The only available text to focus primarily on Acute Respiratory Distress Syndrome (ARDS).

Thoroughly revised content and ten new chapters provide pulmonologists with the latest developments and applications of pharmacological and mechanical therapies needed to treat the debilitating and difficult condition of ARDS.
Key features:
REVISION OF A BESTSELLER-Updated content and ten new chapters cover the latest developments and applications physicians need to treat ARDS
EVALUATION OF CURRENT THERAPIES-Surfactant therapy, glucocorticoid therapy, invasive and non-invasive prone position forms of mechanical ventilation, and mesenchymal stem cells helps clinicians give patients the best possible care
INTERNATIONAL TEAM OF EDITORS AND CONTRIBUTORS-Key opinion leaders with diverse backgrounds and experience provide authoritative guidance physicians want and trust
A COMPLETE STAND-ALONE GUIDE-the only available comprehensive volume to tackle this pertinent issue and cover both its pathophysiology and pathogens

"Achieving Cultural Competency: A Case-Based Approach to Training Health Professionals" provides the necessary tools to meet the ever-growing need for culturally competent practitioners and trainees. Twenty-five self-study cases cover a variety of medical topics, including cardiovascular, pulmonary, neurology, oncology, hematology, immunology, and pediatric disorders. Actual scenarios that occurred in clinical settings help the user gain direct insight into the realities of practice today. Cultural factors covered within the cases include cultural diversity plus gender, language, folk beliefs, socioeconomic status, religion, and sexual orientation.

This book is an approved CME-certifying activity to meet physicians' cultural competency state requirements.

Get 25 pre-approved self-study American Dietetic Association credits at no additional charge when you purchase the book. Email [email protected] for further instructions.

The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. Toxicology of the Nose and Upper Airways presents a culmination of knowledge gained as a result of both human and experimental animal studies over the past decade. With contributions from internationally recognized leaders in the fields of experimental toxicology, respiratory medicine, otolaryngology, allergy, and sensory science, this volume: Examines the effect of selected pollutants on the upper airways of both humans and experimental animals-emphasizing mechanistic issues in the process Discusses epidemiologic findings from populations exposed occupationally or environmentally, comparing and contrasting alternative risk assessment approaches Features clear chapter organization with sections on structure and function, dosimetry and toxicokinetics, functional and pathologic responses and their measurement, responses to specific agents, risk assessment, and special topics This volume is an essential reference for pharmacologists and toxicologists concerned with the nose and upper airway, as well as clinicians, risk assessors, and sensory scientists.

Why the "Second Edition" is the must-have guide for all pulmonologists and particle research scientists:
STAY INFORMED - nine brand new chapters cover recent developments and research, with several chapters focusing solely on the fast-developing area of man-made and naturally occurring nano-sized particles
GAIN FULL UNDERSTANDING OF ALL ASSOCIATED DISCIPLINES - including topics and concerns in pulmonology and respiratory medicine, toxicology, and environmental research
KNOW WHAT TO EXPECT as a disease progresses, from a distinguished team of over 40 experts who detail all stages of particle-lung interactions, from inhalation of particles to clearance from the organism
LEARN MORE ABOUT FREQUENTLY NEGLECTED TOPICS - such as the beneficial developments and uses of inhaled man-made particles and reduced side-effects of alternate therapies

This unique book presents a wealth of information on common presentations and illnesses, presented as medical case studies. It is useful for exam preparation, as a quick reference guide for working doctors, and as an interesting read for all those interested in medicine. 250 Clinical Cases covers a wide variety of conditions, providing in-depth insights into the most relevant topics, classified by system. Cases are accompanied by common viva voce examination questions as well as more advanced level questions that will help the reader develop a deeper understanding. Now in its sixth edition, the book has been fully updated to reflect current evidence and relevance for working doctors. It will help everyone, from medical students to consultants, to find the hidden clinical gems and historical background they need to achieve true clinical excellence. 250 clinical cases in print - provides a comprehensive overview of all relevant topics Conversational and accessible style - suitable for medical students Based on the latest evidence - provides an ideal quick reference guide 'Ward round' type question and answer section - ideal for exam preparation Cases alphabetised by system for easy navigation Easily portable size - fits into any medical bag An enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud Self-assessment by system Interesting medical emergency presentations Procedures for the core medical curriculum Topics updated for clinical relevance Multiple choice questions replaced with open answer questions

