The NATO-Advanced Research Workshop "Esterases, Lipases and Phospholipases: From Structure to Clinical Significance" was held at the University of Bordeaux II, France from 22nd- 24th September 1993 under the Directorship of Professor Michel Clerc of the University of Bordeaux II. The meeting was organised by Hugues Chap (INSERM U 326, Toulouse, France), Georges Ferard (University of Strasbourg, France), Wolfgang Junge (University of Kiel, Germany) and Michael Mackness (University of Manchester, UK). In recent years it has become increasingly apparent that hydrolytic enzymes of the esterase, lipase and phospholipase type play central roles in the pathophysiology of many human diseases. The purpose of this NATO-ARW was to bring together experts (both clinical and scientific) in all three interrelated fields to review the current basic and clinical position and discuss future developments particularly with respect to future research aimed at determining the basic biochemical lesion involving hydrolytic enzymes involved in human disease and the use of these enzymes in diagnosis. As well as formal lectures from established researchers, the meeting also involved a number of lively round-table discussions on future developments and presentations from younger research workers, all of which are recorded in this Proceedings and which contribute to the success of the meeting.

Summarizing state-of-the-art developments in long-term mechanical ventilation use, this comprehensive treatise reviews the applications, complications, and care of breathing disorders affecting the growing population of ventilation-assisted individuals-including neuromuscular and chronic obstructive pulmonary diseases (COPD) and chest wall deformities. Qualitatively considers reimbursement options for management outside of acute care settings! Covering both noninvasive ventilation (NIV) and invasive ventilation techniques and procedures, Long-Term Mechanical Ventilation provides an epidemiology of long-term mechanical ventilation with a review of recent trends examines the pathophysiological mechanisms contributing to chronic respiratory failure, including the pathogenesis and treatment of restrictive thoracic and central hypoventilatory disorders investigates the controversy over conflicting results for NIV management of patients with chronic respiratory failure due to severe stable COPD details critical care for children with severe ventilatory defects such as congenital neuromuscular diseases, cystic fibrosis, and bronchopulmonary dysplasia chronicles new insights into the role of the upper airway and glottis in determining the effectiveness of NIV considers weaning dependent patients off ventilation and methods of care for different sites using the least complicated and most economical means explores tools for measuring the impact and outcomes of long-term mechanical ventilation and determining patients' quality of life and more! Containing over 1400 literature references, tables, drawings, and photographs, Long-Term Mechanical Ventilation is a necessary reference for pulmonary and thoracic specialists, chest physicians, anesthesiologists, physiologists, physiatrists and rehabilitation physicians, respiratory therapists, intensive care specialists, and med

Individuals' responses to their chronic illness or disability (CID) vary widely. Some are positive and productive, some negative and self-defeating, and some have elements of both. Coping with Chronic Illness and Disability synthesizes the growing literature on these coping styles and strategies by analyzing how individuals with CID face challenges, find and use their strengths, and alter their environment to fit their life-changing realities. The book's first section provides readers with the major theories and conceptual perspectives on coping, with special emphasis on social aspects and models of coping with different types of CID. In Part Two, an array of specific medical conditions is covered. Each chapter supplies a clinical description, current empirical findings on coping, effective medical, physical, and psychological interventions, employment issues, and social concerns. conditions, such as cancer, heart disease, diabetes, arthritis, spinal cord injuries, and traumatic brain injury; in-depth coverage of HIV/AIDS, chronic pain, and severe mental illness; coverage of therapeutic modalities adopted for treatment of people with CID; review of the current state of coping theory and research; and, an appendix of instruments frequently used in assessment of coping. The editors' skillful balance between theoretical and practical material will help rehabilitation specialists (particularly psychologists, counselors, social workers, and health-care providers) develop new insights into promoting successful coping, and discern new means of changing its less effective forms. Students in the helping professions, as well as individuals experiencing CID, may also find this multifaceted book useful for understanding some of the psychosocial dynamics of living with CID.

