Widely recognized as one of the most important signaling mechanisms in development and disease, Wnt signaling pathways are networks of proteins that play significant roles in embryogenesis or cancer development. Wnt Signaling in Development and Disease addresses the fundamentals of Wnt signaling and delves into molecular pathway mechanisms, its role in embryogenesis, adult tissue homeostasis, and chronic disease. This comprehensive resource details current knowledge of Wnt signaling while looking ahead to future progress.

This book is the latest volume in the series presenting clinicians and medical students with the latest advances in medicine, with emphasis on endocrine and cardiovascular disorders. Presented as a collection of articles, the first chapters provide an overview of the field and discussion on medical teaching. The following sections cover the diagnosis and management of numerous conditions in everyday clinical practice. Separate chapters explore advances in other sub-specialties such as kidney disease, sepsis and asthma, and several complete sections are dedicated to Covid and associated disorders. Enhanced by clinical photographs and figures, this valuable text serves as a ready reckoner for different approaches to clinical case management. The previous volume (9789389587111) published in 2020.

Interprofessional education (IPE) and collaborative practice (IPCP) are the keys to improving health, safety, satisfaction and cost in the modern healthcare system. This IPE Toolkit provides healthcare educators, administrators, and clinicians with a practical, evidence-based manual for leading change. With these keys, we invite you to unlock meaningful collaboration for the next generation of health professionals, supported by an interprofessional collaboration of authors with more than 50 years of combined experience in education, practice, and scholarship in medicine, nursing, pharmacy, physical therapy, speech-language pathology, instructional design, simulation and online education. Following a step-by-step approach with supporting resources and examples, this guide offers a structured method for successful interprofessional program design, implementation, and assessment. Readers will explore IPE through the context of accreditation standards, administrative leadership, stakeholder buy-in, faculty and professional development, scholarship, teaching and learning, and curriculum development. Ten toolkits give professionals and educators the resources they need to quickly start new IPE learning experiences. This book is the go-to manual to fully explore, successfully launch, and advance quality IPE that creates results. Key Features: * Presents active learning strategies including team-based learning, case-based learning, simulation, and dilemma discussions. * Highlights best practices for virtual and online IPE that help educators overcome major IPE barriers, especially accessibility, scalability and cost. * Offers an abstract, key definitions, and concepts at the beginning of each chapter to set the reader's expectations. * Utilizes illustrations and tables to help clarify and expand on key concepts, enabling readers to more easily understand and apply material. * Includes comprehensive appendices on available resources for IPE and IPCP. * Provides step-by-step checklists, tables and figures on how to build IPE using didactic, simulation, online, and experiential learning andragogies. * Explores techniques to identify and reduce interdisciplinary biases, stereotypes, and prejudices, all barriers to dual professional identity and successful teaming.

The book of 50 clinical cases covers a large part of the internal medicine curriculum. It fills the gap between theoretical knowledge and clinical practice and allows students to practice their clinical diagnostic skills and the development of management plans. Each of the cases is discussed using logical and scientific approaches and provides model answers to questions. Take-home messages throughout outline key points for examination revision. The book will stimulate self-directed learning and a deeper understanding of internal medicine. Readers will be able to test their understanding and the ability to answer short answer questions and multiple-choice questions. More than 50 clinical cases, covering the core undergraduate medicine curriculum Case discussions using a logical and scientific approach to help students achieve their own diagnoses Model answers for comparison, to improve learning outcomes Summary of fundamental points for examination revision Useful up-to-date resources Short-answer and multiple-choice questions to test knowledge Diagrams and tables to deepen understanding and consolidate essential concepts Includes an Enhanced eBook version with purchase. The enhanced eBook allows the end user to access all of the text, figures, and references from the book on a variety of devices

You've read your textbook and your course notes. Now you need to apply your knowledge to real-life clinical situations. The problem-solving approach of Core Clinical Cases guides you to think of the patient as a whole, rather than as a sequence of unconnected symptoms. With its emphasis on everyday practice strongly linked to underlying theory, the series integrates your knowledge with the realities of managing clinical problems, and provides a basis for developing sound analytical and confident decision-making skills. The core areas of undergraduate study are covered in a logical sequence of learning activities; the same questions are asked of each clinical case, followed by detailed explanatory answers. OSCE counselling cases, with related questions and answers, also feature in each section. Key concepts and important information are highlighted, and the reader-friendly layout reflects exactly the type of question you will encounter, making these volumes the perfect revision aid for all types of case-based examination. The Medicine and Medical Specialties volume, in which all medical subjects have been brought together in a single volume for this second edition, focuses on the following topics: diabetes, endocrinology, rheumatology, renal medicine, cardiology, care of elderly people, respiratory medicine, gastroenterology, haematology, oncology emergencies; neurology, infectious diseases, and dermatology. Volumes in the Core Clinical Cases series remain absolutely invaluable in the run up to clinical, written, or OSCE examinations, and ideal course companions for all undergraduate medical students at various stages in their clinical training.

