Medicine has informed and educated students, doctors and other health professionals all over the world, providing a comprehensive account of the practice of medicine. Davidson's Essentials of Medicine provides the core content of the main textbook in a condensed format which will be invaluable whenever you are on the move - whether commuting, travelling between training sites, or on electives. This book provides a distillation of the core information required for clinical studies in medicine. While retaining the acclaimed readability of the main textbook it presents the key information in a format more appropriate for practical clinical work. The scope of the contents was carefully selected by a team of junior doctors, emphasising only the topics that will be essential for clinical studies. The text draws directly on the depth and breadth of experience of the Davidson's authors and its International Advisory Board. Updated to include key changes and new illustrations included in Davidson's Principles and Practice of Medicine. New chapters on Acute Medicine and Ophthalmology

The metabolomics and systems biology approach to research can be applied to many disciplines. This book provides a solid introduction to medical metabolomics and systems biology, and demonstrates how they have been applied to studies in medicine and human health, including nutrition and pathogenic microorganisms. Following core themes of diagnosis, pathology and aetiology of disease, this book provides a reference for health care professionals interested in how to use metabolomics for medical research.

The study of the normal function of the animal and human organisms and of the diseases which disturb that normal func tion is largely the study of control mechanisms. These control mechanisms are essential for the survival of an organism in a more or less hostile environment. In many ways they clearly resemble the control mechanisms devised by electronic engin eers for running machinery of all kinds and there are many remarkable parallels between biology and engineering. However, it should not be forgotten that the biological systems were on the scene first and that the engineering is a parallel and independent development. It is therefore perhaps a pity that in recent years the study of biological control systems has tended to be dominated by mathematicians and engineers who have moved from these more precise disciplines into biology. As a consequence of this dominance, one often gets the impression that the principles of biological control can be understood only after one has undergone a rather high-powered course in elec tronic control theory. It often seems to be assumed that it is electronics which must do all the teaching while biology and medicine must do all the learning. In fact I suspect that biolo gical control mechanisms are considerably more sophisticated than anything yet available in the world of the physical sciences and that in the long run biology will teach more to control engineers than vice versa."

One of the most important developments in diagnostic imaging over the last decade has been magnetic resonance imaging (MRI). Its ability to differentiate between tissues and give patholog ical information about diseases has led to earlier treatment, thus increasing the likelihood of recovery. The images produced using this technique give superb anatomical detail in any plane and are obtained without the use of ionising radiation. The increased use of MRI has presented radiographers with a number of challenges, and because we are no longer dealing with ionising radiation understanding the subject can some times be confusing. We hope that this text will help radiographers and student radiographers to further their knowledge and unravel the mysteries of MRI. Philip T. English Christine Moore Contents 1 Basic Principles . . . . . . . . . 1 History ..... . 1 Atomic Theory . . 1 Magnetic Theory . 2 Resonance 4 Relaxation. . . . . 5 2 Instrumentation........ 9 The Magnet .. 9 Shim Coils ........... . 12 Gradient Coils ......... . 13 RF Transmitter/Receiver Coils. 14 The Computer . . . . . . . . . 18 3 Pulse Sequences. . . . . . . . . 19 Saturation Recovery (Partial Saturation) 19 Spin Echo (SE) . . . . . . . . . . . . . 20 Multiple Spin Echo. . . . . . . . . . . 22 Fast Spin Echo (FSE) or Turbo Spin Echo (TSE). 23 Inversion Recovery (IR) . . . . . . . . . . . . . 26 Gradient Echo .................. . 28 Magnetisation Transfer Contrast Imaging (MTC) 34 4 Image Production. . . . . . . .

Dental defects may be the physical expression of genetic defects, and so they can often be seen in a variety of syndromes associated with malformations of organs. However, dental defects are often not recognized, identified, nor characterised despite representing a possible diagnostic sign for an undiagnosed condition. This book addresses this gap by providing an understanding of dental genetics and its developmental biology counterpart. With approximately seventy well-illustrated examples, the authors present the clinical oro-facial manifestations accompanying various syndromes, providing the necessary knowledge for diagnostic purposes, as well as giving insight into recent development for each specific condition. The clarity and format of this book make it an ideal support guide both in the clinic and while conducting research.