Guest edited by Drs. Marjorie Eskay-Auerbach and Robert Rondinelli, this issue of Physical Medicine and Rehabilitation Clinics will discuss Medical Impairment and Disability Evaluation and Associated Medicolegal Issues. This issue is one of four selected each year by our series Consulting Editor, Dr. Santos Martinez of the Campbell Clinic. Topics in this issue include, but are not limited to: The Physician's Approach to Impairment Rating and Disability Benefits Determinations; Claimant-related Issues; Evaluating Return-to-work ability using Functional Capacity Evaluation; Evaluating Human Functioning Using CAT Methodology for Disability Determination within the SSA; Burden of treatment compliance; Measuring Quality of Life Loss in Litigation; Medical-Legal Causation Analysis; Actuarial Analysis and Life Expectancy Determination after Catastrophic Illness or Injury; Validity Assessment in Acquired Brain Injury Disability Evaluation; Medicolegal Expert Core Competencies & Professionalism; The Physician as Expert Witness; Rehabilitating the Injured Worker to Maximum Medical Improvement (MMI); The Independent Medical Examination (IME); and Life Care Planning, among other topics.

New biological techniques and a revival of interest in both acute and chronic wound healing have led to an enormously improved understanding of the cellular and chemical complexities of the healing process. Exciting developments in the evolution of epidermal biology are creating new opportunities for research and clinical applications in wound healing. Edited by an expert team of researchers and clinicians, The Epidermis in Wound Healing combines current information with the latest research results to provide a complete picture of the most recent advances in the field. The book focuses on biological advances that improve knowledge and stimulate development in wound therapy. The chapter authors address quantifying repair in the epidermis, biological and clinical elements of wound healing, state-of-the-art approaches to understanding and treating wounds, and gene therapy during wound repair. A discussion on the underlying chemistry of acute and chronic healing describes the special challenges presented by chronic wounds. Featuring the most up-to-date information available, the book chronicles the progress and practices in the field of wound therapy over the past 30 years. This reference will be an essential tool in the generation of innovations and applications in epidermal biology.

This updated second edition of Molecular Typing in Bacterial Infections, presented in two volumes, covers both common and neglected bacterial pathogenic agents, highlighting the most effective methods for their identification and classification in the light of their specific epidemiology. New chapters have been included to add new species, as well as another view of how bacterial typing can be used. These books are valuable resources for the molecular typing of infectious disease agents encountered in both research and hospital clinical laboratory settings, as well as in culture collections and in the industry. Each of the 21 chapters provides an overview of specific molecular approaches to efficiently detect and type different bacterial pathogens. The chapters are grouped in five parts, covering respiratory and urogenital pathogens (Volume I), and gastrointestinal and healthcare-associated pathogens, as well as a new group of vector-borne and Biosafety level 3 pathogens including a description of typing methods used in the traditional microbiology laboratory in comparison to molecular methods of epidemiology (Volume II). Comprehensive and updated, Molecular Typing in Bacterial Infections provides state-of-the-art methods for accurate diagnosis and for the correct classification of different types which will prove to be critical in unravelling the transmission routes of human pathogens.

Succinct, easy to read, and highly effective-the highly regarded Secrets Series (R) provides students and practitioners in all areas of health care with focused, engaging resources for quick reference and exam review. In USMLE Step 3 Secrets, 2nd Edition, bestselling review author Dr. Ted O'Connell, along with co-authors Drs. Thomas Blair and Ryan Pedigo, offers practical, up-to-date coverage of the full range of topics on this high-stakes exam, positioning you to clear that final USMLE hurdle with confidence. This enjoyable, easy-to-read book features the Secrets' popular question-and-answer format that prepares you for one of the most important exams you'll take in your medical career. A concise, integrated, clinical overview of Step 3 content, perfect for a refresher and practical preparation for this challenging vignette-style exam. Extensively revised and updated, reflecting high-yield content on the USMLE Step 3. Highly engaging Q&A format interactively reviews your knowledge of diagnosis, treatment, and management of common disorders. New full-color images, figures, tables, and summary boxes provide a concise visual overview of important board-relevant content. Top 100 Secrets, tips, and memory aids offer a fast overview of the secrets you must know for success in practice and on exams. Review board composed of students and residents who performed highly on all steps of the USMLE and have experience with USMLE-style question development. Portable size makes it easy to carry with you for quick reference or review anywhere, anytime. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