This new addition to the popular Essentials series provides a broad, general introduction to the topic of simulation within clinical education. An ideal tool for both teaching and learning, Essential Simulation in Clinical Education provides a theoretical and practical introduction to the subject of simulation, whilst also offering strategies for successful use of simulators within general clinical education and demonstrating best practice throughout. This timely new title provides: The latest information on developments in the field, all supported by an evidence-base Content written by a global team of experts Discussion of policy and strategy initiatives to ground simulation within the healthcare context Practical examples of cases, including inter-professional learning. A superb companion for those involved in multi-disciplinary healthcare teaching, or interested in health care education practices, Essential Simulation in Clinical Education is the most comprehensive guide to the field currently available.

This detailed book gathers a broad collection of experimental approaches to assist researchers in setting up different methods to investigate protein conformational disorders. Beginning with a section on assays focusing on biophysical approaches to study protein (mis)folding, the volume continues with sections on cellular and proteostasis assays as well as assays for protein folding correction and recovery, combining methods such as thermal shift assays, in silico improvement of protein solubility, and compound screening, an important area of research as it may open avenues for therapeutic strategies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Misfolding Diseases: Methods and Protocols serves as an ideal guide for researchers seeking to advance our knowledge of protein conformational disorders.

"Mollison's Blood Transfusion in Clinical Medicine" is an icon in the field of transfusion and the first edition was published in 1951. The book arose from the concept of the transfusionist, as both scientist and expert consultant. For many years, this text has provided the primary, and often the sole, reference for detailed information and practical experience in blood transfusion. The book is completely revised and updated throughout to include the latest advances and developments in the field.

How to Teach Using Simulation in Healthcare provides an ideal introduction and easy-to-use guide to simulation in medical education. Written by a team of experienced medical educators, this practical text packed full of case examples and tips is underpinned by the theory of simulation in education, and explores how to integrate simulation into teaching. Key topics include: * Use of low, medium and high fidelity equipment * Issues of simulation mapping and scenario design * Role of human factors * Formative and summative assessment * New social media and technologies * Detailed explorations of some examples of simulation. How to Teach Using Simulation in Healthcare is invaluable reading for all healthcare professionals interested and involved in the origins, theoretical underpinnings, and design implications of the use of simulation in medical education.

In the evaluation of healthcare, rigorous methods of quantitative assessment are necessary to establish interventions that are both effective and cost-effective. Usually a single study will not fully address these issues and it is desirable to synthesize evidence from multiple sources. This book aims to provide a practical guide to evidence synthesis for the purpose of decision making, starting with a simple single parameter model, where all studies estimate the same quantity (pairwise meta-analysis) and progressing to more complex multi-parameter structures (including meta-regression, mixed treatment comparisons, Markov models of disease progression, and epidemiology models). A comprehensive, coherent framework is adopted and estimated using Bayesian methods.

"Key features: "A coherent approach to evidence synthesis from multiple sources.Focus is given to Bayesian methods for evidence synthesis that can be integrated within cost-effectiveness analyses in a probabilistic framework using Markov Chain Monte Carlo simulation.Provides methods to statistically combine evidence from a range of evidence structures.Emphasizes the importance of model critique and checking for evidence consistency.Presents numerous worked examples, exercises and solutions drawn from a variety of medical disciplines throughout the book.WinBUGS code is provided for all examples.

"Evidence Synthesis for Decision Making in Healthcare" is intended for health economists, decision modelers, statisticians and others involved in evidence synthesis, health technology assessment, and economic evaluation of health technologies.

Fifty years since it was first published and now fully revised, Macleod's remains the textbook of choice for medical students, junior doctors, nurses and allied health practitioners who understand that excellence in clinical examination is integral to good practice. The fifteenth edition will teach you how to take a history and carry out proficient clinical examination, in order to elicit the key clinical symptoms and signs of disease. It covers general principles, relevant history, examination and investigations for all the major body systems - and how to effectively apply these skills to specific clinical situations and prepare for assessment. Macleod's Clinical Examination is enhanced with 32 supplementary videos demonstrating key clinical examination routines described in the book, many new and revised for this edition in line with latest guidance and best practice. Primarily focused on the practical skills required by medical students and early career stage clinicians Explains the physical basis of clinical signs to aid understanding Introduces the formulation of a differential diagnosis Provides logical initial investigations for each body system Comes with access to the complete, fully searchable and downloadable eBook Enhanced sections on adapting skills to particular situations, including the challenges of remote consultation and infection control Updated text and images, to ensure the content is relevant to a diverse readership and patient population Latest clinical decision-making models to aid the learner's diagnostic reasoning 8 brand new videos produced especially for this edition covering: Obstetric examination Gynaecological examination Assessment of fluid balance Examination of the hand and wrist Examination of the foot and ankle Examination of the neck Examination of the foot in diabetes and peripheral vascular disease The timed up and go test

The Understanding the Prostate chart is an overview of a component of the male reproductive system. Zones of the prostate are shown, along with a diagram of a digital rectal exam. Additional graphics and text describe prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer. Heavy gauge 3ml lamination with sealed edges and two metal eyelets for hanging makes chart highly durable. Write-on/wipe-off with dry erase marker (not included).

