This detailed book gathers a broad collection of experimental approaches to assist researchers in setting up different methods to investigate protein conformational disorders. Beginning with a section on assays focusing on biophysical approaches to study protein (mis)folding, the volume continues with sections on cellular and proteostasis assays as well as assays for protein folding correction and recovery, combining methods such as thermal shift assays, in silico improvement of protein solubility, and compound screening, an important area of research as it may open avenues for therapeutic strategies. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips for troubleshooting and avoiding known pitfalls. Authoritative and practical, Protein Misfolding Diseases: Methods and Protocols serves as an ideal guide for researchers seeking to advance our knowledge of protein conformational disorders.

The fifth edition of this bestselling Oxford Medical Handbook is now even better than ever, with the inclusion of three new chapters on day case surgery, remote and rural surgery, and emergency surgery. It has been thoroughly revised with the latest guidelines, management algorithms, and guidance on decision-making. Now with the editorial team expanded to include four new associate editors, this new edition provides an accessible pocket reference for surgical trainees, medical students, and all those involved in the care of the surgical patient. It is thoroughly comprehensive, without sacrificing the clear, concise, and quick-reference style the Oxford Medical Handbooks are known for. It provides surgically relevant anatomy and physiology, quick reference symbols, key diagrams, and a focus on evidence-based practice with key references throughout. This essential guide will ensure you have the information you need at your fingertips.

Get the book and get into medical school. Sound simple? Well, it isn't. But Get into UK Medical School For Dummies contains the information you need to get ahead of the competition and give yourself the best possible shot at success. Doctors Chris Chopdar and Neel Burton guide you through the entire process from deciding whether a career in medicine is right for you to sitting for interviews. Along the way, they provide the proven advice and coaching that has resulted in hundreds of acceptance letters on topic such as Why choose medicine (and why you may decide not to) Long term planning -- The A-levels, extracurricular activities, volunteer opportunities, and work experience that can make you a more attractive candidate; and what to do if you're lacking in these categories. Personal statement -- Plenty of insight and examples to help you create a winning and -- truly personal -- personal statement Research -- Put together a plan that ensures you find a university that's right for you. Test preparation -- An overview of the UKCAT and BMAT, preparation strategies, and sample questions The interview -- Common questions, how to tackle them, and the importance of body language The decision -- Tips on choosing between multiple offers!

The Understanding the Prostate chart is an overview of a component of the male reproductive system. Zones of the prostate are shown, along with a diagram of a digital rectal exam. Additional graphics and text describe prostatitis, benign prostatic hyperplasia (BPH) and prostate cancer. Heavy gauge 3ml lamination with sealed edges and two metal eyelets for hanging makes chart highly durable. Write-on/wipe-off with dry erase marker (not included).

MSC (mesenchymal stem cells) have been reported to initiate revascularization after injury, to facilitate engraftment of blood-forming stem cells, and to reduce the incidence of graft-vs. host disease through their immune-suppressive qualities. Finally, bone marrow-derived MSC have been reported to home to areas of solid tumor revascularization, and thus may be used as delivery vehicles to target ablative agents into dividing tumor cells. Recently the characteristics of human MSC from adipose (fat) tissue have also been identified. The possibility of repairing tissues, speeding stem cell engraftment, and targeting solid tumors for specific killing, using MSC easily harvested from bone marrow, or better yet, from unwanted fat tissue, holds broad appeal, and is an intriguing possibility that could have dramatic effect on health care. This book has information on how to isolate, grow, and characterize MSC from marrow and fat, and gives important insight into how these cells may be used for gene delivery and cellular therapies in the future. Updates on emerging clinical trials are given.

Internal or general medicine is the medical specialty dealing with the prevention, diagnosis and treatment of adult diseases. This second edition provides clinicians and trainees with a complete guide to internal medicine. Divided into 28 sections, the first part of the book is dedicated to the diagnosis and management of cardiac conditions. The second part covers respiratory and pulmonary disorders, gastrointestinal diseases, neurologic disorders, renal conditions and endocrine disorders. The book has been fully revised with new topics added to provide the latest advances in the field. Each chapter examines the pathophysiology and techniques for accurate diagnosis and appropriate therapy. Authored by a recognised, Ottawa-based expert in the field, the new edition features clinical photographs, illustrations and tables to enhance learning. Key points Comprehensive guide to the latest advances in internal medicine Fully revised, second edition covering numerous disorders in different systems of the body Authored by recognised Ottawa-based expert in the field Previous edition (9780812116021) published in 1994

