This book gives a comprehensive overview on the use of image-guided radiation therapy (IGRT) in the treatment of lung cancer, covering step-by-step guidelines for clinical implementations, fundamental principles and key technical advances. It covers benefits and limitations of techniques as well as quality and safety issues related to IGRT practice. Addresses imaging simulation, treatment planning, verification, and delivery Discusses important quality assurance issues Describes current methods using specialized machines and technologies Jing Cai, PhD, is an Associate Professor of Radiation Oncology at Duke University Medical Center. Joe Y. Chang, MD, PhD, is Professor in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center in Houston. Fang-Fang Yin, PhD, is Chief of the Division of Radiation Physics, Professor of Radiation Oncology, and Director of the Medical Physics program at Duke University.

This comprehensive book focuses on multimodality imaging technology, including overviews of the instruments and methods followed by practical case studies that highlight use in the detection and treatment of cardiovascular diseases. Chapters cover PET-CT, SPECT-CT, SPECT-MRI, PET-MRI, PET-optical imaging, SPECT-optical imaging, photoacoustic Imaging, and hybrid intravascular imaging. It also addresses the important issues of multimodality imaging probes and image quantification. Readers from radiology and cardiology as well as medical imaging and biomedical engineering will learn essentials of the field. They will be shown how the field has advanced quantitative analysis of molecularly targeted imaging through improvements in the reliability and reproducibility of imaging data. Moreover, they will be presented with quantification algorithms and case illustrations, including coverage of such topics such as multimodality image fusion and kinetic modeling. Yi-Hwa Liu, PhD is Senior Research Scientist in Cardiovascular Medicine at Yale University School of Medicine and Technical Director of Nuclear Cardiology at Yale New Haven Hospital. He is also an Associate Professor (Adjunct) of Biomedical Imaging and Radiological Sciences at National Yang-Ming University, Taipei, Taiwan, and Professor (Adjunct) of Biomedical Engineering at Chung Yuan Christian University, Taoyuan, Taiwan. He is an elected senior member of Institute of Electrical and Electronic Engineers (IEEE) and a full member of Sigma Xi of The Scientific Research Society of North America. Albert J. Sinusas, M.D., FACC, FAHA is Professor of Medicine (Section of Cardiovascular Medicine) and Radiology and Biomedical Imaging, at Yale University School of Medicine, and Director of the Yale Translational Research Imaging Center (Y-TRIC), and Director of Advanced Cardiovascular Imaging at Yale New Haven Hospital. He is a recipient of the Society of Nuclear Medicine's Hermann Blumgart Award.

This book describes a novel and unique approach to the treatment of human diseases based on the study of natural animal models. A natural animal model is defined as an animal group or species that possesses a set of biochemical/physiological characteristics which are natural and adaptive for that animal, but are quite abnormal for humans. For example, how is it that birds can tolerate blood glucose concentrations which in humans are associated with diabetes. The natural animal model is living proof that a biological answer to this question is available. By studying natural animal models, we can gain valuable insights into the treatment of various human clinical disorders. Covering a wide range of disorders, this book describes in detail how medical scientists can take advantage of all the "research" that nature has already performed over billions of years in biological problem solving through extensive animal design testing and selection.

Here's an extremely handy pocket reference to assist the student, resident, house officer, and busy hospitalist address issues related to the 20 most common disorders seen in the inpatient setting. This brief, small-sized handbook offers you evidence-based information presented in an easy to reference, consistently presented outline and table format. Problem based for quick solutions in diagnosis and therapy in the limited timeframe typical of seeing patients on the wards. Provides a brief presentation of 20 most common inpatient disorders. Provides reliabile diagnosis and treatment options with evidence based recommodations. Handy, pocket book that takes up minimal pocket real estate.

Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences. Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of "dose" dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research. Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop ne

