Haematology Diagnostic haematology requires the assessment of clinical and laboratory data together with a careful morphological assessment of cells in blood, bone marrow and tissue -fluids. Subsequent investigations including flow cytometry, immunohistochemistry, cytogenetics and molecular studies are guided by the original morphological findings. These targeted investigations help generate a prompt unifying diagnosis. Haematology: From the Image to the Diagnosis presents a series of cases illustrating how skills in morphology can guide the investigative process. In this book, the authors capture a series of images to illustrate key features to recognize when undertaking a morphological review and show how they can be integrated with supplementary information to reach a final diagnosis. Using a novel format of visual case studies, this text mimics 'real life' for the practising diagnostic haematologist - using brief clinical details and initial microscopic morphological triage to formulate a differential diagnosis and a plan for efficient and economical confirmatory investigation to deduce the correct final diagnosis. The carefully selected, high-quality photomicrographs and the clear, succinct descriptions of key features, investigations and results will help haematologists, clinical scientists, haematology trainees and haematopathologists to make accurate diagnoses in their day-to-day work. Covering a wide range of topics, and including paediatric as well as adult cases, Haematology: From the Image to the Diagnosis is a succinct visual guide which will be welcomed by consultants, trainees and scientists alike.

This Rapid Review is a concise, evidence-based guide to the diagnosis and treatment of rheumatological and musculoskeletal disorders. Covering the basic principles of joint examination and key clinical skills, the book describes more than 100 clinical cases especially chosen to illustrate both commonly occurring and more unusual conditions. Each case presentation replicates a real-life situation in the busy world of a typical clinic and is illustrated with superb quality colour clinical photographs. Following the case presentation, a series of questions are posed to simulate the diagnosis process along with answers to the questions and a final diagnosis. Tables with lab values supplement the photos and text. Following the case presentations, the book discusses the top ten rheumatological disease categories including rheumatoid arthritis, spondyloarthropathies, lupus, vascultis and other miscellaneous conditions. The book will become an essential 'go to' text for all trainee rheumatologists and general medical practitioners, including specialist nurses, manual therapists and related health professionals. Key Features: Presents clinicians with a series of both common and challenging case presentations that depict the investigation and management of patients with rheumatological and musculoskeletal conditions Covers basic principles as well as the necessary clinical skills Includes more than 100 case presentations with numerous colour illustrations of the highest quality Features a concise format ideal for rapid revision and exam preparation

Clinically-orientated and focused squarely on the core curriculum, Medicine for Finals and Beyond delivers what medical students need to know in a manner that encourages learning and recall. The consistent, easy-to-navigate structure makes locating information simple and is tailored for exam success. Highly illustrated throughout, notes based information is supplemented by 'At A Glance textboxes', 'Emergency Presentations' and 'Must Know Checklists' for quick reference, while online question and answer material allows for self-testing during that inevitable last-minute revision. Key features: * Comprehensive - everything you need to know to pass your medical finals in a single volume * Accessible - systems-based chapters all follow a common structure * Convenient - summarises the ideal approach to the patient, including history and examination, clinical presentations, differential diagnosis and investigations * Focused - covers all the common conditions that medical students need to know for future practice * Relevant - designed with input from lecturers and students This brand-new revision aid for medical students will be a convenient companion throughout clinical studies and an ideal aide-memoire for those approaching their final examinations.

The field’s definitive text―updated with the latest advances in critical care and 1,000+ color images Comprehensive and current, Hall, Schmidt, and Wood's Principles of Critical Care is the authoritative guide to diagnosing and treating the most common problems encountered in the practice of critical care. Written by expert critical care physicians who are also experienced teachers, it features an organization, thoroughness, and clarity unavailable in other critical care resources. This peerless guide provides consensus on the complex and often-conflicting data in the practice of critical care, along with copious diagnostic and treatment algorithms. The text covers every aspect of critical care medicine essential to successful clinical practice, ranging from basic principles to the latest technologies. This updated fifth edition is highlighted by: In-depth, up-to-date descriptions of the unique presentation, differential diagnosis, and management of specific critical illnesses A logical organ system approach that simplifies the search for thorough and practical information necessary to manage a patient's specific condition New chapters on Oxygen Delivery Systems; Ultrasound in Critical Care; Fungal and Viral Infections; Pulmonary Hypertension; Alcohol Withdrawal; and COVID-19 and Hemophagocytic Lymphohistiocytosis (HLH) New material regarding critical care pandemic preparedness and response Enhanced cross-disciplinary chapters addressing the structures and systems of critical care, including staffing, safety, and informatics New contributions on caregiver and family issues and the implications of disordered sleep for the critically ill A full-color presentation