Fully updated for the second edition, these handy pocket-sized study cards remain an innovative and versatile revision solution. Containing vital techniques and tips, the study cards condense revision into short essential bursts. Ideal for revising quickly on the move, students can also use them when carrying out examinations, or as a reminder before ward rounds and teaching sessions. Arranged into clear sections, the cards allow the reader to find and digest topics easily, whilst full colour illustrations aid quick and confident diagnoses. Taking a system-based approach, the set covers all essential diseases and syndromes in just 166 double-sided cards. Each card first describes the clinical examination and symptoms, before covering the need-to-know essentials: aetiology, indications, differential diagnoses, complications and suitable investigations. The final part of each card covers the treatment or management of the disease.

From the author of the bestselling introduction to evidence-based medicine, this brand new title makes sense of the complex and confusing landscape of implementation science, the role of research impact, and how to avoid research waste. How to Implement Evidence-Based Healthcare clearly and succinctly demystifies the implementation process, and explains how to successfully apply evidence-based healthcare to practice in order to ensure safe and effective practice. Written in an engaging and practical style, it includes frameworks, tools and techniques for successful implementation and behavioural change, as well as in-depth coverage and analysis of key themes and topics with a focus on: * Groups and teams * Organisations * Patients * Technology * Policy * Networks and systems. How to Implement Evidence-Based Healthcare is essential reading for students, clinicians and researchers focused on evidence-based medicine and healthcare, implementation science, applied healthcare research, and those working in public health, public policy, and management.

This book is a practical guide for psychiatrists to use when treating patients for medical issues. Over the past 10-20 years, the number of medications prescribed for psychiatric illnesses has steadily increased, and psychiatric practitioners are frequently called upon to manage medical issues and side effects that result from psychotropic treatment. Covering a wide range of conditions from thyroid disorders to cardiac disease, this book is a helpful resource for understanding common adverse medical effects that occur when psychotropic drugs are administered. Presented in a practical format, each chapter discusses management of a particular medical problem or side effect and then provides a summary and flowchart of the major points highlighted in that chapter. Each chapter contains an overview of key medications causing a particular side effect. The book also includes special topics such as psychotropic prescribing in medical illness and tips on electrocardiographic interpretation. This easy-to-reference book aims to bridge the gap between medicine and psychiatry by elaborating on medical conditions seen in routine outpatient psychiatric practice. It serves as an invaluable tool for mental health providers, nurses, health educators, and pharmacologists alike.

This new book for medical students contains over 60 of the most commonly encountered OSCE stations in medicine and surgery. The OSCEs are arranged according to type of skill; for example history-taking, ethics and communication, physical examination. This is an accessible book for students under pressure who are revising for a clinical OSCE. It provides simple advice, tips about preparation, and will be easily understood. It provides sample OSCE station questions and simulated patient scripts (with answers) for practice at home.

Focusing on the essential information you need to know for the most commonly encountered problems in outpatient internal medicine, this practical volume in the Washington Manual® series provides concise, high-yield content that reflects today’s advances in patient evaluation and management. In one convenient, portable resource, you’ll find complete coverage of everything from hypertension and diabetes to sleep disorders, nutrition, and care of the cancer patient—all at your fingertips for quick review and reference. Edited by Drs. Maureen D. Lyons, Peter J. McDonnell, and Jennifer M. Schmidt, The Washington Manual® of Outpatient Internal Medicine, 3rd Edition, is an excellent companion to the Washington Manual® of Medical Therapeutics, which thoroughly covers inpatient care.   Covers common ambulatory/outpatient problems encountered in each medical subspecialty, all in the famous fast-access Washington Manual® outline format that includes easy-to-follow guidelines, diagrams, and algorithms. Thoroughly revised from cover to cover, including new content on telehealth, the trauma-informed approach, immunization reaction and allergy, functional assessment and safe prescribing for pain, breast masses, sexually transmitted infections, and more. Includes a new, full-color insert of dermatologic images to illustrate skin diagnoses and rashes. Addresses all areas of medicine and core subspecialties, including neurology and toxicology. Provides need-to-know diagnostic and therapeutic guidance from the outstanding house staff and faculty at Washington University School of Medicine in St. Louis. The Washington Manual® is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by Wolters Kluwer Health under license from Washington University.   Enrich Your eBook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech.