The porphyrins, chlorophylls, bilins and related tetrapyrroles are vital for all living organisms. Natural and synthetic tetrapyrroles are used extensively in foods, cosmetics, biotechnology, pharmaceuticals, diagnostics and medicine. Methods for their separation and characterization therefore, have a very wide area of applications. Yet, there is a dearth of books dedicated to HPLC and HPLC/MS of tetrapyrroles. Lim addresses this problem admirably by providing practical HPLC and HPLC/MS protocols coupled with in-depth chromatographic and mass spectrometric reference data. These are invaluable in the analysis, identification and characterization of porphyrins, chlorophylls, bilins and other related compounds found in biological and clinical materials. HPLC method development and optimization for coupling to mass spectrometry are also described in rich detail. Sample preparation, and suggestions for avoiding procedural artifacts during extraction of clinical and biological samples are discussed. Clinical biochemists involved in biochemical diagnosis of human porphyrias will find this monograph assuredly helpful, as would analysts, biochemists and chemists involved in the separation, isolation and characterization of natural and synthetic tetrapyrroles. Undoubtedly, Lim has contributed a master-piece containing sufficient background material for beginners and up-to-date references for all researchers in the field.

Intended for clinicians & students at all levels, this volume offers a detailed guide to the clinical trial process. It aims to help health workers discuss the pros and cons of participation with patients.

This Side of Doctoring: Reflections for Women in Medicine offers up an intimate collection of stories, poems, essays, and quotations that captures the joy and heartbreak of being women and being a physician. Editor Eliza Lo Chin (MD, Harvard Medical School) has gathered more than 100 voices that speak to the trials, rewards, and surprises of practicing medicine. Beginning with the writings of early medical pioneers, the anthology weaves a rich patchwork of experiences.

Practical Transfusion Medicine Practical Transfusion Medicine, Sixth Edition The pace of change in transfusion medicine is relentless, with new scientific and technological developments and continuing efforts to improve transfusion practice. This sixth edition of Practical Transfusion Medicine has been updated significantly to reflect the rapid changes in transfusion medicine since the fifth edition was published in 2017. The primary purpose of this edition remains the same as the first: to provide a comprehensive guide to transfusion medicine. This book contains more depth of information than standard handbooks on transfusion medicine, whilst being more concise and approachable than a standard reference text. This book covers the principles of transfusion medicine, the complications of transfusion, practice in blood centres and hospitals and clinical transfusion practice. This sixth edition includes a new section on patient blood management, cellular and tissue therapy, organ transplantation and the development of the evidence base for transfusion. It also features a new chapter on transfusion-associated circulatory overload to underline its importance as a complication of transfusion, and a reconfiguration of the section on clinical transfusion practice to allow consideration of the transfusion management of medical, surgical and haematology patients with and without bleeding. This sixth edition of Practical Transfusion Medicine provides accessible and comprehensive coverage of the field of transfusion medicine. It is a standalone text that will be useful to clinical and scientific staff: not only for trainees who require an overview of the field, but also for established practitioners who are involved in some aspect of transfusion medicine and require a comprehensive, accessible reference book.