Succinct, easy to read, and highly effective-the highly regarded Secrets Series (R) provides students and practitioners in all areas of health care with focused, engaging resources for quick reference and exam review. In USMLE Step 3 Secrets, 2nd Edition, bestselling review author Dr. Ted O'Connell, along with co-authors Drs. Thomas Blair and Ryan Pedigo, offers practical, up-to-date coverage of the full range of topics on this high-stakes exam, positioning you to clear that final USMLE hurdle with confidence. This enjoyable, easy-to-read book features the Secrets' popular question-and-answer format that prepares you for one of the most important exams you'll take in your medical career. A concise, integrated, clinical overview of Step 3 content, perfect for a refresher and practical preparation for this challenging vignette-style exam. Extensively revised and updated, reflecting high-yield content on the USMLE Step 3. Highly engaging Q&A format interactively reviews your knowledge of diagnosis, treatment, and management of common disorders. New full-color images, figures, tables, and summary boxes provide a concise visual overview of important board-relevant content. Top 100 Secrets, tips, and memory aids offer a fast overview of the secrets you must know for success in practice and on exams. Review board composed of students and residents who performed highly on all steps of the USMLE and have experience with USMLE-style question development. Portable size makes it easy to carry with you for quick reference or review anywhere, anytime. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Comprehensive, accessible, and grounded in case law, Occupational Health Law has been an established authority in the field for over thirty years, and continues to provide practical coverage of occupational health, incorporating changes in the legal framework to reflect the very latest developments. The sixth edition of this indispensable reference work includes substantial new information on European law, the legal and ethical duties of occupational health professionals, medical records and confidentiality, data protection, compensation for work-related injury, the gig economy, the Equality Act and disability discrimination, and much more. Covers the provision of occupational health services, the legal liability of occupational health professionals, confidentiality, health surveillance, compensation and equal opportunity legislation Includes extensively revised content which aligns with current legislation and case law Contains new chapter summaries and highlighted key information boxes throughout Occupational Health Law, Sixth Edition, is the definitive resource for occupational health and safety professionals, from nurses, physicians and safety officers to HR managers, policy makers, risk managers, and employment lawyers.

A comprehensive review of clinical and exploratory aspects of lung (LT) and heart-lung transplantation (HLT), this reference focuses on cumulative data from the International Registry with data on outcomes associated with LT and HLT worldwide. Collecting in-depth discussions on graft dysfunction, infectious complications, and indications of LT for specific disease states including emphysema, cystic fibrosis, myriad interstitial lung diseases, and pulmonary hypertension, this guide explores the most current technologies and best practices affecting lung and heart-lung transplant surgeries.

This reference surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI) and spans the many pathways and mechanisms of VILI including cell injury and repair, the modulation of alveolar-capillary barrier properties, and lung and systemic inflammatory consequences of injurous mechanical ventilation. Considering many emerging therapeutic options, this guide also reviews the wide array of clinical studies on lung protection strategies and approaches to ARDS patients at risk for VILI.

A cluster randomization trial is one in which intact social units, or clusters of individuals, are randomized to different intervention groups. Trials randomizing clusters have become particularly widespread in the evaluation of non-therapeutic interventions, including lifestyle modification, educational programmes and innovations in the provision of health care. The increasing popularity of this design among health researchers over the past two decades has led to an extensive body of methodology on the subject. This is the first book to present a systematic and united treatment of this topic; it contains distinctive chapters on the history of cluster randomized trials, ethical issues and reporting guidelines.

The unique and award-winning Unofficial Guides series is a collaboration between senior students, junior doctors and specialty experts. This combination of contributors understands what is essential to excel on your course, in exams and in practice - as well as the importance of presenting information in a clear, fun and engaging way. Packed with hints and tips from those in the know, when you are in a hurry and need a study companion you can trust, reach for an Unofficial Guide. Designed for medical students, nurses, junior doctors and other healthcare professionals, The Unofficial Guide to Practical Skills contains step-by-step guidance to over 50 core practical procedures. Information is easy to follow and procedures are explained clearly - along with expert practical tips. This book covers the essential skills you'll need throughout your course and for the OSCEs. It also provides a succinct, day-to-day reference for those in practice. Wide range of procedures covered - more than any other book of its kind Accompanying mark schemes and typical exam questions to simulate real-life assessment Fully illustrated with over 200 color photos/illustrations Model answers so you can check how well you are performing Content aligned to the latest GMC/MLA requirements Additional stations covering lateral flow tests, PPE, using a hospital bed Standardisation of different scenarios New COVID guidance More answers to examiner questions in each scenario

Addressing issues at the forefront of interest for the Clinical Trial Materials Professional (CTMP), this Second Edition highlights the most critical concepts related to the planning, manufacturing, packaging, labeling, distribution, reconciliation, and quality and regulatory control of clinical trial materials. It offers authoritative chapters by esteemed researchers and consultants in industry on the current and evolving state of clinical supplies operations. Tracking emerging trends and the development of new technologies, this Second Edition helps the CTMP operate effectively in the international sphere and reviews regulatory processes for drug approvals in the United States and Europe.

