With increasing urgency, decisions about the digitalized future of healthcare and implementations of new assistive technologies are becoming focal points of societal and scientific debates and addresses large audiences. Decisions require a careful weighing of risks and benefits and contextualizing in-depth ethical analysis with robust empirical data. However, up to now, research on social assistive technologies is mostly dispersed over different academic fields and disciplines. A comprehensive overview on discussions regarding values at stake and ethical assessment of recent developments especially in healthcare is largely missing. This publication initiates an interdisciplinary discourse on ethical, legal and social implications of socially assistive technologies in healthcare. Contributions include perspectives from nursing science, social sciences, philosophy, medical ethics, economics and law to present an - to our knowledge - first and comprehensive overview on different aspects of the use and implementation of socially assistive technologies from an ethical perspective. It combines practically relevant insights and examples from current research and development with ethical analysis to uncover exemplary moral tipping points between promotion of participation or well-being and risks and damages to these values. Healthcare professionals involved in implementation of smart technologies as well as scholars from the field of humanities, nursing and medicine, interested in the discussions on ethics and technology in healthcare, will benefit from this new contribution. The publication is part of the international DigitAs conference "Aging between Participation and Simulation - Ethical Dimensions of Socially Assistive Technologies" held at the Institute of Medical Ethics and History of Medicine (Ruhr University Bochum) from 4 February to 8 February 2019. Within this framework, twelve young scholars were invited to discuss their contributions with renowned experts in the field. The Institute of Medical Ethics and History of Medicine is one of the leading institutes in empirically informed ethical analysis in healthcare and medicine and is a member of the European Association of Centres of Medical Ethics (EACME).

Clinical professionalism is a set of values, behaviours and relationships which underpins the public's trust in healthcare providers both as individuals and organisations. 'First, do no harm' is expressed most clearly today in the patient safety movement and the imperative for transparency and candour in the delivery of healthcare. Professional conduct is essential for safe and high quality clinical care. The ABC of Clinical Professionalism considers recent evidence on how healthcare practitioners maintain professionalism including how values are developed and affected by the working environment, the challenges of maintaining personal and organisational resilience and the ethical and regulatory framework in which practice is conducted. Topics covered include: Acquiring and developing professional values Patient-centred care Burnout and resilience Confidentiality and social media The culture of healthcare Ensuring patient safety Leadership and collaboration Ethical and legal aspects of professionalism Teaching and assessing professionalism Regulation of healthcare professionals The chapter authors come from a range of countries and have experience of working in multidisciplinary clinical teams, research, and in the training of future healthcare practitioners including their development as professionals.

Getting involved in medical and biomedical research through necessity or personal choice can be a testing experience. Each step of the process throws up its own challenges, from liaising with supervisors, to the lack of opportunities to promote completed research. This brand new How to provides a complete guide to the process: from the planning stages, to execution, write-up, preparation for the viva examination, and how to maximise the impact of your research. It ensures you get the most out of the experience, both in terms of personal development and academic achievement, and even provides guidance on what to do when things don't quite go to plan. An ideal companion, written by an experienced postgraduate tutor, this concise and user-friendly manual is full of practical exercises, key points, and hints and tips, which will give you the edge when dealing with the more elusive realities of medical and healthcare research.

"This book is an informative contribution to the education of future practioners during medical school and residency training. Daly tells the story of the evolution of EBM by recounting the intellectual contributions, spanning four decades, of individuals wishing to see the best available evidence about the management of clinical conditions incorporated into the practice of medicine."--Michael Whitcomb, Senior VP and Director of Division of Medical Education at the Association of American Medical Colleges"This book is an engaging account of the evolution of evidence-based medicine, and an incisive analysis of this approach to improving healthcare. Daly's critique is a refreshing and scholarly contrast with the erection and demolition of straw men by many critics of EBM, as she poses important challenges to practitioners, policy makers, patients, researchers and others who wish to play their part in improving clinical care."--Sir Iain Chalmers, Editor at the James Lind Library "Daly's deep and wide examination reveals how bioscientific evidence has risen to fresh importance in clinical medical practice and health policy development in the past 30 years. Her account reveals why evidence-based medicine has pentrated into North America and U.K. medical practice and beyond. She uses her critical acuity as a social scientist to observe with warmth the Pilgrims who have blazed the EBM trail. This is the history of EBM that we needed."--Stephen R. Leeder, author of "A Race Against Time