How can suicide be prevented and treated by mental health professionals?
This book offers a clinical guide to the assessment, treatment and prevention of suicidal behaviour, from a new and useful theoretical perspective - a developmental process approach. The book presents the arguments and research evidence that suicidal behaviour is not just a response to current emotional crises, but is influenced by persistent characteristics that can be defined in psychological and biological terms.
The authors bring together research-based evidence that establishes three key aspects of the developmental process approach: suicidal behaviour results from the interaction between stressful life events and an individual vulnerability; this individual vulnerability is itself the product of psychobiological factors, genetics and past life events; vulnerability, in this sense, influences how the individual perceives, interprets and reacts to adverse life events, perhaps leading to hopelessness and suicidal behaviour.
Psychologists, psychiatrists, nurses and other mental health practitioners will appreciate the conceptual and clinical value of this book based on its:

• Description of biological and psychological developmental processes leading to suicide, integrating evidence-based information from a broad range of disciplines
• Psychobiological definition of long- and short-tem risk factors for suicide, and innovative approach to psychological and biological targets for treatment and prevention
• Cutting-edge discussion of implications for the study and treatment of suicidal behaviour, by some of the leading authorities in the field.

  
  

Fosters a thorough understand of radiation dosimetry concepts: detailed solutions to the exercises in the textbook "Fundamentals of Ionizing Radiation Dosimetry"!

The problem of time wasting, unnecessary referral to specialists by primary care practitioners is universal. This book provides young doctors with a series of cases from which they can develop their judgement of whether to refer or not.

Selected as a Doody's Core Title for 2022! For more than 30 years, Designing Clinical Research has set the standard as the most practical, authoritative guide for physicians, nurses, pharmacists, and other practitioners involved in all forms of clinical and public health research. Using a reader-friendly writing style, Drs. Warren S. Browner, Thomas B. Newman, Steven R. Cummings, Deborah G. Grady, Alison J. Huang, Alka M. Kanaya, and Mark J. Pletcher, all of the University of California, San Francisco, provide up-to-date, commonsense approaches to the challenging judgments involved in designing, funding, and implementing a study. This state-of-the-art fifth edition features new figures, tables, and design, as well as new editors, new content, and extensively updated references to keep you current. Covers clinical research in its many forms, including clinical trials, observational studies, translational science, and patient-oriented research. Presents epidemiologic terms and principles and advanced conceptual material in a practical and reader-friendly manner. Discusses key changes in the field, including confounding and directed acyclic graphs, surrogate outcomes and biomarkers, instrumental variables and Mendelian randomization, regression discontinuity designs, alternative data sources, AI and machine learning, pilot studies, as well as an update on P values and Bayesian analysis.. Covers modifications of classic randomized trials, such as pre/post, interrupted time series, difference-in-differences, stepped wedge and cluster randomized designs, as well as randomized trials in health systems. Adds new chapters on qualitative approaches to clinical research and on community-engaged research Enrich Your eBook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone Easily convert to audiobook,powering your content with natural language text-to-speech

Fully updated for the second edition, these handy pocket-sized study cards remain an innovative and versatile revision solution. Containing vital techniques and tips, the study cards condense revision into short essential bursts. Ideal for revising quickly on the move, students can also use them when carrying out examinations, or as a reminder before ward rounds and teaching sessions. Arranged into clear sections, the cards allow the reader to find and digest topics easily, whilst full colour illustrations aid quick and confident diagnoses. Taking a system-based approach, the set covers all essential diseases and syndromes in just 166 double-sided cards. Each card first describes the clinical examination and symptoms, before covering the need-to-know essentials: aetiology, indications, differential diagnoses, complications and suitable investigations. The final part of each card covers the treatment or management of the disease.