Drawing on interdisciplinary, cross-national perspectives, this open access book contributes to the development of a coherent scientific discourse on social exclusion of older people. The book considers five domains of exclusion (services; economic; social relations; civic and socio-cultural; and community and spatial domains), with three chapters dedicated to analysing different dimensions of each exclusion domain. The book also examines the interrelationships between different forms of exclusion, and how outcomes and processes of different kinds of exclusion can be related to one another. In doing so, major cross-cutting themes, such as rights and identity, inclusive service infrastructures, and displacement of marginalised older adult groups, are considered. Finally, in a series of chapters written by international policy stakeholders and policy researchers, the book analyses key policies relevant to social exclusion and older people, including debates linked to sustainable development, EU policy and social rights, welfare and pensions systems, and planning and development. The book's approach helps to illuminate the comprehensive multidimensionality of social exclusion, and provides insight into the relative nature of disadvantage in later life. With 77 contributors working across 28 nations, the book presents a forward-looking research agenda for social exclusion amongst older people, and will be an important resource for students, researchers and policy stakeholders working on ageing.

Summarizing discussions from the Vancouver Orbital Symposium, this reference assembles recent perspectives from world renowned orbital specialists, pathologists, radiologists, and scientists to highlight advances and challenges in the diagnosis and management of orbital disease-covering recent aspects of orbital inflammatory and infectious disorders, issues in oncology, thyroid disease, and orbital vascular disorders, as well as topics concerning the future of imaging and orbital surgery.

Ancient Egyptian medicine employed advanced surgical practices, while the prevention and treatment of diseases relied mostly on natural remedies and magical incantations. Following the successful first volume of The Medicine of the Ancient Egyptians, which dealt with surgical practices and the treatment of women and children, this second volume explores a wide range of internal medical problems that the Egyptian population suffered in antiquity, and various methods of their treatment. These include ailments of the respiratory, digestive, and circulatory systems, chiefly heart diseases of various types, coughs, stomachaches, constipation, diarrhea, internal parasites, and many other medical conditions. Drawing on formulas and descriptions in the Ebers papyrus and other surviving ancient Egyptian medical papyri, as well as physical evidence and wall depictions, the authors present translations of the medical treatises together with commentaries and interpretations in the light of modern medical knowledge. The ancient texts contain numerous recipes for the preparation of various remedies, often herbal in the form of pills, drinks, ointments, foods, or enemas. These reveal a great deal about ancient Egyptian physicians and their deep understanding of the healing properties of herbs and other medicinal substances. Illustrated with thirty-five photographs and line drawings, The Medicine of the Ancient Egyptians: 2: Internal Medicine is highly recommended reading for scholars of ancient Egyptian medicine and magic, as well as for paleopathologists, medical historians, and physical anthropologists.

Analyzing ground-breaking research, this reference highlights the impact of sleep deprivation on the well-being of the individual and society-presenting current theories on the function of sleep, the effects of sleep deprivation on patients with medical and psychiatric conditions, as well as providing interpretative and methodological results in comparative studies of sleep deprivation.

Attracting the attention of the medical community, exhaled breath condensate is a completely non-invasive method for sampling secretions from the airways. Analysis of exhaled breath condensate is potentially useful for monitoring airway inflammation and in pharmacological therapy. With its non-invasive nature, this method may be suitable for longitudinal studies even in children and in patients with lung severe disease. New Perspectives in Monitoring Lung Inflammation provides an introduction to the analysis of exhaled breath condensate for monitoring lung inflammation. The book presents current knowledge on the physicochemical properties of exhaled breath condensate and its formation in the airways and covers important aspects of the methodology. It details markers, and classes of markers, of airway inflammation in separate chapters and discusses the use of the technique in adults and children. The text also reviews the implications for drug development and future research. The volume concludes with an overview of lung inflammation focusing on basic and clinical pharmacology of important mediators. Presenting a comprehensive view of exhaled breath condensate, the text explains how this method could play a major role in the diagnosis and therapy of lung diseases, and may launch a new era in respiratory medicine.

Since publication of the initial version of "Plagues & Poxes" in 1987, which had the optimistic subtitle "The Rise and Fall of Epidemic Disease," the rise of new diseases such as AIDS and the deliberate modification and weaponization of diseases such as anthrax have changed the way we perceive infectious disease.