Medical decision making has evolved in recent years, as more complex problems are being faced and addressed based on increasingly large amounts of data. In parallel, advances in computing power have led to a host of new and powerful statistical tools to support decision making. Simulation-based Bayesian methods are especially promising, as they provide a unified framework for data collection, inference, and decision making. In addition, these methods are simple to implement and can help to address the most pressing practical and ethical concerns arising in medical decision making.

• Provides an overview of the necessary methodological background, including Bayesian inference, Monte Carlo simulation, and utility theory.
• Driven by three real applications, presented as extensively detailed case studies.
• Case studies include simplified versions of the analysis, to approach complex modelling in stages.
• Features coverage of meta-analysis, decision analysis, and comprehensive decision modeling.
• Accessible to readers with only a basic statistical knowledge.

Handbook of Food Fortification and Health: From Concepts to Public Health Applications Volume 1 represents a multidisciplinary approach to food fortification. This book aims to disseminate important material pertaining to the fortification of foods from strategic initiatives to public health applications. Optimal nutritional intake is an essential component of health and wellbeing. Unfortunately situations arise on a local or national scale when nutrient supply or intake is deemed to be suboptimal. As a consequence, ill health occurs affecting individual organs or causing premature death. In terms of public health, malnutrition due to micronutrient deficiency can be quite profound imposing economic and social burdens on individuals and whole communities. This comprehensive text examines the broad spectrum of food fortification in all its manifestations. Coverage includes sections on definitions of fortifications, fortified foods, beverages and nutrients, fortifications with micronutrients, biofortification, impact on individuals, public health concepts and issues, and selective methods and food chemistry. Handbook of Food Fortification and Health: From Concepts to Public Health Applications Volume 1 is an indispensable text designed for nutritionists, dietitians, clinicians and health related professionals.

Clinical Acupuncture and Ancient Chinese Medicine weaves together historical perspectives, ancient wisdom, and modern medicine to provide a holistic, effective, and rewarding way to understand and apply acupuncture in clinical practice. Methodology for memorizing the function of acupuncture meridians and points is supplemented by nearly 600 high-quality images that illustrate point locations and needle insertion techniques. Algorithms for making diagnostic formulations, developing treatment strategies, and implementing effective therapeutic interventions are emphasized. Chapters also cover published outcomes data, the critical role of human psychology and spirituality in healing, and adjunctive therapies to acupuncture such as medicinal herbs and cupping. Authored by Dr. Jingduan Yang and Dr. Daniel A. Monti, two internationally known leaders and teachers of Chinese Medicine and Integrative Health, Clinical Acupuncture and Ancient Chinese Medicine is an ideal resource for a diverse range of health care practitioners and trainees including physicians, chiropractors, and licensed acupuncturists.

This book provides medical students and physicians with a practical, step-by-step guide on how to write and publish a medical case report. The case report is the traditional way for physicians to describe their unique or unusual cases to a broad audience and it plays an important role in the discovery of new diseases or syndromes, unusual manifestations of disease, important adverse drug reactions, and the generation of hypotheses for further study. This book guides readers through the process from choosing a case to report on to finding a publisher and then comment on future directions and potential new uses of case reports, including expanded computer case databases to optimize care for individual patients and new applications in medical education. Interspersed throughout the text are example case reports, many written by the authors, with commentary on their experiences working with those reports to provide context and aid readers in creating clear, concise, and useful case reports.

Over the past decade, the healthcare industry has adopted games as a powerful tool for promoting personal health and wellness. Utilizing principles of gamification to engage patients with positive reinforcement, these games promote stronger attention to clinical and self-care guidelines, and offer exciting possibilities for primary prevention. Targeting an audience of academics, researchers, practitioners, healthcare professionals, and even patients, the Handbook of Research on Holistic Perspectives in Gamification for Clinical Practices reviews current studies and empirical evidence, highlights critical principles of gamification, and fosters the increasing application of games at the practical, clinical level.

