Succinct, easy to read, and highly effective-the highly regarded Secrets Series (R) provides students and practitioners in all areas of health care with focused, engaging resources for quick reference and exam review. In USMLE Step 3 Secrets, 2nd Edition, bestselling review author Dr. Ted O'Connell, along with co-authors Drs. Thomas Blair and Ryan Pedigo, offers practical, up-to-date coverage of the full range of topics on this high-stakes exam, positioning you to clear that final USMLE hurdle with confidence. This enjoyable, easy-to-read book features the Secrets' popular question-and-answer format that prepares you for one of the most important exams you'll take in your medical career. A concise, integrated, clinical overview of Step 3 content, perfect for a refresher and practical preparation for this challenging vignette-style exam. Extensively revised and updated, reflecting high-yield content on the USMLE Step 3. Highly engaging Q&A format interactively reviews your knowledge of diagnosis, treatment, and management of common disorders. New full-color images, figures, tables, and summary boxes provide a concise visual overview of important board-relevant content. Top 100 Secrets, tips, and memory aids offer a fast overview of the secrets you must know for success in practice and on exams. Review board composed of students and residents who performed highly on all steps of the USMLE and have experience with USMLE-style question development. Portable size makes it easy to carry with you for quick reference or review anywhere, anytime. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences. Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of "dose" dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research. Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop ne

This research-level reference provides a review of the morphological techniques that have become a primary method of anatomical study correlating structure and function in lung physiology and pathology. Detailing the evolution of anatomy as a research discipline, it explores general structural techn

New biological techniques and a revival of interest in both acute and chronic wound healing have led to an enormously improved understanding of the cellular and chemical complexities of the healing process. Exciting developments in the evolution of epidermal biology are creating new opportunities for research and clinical applications in wound healing. Edited by an expert team of researchers and clinicians, The Epidermis in Wound Healing combines current information with the latest research results to provide a complete picture of the most recent advances in the field. The book focuses on biological advances that improve knowledge and stimulate development in wound therapy. The chapter authors address quantifying repair in the epidermis, biological and clinical elements of wound healing, state-of-the-art approaches to understanding and treating wounds, and gene therapy during wound repair. A discussion on the underlying chemistry of acute and chronic healing describes the special challenges presented by chronic wounds. Featuring the most up-to-date information available, the book chronicles the progress and practices in the field of wound therapy over the past 30 years. This reference will be an essential tool in the generation of innovations and applications in epidermal biology.

Recent developments have provided new data on the subject of inhalation toxicology, requiring an update of the previous edition of this popular text. Like the first, this second edition explains the basic concepts and quantitative approaches in inhalation toxicology, and it gives a comprehensive treatment of evaluations of respiratory responses to inhaled particles and gases. The author here explores new understanding of the role of cytokines in pulmonary inflammation and risk assessment. Immunologists, oncologists, respiratory specialists and students in those fields will find Concepts In Inhalation Toxicology to be essential to their practice.

Discusses three major classes of asthma therapies-bronchodilators, antiinflammatories, and antiallergics-as well as potential new therapeutic approaches! This comprehensive volume addresses the latest treatment strategies for asthma, keying in on the genetics and molecular biology of asthma and pointing the way toward new, commercially viable therapies. Presents the most up-to-date information available on the genetics, epidemiology, pathology, pharmacology, and pulmonology of asthma. Written by more than 20 leading international experts, New and Exploratory Therapeutic Agents for Asthma explores asthma both as incidence of dysfunctional airway smooth muscle and as a disorder of the immune system examines the role of monoclonal antibodies in allergy and asthma describes functions and pharmacokinetic profiles of bronchodilator 2 agonists, anticholinergics, and inhaled glucocorticosteroids investigates the controversy of different types of asthma illustrates the connections between clinical symptoms and the immunopathology of eosinophilic inflammation assesses prospects for the development of a successful oral anti-inflammatory therapy, an immunomodulator that lowers antigen-specific IgE, an anticytokine compound, and an agent that safely combines bronchospasmolytic and anti-inflammatory properties reviews the impact of the recent introduction of antileukotriene agents, clinical findings with PAF antagonists, and selective antimuscarinics evaluates the relationship between improvements in laboratory results and clinical effectiveness and more! Containing over 2000 bibliographic citations and a concise introduction for each chapter, New and Exploratory Therapeutic Agents for Asthma is indispensable for pulmonologists, pediatricians, physiologists, immunologists, allergists, pharmaceutical industry scientists, primary care physicians, and medical s