The clinical approaches to the chronic degenerative diseases that drain our resources, and compromise our well-being, have become almost exclusively symptom-focused. The common wisdom is that they are idiopathic with final outcomes to be managed rather than prevented or cured. That they are potentially reversible rarely enters into any discussion between doctor and patient.

A Homeostatic approach to Cure and Prevention for Researchers and Clinicians Working in Toxicology, Immunology, Neurology, and Internal Medicine

Reversibility of Chronic Degenerative Disease and Hypersensitivity, a four-part encyclopedia, offers a much different perspective on chronic degenerative disease, one that disputes the idiopathic label attached to most, as well as the usual fatalistic prognosis. The first volume, Regulating Mechanisms of Chemical Sensitivity, demonstrates that one aspect common to chronic diseases is the disruption of systemic and cellular homeostasis. Environmental pollutants play a large role, along with the contributions of genetic and life style factors, in disrupting the self-regulating mechanisms built into our normally adaptive cells.

"As dyshomeostasis develops in the nervous system, causes should be found and removed before the metabolicinduced tissue changes take place and cause autonomous, irreversible fixednamed diseases to occur. Single and multiple chemicals in various doses either individually and/or in combinations can cause individual or multiorgan dysfunction of the endocrine system. The astute clinician must be aware of these factors in order to help the patient with hypersensitivity and/or chronic degenerative disease." Chapter 2

Drawing on a vast amount of data and clinical cases attended to by the authors in their own medical practices, this volume examines the complex relation that environmental pollution has with chronic degenerative diseases. It considers its impact on the body s vast communication networks and what excessive overload does to homeostatic mechanisms.

The authors factor in both general and specific environmental loads and how they alter and trigger genetic and non-genetic responses. Volume 1 begins with an overview of the physiologic basis of homeostasis, exploring various ways that the body deals with toxins and the networks it uses to communicate news of assault and makes provisions for adaptation. The text delves into the connective tissue matrix and considers vascular, neural, endocrine, and immune system responses to a variety of noxious assaults.

"Both innate and acquired immunity can be and are altered in individuals with chemical sensitivity and chronic degenerative disease. With pollutant overload changes can occur in the lymphatic channels, the lymph nodes, and lymph node egress as well as the lymphatic cells. Changes in mucosal function and the effects of the autonomic nervous system are evident with environmental pollutant overload." Chapter 3

Written by two very knowledgeable clinicians, it brings together research of the highest caliber and provides extensive discussions involving sophisticated biochemical, endocrine, and neural science. The text provides clinicians with the knowledge to understand the triggering and processes of degenerative diseases, so that they might develop more efficient treatment and prevention plans. The book also supplies the knowledge and perspective that can lead research to more effective treatments.

"The ground regulation system consisting of the connective tissue matrix, fibroblast, macrophages, mast cell, leukocyte, end capillary vessel and autonomic nerves, is a global information system for regulating the dynamics of homeostasis in the body. One s knowledge of this process must be the guide to move through the onset of early end-stage disease and, eventually, see the manifestations to fixed-named autonomous diseases. It is this knowledge that offers us the greatest potential for preventing and reversing early homeostatic dysfunction." Chapter 1

The 101 vital medical tips other textbooks don't teach you - Following the success of the award winning Cynical Acumen, John Larkin outlines key knowledge for medical students and junior doctors. Clustered around the headings of cynical, survival, clinical, career and miscellaneous tips, gems on offer here include: * Don't tell the patient what you're examining unless it's absolutely necessary * Always put your hand on the bed before sitting on it * Status epilepticus starts at twenty minutes * Don't have an affair with your secretary * Pick an idiosyncratic format for your tea/coffee. Packed with anecdotes and with fully explained rationales for each tip, there's more memorable - and sometimes downright vital - information in this book than you could hope for

Human factors relates to the interaction of humans and technical systems. Human factors engineering analyzes tasks, considering the components in relation to a number of factors focusing particularly on human interactions and the interface between people working within systems. This book will help instructors teach the topic of human factors.