This second edition of the popular pocket book is designed to make the best available evidence easily accessible to mental health practitioners, general practitioners and students. The content is drawn from the very successful multidisciplinary edition (circulated to 600,000 health care professionals worldwide), and maintains the same high standards of rigorous quality control and ease of access to relevant evidence. The literature has been thoroughly searched, appraised and condensed into concise but comprehensive summaries.

All practitioners and pharmacists interested in treatment with herbal remedies should have this book at their disposal. It is the definitive practice-oriented introduction - now in its fifth edition - to phytotherapy. Methodically classified by organic systems and fields of application, the text provides a quick insight into dosage, form of application and effects of the most important herbal remedies. Only those herbal remedies that are of pharmacological and clinical efficiency have been considered. The authors are highly experienced in the field of postgraduate medical education, and, with this work, present an indispensable reference book for the medical practice.

Legal action involving doctors, either as defendants or expert witnesses, has greatly increased over the past decade and few can now remain aloof from this aspect of their profession. Written by doctors (including five Council Members of the Medical Defence Union of Great Britain) and lawyers, this practical guide offers clear and comprehensive advice to all concerned. Part I discusses how to write medical reports, especially when consent is required or confidential information is involved. Part II covers contentious issues in various clinical specialties which repeatedly arise in litigation; well-known examples are cases involving whiplash injuries or perinatal brain damage. In Part III lawyers discuss the medico-legal problems of the solicitor's role, court testimony and medical negligence. This book is a valuable reference to all members of the medical profession. Lawyers, officials and others outside the medical profession who come into contact with medical litigation but have limited medical knowledge will find much helpful information.

also occurs. New outbreaks of yellow fever have occurred in Colombia and Trinidad and new outbreaks of rift valley fever have occurred in Egypt. Chapter 6, Arenaviruses: The biochemical and physical properties have now been clar ified, and they show a remarkable uniformity in the various viruses constituting the group. The possibility that prenatal infection with LCM may result in hydrocephalus and chorioretinitis has been raised. Serologic surveys have suggested the existence of Lassa virus infection in Guinea, Central African Empire, Mali, Senegal, Cameroon, and Benin, in addition to earlier identification in Nigeria, Liberia, and Sierra Leone. Chapter 7, Coronaviruses: New studies have confirmed the important role of these viruses in common respiratory illnesses of children and adults. The viruses are now known to contain a single positive strand of RNA. About 50% of corona virus infections result in clinical illness. About 5% of common colds are caused by strain DC 43 in winter. Chapter 8, Cytomegalovirus: Sections on pathogenesis of CMV in relation to organ transplantation and mononucleosis, as well as sections on the risk and features of con genital infection and disease, have been expanded. There are encouraging preliminary results with a live CMV vaccine, but the questions of viral persistence and oncogenicity require further evaluation."

This series of books is designed to help general practitioners. So are other books. What is unusual in this instance is their collec tive authorship; they are written by specialists working at district general hospitals. The writers derive their own experi ence from a range of cases less highly selected than those on which textbooks are traditionally based. They are also in a good position to pick out topics which they see creating difficulties for the practitioners of their district, whose personal capacities are familiar to them; and to concentrate on contexts where mistakes are most likely to occur. They are all well-accustomed to working in consultation. All the authors write from hospital experience and from the viewpoint of their specialty. There are, therefore, matters important to family practice which should be sought not within this series, but elsewhere. Within the series much practical and useful advice is to be found with which the general practitioner can compare his existing performance and build in new ideas and improved techniques. These books are attractively produced and I recommend them."

Interest in policy influences on health care is high, and will remain high as long as health care costs continue to rise and health care reform remains a hot topic in the news. There are inevitable and frequent points of interface between health care public policy and the health professions; in their daily work, clinicians see the problems with the health care system but often feel powerless and unsure how to advocate for system changes. Clinicians and Health Care Advocacy is written by clinicians for clinicians and focuses on how policy works and what individual professionals can do to affect policy. It looks at the facts and processes in an accessible way that employs case-based examples of clinician adavocacy to illustrate its points. The book is nonpartisan and will stay neutral on preferences for one public policy solution versus another (single payer vs. market reform, for example). Instead, it encourages a model of clinicians as responsible for healing not only the individual patient but also the larger health care system in which they work.