This handy guide is packed full of information to support medical students, junior doctors and other health professionals in making an accurate diagnosis in relation to different presenting complaints. Now in its fifth edition, the Pocketbook takes the reader through the key steps of narrowing a differential diagnosis, including history, examination and investigation findings. It has been fully updated to cover the full range of common presenting problems facing clinicians today. This book is easy-to-read and logical, making it useful for all clinicians within a variety of settings, from the classroom to emergency department and primary care. This Fifth Edition covers 125 common presenting problems in both medicine and surgery in a consistent format. Each topic includes a list of all potential causes of the condition, colour coded to indicate common, occasional or rare causes. Important geographical variations are also highlighted. Two sections cover the differential diagnosis of biochemical and haematological disorders which provide a ready check when reviewing abnormal results The text includes a targeted guide to the relevant general and specific follow-up investigations which should be carried out as appropriate. Each topic ends with a box highlighting important learning points, or indicating symptom and signs suggestive of significant pathology which require urgent action. A new authorial team have thoroughly revised the contents and ensured the coverage is entirely appropriate for the book's readership.

This issue of Medical Clinics, Guest Edited by Dr. Ali I. Musani MD, FCCP, is devoted to Pulmonary Disease. Articles in this issue include: Interventional Pulmonology; Pulmonary Hypertension; Lung Transplantation; Interstitial Lung Disease; Asthma; COPD; Lung Cancer; Pleural Diseases; Community Acquired Pneumonia; Orphan Lung Diseases; Palliative Care in Pulmonary Diseases; Sarcoidosis and Granulomatous Diseases of Lungs; Occupational Lung Disease; Pulmonary Embolism; Pulmonary Function Testing and Cardiopulmonary Exercise Testing; Pulmonary Rehabilitation; Imaging in Pulmonary Diseases (CXR, CT, PET); and Preoperative Pulmonary Evaluation.

Part of the Masterpass series, Focused clinical Assessment in 10 Minutes for MRCGP is the definitive study guide for GP trainees at any stage of their specialist training, in particular, those preparing for the CSA. This comprehensive yet straightforward book provides a unique structure for the focused clinical assessment and a new approach to the management of everyday problems encountered in general practice, in 10 minutes. It bridges the gap between consultation theory and the real world; combining language, motivation, knowledge and empathy, enabling GP trainees to gather information, organise their thoughts, pinpoint a diagnosis and communicate this to both patient and examiner.

Incidences of inflammatory airway diseases are on the rise across the world. Existing therapeutic options are ineffective, unsafe, and expensive, and severe cases are nonresponsive to conventional therapy. Therefore, it is imperative that research be undertaken to discover new treatment options. Obstructive Airway Diseases: Role of Lipid Mediators discusses clinically successful and potential lipid targets that can make a difference in treating some of the most intractable disease states. Topics discussed include: Obstructive airway diseases, etiology, pathophysiology, and existing therapeutic options What constitutes a lipid and how it is broken down to generate biologically active mediators The role of enzymes in the process of lipid mediator synthesis The biology of arachidonic acid, platelet-activating factor, and lysophosphatidic acid and the role they play in airway inflammation Products of arachidonic acid metabolism such as leukotrienes, prostaglandins, epieicosatrienoic acid, and oxoeicosatetraenoic acid Proresolution lipid mediators in inflammatory airway disease conditions The role of sphingosine and ceramide in inflammatory airway disease Protein kinases activated by lipid mediators and those that trigger the generation of lipid messengers The combined input of a panel of international authorities on lipid mediators makes this volume a valuable resource for all those involved in researching, teaching, and studying airway inflammation as well as those involved in drug discovery research. Punit Srivastava maintains a blog with additional information about the book and his work.