This issue of Medical Clinics, Guest Edited by Dr. Kerry B. Dunbar, is devoted to Gastroenterology. Articles in this issue include: Proton Pump Inhibitors: What the Internist Needs to Know; Management of Refractory GERD; Colonoscopy, Polypectomy, and the Risk of Bleeding; Pancreatic Cysts: Sinister Findings or 'Incidentalomas'?; The Future of Non-Alcoholic Fatty Liver Disease Treatment; Effective Treatments for Irritable Bowel Syndrome; The Revolution in Treatment of Hepatitis C; Diet and the Role of Food in GI Symptoms; Eosinophilic Esophagitis; Colorectal Cancer Screening: Is Colonoscopy the Best Option?; Celiac Disease and Gluten Sensitivity; Management of Chronic Pancreatitis; and Helping Patients with Gastroparesis.

This handy guide is packed full of information to support medical students, junior doctors and other health professionals in making an accurate diagnosis in relation to different presenting complaints. Now in its fifth edition, the Pocketbook takes the reader through the key steps of narrowing a differential diagnosis, including history, examination and investigation findings. It has been fully updated to cover the full range of common presenting problems facing clinicians today. This book is easy-to-read and logical, making it useful for all clinicians within a variety of settings, from the classroom to emergency department and primary care. This Fifth Edition covers 125 common presenting problems in both medicine and surgery in a consistent format. Each topic includes a list of all potential causes of the condition, colour coded to indicate common, occasional or rare causes. Important geographical variations are also highlighted. Two sections cover the differential diagnosis of biochemical and haematological disorders which provide a ready check when reviewing abnormal results The text includes a targeted guide to the relevant general and specific follow-up investigations which should be carried out as appropriate. Each topic ends with a box highlighting important learning points, or indicating symptom and signs suggestive of significant pathology which require urgent action. A new authorial team have thoroughly revised the contents and ensured the coverage is entirely appropriate for the book's readership.

Part of the Masterpass series, Focused clinical Assessment in 10 Minutes for MRCGP is the definitive study guide for GP trainees at any stage of their specialist training, in particular, those preparing for the CSA. This comprehensive yet straightforward book provides a unique structure for the focused clinical assessment and a new approach to the management of everyday problems encountered in general practice, in 10 minutes. It bridges the gap between consultation theory and the real world; combining language, motivation, knowledge and empathy, enabling GP trainees to gather information, organise their thoughts, pinpoint a diagnosis and communicate this to both patient and examiner.

This issue of Medical Clinics, guest edited by Dr. Cheston B. Cunha, is devoted to Antimicrobial Stewardship. Articles in this issue include: Principles of Antimicrobial Stewardship; Antibiotic Resistance in Stewardship; Therapy of Resistant Organisms: A Stewardship Approach; Optimal Antibiotic Dosing Strategies; The Importance of Interdisciplinary Collaboration in Antimicrobial Stewardship; Role of Education in Antimicrobial Stewardship; Role of the Hospital Epidemiologist in Antimicrobial Stewardship; Role of the Clinical Microbiology Laboratory in Antimicrobial Stewardship; Role of New and Rapid Diagnostics In Antimicrobial Stewardship; Antimicrobial Stewardship in the Community Hospital; Antimicrobial Stewardship in Long-Term Care Facilities; Role of the Pharmacist in Antimicrobial Stewardship; Pharmacoeconomic Considerations of Antimicrobial Stewardship Programs; Principles of IV-to-PO Switch and PO therapy; Role of Technology in Antimicrobial Stewardship; and Metrics of Antimicrobial Stewardship Programs.

Guest edited by Drs. Jonathan Essary Becker and Christopher Todd Maley, this issue of Child and Adolescent Psychiatric Clinics will cover several key areas of interest related to Neuromodulation in Child and Adolescent Psychiatry. This issue is one of four selected each year by our series Consulting Editor, Dr. Todd Peters. Articles in this issue include: Ethical/Legal issues with neuromodulation, Pediatric anesthesia and ECT, TMS, depression, and adolescents, Psychosis and ECT in children/adolescents, Anti-NMDA receptor encephalitis and ECT, Autism and ECT, Catatonia and children/adolescents and ECT, and Transcranial direct current stimulation.