With major modifications to deal with this new reality, the acclaimed author of "Civil War Medicine: Challenges and Triumphs" has updated and revised this series of essays about changing disease patterns in history and some of the key events and people involved in them. It deals with the history of major outbreaks of disease - both infectious diseases such as plague and smallpox and noninfectious diseases - and shows how they are in many cases caused inadvertently by human actions, including warfare, commercial travel, social adaptations, and dietary modifications. To these must now be added discussion of the intentional spreading of disease by acts of bioterrorism, and the history and knowledge of those diseases that are thought to be potential candidates for intentional spread by bioterrorists.

Among the many topics discussed are:

How the spread of smallpox and measles among previously unexposed populations in the Americas, the introduction of malaria and yellow fever from Africa via the importation of slaves into the Western hemisphere, and the importation of syphilis to Europe all are related to the modern interchange of diseases such as AIDS.

How the ever-larger populations in the cities of Europe and North America gave rise to "crowd diseases" such as polio by permitting the existence of sufficient numbers of non-immune people in sufficient numbers to keep the diseases from dying out.

How the domestication of animals allowed diseases of animals to affect humans, or perhaps become genetically modified to become epidemic human diseases.

Why the concept of deficiency diseases was not understood before the early twentieth century; disease, after all, was the presence of something abnormal, how could it be due to the absence of something? In fact, the first epidemic disease in human history probably was iron deficiency anemia.

How changes in the availability and nature of specific foods have affected the size of population groups and their health throughout history. The introduction of potatoes to Ireland and corn to Europe, and the relationship between the modern technique of rice milling and beriberi, all illustrate the fragile nutritional state that results when any single vegetable crop is the main source of food.

Why biological warfare is not a new phenomenon. There have been attempts to intentionally cause epidemic disease almost since the dawn of recorded history, including the contamination of wells and other water sources of armies and civilian populations; of course, the spread of smallpox to Native Americans during the French and Indian War is known to every schoolchild. With our increased technology, it is not surprising that we now have to deal with problems such as weaponized spores of anthrax.

Does the psyche have an affect on health? The Psyche of the Body is a passionate and well-informed plea for a Jungian version of psychosomatic medicine and psychotherapy. Many cases of physical illness show evidence of the effect of psychic involvement, both in origin and treatment. Yet to date the majority of study into psychosomatic illness has been purely empirical, with little theory to help interpret and put results into context. Illustrated by vivid clinical illustrations of case histories, The Psyche of the Body reviews the long history of psychosomatic medicine and models of the relationship between psyche and body that have evolved over time, and presents a full revision of research in the field over the last twenty years. It presents a much-needed theoretical model together with practical guidelines that demonstrate how the psychological aspects of specific illnesses should be handled in therapy and analysis. Practicing and training Jungian analysts, as well as all those involved in clinical treatment, will find the interdisciplinary approach to psychosomatic medicine promoted in this book fascinating reading.

Does the psyche have an affect on health? The Psyche of the Body is a passionate and well-informed plea for a Jungian version of psychosomatic medicine and psychotherapy. Many cases of physical illness show evidence of the effect of psychic involvement, both in origin and treatment. Yet to date the majority of study into psychosomatic illness has been purely empirical, with little theory to help interpret and put results into context. Illustrated by vivid clinical illustrations of case histories, The Psyche of the Body reviews the long history of psychosomatic medicine and models of the relationship between psyche and body that have evolved over time, and presents a full revision of research in the field over the last twenty years. It presents a much-needed theoretical model together with practical guidelines that demonstrate how the psychological aspects of specific illnesses should be handled in therapy and analysis. Practicing and training Jungian analysts, as well as all those involved in clinical treatment, will find the interdisciplinary approach to psychosomatic medicine promoted in this book fascinating reading.

At the present time, 430 drugs are known to cause respiratory injury. This represents an increase of almost 200 in the last ten years, and the number is still increasing. This comprehensive, definitive reference work, with an outstanding range of international expert contributors and two of the world's leading editors, provides an essential reference for the practising respiratory physician. Key features: The text builds upon basics with a review of basic sciences. The book covers imaging, varied drug-induced interstitial lung disease including pulmonary edema and diffuse alveolar hemorrhage, acute respiratory failure, pleural involvement and upper to lower airway disease A wide range of diseases are detailed from chemotherapy and radiation to biologic-induced lung disease, drug misuse, and special groups such as recipients of stem cell and solid organ transplants. A range of world class contributions from key opinion leaders. This book provides essential information for recognizing and managing drug-induced respiratory disease for all pulmonologists and respiratory care physicians. It will be of great interest to: critical care medicine specialists, hematologists, oncologists, cardiologists, allergists, rheumatologists, neurologists, internists, blood-bank specialists, pathologists and primary care physicians.