This issue of Medical Clinics, Guest Edited by Dr. Kerry B. Dunbar, is devoted to Gastroenterology. Articles in this issue include: Proton Pump Inhibitors: What the Internist Needs to Know; Management of Refractory GERD; Colonoscopy, Polypectomy, and the Risk of Bleeding; Pancreatic Cysts: Sinister Findings or 'Incidentalomas'?; The Future of Non-Alcoholic Fatty Liver Disease Treatment; Effective Treatments for Irritable Bowel Syndrome; The Revolution in Treatment of Hepatitis C; Diet and the Role of Food in GI Symptoms; Eosinophilic Esophagitis; Colorectal Cancer Screening: Is Colonoscopy the Best Option?; Celiac Disease and Gluten Sensitivity; Management of Chronic Pancreatitis; and Helping Patients with Gastroparesis.

HANDBOOK OF MRI TECHNIQUE FIFTH EDITION Distinguished educator Catherine Westbrook delivers a comprehensive and intuitive resource for radiologic technologists in this newly revised Fifth Edition of the Handbook of MRI Technique. With a heavy emphasis on protocol optimisation and patient care, the book guides the uninitiated through scanning techniques and assists more experienced technologists with image quality improvement. The new edition includes up-to-date scanning techniques and an additional chapter on paediatric imaging. The latest regulations on MRI safety are referenced and there are expanded sections on slice prescription criteria. The book also includes the contributions of several clinical experts, walking readers through key theoretical concepts, discussing practical tips on cardiac gating, equipment use, patient care, MRI safety, and contrast media. Step-by-step instruction is provided on scanning each anatomical area, complete with patient positioning and image quality optimisation techniques. The book includes: A thorough introduction to the concepts of parameters and trade-offs, as well as pulse sequences, flow phenomena, and artefacts Comprehensive explorations of cardiac gating and respiratory compensation techniques, patient care and safety, contrast agents, and slice prescription criteria Practical discussions of a wide variety of examination areas, including the head and neck, spine, chest, abdomen, pelvis, the upper and lower limbs, and paediatric imaging A companion website with self-assessment questions and image flashcards Perfect for radiography students and newly qualified practitioners, as well as practitioners preparing for MRI-based certification and examination, the Handbook of MRI Technique will also prove to be an invaluable addition to the libraries of students in biomedical engineering technology and radiology residents.

This issue of Medical Clinics, guest edited by Dr. Cheston B. Cunha, is devoted to Antimicrobial Stewardship. Articles in this issue include: Principles of Antimicrobial Stewardship; Antibiotic Resistance in Stewardship; Therapy of Resistant Organisms: A Stewardship Approach; Optimal Antibiotic Dosing Strategies; The Importance of Interdisciplinary Collaboration in Antimicrobial Stewardship; Role of Education in Antimicrobial Stewardship; Role of the Hospital Epidemiologist in Antimicrobial Stewardship; Role of the Clinical Microbiology Laboratory in Antimicrobial Stewardship; Role of New and Rapid Diagnostics In Antimicrobial Stewardship; Antimicrobial Stewardship in the Community Hospital; Antimicrobial Stewardship in Long-Term Care Facilities; Role of the Pharmacist in Antimicrobial Stewardship; Pharmacoeconomic Considerations of Antimicrobial Stewardship Programs; Principles of IV-to-PO Switch and PO therapy; Role of Technology in Antimicrobial Stewardship; and Metrics of Antimicrobial Stewardship Programs.