Hyponatremia is a common electrolyte disorder found in a variety of settings. Manifestations range from subtle abnormalities to convulsions and death. New treatment options, such as Antidiuretic Hormone (ADH) antagonists, have created the need for a resource presenting the latest evidence and clinical approaches. Hyponatremia: Evaluation and Treatment is a comprehensive review of hyponatremia, with an emphasis on managing this disorder from diagnosis to treatment. The incidence and occurrence of acute and chronic hyponatremia in general terms are covered, as well as disorders of the central nervous system, heart and liver with their relation to hyponatremia. Common clinical scenarios are presented along with both traditional and new methods of treatment. Authored by experts on this disorder from around the world, experienced members of the medical community and trainees alike will find Hyponatremia as an indispensible guide to diagnosis, managing and treating patients with hyponatremia.

Sold worldwide and translated into 13 languages, John Murtagh's General Practice is widely recognised as the gold standard reference for general practice and primary health care. Its emphasis on the importance of clinical reasoning, early diagnosis and treatment makes this the essential reference for medical students, trainees and general practitioners. Written by renowned general practitioners and educators, and with all content reviewed for currency by leading experts, the eighth edition provides fundamental knowledge and skills required for the challenging field of general practice. Key features: *Diagnostic strategy models for common presenting problems, including diagnostic triads *Clinical frameworks, including management and treatment *Evidence-based research, with all content reviewed for currency by leading experts *Extensive coverage of mental health, health promotion, women's health, and paediatric and geriatric care New to this edition: *New chapters on obesity, mood disorders, breast disorders, and traveller's health and tropical medicine *Updated and new information on genetic disorders, chronic pain and infectious diseases, including acute respiratory distress syndrome with reference to coronaviruses and COVID-19 *Restructure of table of contents to allow for easier navigation About the authors John Murtagh is Emeritus Professor in General Practice at Monash University; Professional Fellow of General Practice at the University of Melbourne; and Adjunct Clinical Professor in the Graduate School of Medicine, University of Notre Dame. Jill Rosenblatt is a general practitioner and was Adjunct Senior Lecturer in the School of Primary Health Care at Monash University. She received a Distinguished Service Award of the RACGP in 2014. Jill has a wealth of rural and urban medical experience. Justin Coleman is a general practitioner in the Tiwi Islands and was Senior Lecturer at Flinders University. He's on the Editorial Advisory Board of Diabetes Management Journal, a member of Choosing Wisely Australia (NPS) and a prolific writer for a number of publications. Clare Murtagh is a general practitioner in Sydney. She holds postgraduate qualifications in Dermatology, Medical Education, and Sexual and Reproductive Health.

Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is imperative that research be undertaken to discover new treatment options. Obstructive Airway Diseases: Role of Lipid Mediators discusses clinically successful and potential lipid targets that can make a difference in treating some of the most intractable disease states. Topics discussed include: Obstructive airway diseases, etiology, pathophysiology, and existing therapeutic options What constitutes a lipid and how it is broken down to generate biologically active mediators The role of enzymes in the process of lipid mediator synthesis The biology of arachidonic acid, platelet-activating factor, and lysophosphatidic acid and the role they play in airway inflammation Products of arachidonic acid metabolism such as leukotrienes, prostaglandins, epieicosatrienoic acid, and oxoeicosatetraenoic acid Proresolution lipid mediators in inflammatory airway disease conditions The role of sphingosine and ceramide in inflammatory airway disease Protein kinases activated by lipid mediators and those that trigger the generation of lipid messengers The combined input of a panel of international authorities on lipid mediators makes this volume a valuable resource for all those involved in researching, teaching, and studying airway inflammation as well as those involved in drug discovery research. Punit Srivastava maintains a blog with additional information about the book and his work.

Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations. Written by today's top experts, Chronic Obstructive Pulmonary Disease Exacerbations: is formatted into separate sections covering imaging diagnosis and treatment, making this text practical and easy-to-use examines current and breakthrough pharmacologic and non-pharmacologic treatments includes COPD-causing exacerbations such as viral and bacterial infections discusses the negative environmental factors relating to COPD

Inflammation is important in many diseases, yet it is hard to find current information on the pertinent cellular and molecular mechanisms of inflammation. This book is a current and authoritative review of various aspects of inflammation in mammalian organisms. Basic principles, including regulation by cytokines, lipid mediators, reactive oxygen species and leukocyte recruitment are followed by chapters on integrative aspects of inflammation, such as neutrophil extracellular traps, sepsis and granulomatous inflammation.