Now in its sixth edition, this guide sets out international and standard practice and is an invaluable reference for medical and scientific editors and authors. Scholarly journals often quote this booklet as a guide in their instructions to authors. An invaluable reference for editors and authors Includes fully updated sections on metrication and SI units, symbols and nomenclature, layout of references and proof correction

At the present time, 430 drugs are known to cause respiratory injury. This represents an increase of almost 200 in the last ten years, and the number is still increasing. This comprehensive, definitive reference work, with an outstanding range of international expert contributors and two of the world's leading editors, provides an essential reference for the practising respiratory physician. Key features: The text builds upon basics with a review of basic sciences. The book covers imaging, varied drug-induced interstitial lung disease including pulmonary edema and diffuse alveolar hemorrhage, acute respiratory failure, pleural involvement and upper to lower airway disease A wide range of diseases are detailed from chemotherapy and radiation to biologic-induced lung disease, drug misuse, and special groups such as recipients of stem cell and solid organ transplants. A range of world class contributions from key opinion leaders. This book provides essential information for recognizing and managing drug-induced respiratory disease for all pulmonologists and respiratory care physicians. It will be of great interest to: critical care medicine specialists, hematologists, oncologists, cardiologists, allergists, rheumatologists, neurologists, internists, blood-bank specialists, pathologists and primary care physicians.

"Medicine and Surgery" is an exciting new book that contains the core information needed by medical students in the run up to exams.

This is the only book available that covers both medicine and surgery.

It encompasses all of the major systems and core subjects
Every condition is discussed under the key headings of definition, epidemiology, aetiology, pathophysiology, clinical features, investigations, management and prognosis
The content follows a very consistent and familiar style, so that information is easily accessible, digestible and memorable
Each chapter opens with an overview of clinical method before discussing the most common conditions relevant to that speciality

"Medicine and Surgery: A Concise Textbook" is written specifically for medical students as essential revision preparation, for junior doctors as a refresher on the wards and for other allied health professionals who want a quick reminder of key facts and data.

Reviews

"I like the way the book goes through each disease using the same system of definition, aetiology etc. This makes it easier to learn....The content is exactly what the undergraduate brain needs"

Final year student, University of Oxford

ABC of Clinical Resilience ABC of Clinical Resilience For the healthcare professional, clinical resilience is about reconnecting with those stirrings which first motivated us to spend a career in the service of others. It is about recovering and maintaining the joy of practice which nourishes and satisfies our curiosity about the uniqueness of every person in our care. Being a resilient practitioner is essential for our personal wellbeing and also for the safety of our patients, who depend on our ability to optimise our physical and cognitive performance. Yet many healthcare professionals report experiencing burnout. ABC of Clinical Resilience summarises current evidence on how cognitive performance and wellbeing of healthcare professionals are affected by the emotional context of providing care and the organisational culture of working environments. As well as considering impacts of individuals and teams, we also consider how resilience can be recovered for the benefit of everyone. Topics include: The emotional impact of working in healthcare Resilience and cognitive performance Practicing self-care The physiology of resilience Intelligent kindness Kindness in teams Resilience in practice Organisational kindness Teaching resilience Perfect for both novice and experienced healthcare professionals, including those working in mental health, ABC of Clinical Resilience will also earn a place in the libraries of professionals who treat healthcare workers and readers interested in the psychology and prevention of burnout, vicarious trauma, and moral injury. About the ABC series The ABC series has been designed to help you access information quickly and deliver the best patient care, and remains an essential reference tool for GPs, junior doctors, medical students and healthcare professionals. Now offering over 80 titles, this extensive series provides you with a quick and dependable reference on a range of topics in all the major specialties. The ABC series is the essential and dependable source of up-to-date information for all practitioners and students in primary healthcare. To receive automatic updates on books and journals in your specialty, join our email list. Sign up today at www.wiley.com/email

This book describes a novel and unique approach to the treatment of human diseases based on the study of natural animal models. A natural animal model is defined as an animal group or species that possesses a set of biochemical/physiological characteristics which are natural and adaptive for that animal, but are quite abnormal for humans. For example, how is it that birds can tolerate blood glucose concentrations which in humans are associated with diabetes. The natural animal model is living proof that a biological answer to this question is available. By studying natural animal models, we can gain valuable insights into the treatment of various human clinical disorders. Covering a wide range of disorders, this book describes in detail how medical scientists can take advantage of all the "research" that nature has already performed over billions of years in biological problem solving through extensive animal design testing and selection.