Now in its fourth edition, Medical Statistics at a Glance is a concise and accessible introduction to this complex subject. It provides clear instruction on how to apply commonly used statistical procedures in an easy-to-read, comprehensive and relevant volume. This new edition continues to be the ideal introductory manual and reference guide to medical statistics, an invaluable companion for statistics lectures and a very useful revision aid. This new edition of Medical Statistics at a Glance Offers guidance on the practical application of statistical methods in conducting research and presenting results Explains the underlying concepts of medical statistics and presents the key facts without being unduly mathematical Contains succinct self-contained chapters, each with one or more examples, many of them new, to illustrate the use of the methodology described in the chapter. Now provides templates for critical appraisal, checklists for the reporting of randomized controlled trials and observational studies and references to the EQUATOR guidelines for the presentation of study results for many other types of study Includes extensive cross-referencing, flowcharts to aid the choice of appropriate tests, learning objectives for each chapter, a glossary of terms and a glossary of annotated full computer output relevant to the examples in the text Provides cross-referencing to the multiple choice and structured questions in the companion Medical Statistics at a Glance Workbook Medical Statistics at a Glance is a must-have text for undergraduate and post-graduate medical students, medical researchers and biomedical and pharmaceutical professionals.

ABC of Dementia is a practical guide, written with the needs of professionals in training in mind. Its aim is to enable readers to explore attitudes towards dementia, and find the knowledge and skills required in the important task of supporting the lives of people with dementia and their carers. This new edition is designed to assist students and practitioners working within both primary and secondary care settings with the diagnosis, treatment and provision of care. It covers the causes of dementia, diagnostic assessment, early intervention, pharmacological treatment, person-centred care, legal and ethical issues, and more. This resource has been thoroughly revised to reflect the most recent research and evidence-based practice. New and expanded content addresses dementia and frailty in care homes, explores the role of technology in the treatment of dementia, discusses working with minority groups, and examines case studies. Aids healthcare professionals in developing the knowledge, skills and confidence to care for those with dementia Highlights the importance of person-centred care and the effects of dementia on families and carers. Describes the cognitive changes and neurological disorders central to dementia Addresses the needs of younger people developing dementia Provides guidance on managing dementia in primary care, the acute hospital and end-of-life care settings Covers the Neuropsychiatric Symptoms of Dementia (NPSD) Features numerous full-colour photographs and illustrations ABC of Dementia is a must-have for healthcare students, general practitioners, and other healthcare professionals caring for people with dementia. It will also be of interest to members of the general public who wish to know more about dementia.

Hyponatremia is a common electrolyte disorder found in a variety of settings. Manifestations range from subtle abnormalities to convulsions and death. New treatment options, such as Antidiuretic Hormone (ADH) antagonists, have created the need for a resource presenting the latest evidence and clinical approaches. Hyponatremia: Evaluation and Treatment is a comprehensive review of hyponatremia, with an emphasis on managing this disorder from diagnosis to treatment. The incidence and occurrence of acute and chronic hyponatremia in general terms are covered, as well as disorders of the central nervous system, heart and liver with their relation to hyponatremia. Common clinical scenarios are presented along with both traditional and new methods of treatment. Authored by experts on this disorder from around the world, experienced members of the medical community and trainees alike will find Hyponatremia as an indispensible guide to diagnosis, managing and treating patients with hyponatremia.

Human Genome Informatics: Translating Genes into Health examines the most commonly used electronic tools for translating genomic information into clinically meaningful formats. By analyzing and comparing interpretation methods of whole genome data, the book discusses the possibilities of their application in genomic and translational medicine. Topics such as electronic decision-making tools, translation algorithms, interpretation and translation of whole genome data for rare diseases are thoroughly explored. In addition, discussions of current human genome databases and the possibilities of big data in genomic medicine are presented. With an updated approach on recent techniques and current human genomic databases, the book is a valuable source for students and researchers in genome and medical informatics. It is also ideal for workers in the bioinformatics industry who are interested in recent developments in the field.