A collection of challenging and unusual cases from the author's extensive experience as a Medical Toxicologist, these cases demonstrate medical problem solving and differential diagnosis in action from the perspective of an experienced clinician. Written in an engaging style and giving a fascinating account of some complex cases from real practice, this book will provide a good supplementary learning text for graduate students or those at an early stage in their professional career.

Neonatal Haematology This unique handbook contains comprehensive coverage of neonatal haematology and aids diagnosis via high-quality images, diagnostic algorithms, case studies, and tables. With illustrations accompanying the diagnosis at each stage and clear explanations provided throughout, the book is ideal for trainees and experts alike. Authored by two of the world's leading haematologists, Professor Irene Roberts and Professor Barbara Bain, this book provides a depth of knowledge that is unequalled in other texts. To aid in reader comprehension, it is neatly organised by clinical problems and covers sample topics such as: Red cells: morphology, membrane, enzymes, and changes over the first 4 weeks of life Haemolytic anaemias: causes of neonatal haemolysis, diagnostic clues, and immune haemolysis (haemolytic disease of the newborn) Neonatal anaemia due to blood loss: causes of blood loss, diagnostic clues, feto-maternal haemorrhage, and twin-to-twin transfusion Haematological signs of neonatal infection: causes of neutrophil left shift, leucoerythroblastosis, and toxic granulation Paediatric haematologists, consultant haematologists, and trainees in haematology can use the succinct, well-written content in this book as a useful helping hand during consultation. Biomedical scientists will also value the work as a laboratory reference.

This new edition of this standard has been extensively revised to serve the ever-increasing number of investigators who, with only a year or so of statistical training, are performing sophisticated statistical analyses on computers. It provides sound statistical methodology, practical advice on the application of this methodology, and information relating the statistics to computer manipulation and output.

This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in liver, lung and heart regeneration. All chapters are contributed by pre-eminent scientists in the field and covers such topics as cell therapy in the treatment of cirrhosis and other liver, heart and lung diseases, characteristics of hepatic progenitor cells, future directions of the discussed therapies and much more. Liver, Lung and Heart Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

The astounding diversity of the immune system and the complexity of its regulatory pathways makes immunology a combinatorial science. Computational analysis has therefore become an essential element of immunology research and this has led to the creation of the emerging field of immunoinformatics. This book is the first to feature thorough coverage of this new field.

Immunoinformatics facilitates the understanding of immune function by modelling the interactions among immunological components. Biological research provides ever deeper insights into the complexity of living organisms while computer science provides an effective means to store and analyse large volumes of complex data. Combining the two fields increases the efficiency of biological research and offers the potential for major advances in the study of biological systems.

This book encompasses key developments in immunoinformatics, including immunological databases, sequence analysis, structure modelling, mathematical modelling of the immune system, simulation of laboratory experiments, statistical support for immunological experimentation and immunogenomics.

The difficulties in effective application of bioinformatic tools in immunology arise at both ends of the spectrum: most immunologists have only a limited comprehension of sophisticated data analysis and applicability and limitations, while the average computer scientist lacks knowledge of the depth and complexity of biological data. The purpose of this book, therefore, is to present contributions from a multidisciplinary team of biologists and computer scientists to explore the issues related to better understanding of immune function and, in particular, to help apply new computer science methods to immunological research.

Related Novartis Foundation symposia:

247 In Silico Simulation of Biological Processes

Chair: Denis Noble

252 Generation and effector functions of regulatory lymphocytes

Chair: Jean-François Bach

This updated volume explores a wide variety of clinical applications of PCR such as detecting DNA methylation, detection of viruses and protozoa in infectious diseases, estimation of gene copy number aberrations, primer extension coupled with mass spectroscopy, and high throughput NGS techniques. The application of PCR has shown incredible value in the study of genomics and transcriptomics, not only for discovery but also for routine clinical applications, and it forms the cornerstone of personalized medicine. Written for the highly successful Methods in Molecular Biology series, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and authoritative, Clinical Applications of PCR, Third Edition serves as an ideal guide for researchers aiming to understand the principles behind each application and for their implementation in the laboratory.

Written with the student in mind, Netter's Introduction to Clinical Procedures, by Drs. Marios Loukas, R. Shane Tubbs, and Joseph Feldman, uses the well-known Netter anatomy art as a foundation for reinforcing the relevant clinical anatomy needed to successfully understand and perform basic procedures. Learn the practical application of this knowledge with step-by-step guides incorporating concise text, interactive images, and animation. Didactic Netter illustrations provide clear informative visuals for quick understanding of anatomical relationships. Concise explanations enhance understanding of clinical underpinnings and implications. More than 30 common clinical procedures are explained and demonstrated with step-by-step illustrations. Multiple choice questions reinforce key concepts and challenge your knowledge. Student Consult eBook version included with purchase. This enhanced eBook experience includes access -- on a variety of devices -- to the complete text, animation, "test yourself" images, and references from the book.