Recent research on skin immunity and the skin microbiome reveals the complexity of the skin and its importance in the development of immunity against arthropod-borne diseases. In diseases such as malaria, borreliosis, leishmaniasis, trypanosomiasis, etc., the skin interface has been shown as an essential site for pathogens to hide from the immune system, and as a potential site of persistence. Only very few vaccines have been successfully developed so far against these diseases, likely because of an insufficient understanding on the development of skin immunity against pathogens. Skin and Arthropod Vectors expands our knowledge on the role of the skin interface during the transmission of arthropod-borne diseases and particularly its immunity. This work may support researchers who strive for developing more efficient diagnostic tools and vaccines. It also gives scientists and advanced students working in related areas a better insight on how humans and animals are attractive to arthropods to develop better repellents, or to set up transgenic arthropods.

Advances in Molecular Toxicology, Volume 11, features the latest advances in the subspecialties of the broad area of molecular toxicology. This series details the study of the molecular basis of toxicology by which a vast array of agents encountered in the human environment, and produced by the human body, manifest themselves as toxins. The book is not strictly limited to documenting these examples, but also covers the complex web of chemical and biological events that give rise to toxin-induced symptoms and disease. The new technologies that are being harnessed to analyze and understand these events are also reviewed by leading experts in the field.

The only available text to focus primarily on Acute Respiratory Distress Syndrome (ARDS).

Thoroughly revised content and ten new chapters provide pulmonologists with the latest developments and applications of pharmacological and mechanical therapies needed to treat the debilitating and difficult condition of ARDS.
Key features:
REVISION OF A BESTSELLER-Updated content and ten new chapters cover the latest developments and applications physicians need to treat ARDS
EVALUATION OF CURRENT THERAPIES-Surfactant therapy, glucocorticoid therapy, invasive and non-invasive prone position forms of mechanical ventilation, and mesenchymal stem cells helps clinicians give patients the best possible care
INTERNATIONAL TEAM OF EDITORS AND CONTRIBUTORS-Key opinion leaders with diverse backgrounds and experience provide authoritative guidance physicians want and trust
A COMPLETE STAND-ALONE GUIDE-the only available comprehensive volume to tackle this pertinent issue and cover both its pathophysiology and pathogens

Realizing the Promise of Precision Medicine: The Role of Patient Data, Mobile Technology, and Consumer Engagement explains the potential of personalized medicine and the value of those approaches in making that potential a reality. The book helps transform one-size-fits-all healthcare into a system that focuses on individual needs and the unique needs of each family member, discussing topics such as U.S. sponsored precision medicine initiative, genomics, the role of electronic health records and mobile medicine, patient engagement and empowerment, health information exchange and patient data protection. In addition, the book discusses the barriers and limitations of precision medicine and how to overcome them. Readers will find valuable insights into how big data, patient engagement, mobile technology, and genomics help individualize medical care and offer a pathway to help detect many undiscovered causes of diseases.

This volume provides a selection of chapters on new developments in various areas of clinical medicine, including dental, surgery, and general practice. These scientific chapters analyze the diagnostic processes and inform of new and novel diagnostic techniques. This book is divided into two sections; the first section contains review papers and includes an overview of experimental and clinical medicine, explaining its history to modern times. The second section presents a selection of original research papers from respected authors on a variety of topics.

The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pathogenesis of human diseases, biomarkers of oxidative damage, antioxidants, phytonutrients and other related health concerns of modern society. The present book is aimed at graduate students, researchers in academia, industry and clinicians with the interest in redox biology. Special attention has been devoted to the topic of ROS signalling, oxidative stress induced human pathologies & antioxidative therapies. The book consists of four parts in specified topics based on the current literatures for the better understanding of the readers with respect to their subject-wise interests. The first section of the book provides an overview about the ROS production and their measuring tools and techniques followed by the mechanisms involved in the oxidative stress in the second section. The third section describes the involvement of oxidative stress in different human diseases and the last section focuses on the different strategies to ameliorate oxidative stress induced stress.

Animal Models for the Study of Human Disease, Second Edition, provides needed information on model sharing, animal alternatives, animal ethics and access to databanks of models, bringing together common descriptions of models for busy researchers across biomedical and biological sciences. Offering easily searchable advantages and disadvantages for each animal model and organized by disease topics, this resource aids researchers in finding the best animal model for research in human disease.