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In Vivo Models of Inflammation - Volume 2 (Hardcover, 2nd ed. 2006)
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In Vivo Models of Inflammation - Volume 2 (Hardcover, 2nd ed. 2006)
Series: Progress in Inflammation Research
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In Vivo Models of Inflammation (Volume 1 and Volume 2) provides the
biomedical researcher in both the pharmaceutical industry and
academia with a description of the state of the art animal model
systems used to emulate diseases with components of inflammation.
This second edition acts as a complement to the first edition by
describing and updating the standard models that are most utilized
for specific disease areas. In addition, new models are included
exploring emerging areas of inflammation research. The format is
designed with the laboratory in mind: Both volumes provide detailed
descriptions of the methodologies and uses of the most significant
models. This includes current information regarding agents that
demonstrate efficacy, those that do not and those that can be used
as standard controls. The focus remains on those models that serve
as pre-clinical correlates to human disease as well as those that
represent components of the inflammatory response. Pioneering ideas
and provocative comments about future directions are meant to
challenge the status quo and stimulate new thinking. Therefore, new
approaches to the development of future models in selected
therapeutic areas have been highlighted. The focus on novel
technologies that are vital for innovative in vivo research has
been expanded to include chapters on the use of transgenic and gene
transfer technologies, nanotechnology, and stem cells. This
up-to-date reference manual helps to select the best animal model
for a specific question. At the same time, this set of books
continues to acknowledge the solemn responsibility in vivo research
carries with it and extends the coverage of animal respect and
welfare when used in experimental settings. Chapters describing
current regulations in the United States, United Kingdom, and Japan
address these concerns. Thus, the ultimate aim of this set of books
is to provide current best practices for obtaining the maximum
informat
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