Ancient Egyptian medicine employed advanced surgical practices, while the prevention and treatment of diseases relied mostly on natural remedies and magical incantations. Following the successful first volume of The Medicine of the Ancient Egyptians, which dealt with surgical practices and the treatment of women and children, this second volume explores a wide range of internal medical problems that the Egyptian population suffered in antiquity, and various methods of their treatment. These include ailments of the respiratory, digestive, and circulatory systems, chiefly heart diseases of various types, coughs, stomachaches, constipation, diarrhea, internal parasites, and many other medical conditions. Drawing on formulas and descriptions in the Ebers papyrus and other surviving ancient Egyptian medical papyri, as well as physical evidence and wall depictions, the authors present translations of the medical treatises together with commentaries and interpretations in the light of modern medical knowledge. The ancient texts contain numerous recipes for the preparation of various remedies, often herbal in the form of pills, drinks, ointments, foods, or enemas. These reveal a great deal about ancient Egyptian physicians and their deep understanding of the healing properties of herbs and other medicinal substances. Illustrated with thirty-five photographs and line drawings, The Medicine of the Ancient Egyptians: 2: Internal Medicine is highly recommended reading for scholars of ancient Egyptian medicine and magic, as well as for paleopathologists, medical historians, and physical anthropologists.

Here's an extremely handy pocket reference to assist the student, resident, house officer, and busy hospitalist address issues related to the 20 most common disorders seen in the inpatient setting. This brief, small-sized handbook offers you evidence-based information presented in an easy to reference, consistently presented outline and table format. Problem based for quick solutions in diagnosis and therapy in the limited timeframe typical of seeing patients on the wards. Provides a brief presentation of 20 most common inpatient disorders. Provides reliabile diagnosis and treatment options with evidence based recommodations. Handy, pocket book that takes up minimal pocket real estate.

"Vital Notes on Accountability" is a concise, accessible guide which provides students and newly qualified staff with an understanding of key issues in professional practice. Nurses are accountable for their own practice and require a thorough understanding of their core responsibilities which underpin everyday practice in the health service today.

This introductory text in the 'Vital Notes for Nurses' series sets out a framework for accountability which consists of four 'pillars' - legal, ethical, employment and professional accountability - against which clinical issues can be considered.

* Presents legal, ethical, employment and professional issues in an accessible way
* Explores accountability, professional regulation, sources of funding and treatment in the health service
* Examines complaints, human rights, negligence, consent, and confidentiality
* Explores further applications in accountability
* Each chapter includes learning objectives, scenarios and case studies

STATISTICAL THINKING FOR NON-STATISTICIANS IN DRUG REGULATION Statistical methods in the pharmaceutical industry are accepted as a key element in the design and analysis of clinical studies. Increasingly, the medical and scientific community are aligning with the regulatory authorities and recognizing that correct statistical methodology is essential as the basis for valid conclusions. In order for those correct and robust methods to be successfully employed there needs to be effective communication across disciplines at all stages of the planning, conducting, analyzing and reporting of clinical studies associated with the development and evaluation of new drugs and devices. Statistical Thinking for Non-Statisticians in Drug Regulation provides a comprehensive in-depth guide to statistical methodology for pharmaceutical industry professionals, including physicians, investigators, medical science liaisons, clinical research scientists, medical writers, regulatory personnel, statistical programmers, senior data managers and those working in pharmacovigilance. The author's years of experience and up-to-date familiarity with pharmaceutical regulations and statistical practice within the wider clinical community make this an essential guide for the those working in and with the industry. The third edition of Statistical Thinking for Non-Statisticians in Drug Regulation includes: A detailed new chapter on Estimands in line with the 2019 Addendum to ICH E9 Major new sections on topics including Combining Hierarchical Testing and Alpha Adjustment, Biosimilars, Restricted Mean Survival Time, Composite Endpoints and Cumulative Incidence Functions, Adjusting for Cross-Over in Oncology, Inverse Propensity Score Weighting, and Network Meta-Analysis Updated coverage of many existing topics to reflect new and revised guidance from regulatory authorities and author experience Statistical Thinking for Non-Statisticians in Drug Regulation is a valuable guide for pharmaceutical and medical device industry professionals, as well as statisticians joining the pharmaceutical industry and students and teachers of drug development.