This book reviews important findings from the Extremely Low Gestational Age Newborn Study (ELGAN), the largest cohort study ever completed involving individuals born extremely prematurely. With a focus on pre-, peri-, and post-natal inflammation, this study identified potentially modifiable risk factors and pathways antecedent to a broad range of neurodevelopmental impairments, as well as asthma and obesity, during middle childhood. These findings will be of interest to both practicing neonatologists and developmental paediatricians, as well as researchers interested in the prevention of adverse child health outcomes and promotion of positive health among individuals born extremely preterm. The only book to summarise findings from the Extremely Low Gestational Age Newborn Study, the largest and most comprehensive cohort study ever conducted of this high-risk group. A comprehensive 'one-stop-shopping' resource. A broad range of neurodevelopmental outcomes are included, as well as the relationship of these outcomes to pre-, peri-, and post-natal risk factors. A focus of the study was perinatal inflammation, and the methods used to evaluate inflammation are the most comprehensive ever undertaken in an epidemiologic study of individuals born extremely preterm. The results of the ELGAN study will help Make a difference in the care and outcome of children born very early and make an important contribution to preventing learning and behavioural problems in children.

Alcohol, Drugs, Genes and the Clinical Laboratory provides an overview and quick reference to genetic relationships and clinical laboratory information related to the serious public health issue of alcohol and drug abuse. Written in a clear and concise manner, this book discusses the necessary information for health and safety professionals working in public health to learn about complex issues quickly to better help their patients, employees, and others affected by alcohol and drug abuse. Alcohol, Drugs, Genes and the Clinical Laboratory covers the important aspects of drugs and alcohol abuse including genetic aspects along with laboratory methods for analysis of alcohol and abused drugs with emphasis on false positive test results. The book is helpful to healthcare professionals, such as pathologists who oversee alcohol and drug testing, emergency room physicians, family practice physicians who are first healthcare professionals who identify patients susceptible to drug and alcohol abuse, and psychiatrists involved with drug and alcohol rehabilitation programs. It will also be useful to safety professionals who have to assess individuals for workplace responsibilities, ranging from police and recruitment to occupational safety and occupational medicine and public health officials.

Metabolomics and Microbiomics: Personalized Medicine from the Fetus to the Adult encompasses the most recent advances on the usage of metabolomics and microbiome research to improve disease diagnosis and healthcare. Medicine is changing from epidemiologic, descriptive, reductionist, and reactive approaches to individualized, predictive, and holistic ones by applying microbiomics to understand the functionality of the human body. The book discusses topics such as systems biology approaches, omics technologies, perinatal programming, and personalized medicine. It also discusses the ethical implications of microbiomics research and new pathways of research, such as renal regenerative medicine, gender medicine in perinatology, and animals and the science of healing. The book is a valuable resource for medical professionals and researchers in metabolomics, nutrition, microbiology, and personalized-predictive medicine. The book also will appeal to non-specialized professionals who may take advantage of its captivating and simple language.

"Diagnostic Techniques in Genetics" offers a comprehensive coverage of the theory and practice of the molecular biology techniques used within medical genetics. The first part of the book focuses on DNA/RNA applications and includes many of the latest developments in the field combined with routine procedures of genetic diagnoses, for example cling and sequencing DNA. The DNA applications prese4nted are then each applied to a specific kind of genetic diagnosis and the text concludes with a chapter devoted to population genetics.

The book provides a broad overview of the fundamental theory and applications used in the diagnosis of numerous genetic diseases. Each chapter has been written by leading professionals in the field and is intended to show how molecular biology( DNA or RNA technology) may be applied to a large set of genetic diagnoses. Comprehensive coverage of DNA applications and genetic diagnoses includes a chapter on population genetics essential reading for students taking courses in medical genetics, medicine and molecular biology

This book is dedicated to those who died of malignant hyperthermia and to their families. It contains cases studies that would be helpful for anesthesiologists, surgeons, physiologists, molecular biologists, biophysicists, biochemists, pathologists, students, and post doctoral fellows.

