Genomic Data Sharing: Case Studies, Challenges, and Opportunities for Precision Medicine provides a comprehensive overview of current and emerging issues in genomic data sharing. In this book, international leaders in genomic data examine these issues in-depth, offering practical case studies that highlight key successes, challenges and opportunities. Sections discuss the eMERGE Network, Undiagnosed Disease Network, Vanderbilt Biobank, Marshfield Clinic Biobank, Minnesota Authorization, Rochester Epidemiology Project, NIH sponsored biobanks, GINA, and Global Alliance for Genomics and Health (GA4GH). In addition to these perspectives from the frontlines, the book also provides succinct overviews of ethical, legal, social and IT challenges. Clinician investigators, clinicians affiliated with academic medical centers, policymakers and regulators will also gain insights that will allow them to navigate the increasingly complex ethical, social and clinical landscape of genomic data sharing.

Mastery of quality health care and patient safety begins as soon as we open the hospital doors for the first time and start acquiring practical experience. The acquisition of such experience includes much more than the development of sensorimotor skills and basic knowledge of the sciences. It relies on effective reasoning, decision making, and communication shared by all health professionals, including physicians, nurses, dentists, pharmacists, physiotherapists, and administrators. A Primer on Clinical Experience in Medicine: Reasoning, Decision Making, and Communication in Health Sciences is about these essential skills. It describes how physicians and health professionals reason, make decisions, and practice medicine. Covering the basic considerations related to clinical and caregiver reasoning, it lays out a roadmap to help those new to health care as well as seasoned veterans overcome the complexities of working for the well-being of those who trust us with their physical, mental, and spiritual health. The book provides a step-by-step breakdown of the reasoning process for clinical work and clinical care. It examines both general and medical ways of thinking, reasoning, argumentation, fact finding, and using evidence. Outlining the fundamentals of decision making, it integrates coverage of clinical reasoning, risk assessment, diagnosis, treatment, and prognosis in evidence-based medicine. It also: Describes how to evaluate the success (effectiveness and cure) and failure (error and harm) of clinical and community actions Considers communication with patients and outlines strategies, successes, failures, and possible remedies-including offices, bedside, intervention, and care settings Examines strategies, successes, failures, and possible remedies for communication with peers-including interpersonal communication, morning reports, rounds, and research gatherings The book describes vehicles, opportunities, and environments for enhanced professional communication, including patient interviews, clinical case reports, and morning reports. It includes numerous examples that demonstrate the importance of sound reasoning, decision making, and communication and also considers future implications for research, management, planning, and evaluation.

The Changing Era of Diseases not only explores how to end humanity's suffering from illness, but also attempts to explain the challenging problems that may arise from the control of future disease. It provides a novel perspective on how to understand the changing patterns of disease, disease development, and defense from an evolutionary point-of-view in an effort to ally the life sciences and historical approaches. Topics cover the origin of disease, its pandemic infectious manifestation, chronic and late chronic diseases, strategies of the human body to fight diseases, methods of ending diseases, and future medical systems are featured. The book is a valuable source for researchers interested in systematic approaches to disease and students who are interested in understanding the evolution of diseases and how we have succeeded in fighting them.

MSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs. host disease through their immune-suppressive qualities. Finally, bone marrow-derived MSC have been reported to home to areas of solid tumor revascularization, and thus may be used as delivery vehicles to target ablative agents into dividing tumor cells. Recently the characteristics of human MSC from adipose (fat) tissue have also been identified. The possibility of repairing tissues, speeding stem cell engraftment, and targeting solid tumors for specific killing, using MSC easily harvested from bone marrow, or better yet, from unwanted fat tissue, holds broad appeal, and is an intriguing possibility that could have dramatic effect on health care. This book has information on how to isolate, grow, and characterize MSC from marrow and fat, and gives important insight into how these cells may be used for gene delivery and cellular therapies in the future. Updates on emerging clinical trials are given.