A cluster randomization trial is one in which intact social units, or clusters of individuals, are randomized to different intervention groups. Trials randomizing clusters have become particularly widespread in the evaluation of non-therapeutic interventions, including lifestyle modification, educational programmes and innovations in the provision of health care. The increasing popularity of this design among health researchers over the past two decades has led to an extensive body of methodology on the subject. This is the first book to present a systematic and united treatment of this topic; it contains distinctive chapters on the history of cluster randomized trials, ethical issues and reporting guidelines.

This reference surveys current best practices in the prevention and management of ventilator-induced lung injury (VILI) and spans the many pathways and mechanisms of VILI including cell injury and repair, the modulation of alveolar-capillary barrier properties, and lung and systemic inflammatory consequences of injurous mechanical ventilation. Considering many emerging therapeutic options, this guide also reviews the wide array of clinical studies on lung protection strategies and approaches to ARDS patients at risk for VILI.

Here are 101* of the best ideas to make the most effective use of your time on the ward. Over 250 contributors, including students, doctors, nurses, pharmacists, and therapists from 18 countries, help make you the finest doctor you can be

Pocket-sized for 'dipping into' during a spare moment or a couple of hours on the ward, this short guide is ideal for medical students on rotation or junior doctors who wish to boost learning and motivation.

*There are actually 100 ideas. Now it's your turn to develop tip 101 Submit your ideas to www.101things.org

Addressing issues at the forefront of interest for the Clinical Trial Materials Professional (CTMP), this Second Edition highlights the most critical concepts related to the planning, manufacturing, packaging, labeling, distribution, reconciliation, and quality and regulatory control of clinical trial materials. It offers authoritative chapters by esteemed researchers and consultants in industry on the current and evolving state of clinical supplies operations. Tracking emerging trends and the development of new technologies, this Second Edition helps the CTMP operate effectively in the international sphere and reviews regulatory processes for drug approvals in the United States and Europe.

Summarizing discussions from the Vancouver Orbital Symposium, this reference assembles recent perspectives from world renowned orbital specialists, pathologists, radiologists, and scientists to highlight advances and challenges in the diagnosis and management of orbital disease-covering recent aspects of orbital inflammatory and infectious disorders, issues in oncology, thyroid disease, and orbital vascular disorders, as well as topics concerning the future of imaging and orbital surgery.

"This Handbook is a sparkling addition to the neurological library, a concise and clear guide to clinical practice in neurology, written in elegant prose, a tribute to Queen Square and to the contribution that both Hospital and Institute have made to neurology. It is the encapsulation of wisdom gained in a long career. For practitioners in the art of neurology, junior and senior this is required reading." --Simon Shorvon, National Hospital for Neurology & Neurosurgery, Queen Square Neurology: A Clinical Handbook is a practical text, for both neurologists and general physicians, in the wards, the office or at home. This book spans the breadth of neurology and its challenges, for those who require a rapid resource in accessible language. The Handbook is also aimed at those considering entering neurology, neurophysiology and neurorehabilitation and for medical trainees and consultants in many specialities. It is an invaluable source for the MRCP, a ready-made reference for clinical practice and for the specialist nurse and therapist. The book deals with essentials - of neuroanatomy, clinical examination, mechanisms of neurological disease and the major issues of dementia and stroke in an ageing population. More specific aspects of neurology are also addressed, including the specialist fields of nerve and muscle disease, the spinal cord, headache and the cranial nerves, infection in the nervous system, MS and sleep disorders. The allied disciplines of neurorehabilitation, neuropsychiatry, neuro-oncology, uro-neurology, neuro-otology and neuro-ophthalmology are also covered. The aim is to provide both an introduction and a summary - of general neurological practice and the specialist aspects of neurology and neuroscience.