The seventh edition of this BMA award-winning pocket guide provides essential information for doctors based on the comprehensive Kumar & Clark's Clinical Medicine - the highly respected, gold-standard textbook on the treatment and management of medical conditions. Essentials is intended as an easy-to-access revision reference that provides important information for doctors on the ward, including normal values, medical emergencies, useful websites, abbreviations and a dictionary of terms. This best-selling book has been fully updated and is accessible, coherent and concise, making it an essential companion for medical students, doctors and health professionals in the UK and around the world. Small and compact - can be taken anywhere Clearly laid out, logical and easy to follow Emergency guide for quick reference Illustrations and tables to enhance understanding New section on COVID-19 New chapter on Elderly Medicine and Frailty Winner of the Internal Medicine category at the 2018 BMA Medical Book Awards Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices. New co-editor Euan Sandilands New chapter on Elderly Medicine and Frailty

"It is a very thorough and up-to-date clinical handbook and reference for the primary care Doc or nurse. . . . if you have a favorite Family Doc or Internist or Nurse Practitioner--or administrator--and you want them to have a nice gift, buy them this book. But read it before you give it away."
--JOURNAL OF NEUROTHERAPY

The Handbook of Mind-Body Medicine for Primary Care introduces an evidence-based mind-body approach to the medical and behavioral problems of primary care patients. Evidence-based mind-body practice draws on the best available scientific research and advocates the integration of well-documented mind-body therapies into primary health care. The handbook summarizes current mind-body practice and provides an overview of the basic techniques, including biofeedback, neurofeedback, relaxation therapies, hypnotherapy, cognitive-behavioral therapies, acupuncture, and spiritual therapies. The editors also thoroughly demonstrate the application of these techniques to common disorders such as headache, chronic pain, and essential hypertension, as well as anxiety, depression, chronic fatigue syndrome, fibromyalgia, and sleep disorders.

The Handbook includes educational models with guidelines for physicians, nurses, physicians? assistants, and behavioral health practitioners. The book closes with a look at the existential and spiritual side of the human encounter with sickness and disease. This handbook will benefit a wide variety of health providers in primary care.

The Handbook is divided into four parts:

• Part I introduces the conceptual models from the psychophysiological perspective for understanding functional medical problems.
• Part II describes specific clinical tools and interventions.
• Part III overviews the best documented cognitive-behavioral approaches and alternative therapies to common disorders.
• Part IV provides educational models for practitioners in each of the mind-body disciplines.

Donald Moss, Ph.D., is Director of Chronic Pain Services at West Michigan Behavioral Health Services.

Angele V. McGrady, Ph.D., is a Professor of Psychiatry and Adjunct Professor of Physiology and Molecular Medicine at Medical College of Ohio.

Terence C. Davies, MD, is Chairman of Family and Community Medicine at Eastern Virginia Medical School.

Ian Wickramasekera, Ph.D., is a Professor of psychology at Saybrook Graduate School, Clinical Professor of Psychiatry at Stanford Medical School, and Professor of Family Medicine at Eastern Virginia Medical School.

The Complete Guide to Nutrition in Primary Care Edited by Darwin Deen, MD, MS Lisa Hark, PhD, RD Clinicians and patients agree that primary care office visits should include routine nutrition assessment and counseling. But how do you fit it into an already crowded consultation? And what is the most up-to-date advice? With The Complete Guide to Nutrition in Primary Care, Drs. Deen and Hark provide the necessary tools. This comprehensive overview of nutrition answers your questions on: * Nutrition as Preventive Medicine * Nutrition through the Lifecycle * Improving Health by Changing Diet and Lifestyle Behaviors * Vitamins, Minerals, Dietary Supplements, and the Alternative * Successful Changes to the Environment This timely paperback contains everything the primary care clinician needs to counsel patients on diet and lifestyle issues. Keep it close at hand for the frequent consultation it is sure to receive. Dr. Darwin Deen is one of the nation's foremost authorities on nutrition. Currently Professor of Clinical, Family and Social Medicine and Director of Medical Student Education at the Albert Einstein College of Medicine in New York, he has trained a generation of physicians on the connection between nutrition and health. He has played a leading role in revising medical school curricula to incorporate nutrition training. An award-winning teacher and noted author, he serves as Chair of the Task Force on Medical Nutrition Education of the American College of Nutrition and co-chairs the Group on Nutrition of the Society of Teachers of Family Medicine. His years of experience as a family physician make him perfectly suited to advise clinicians on counseling their patients on diet and lifestyle. Dr. Lisa Hark is a renowned family nutrition expert, with more than 20 years of experience in nutrition counseling and promoting the benefits of healthy eating in children and adults. As Director of the Nutrition Education Program at the University of Pennsylvania School of Medicine in Philadelphia, she developed a model medical school curriculum and textbook, Medical Nutrition and Disease, which has become one of the most widely used texts in nutrition education. She was given the Excellence in Medical/Dental Nutrition Education award from the American Society for Nutrition. Dr. Hark was also the host of the TV show, "Honey, We're Killing the Kids," which airs on TLC, and is a widely sought after speaker who communicates nutrition concepts effectively to health professionals, patients, and the media. Approved by the American Dietetic Association for 42 Continuing Education (CE) credits www.blackwellmedicine.com