Cessation of tobacco use is the need of the hour given that it is the single largest cause of disease and premature death in the world. This book covers epidemiology and risks, user classification, nicotine replacement therapy, pharmacological aids, behavioral modification and patient counseling techniques, along with personalized action plan development. Key Features Covers all aspect of tobacco cessation. Provides guidance on differential diagnosis and includes useful decision-making flowcharts. Provides step-by-step guidance to counsel tobacco users in routine clinical practice. Discusses the process of setting up a cessation centre. Facilitates in-depth understanding of the subject through case studies at the end of each chapter

Currently and for centuries past, sickness has been understood to be primarily the physical result of bodily disease. Yet this definition of illness is out-of-date and untrue to life at a time when chronic illness and the problems of disability and aging are increasingly common. When persons are sick, it pervades their whole being. The Nature of Healing is based on a different definition of sickness, one that recognizes persons as sick when they cannot achieve their goals and purposes because of impairments of function, ranging from the molecular to the spiritual, which they believe to fall under the scope of medicine. Such impairments may result from disease, but certainly not all.
As the sick person has increasingly become the focus of medicine, there have been repeated but mostly failed attempts to achieve both technological and humanistic goals in caring for patients. This approach is flawed because there is only one ultimate goal -- the well-being of the patient. Whether it involves the personal action of the clinician or the use of technology, everything done toward the goal of well-being is part of the healing enterprise. In this book, Eric Cassell explores what sickness is, what persons are, and how to understand function and its impairments. He explains healing skills and actions, as well as the nature of healing for sick and suffering patients. This book concludes with a discussion of the moral basis of the relationship between patient and healer, as well as the goals of healing.

Psychosocial problems appear within a medical context worldwide, and are a major burden to health. Psychosomatic Medicine: An International Primer for the Primary Care Setting takes a uniquely global approach in laying the foundations of bio psychosocial basic care (such as recognizing psychosocial and psychosomatic problems, basic counseling and collaboration with mental health specialists) and provides relevant information about the most common mental and psychosomatic problems and disorders. The scope of the book is intercultural-it addresses global cultures, subcultures living in a single country and strengthening the care given by physicians working abroad. This clinically useful book outlines best practices for diagnosing the most common bio psychosocial problems and mastering the most common communication challenges (e.g. doctor-patient conversation, breaking bad news, dealing with difficult patients, family and health systems communication and collaboration). Every chapter integrates basic theoretical background and practical skills and includes trans-culturally sensitive material, important for work with patients from different cultures. Psychosomatic Medicine: An International Primer for the Primary Care Setting serves as an excellent resource for clinicians hoping to gain and develop knowledge and skills in psychosomatic medicine.

The metabolic syndrome is a common syndrome affecting about 20 % of the adult population in Europe, and probably the prevalence is of the same magnitude in other industrialised countries worldwide. It is mainly caused by western lifestyle resulting in abdominal obesity, but also a genetic predisposition plays a role. This syndrome, which is linked to leisure lifestyle and overeating/obesity, can develop into type 2 diabetes, cardiovascular disease and cancer. Therefore, proper treatment and prevention are heavily needed. This book discusses lifestyle intervention and treatment, specifically with pharmacological compounds, in order to formulate a strategy for treating the metabolic syndrome in the daily clinic.

This concise, easy-to-read guidebook is designed as a go-to resource for clinician educators working to establish the foundation for a successful academic career. This book begins with preliminary lessons such as interviewing for a first faculty position, how to prepare a robust curriculum vitae, how to evaluate a letter of offer, and understanding the process of academic promotion. Further chapters highlight the refinement of essential academic skills, including how to effectively give a lecture, how to approach clinical supervision, incorporating technology in educational innovation, and how to give feedback, among other topics. Chapters pertaining to clinical care cover a range of topics, including how to maintain excellent clinical documentation, how to evaluate clinical research, and how to avoid medico-legal problems. Clinician educators, while essential to the academic workforce, often feel overwhelmed by the newness and breadth of responsibilities that go with their first faculty job. Addressing that problem, this guidebook also emphasizes careful attention to preserving a healthy work/life balance as clinician educators navigate the demands of their professional and personal lives. The Clinician Educator Guidebook: Steps and Strategies for Advancing Your Career is derived from the larger acclaimed text, The Academic Medicine Handbook, and is an indispensable resource for a unique group of dedicated faculty who play an essential role in academic medicine.

The scope for improving health care using stem cell therapies is thrilling, but has considerable technical challenges and methodological constraints that need to be addressed. Keeping with the tradition of Humana Press to bring these developments to the forefront in a timely manner, this book presents scientific advances in stem cell methods for a wider use by novice and expert scientists, through the series of Methods in Molecular Biology.

MRI has become the main paraclinical test in the diagnosis and management of multiple sclerosis. More than 400 pictures of different typical and atypical MS lesions are demonstrated in this atlas. Each image has a teaching point. New diagnostic criteria and differential diagnosis are discussed.