Modern medicine is one of humankind's greatest achievements.Yet today, frequent medical errors and irreproducibility in biomedical research suggest that tremendous challenges beset it. Understanding these challenges and trying to remedy them have driven considerable and thoughtful critical analyses, but the apparent intransigence of these problems suggests a different perspective is needed. Now more than ever, when we see options and opportunities for healthcare expanding while resources are diminishing, it is extremely important that healthcare professionals practice medicine wisely. In Medical Reasoning, neurologist Erwin B. Montgomery, Jr. offers a new and vital perspective. He begins with the idea that the need for certainty in medical decision-making has been the primary driving force in medical reasoning. Doctors must routinely confront countless manifestations of symptoms, diseases, or behaviors in their patients. Therefore, either there are as many different "diseases" as there are patients or some economical set of principles and facts can be combined to explain each patient's disease. The response to this epistemic conundrum has driven medicine throughout history: the challenge is to discover principles and facts and then to develop means to apply them to each unique patient in a manner that provides certainty. This book studies the nature of medical decision making systematically and rigorously in both an analytic and historical context, addressing medicine's unique need for certainty in the face of the enormous variety of diseases and in the manifestations of the same disease in different patients. The book also examines how the social, legal, and economic circumstances in which medical decision-making occurs greatly influence the nature of medical reasoning. Medical Reasoning is essential for those at the intersection of healthcare and philosophy.

Ancient Egyptian medicine employed advanced surgical practices, while the prevention and treatment of diseases relied mostly on natural remedies and magical incantations. Following the successful first volume of The Medicine of the Ancient Egyptians, which dealt with surgical practices and the treatment of women and children, this second volume explores a wide range of internal medical problems that the Egyptian population suffered in antiquity, and various methods of their treatment. These include ailments of the respiratory, digestive, and circulatory systems, chiefly heart diseases of various types, coughs, stomachaches, constipation, diarrhea, internal parasites, and many other medical conditions. Drawing on formulas and descriptions in the Ebers papyrus and other surviving ancient Egyptian medical papyri, as well as physical evidence and wall depictions, the authors present translations of the medical treatises together with commentaries and interpretations in the light of modern medical knowledge. The ancient texts contain numerous recipes for the preparation of various remedies, often herbal in the form of pills, drinks, ointments, foods, or enemas. These reveal a great deal about ancient Egyptian physicians and their deep understanding of the healing properties of herbs and other medicinal substances. Illustrated with thirty-five photographs and line drawings, The Medicine of the Ancient Egyptians: 2: Internal Medicine is highly recommended reading for scholars of ancient Egyptian medicine and magic, as well as for paleopathologists, medical historians, and physical anthropologists.

EMQs are a popular method of assessing how broad a knowledge of medicine an undergraduate has acquired. They can, however, be difficult to prepare for, and the best way to build understanding and confidence is with practice. Presenting 100 key EMQs covering the core areas of medicine and surgery, care had been taken by the authors to structure the questions and answers so that they reflect accurately the themes uncountered during study and, specifically, in final exams. Each subject covered is accompanied by a revision section which summarises key points and cross references them to other questions for revision purposes. Questions related to pharmacology, an area which many students find particularly challenging, are threaded throughout the book where relevant, mirroring the integrated teaching methods common to most medical schools. The second edition of EMQs in Clinical Medicine has been thoroughly revised and updated to reflect medical developments, while retaining the clear and comprehensive approach and popular revision boxes of its predecessor. The authors' first-hand experience of EMQ-based examinations, and awareness of the importance of reliable and accurate revision guides to medical students, ensure EMQs in Clinical Medicine remains and invaluable resource for all medical students undertaking the clinical part of their training, and an ideal companion during finals preparation.