Psychodynamic Formulation A leading text for psychodynamic clinicians and practitioners Psychodynamic Formulation: An Expanded Approach delivers an exceptional exploration of psychodynamic explanations and hypotheses that seek to explain how a person's conscious and unconscious thoughts and feelings may have developed and may be causing or contributing to the challenges they face. This latest edition of the leading reference includes a refreshed and reinvigorated emphasis on the impacts of culture and society, as well as the importance of diversity and inclusion, on psychodynamic formulation. It puts new focus on lived experience, including trauma, and on how clinical bias can contribute to the perpetuation of trauma. In addition to newly included activities and exercises, readers will find: A practical, step-by-step guide to collaboratively creating psychodynamic formulations Comprehensive discussions about how what we're born with and environmental influences contribute to development Suggestions for using psychodynamic formulations in many clinical settings, including acute care and psychopharmacologic treatment An educator's guide to teaching psychodynamic formulation Perfect for mental health practitioners with a professional or personal interest in psychodynamics/psychoanalysis, Psychodynamic Formulation: An Expanded Approach will earn a place in the libraries of trainees in all mental health fields.

Part of a two-component product with a companion therapist's guide, CBT for Hoarding Disorder: Client Workbook guides patients struggling with hoarding disorder who are enrolled in a comprehensive CBT group program through the therapeutic process of addressing and overcoming their difficulties. Designed for participants in group cognitive-behavioral therapy for hoarding disorder - an evidence-based program created by experts in the field Helps readers to work on the many factors that contribute to ongoing difficulties with clutter, in order to learn how to make quicker, more efficient decisions that are less stressful and draining. Addresses many of the barriers to successful decluttering, such as time management, organizational skills, and problem-solving Shows that while living with hoarding disorder can be frustrating, both for the sufferer and for family and friends, there is a way forward and nobody has to live with clutter.

Innovations in technology have hugely enhanced the diagnostic capabilities of today's practising clinicians. Yet the traditional art of detecting clinical signs through expert examination techniques remains a fundamental competence for training and practising clinicians, central to the delivery of safe and effective patient care. This first edition of Macleod's Essential Examination provides an innovative, concise account of each body system examination, delivering the information in a compact, portable format for use at home and in the clinical environment. It can be used in conjunction with the more extensive and hugely successful 'parent' textbook Macleod's Clinical Examination, with which it is closely integrated, or as a stand-alone aide-memoire. This quick-reference, highly practical guide will assist in preparation for OSCEs and in clinical practice. Each chapter follows a consistent format, opening with typical OSCE scenarios followed by a concise 'point by point' examination template. This is then expanded with a detailed description of each aspect of the examination process, including specific instructions around technique and information about key clinical signs to consider. Exam tips are also provided, along with typical questions likely to be asked during an OSCE. Answers are given are at the end of each chapter, making it an invaluable resource for both self-assessment and in peer-to-peer learning. The book provides a standardised framework for examination of all the major body systems. Using a novel tabular approach the book provides a clear set of guidelines on what to do at each stage of the clinical examination. It also reminds the reader what are the corresponding key points to think about and sets out associated exam tips. The exam tips are subsequently linked to potential examiner's questions. Each system ends with a reminder of how to present the findings and relevant tips to maximise your success.