Contents:
1. The Importance of Rhinitis 2. Causes of Rhinitis 3. Making a Diagnosis 4. Examination 5. Investigations 6. Airway Tests 7. Tests of Mucociliary Clearance 8. Imaging 9. Other Tests

"Enduring Change in Eating Disorders" provides a unique perspective on the successful treatment of eating disorders, which are among the most debilitating and recalcitrant psychiatric diseases. Unique in the field, this book details effective Structural Family therapy with qualitative follow-ups of up to 20 years. A practical approach providing concrete tools to the clinician to creating change that holds over time with bulimia, anorexia, and compulsive overeating.
The text draws on cases from the author's practice of over twenty-five years and follow his approach in the theoretical tradition of Intensive Structural Family Therapy (IST). Chapters discuss the nature and significance of eating disorders, a review of current treatment approaches, and the importance of the family in the therapeutic process. Cases of eating disorders in youths and adults are provided as well as instances of bulimia, anorexia, and compulsive overeating. Three appendices provide the reader with information regarding the scientific basis of the IST model, the effectiveness of the approach in treating conditions other thank eating disorders and preventing eating disorders.

Clinical practice guidelines were initially developed within the context of evidence-based medicine with the goal of putting medical research findings into practice. However, physicians do not always follow them, even when they seem to apply to the particular patient they have to treat. This phenomenon, known as clinical inertia, represents a significant obstacle to the efficiency of care and a major public health problem, the extent of which is demonstrated in this book. An analysis of its causes shows that it stems from a discrepancy between the objective, essentially statistical nature of evidence-based medicine on the one hand and the physician's own complex, subjective view (referred to here as "medical reason") on the other. This book proposes a critique of medical reason that may help to reconcile the principles of evidence-based medicine and individual practice. The author is a diabetologist and Professor of Endocrinology, Diabetology and Metabolic Diseases at Paris 13 University. He has authored several books, including one to be published by Springer (Philosophy and Medicine series) under the title: The Mental Mechanisms of Patient Adherence to Long Term Therapies, Mind and Care. , Diabetology and Metabolic Diseases at the Paris 13-University. He has also published Pourquoi Se soigne-t-on, Enquete sur la rationalite morale de l'observance (2007), Clinique de l'Observance, L'Exemple des diabetes (2006), and Une theorie du soin, Souci et amour face a la maladie (2010). An English adaptation of the first book is published by Springer (Philosophy and Medicine) under the title: The Mental Mechanisms of Patient Adherence to Long Term Therapies, Mind and Care.

Nutritional Aspects of Bone Health provides an in-depth review of the role of diet in the development and maintenance of bone health throughout the lifecycle, and prevention of osteoporosis in later life. The book is multi-authored by the world's leading researchers in this area, who have come together to formulate the first ever textbook on nutritional aspects of bone health, and includes the current and cutting edge science underpinning the prevention of bone disease. The book is structured such that, in the first section, an overview is provided on what is meant by the terms bone health and osteoporosis and includes key areas such as epidemiology, genetics and the impact of non-nutritional exogenous factors influencing the skeleton. The second section details the established nutritional factors affecting bone health, namely calcium and vitamin D. Section three focuses on the role of macronutrients and macrominerals in bone health, namely protein, phosphorus, sodium and potassium, including the criticality of acid-base homeostasis to skeletal integrity. Section four addresses the effects of microminerals, trace elements, vitamin K, vitamin A and isoflavones on bone. Section five focuses attention on key issues connected with the influence of diet and anorexia and bulimia on bone health including nutrition and bone growth; nutrient: gene interactions; nutrient: drug interactions; and the final section discusses the effect of diet on reduction of fracture risk; the cost-effectiveness of nutritional supplements; and nutritional strategies for prevention and treatment of osteoporosis. The book is targeted at a number of key audiences. Whilst there is a focus on the academic research world and those principally involved in education, at both undergraduate and postgraduate levels, the book will also be of considerable interest to those participating in the treatment and prevention of osteoporosis, namely those working in the medical and health promotion fields. Furthermore, Nutritional Aspects of Bone Health will be of particular interest to the food industry as the popularity of foods designed to target specific health issues increases, and nutritional therapy has a critical role to play in this major public health problem.