Clinical Research Computing: A Practitioner's Handbook deals with the nuts-and-bolts of providing informatics and computing support for clinical research. The subjects that the practitioner must be aware of are not only technological and scientific, but also organizational and managerial. Therefore, the author offers case studies based on real life experiences in order to prepare the readers for the challenges they may face during their experiences either supporting clinical research or supporting electronic record systems. Clinical research computing is the application of computational methods to the broad field of clinical research. With the advent of modern digital computing, and the powerful data collection, storage, and analysis that is possible with it, it becomes more relevant to understand the technical details in order to fully seize its opportunities.

A full-color case-based review of the essentials of pathophysiology covering all major organs and systems More than 130 case studies with Q&A The goal of this trusted text is to introduce you to clinical medicine by reviewing the pathophysiologic basis of 132 diseases (and associated signs and symptoms) commonly encountered in medical practice. The authors, all experts in their respective fields, have provided a concise review of relevant normal structure and function of each body system, followed by a description of the pathophysiologic mechanisms that underlie several common diseases related to that system. The accessible presentation features high-quality full-color illustrations, and numerous tables and diagrams. Each chapter of Pathophysiology of Disease concludes with a collection of case studies and questions designed to test your understanding of the pathophysiology of each clinical entity discussed. These case studies allow you to apply your knowledge to specific clinical situations. Detailed answers to each case study question are provided at the end of the book. This unique interweaving of physiological and pathological concepts will put you on the path toward thinking about signs and symptoms in terms of their pathophysiologic basis, giving you an understanding of the "why" behind illness and treatment. HERE ARE SOME OF THE MANY UPDATES AND ADDITIONS:*Twelve additional case studies, bringing the total to 132, one for each of the clinical entities discussed in the book's 24 chapters*More than 2/3 of the chapters are enhanced and refreshed by the input of new contributors*Totally revised chapter on neoplasia*New chapter sections on urticaria, spinocerebellar ataxia, idiopathic pulmonary fibrosis, and spondyloarthropathies*New tables summarizing adverse prognostic signs in acute pancreatitis, genetic syndromes associated with pancreatic cancer, and causes of end-stage renal disease*New diagnosis and etiologic classification of diabetes mellitus, and review of mechanisms of newest pharmacologic agents for its treatment*Updates on fine-needle aspiration biopsy of thyroid nodules, and thyroid disorders in pregnancy*Updated references throughout the book

Wilson Disease: Pathogenesis, Molecular Mechanisms, Diagnosis, Treatment and Monitoring translates both clinical and experimental findings into a comprehensive approach for anyone involved in research and patient care. While the clinical variability of Wilson Disease poses a challenge from a diagnostic approach, the book uses the translational impact of new research findings to relate to new treatment concepts. Comprehensive chapters include common knowledge, guideline consensus statements, and discussions of clinical evidence. This is a must-have reference for researchers and clinicians in translational research.

Eye Movement Integration Therapy is the first book to detail one of the most innovative and effective new treatments available to psychotherapists today. Filled with case examples and informed by extensive experience teaching the technique, the book is accessible to informed lay persons, as well as to all readers with prior training in psychology. teachers of psychotherapy that I have ever encountered. Eye Movement Integration Therapy is just one of her many valuable contributions. - Jeffrey K. Zeig, PhD, Director, The Milton H. Erickson Foundation been in private practice as a psychologist since 1992. She is a much sought after speaker and lecturer at symposia all over the world. Danie publishes her own books and guides on Impact Therapy and related techniques in the French language via Editions Academie Impact.

This groundbreaking book unleashes a brilliant new plan for permanently curing heartburn by relieving the root cause of the problem: low stomach acid. The fact is that heartburn is caused by too little stomach acid -- not too much, as many doctors profess. As explained in this book, the current practice of reducing stomach acid may be a temporary fix, but this fix comes at a cost to our long-term health that is being ignored by the pharmaceutical companies, the FDA, and the thousands of physicians that prescribe anti-acid drugs like Prilosec, Tagamet, Zantac, Pepcid, and others.