Scientific, evidence-based medicine is increasingly seen as fundamental to providing effective healthcare, but narrative-based medicine sheds light on social and interpersonal aspects of the practitioner-patient interaction which can also greatly affect healthcare outcomes. The philosophies underlying these two approaches seem to contrast, yet those who can integrate both into their practice are among the most successful medical professionals. Integrating Narrative Medicine and Evidence-based Medicine provides answers to the key question of how medical practitioners can best put both approaches into practice. It anticipates a future where evidence-based practice will be expected of all medical professionals, but contends that the integration of a narrative-based approach will also be crucial, presenting a unique perspective on structuring the patient-professional encounter for optimum results. It develops a cultural analysis and socio-cultural theory of the science of healing, and describes an efficient method by which medical practitioners can find and use medical research at the point of care with current technology and skills. This addresses the need for translational science - moving research into practice - identified by the National Institutes of Health. This book will be essential reading for educators of medical students and postgraduate trainees, behavioral scientists, psychologists, social scientists working in medical settings, and health managers and administrators. Medical students and postgraduate trainees will also find it useful in their learning.

Pocket Medicine, 8th Edition, is a must-have resource for fast answers to the diagnostic and therapeutic questions you'll face on rounds and exams. Edited by Dr. Marc S. Sabatine and compiled by residents, fellows, and attending physicians at the world-renown Massachusetts General Hospital, this best-selling reference provides dependable, up-to-date information needed to make an accurate diagnosis and develop a state-of-the-art treatment plan. Featuring easily accessible bulleted lists, tables, and algorithms, Pocket Medicine provides focused coverage of internal medicine in the traditional, easy-to-use binding you know and love. Offers fast and easy access to essential information on the most common disorders in cardiology, pulmonary medicine, gastroenterology, nephrology, hematology-oncology, infectious diseases, endocrinology, rheumatology, and neurology. Includes references to landmark papers to help you intelligently answer questions on rounds-all from a trusted source acceptable for use on rounds. Features user-friendly tabs and a two-color design to help you find information quickly, as well as a full-color, 16-page insert featuring radiology and pathology images. Provides ideal coverage for medical students, interns, residents, advanced practice nurses, and PAs. Prepare for board exams! Mirroring the organization of Pocket Medicine, Pocket Medicine High-Yield Board Review features 500 practice questions so you can practice for your board exam.

The use of thermodynamics in biological research can be equated to an energy book-keeping system. While the structure and function of a molecule is important, it is equally important to know what drives the energy force. This volume presents sophisticated methods for estimating the thermodynamic parameters of specific protein-protein, protein-DNA and small molecule interactions.

* Elucidates the relationships between structure and energetics and their applications to molecular design, aiding researchers in the design of medically important molecules * Provides a "must-have" methods volume that keeps MIE buyers and online subscribers up-to-date with the latest research * Offers step-by-step lab instructions, including necessary equipment, from a global research community

The need for evidence-based decisions that take account of both effectiveness and economics is greater now than ever. Using case studies and illustrative examples throughout the authors describe how the activities and outputs of evidence synthesis, systematic review, economic analysis and decision-making interact within and across different spheres of health and social policy and practice. Expanding on the first edition the book now covers approaches to evidence synthesis that combine economics and systematic review methods in the applied fields of social welfare, education and criminal justice, as well as health care. Written by economists and health services researchers closely involved in developing evidence-based policy and practice it showcases current state-of-the-art methodology and will be an invaluable read for all policy-makers and practitioners using evidence to inform decisions, analysts conducting research to support decisions and students discovering the need for evidence-based decisions to incorporate economic perspectives and evidence.