Now fully revised and updated, Clinical Biochemistry, third edition is essential reading for specialty trainees, particularly those preparing for postgraduate examinations. It is also an invaluable current reference for all established practitioners, including both medical and scientist clinical biochemists. Building on the success of previous editions, this leading textbook primarily focuses on clinical aspects of the subject, giving detailed coverage of all conditions where clinical biochemistry is used in diagnosis and management - including nutritional disorders, diabetes, inherited metabolic disease, metabolic bone disease, renal calculi and dyslipidaemias. The acquisition and interpretation of clinical biochemical data are also discussed in detail. From the author of the popular Clinical Chemistry medical student textbook there are many competing texts on clinical chemistry, the vast majority concentrate on the technology; this book concentrates on the clinical Ideally suited for preparation for the MRCPath and similar examinations Expanded sections on haematology and immunology for clinical biochemists provide a thorough understanding of both laboratory and clinical aspects New chapters are included on important evolving areas such as the metabolic response to stress, forensic aspects of clinical biochemistry and data quality management An extended editorial team - including three expert new additions - ensures accuracy of information and relevance to current curricula and clinical practice A superb new accompanying electronic version provides an enhanced learning experience and rapid reference anytime, anywhere! Elsevier ExpertConsult.com Enhanced eBooks for medical professionals Compatible with PC, Mac (R), most mobile devices and eReaders, browse, search, and interact with this title - online and offline. Redeem your PIN at expertconsult.com today! Straightforward navigation and search across all Elsevier titles Seamless, real-time integration between devices Adjustable text size and brightness Notes and highlights sharing with other users through social media Interactive content

This volume discusses current research on glial-neuronal interactions in several neuroendocrine systems. Glial-neuronal bidirectional transmission represents one of the fastest-growing areas of investigation in neuroscience today. Unraveling the interactions and signaling synergy between glial cells and neurons is critical to advancing our understanding of brain function. Consequently, this book summarizes the latest findings on the roles of astrocytes, microglia and tanycytes in the control of synaptic transmission, synaptic plasticity, blood-brain signaling, neuroinflammation and immune signaling. In addition, leading experts in the field discuss how reproductive function, the stress response and energy homeostasis are regulated by glial-neuronal communication. Given its scope, the book is essential reading for undergraduate and graduate students in the neurosciences, as well as postdoctoral fellows and established researchers who are looking for a comprehensive overview of glial-neuronal crosstalk in neuroendocrine systems. This is the eleventh volume in the International Neuroendocrine Federation (INF) Masterclass in Neuroendocrinology series (Volumes 1-7 published by Wiley), which aims to illustrate the highest standards and highlight the latest technologies in basic and clinical research, and aspires to provide inspiration for further exploration into the exciting field of neuroendocrinology.

Exposure to particles in industry and mining and from accidental anthropogenic sources constitutes an ongoing threat. Most recently nanoparticles arising from advances in technology are exposing a wider population to pathogenic stimuli. The effects of inhaled particles are no longer confined to the lung as nanoparticles have the potential to translocate to the bloodstream, the brain, and other target sites. The new questions posed by nanoparticles underscore the importance of interdisciplinary research and exchange and highlight the need for new collaborations among disciplines in medicine, toxicology, chemistry, and material sciences. Particle Toxicology brings together the state of the science in particle physico-chemistry, cell biology, and toxicology in a single volume. While organized around the classical toxicology paradigm of exposure - dose - response, the book is unique in its emphasis on mechanistic toxicology. Preparing the reader with a brief historical overview and a conceptual framework for particle research, the book provides reviews on the mechanisms and properties of pathogenic particles and their effects on target cells at various sites in the body. The text describes how adverse effects are a consequence of deposition, translocation, and the complex issue of "dose" dominates. Contributions from leading researchers address particle-associated pro-inflammatory effects and inflammatory signaling, cellular and extracellular oxidative and nitrosative stress, particulate interactions in the pulmonary, cardiovascular, and central nervous systems, as well as genotoxic effects. Exemplar particles include quartz, asbestos, particulate material and nanoparticles. The book also covers mathematical modeling and human studies as avenues for future research. Responding to the evolving trend of consumer applications for particulate matter, Particle Toxicology provides the comprehensive resource for current knowledge from which to develop ne

This Second Edition of the highly popular Clinical Skills for OSCEs is the most comprehensive guide to basic clinical skills available, covering all the pertinent skills taught at medical school, from third year to finals. With its clear and concise, yet informative style, Clinical Skills for OSCEs, Second Edition is the ideal revision tool for all exam candidates preparing for their OSCE or PLAB exams.