Guest edited by Drs. Jonathan Essary Becker and Christopher Todd Maley, this issue of Child and Adolescent Psychiatric Clinics will cover several key areas of interest related to Neuromodulation in Child and Adolescent Psychiatry. This issue is one of four selected each year by our series Consulting Editor, Dr. Todd Peters. Articles in this issue include: Ethical/Legal issues with neuromodulation, Pediatric anesthesia and ECT, TMS, depression, and adolescents, Psychosis and ECT in children/adolescents, Anti-NMDA receptor encephalitis and ECT, Autism and ECT, Catatonia and children/adolescents and ECT, and Transcranial direct current stimulation.

Sold worldwide and translated into 13 languages, John Murtagh's General Practice is widely recognised as the gold standard reference for general practice and primary health care. Its emphasis on the importance of clinical reasoning, early diagnosis and treatment makes this the essential reference for medical students, trainees and general practitioners. Written by renowned general practitioners and educators, and with all content reviewed for currency by leading experts, the eighth edition provides fundamental knowledge and skills required for the challenging field of general practice. Key features: *Diagnostic strategy models for common presenting problems, including diagnostic triads *Clinical frameworks, including management and treatment *Evidence-based research, with all content reviewed for currency by leading experts *Extensive coverage of mental health, health promotion, women's health, and paediatric and geriatric care New to this edition: *New chapters on obesity, mood disorders, breast disorders, and traveller's health and tropical medicine *Updated and new information on genetic disorders, chronic pain and infectious diseases, including acute respiratory distress syndrome with reference to coronaviruses and COVID-19 *Restructure of table of contents to allow for easier navigation About the authors John Murtagh is Emeritus Professor in General Practice at Monash University; Professional Fellow of General Practice at the University of Melbourne; and Adjunct Clinical Professor in the Graduate School of Medicine, University of Notre Dame. Jill Rosenblatt is a general practitioner and was Adjunct Senior Lecturer in the School of Primary Health Care at Monash University. She received a Distinguished Service Award of the RACGP in 2014. Jill has a wealth of rural and urban medical experience. Justin Coleman is a general practitioner in the Tiwi Islands and was Senior Lecturer at Flinders University. He's on the Editorial Advisory Board of Diabetes Management Journal, a member of Choosing Wisely Australia (NPS) and a prolific writer for a number of publications. Clare Murtagh is a general practitioner in Sydney. She holds postgraduate qualifications in Dermatology, Medical Education, and Sexual and Reproductive Health.

Chronic Obstructive Pulmonary Disease Exacerbations covers the definition, diagnosis, epidemiology, mechanisms, and treatment associated with COPD exacerbations. This text also addresses imaging and how it plays a pivotal role in the diagnosis and study of exacerbations. Written by today's top experts, Chronic Obstructive Pulmonary Disease Exacerbations: is formatted into separate sections covering imaging diagnosis and treatment, making this text practical and easy-to-use examines current and breakthrough pharmacologic and non-pharmacologic treatments includes COPD-causing exacerbations such as viral and bacterial infections discusses the negative environmental factors relating to COPD

When Dr. Ellen Einterz first arrives in the town of Kolofata in Cameroon, the situation is dire: patients are exploited by healthcare workers, unsterilized needles are reused, and only the wealthy can afford care. In Life and Death in Kolofata: An American Doctor in Africa, Einterz tells her remarkable story of delivering healthcare for 24 years in one of the poorest countries in the world, revealing both touching stories of those she is able to help and the terrible suffering of people born in extreme poverty. In one case, a 6-year-old burn victim suffers after an oil tanker tips and catches fire; in another story, Dr. Einterz delivers a child in the front yard of her home. In addition to struggling to cure diseases and injuries and combat malnutrition, Einterz faced another kind of danger: the terrorist organization Boko Haram had successively kidnapped politicians from Cameroon and foreigners, and they had set their sights on Americans in particular. It would only be a matter of time before they would come for her. Tragic, heartwarming, and at times even humorous, Life and Death in Kolofata illustrates daily life for the people of Cameroon and their doctor, documenting both the incredible human suffering in the world and the difference that can be made by those willing to help.