This comprehensive book focuses on multimodality imaging technology, including overviews of the instruments and methods followed by practical case studies that highlight use in the detection and treatment of cardiovascular diseases. Chapters cover PET-CT, SPECT-CT, SPECT-MRI, PET-MRI, PET-optical imaging, SPECT-optical imaging, photoacoustic Imaging, and hybrid intravascular imaging. It also addresses the important issues of multimodality imaging probes and image quantification. Readers from radiology and cardiology as well as medical imaging and biomedical engineering will learn essentials of the field. They will be shown how the field has advanced quantitative analysis of molecularly targeted imaging through improvements in the reliability and reproducibility of imaging data. Moreover, they will be presented with quantification algorithms and case illustrations, including coverage of such topics such as multimodality image fusion and kinetic modeling. Yi-Hwa Liu, PhD is Senior Research Scientist in Cardiovascular Medicine at Yale University School of Medicine and Technical Director of Nuclear Cardiology at Yale New Haven Hospital. He is also an Associate Professor (Adjunct) of Biomedical Imaging and Radiological Sciences at National Yang-Ming University, Taipei, Taiwan, and Professor (Adjunct) of Biomedical Engineering at Chung Yuan Christian University, Taoyuan, Taiwan. He is an elected senior member of Institute of Electrical and Electronic Engineers (IEEE) and a full member of Sigma Xi of The Scientific Research Society of North America. Albert J. Sinusas, M.D., FACC, FAHA is Professor of Medicine (Section of Cardiovascular Medicine) and Radiology and Biomedical Imaging, at Yale University School of Medicine, and Director of the Yale Translational Research Imaging Center (Y-TRIC), and Director of Advanced Cardiovascular Imaging at Yale New Haven Hospital. He is a recipient of the Society of Nuclear Medicine's Hermann Blumgart Award.

This groundbreaking book unleashes a brilliant new plan for permanently curing heartburn by relieving the root cause of the problem: low stomach acid. The fact is that heartburn is caused by too little stomach acid -- not too much, as many doctors profess. As explained in this book, the current practice of reducing stomach acid may be a temporary fix, but this fix comes at a cost to our long-term health that is being ignored by the pharmaceutical companies, the FDA, and the thousands of physicians that prescribe anti-acid drugs like Prilosec, Tagamet, Zantac, Pepcid, and others.

With over 430 patient instruction fact sheets and an additional 123 patient instruction sheets online, the new edition of Griffith's Instructions for Patients by Stephen W. Moore, MD, helps patients understand what their illness is, how it will affect their regular routine, what self care is required, and when to call a doctor. Consistently formatted and organized by topic for easy use, it provides descriptions of each illness, including frequent signs and symptoms, possible causes, risks, preventive measures, expected outcomes, possible complications, and treatments. Newly added topics include Chronic Pain Syndrome; Dry Eye Syndrome; Incontinence, Fecal; In?uenza, H1N1; Methicillin-Resistant Staphylococcus Aureus (MRSA); Mold Allergy; Patellofemoral Pain Syndrome; Perimenopause; Sarcopenia; Spinal Stenosis; and Stroke, Silent. Printable instruction sheets in English and Spanish, 23 separate patient information guides to various types of diets (from "Adult Regular Healthy Diet" to "Weight-Reduction Diet") are downloadable at expertconsult.com. Quickly find what you need with consistently formatted guides - organized by topic for easy use! Help your patients understand what their illness is, how it will affect their regular routine, what self care is required, and when to call a doctor thanks to over 430 patient education guides (and an additional 123 guides online!) reflecting the latest therapeutic information. Ensure the best patient encounters and outcomes with downloadable, customizable English and Spanish patient education guides on expertconsult.com. Educate your patients about timely topics such as Chronic Pain Syndrome; Dry Eye Syndrome; Incontinence, Fecal; In?uenza, H1N1; Methicillin-Resistant Staphylococcus Aureus (MRSA); Mold Allergy; Patellofemoral Pain Syndrome; Perimenopause; Sarcopenia; Spinal Stenosis; and Stroke, Silent. Improve patient compliance, speed recovery and increase understanding with this fully updated edition.