The new edition of the excellent introduction to basic concepts and instrumentation of nuclear medicine, featuring numerous high-quality illustrations and practical examples Essentials of Nuclear Medicine Physics, Instrumentation, and Radiation Biology provides a concise, highly illustrated introduction to fundamental nuclear medicine-related physics and engineering concepts. Gradually progressing from basic principles to more advanced topics, this book offers clear guidance on basic physics related to nuclear medicine, gamma camera imaging and image reconstruction, x-ray computed tomography, magnetic resonance imaging, radiopharmaceutic therapy, radiation dosimetry and safety, quality control, information technology, and more. Throughout the text, a wealth of examples illustrate the practice of nuclear medicine in the real world. This new fourth edition features fully revised content throughout, including brand-new chapters on basic MRI physics and instrumentation as well as radiopharmaceutical therapy. There are expanded discussions of current nuclear medicine technologies including positron emission tomography (PET) and single-photon emission computed tomography (SPECT), as well as up-to-date coverage of SPECT-CT, PET-CT hybrid scanning systems with an introduction to PET-MRI hybrid systems. Essential reading for anyone entering the field of nuclear medicine, this book: Contains introductory chapters on relevant atomic structure, methods of radionuclide production, and the interaction of radiation with matter Describes the basic function of the components of scintillation and non-scintillation detectors Details image acquisition and processing for planar and SPECT gamma cameras and PET scanners, and introduces acquisition and processing for CT and MRI scanners Discusses digital imaging and communications in medicine (DICOM) and picture archiving and communication systems (PACs) Includes a new chapter on radiopharmaceutical theranostics imaging and therapy Includes new coverage of quality control procedures and updated chapters on radiation safety practices, radiation biology, and management of radiation accident victims Essentials of Nuclear Medicine Physics, Instrumentation, and Radiation Biology is a must-have for all residents, fellows, trainees, and students in nuclear medicine, and a valuable quick-reference for radiologists and nuclear medicine physicians and technologists.

Offering an authoritative account of the relationship between literature and medicine between approximately 1800 and 1900, this volume brings together leading scholars in the field to provide a valuable overview of how two dynamic fields influenced and shaped each during a period of revolutionary change. During the nineteenth century, medicine was being redefined as a subject in which experimental methodologies could transform the healing art, and was simultaneously branching off into new specialisms and subdivisions. Questions addressed in this volume include the influence of physics on poetry, the role of medical professionalism in fiction, the cultural and literary representation of sanitation, and the interdisciplinary nature of controversy and negligence. Along with its sister publication, Literature and Medicine in the Eighteenth Century, this volume offers a major critical overview of the study of literature and medicine.

the Atlas of AIDS Co-infection illustrates imaging features and clinical outcomes of AIDS related diseases. The common/uncommon opportunistic infections and malignancies are well covered, including bacterial (e.g. Staphylococcus, Rhodococcus equi), fungal (e.g. Penicillium marneffei, Pneumocystis pneumonia, Pulmonary aspergillosis, Mucormycosis) and mycobacterial infections (Mycobacterium tuberculosis, Non-tuberculous Mycobacteria), lymphoma, as well as AIDS related disease in children with AIDS. Excellent photographs (X-ray and CT imaging) reveal the common imaging features of different diseases in different stages of treatment. Co-infections are common in the late stage of AIDS, consistent with considerable overlap of CT findings that are displayed in one single section and some of the cases in several sections. At last, there are excellent descriptions of differential diagnosis based on the same appearance (e.g. diffuse pulmonary miliary nodules, mediastinal and abdominal lymphadenopathy). Learning variety of different imaging will enrich the radiologists experience and knowledge about AIDS-related diseases, and also help clinicians making timely diagnosis and appropriate optimal treatment. It belongs in the library of each Radiologist, HIV expert and all of who care about Infectious Diseases.

Based on the award winning "Wiley Encyclopedia of Chemical Biology," this book provides a general overview of the unique features of the small molecules referred to as "natural products," explores how this traditionally organic chemistry-based field was transformed by insights from genetics and biochemistry, and highlights some promising future directions. The book begins by introducing natural products from different origins, moves on to presenting and discussing biosynthesis of various classes of natural products, and then looks at natural products as models and the possibilities of using them in medicine.