This book gives a comprehensive overview on the use of image-guided radiation therapy (IGRT) in the treatment of lung cancer, covering step-by-step guidelines for clinical implementations, fundamental principles and key technical advances. It covers benefits and limitations of techniques as well as quality and safety issues related to IGRT practice. Addresses imaging simulation, treatment planning, verification, and delivery Discusses important quality assurance issues Describes current methods using specialized machines and technologies Jing Cai, PhD, is an Associate Professor of Radiation Oncology at Duke University Medical Center. Joe Y. Chang, MD, PhD, is Professor in the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center in Houston. Fang-Fang Yin, PhD, is Chief of the Division of Radiation Physics, Professor of Radiation Oncology, and Director of the Medical Physics program at Duke University.

Succinct, easy to read, and highly effective-the highly regarded Secrets Series (R) provides students and practitioners in all areas of health care with focused, engaging resources for quick reference and exam review. In USMLE Step 3 Secrets, 2nd Edition, bestselling review author Dr. Ted O'Connell, along with co-authors Drs. Thomas Blair and Ryan Pedigo, offers practical, up-to-date coverage of the full range of topics on this high-stakes exam, positioning you to clear that final USMLE hurdle with confidence. This enjoyable, easy-to-read book features the Secrets' popular question-and-answer format that prepares you for one of the most important exams you'll take in your medical career. A concise, integrated, clinical overview of Step 3 content, perfect for a refresher and practical preparation for this challenging vignette-style exam. Extensively revised and updated, reflecting high-yield content on the USMLE Step 3. Highly engaging Q&A format interactively reviews your knowledge of diagnosis, treatment, and management of common disorders. New full-color images, figures, tables, and summary boxes provide a concise visual overview of important board-relevant content. Top 100 Secrets, tips, and memory aids offer a fast overview of the secrets you must know for success in practice and on exams. Review board composed of students and residents who performed highly on all steps of the USMLE and have experience with USMLE-style question development. Portable size makes it easy to carry with you for quick reference or review anywhere, anytime. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

The application of molecular biologic methods, recognition of neurogenic inflammatory processes, and utilization of genetic knockout animals are just some of the advances in toxicology of the upper airways in recent years. Toxicology of the Nose and Upper Airways presents a culmination of knowledge gained as a result of both human and experimental animal studies over the past decade. With contributions from internationally recognized leaders in the fields of experimental toxicology, respiratory medicine, otolaryngology, allergy, and sensory science, this volume: Examines the effect of selected pollutants on the upper airways of both humans and experimental animals-emphasizing mechanistic issues in the process Discusses epidemiologic findings from populations exposed occupationally or environmentally, comparing and contrasting alternative risk assessment approaches Features clear chapter organization with sections on structure and function, dosimetry and toxicokinetics, functional and pathologic responses and their measurement, responses to specific agents, risk assessment, and special topics This volume is an essential reference for pharmacologists and toxicologists concerned with the nose and upper airway, as well as clinicians, risk assessors, and sensory scientists.

"Achieving Cultural Competency: A Case-Based Approach to Training Health Professionals" provides the necessary tools to meet the ever-growing need for culturally competent practitioners and trainees. Twenty-five self-study cases cover a variety of medical topics, including cardiovascular, pulmonary, neurology, oncology, hematology, immunology, and pediatric disorders. Actual scenarios that occurred in clinical settings help the user gain direct insight into the realities of practice today. Cultural factors covered within the cases include cultural diversity plus gender, language, folk beliefs, socioeconomic status, religion, and sexual orientation.

This book is an approved CME-certifying activity to meet physicians' cultural competency state requirements.

Get 25 pre-approved self-study American Dietetic Association credits at no additional charge when you purchase the book. Email [email protected] for further instructions.

The only available text to focus primarily on Acute Respiratory Distress Syndrome (ARDS).

Thoroughly revised content and ten new chapters provide pulmonologists with the latest developments and applications of pharmacological and mechanical therapies needed to treat the debilitating and difficult condition of ARDS.
Key features:
REVISION OF A BESTSELLER-Updated content and ten new chapters cover the latest developments and applications physicians need to treat ARDS
EVALUATION OF CURRENT THERAPIES-Surfactant therapy, glucocorticoid therapy, invasive and non-invasive prone position forms of mechanical ventilation, and mesenchymal stem cells helps clinicians give patients the best possible care
INTERNATIONAL TEAM OF EDITORS AND CONTRIBUTORS-Key opinion leaders with diverse backgrounds and experience provide authoritative guidance physicians want and trust
A COMPLETE STAND-ALONE GUIDE-the only available comprehensive volume to tackle this pertinent issue and cover both its pathophysiology and pathogens

Why the "Second Edition" is the must-have guide for all pulmonologists and particle research scientists:
STAY INFORMED - nine brand new chapters cover recent developments and research, with several chapters focusing solely on the fast-developing area of man-made and naturally occurring nano-sized particles
GAIN FULL UNDERSTANDING OF ALL ASSOCIATED DISCIPLINES - including topics and concerns in pulmonology and respiratory medicine, toxicology, and environmental research
KNOW WHAT TO EXPECT as a disease progresses, from a distinguished team of over 40 experts who detail all stages of particle-lung interactions, from inhalation of particles to clearance from the organism
LEARN MORE ABOUT FREQUENTLY NEGLECTED TOPICS - such as the beneficial developments and uses of inhaled man-made particles and reduced side-effects of alternate therapies

This issue of the Medical Clinics of North America brings the practicing clinician up to date on the current challenges, new concepts, and management of hypertensive disease. Topics covered include risks in hypertension; new biological concepts of target organ involvement in hypertension; hypertension and the metabolic syndrome; aging versus hypertension; hypertension, systolic blood pressure, and large arteries; oxidative stress, endothelial dysfunction, and hypertension; current thinking about hypertensive heart disease; diastolic dysfunction as a link between hypertension and heart failure; hypertension and cardiac failure in its various forms; hypertension and atherogenesis; the kidney, hypertension, and remaining challenges; current thinking about renovascular hypertension; obesity and hypertension; and barriers to adherence in hypertension management.

Providing a comprehensive introduction to the study of tropical medicine, this new edition has been thoroughly revised and updated to include new content and more illustrations and clinical photographs to aid understanding. Now fully supported by a companion website containing hundreds of interactive multiple-choice questions, and available in a range of digital formats, Tropical Medicine Lecture Notes is the perfect resource for study and revision, and is the ideal companion for those practising medicine in tropical and sub-tropical regions. * New edition of the best-selling tropical medicine textbook * Brand new chapters covering Ophthalmology and Neglected Tropical Diseases (NTDs) * Increased coverage of malaria, tuberculosis and HIV/AIDS * More colour illustrations and photographs for greater clarity and understanding * Fully supported by a companion website at www.lecturenoteseries.com/tropicalmed containing figures and summaries from the book in PowerPoint format, and hundreds of interactive MCQs (written by Dom Colbert) * Now available in a range of digital formats - perfect for on-the-go study and clinical practice

This Side of Doctoring: Reflections for Women in Medicine offers up an intimate collection of stories, poems, essays, and quotations that captures the joy and heartbreak of being women and being a physician. Editor Eliza Lo Chin (MD, Harvard Medical School) has gathered more than 100 voices that speak to the trials, rewards, and surprises of practicing medicine. Beginning with the writings of early medical pioneers, the anthology weaves a rich patchwork of experiences.

Atrial fibrillation is the most common sustained arrhythmia in humans. An incredible worldwide effort from physicians, scientists and industry over the last decade has brought forth new insights and therapeutic tools. We are fortunate to have achieved a level of understanding about this complex disease that we can indeed cure some patients. While we proceed at full speed ahead looking for cures for the rest, we have taken this opportunity in the Medical Clinics of North America to reflect on how much we have learned and on the task that lies ahead. This issue opens with a historical perspective, discusses many of the clinical issues in the management of atrial fibrillation, such as cardioversion, anticoagulation and ablation, and concludes with the current guidelines for treatment and a view of the future.