A new, fully updated edition of the world's most famous book on liver diseases--with updating of all areas and inclusion of new specific topics, by internationally renowned specialists This brand new edition of the classic book on hepatology provides a concise, clearly presented and well-structured review across the whole spectrum of hepatobiliary diseases by some of the world's leading hepatologists and hepatobiliary specialists. Where many other hepatology textbooks provide detailed accounts of basic science and clinical management, Sherlock's Diseases of the Liver and Biliary System, 13th Edition takes a different approach. Concentrating on the clinical decisions to be taken and the relevant supporting data, it is written and edited to maintain Sheila Sherlock's unique approach, in particular the clarity and layout of the text, and the explanatory figures and tables. The book is thus concise, highly accessible, and generously illustrated with over 700 attractive color figures. There is a pithy approach to each disease based both on evidence and on the authors' experience, the hallmark of this book. Based on these elements, the 12th edition was awarded first prize in the 2012 British Medical Association Book Awards in the Internal Medicine category. Sherlock's Diseases of the Liver and Biliary System begins by introducing the anatomy and function of the liver to readers, continuing then with in-depth coverage of liver biopsy techniques and interpretation, and fibrogenesis and its assessment. There are then chapters on all aspects of liver and biliary disease including acute liver failure, cirrhosis, portal hypertension, hepatic encephalopathy, ascites, hepatitis B and C, alcohol and the liver, non-alcoholic fatty liver disease, drug related liver reactions, cholestatic, autoimmune and genetic liver diseases, benign and malignant tumours and not least liver transplantation. There are also chapters on the liver in pregnancy, in the neonate, infancy and childhood, in systemic diseases and in infections. This new edition also features four new individual chapters focusing on coagulation, non-invasive assessment of fibrosis and cirrhosis; vascular diseases of the liver and portal vein thrombosis, and nutrition in liver disease. Digital downloads of the figures from this edition are offered on a companion website. Internationally recognized and loved, world-renowned hepatology book, first published in 1955 Takes a one-of-a-kind, clinical approach maintaining Sheila Sherlock's clarity and legacy of presentation Full colour throughout with 700 illustrative figures Wide faculty of international contributors Sherlock's Diseases of the Liver and Biliary System, 13th Edition is an ideal primer in hepatology for students and trainees in hepatology and gastroenterology, and a valuable resource for all specialist gastroenterologists and hepatologists, paediatricians, pathologists, radiologists, general physicians and specialist nurses.

The overall aim of this work is to provide a reference book which describes the general framework for conducting GCP-compliant clinical research, particularly pharmaceutical industry clinical research. Wendy Bohaychuk and Graham Ball run a consultancy, GCRP Ltd., which has conducted over 820 GCP audits involving more than 200 companies in the last 10 years. More than 5,000 individuals have been involved in their training courses to help people perform GCP-compliant clinical research. They have authored several books and articles including:

• Standard operating procedures for investigators
• Standard operating procedures for sponsors and CROs
• GCP — an indexed reference

Drawing on their wealth of experience, they have produced this enlightening and practical reference work which fills an educational gap in the understanding of GCP at all levels. Written in concise language simple enough to be accessible to those new in the field, the dozens of real-life stories and detailed case studies at the end of each chapter make the book an invaluable resource for the more experienced, highlighting what can go wrong in a clinical study: A study of prostate cancer in the UK - An investigator brochure was not provided. The company argued that a brochure was unnecessary because the drug was already marketed. Indeed it was — for hypertension! A study of cardiovascular surgery in the UK - The consent dates were changed (by overwriting) to indicate that the patients had provided consent before the study started. The original dates post-dated the start of the study. A study of hypertension in Germany - The investigator brochure predated the study by nine years! Checklists are provided throughout the book to help monitors, auditors and investigators ensure that nothing important is overlooked. The authors present the topic of GCP with remarkable clarity, insight and enthusiasm emphasizing that this code of practice was not designed to make studies more difficult for investigators or more expensive for sponsors and CROs but, in the final analysis, to ensure the safety and well-being of study participants and future patients who will benefit from well-conducted, GCP-compliant studies.

This new addition to the popular Essentials series provides a broad, general introduction to the topic of simulation within clinical education. An ideal tool for both teaching and learning, Essential Simulation in Clinical Education provides a theoretical and practical introduction to the subject of simulation, whilst also offering strategies for successful use of simulators within general clinical education and demonstrating best practice throughout. This timely new title provides: The latest information on developments in the field, all supported by an evidence-base Content written by a global team of experts Discussion of policy and strategy initiatives to ground simulation within the healthcare context Practical examples of cases, including inter-professional learning. A superb companion for those involved in multi-disciplinary healthcare teaching, or interested in health care education practices, Essential Simulation in Clinical Education is the most comprehensive guide to the field currently available.