The inability of the human body to be able significantly to self repair injured organs and tissues results in a considerable medical and social problem. During the last few years there has been incredible progress, and the achievements in experimental strategies for tissue regeneration, particularly in cell transplantation and stem cell research, have led to potential treatment options for many otherwise fatal conditions. These innovations hold promise for treating or preventing end-stage organ failure; cell therapy and tissue engineering of viable grafts with the potential to grow and remodel could provide prospective new solutions to the serious problems of organ donor shortage.

Regenerative medicine a" stem cell and gene-based therapy a" offers a new approach for restoring function of damaged organs and tissues. Several books have been published on particular aspects of organ and/or tissue replacement but none cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine, allowing practitioners to gain knowledge not only of how regenerative medicine applies to their discipline directly but also how it could benefit their patients in the years to come.

This state-of-the-art reference provides current and effective disease-specific strategies for the management of patients receiving mechanical ventilation-emphasizing weaning processes, monitored sedation, minimization of complications and infection, and new modes of treatment for patients in critical care. Exploring ancillary approaches, noninvasive positive pressure ventilation, oxygenation, and bronchodilator therapy as options to optimize cost and reduce injury, Ventilator Management Strategies for Critical Care discusses -methods to diagnose, manage, and avoid ventilator-associated pneumonia -consequences of extubation failure -mechanics of true closed-loop ventilation -neuromuscular blocking agents and physiological disturbances -therapy for chronic obstructive pulmonary disease (COPD) -and more! With contributions by over 40 seasoned experts in the field, Ventilator Management Strategies for Critical Care is a valuable resource for intensive or critical care and pulmonary or critical care specialists, surgical critical care specialists, anesthesiologists, physiologists, physiatrists and rehabilitation physicians, respiratory therapists, and medical school and graduate students in these disciplines.

Mass Spectrometry for the Clinical Laboratory is an accessible guide to mass spectrometry and the development, validation, and implementation of the most common assays seen in clinical labs. It provides readers with practical examples for assay development, and experimental design for validation to meet CLIA requirements, appropriate interference testing, measuring, validation of ion suppression/matrix effects, and quality control. These tools offer guidance on what type of instrumentation is optimal for each assay, what options are available, and the pros and cons of each. Readers will find a full set of tools that are either directly related to the assay they want to adopt or for an analogous assay they could use as an example. Written by expert users of the most common assays found in a clinical laboratory (clinical chemists, toxicologists, and clinical pathologists practicing mass spectrometry), the book lays out how experts in the field have chosen their mass spectrometers, purchased, installed, validated, and brought them on line for routine testing. The early chapters of the book covers what the practitioners have learned from years of experience, the challenges they have faced, and their recommendations on how to build and validate assays to avoid problems. These chapters also include recommendations for maintaining continuity of quality in testing. The later parts of the book focuses on specific types of assays (therapeutic drugs, Vitamin D, hormones, etc.). Each chapter in this section has been written by an expert practitioner of an assay that is currently running in his or her clinical lab.

An essential handbook for clinicians planning to involve the parents of trauma-impacted children in the treatment process In Trauma-Informed Parenting Program: TIPs for Clinicians to Train Parents of Children Impacted by Trauma & Adversity, distinguished behavioral healthcare practitioner, Dr. Carryl P. Navalta, delivers a practical and hands-on guide for clinicians to assist clients, and their families with emotion regulation in the face of trauma. In the book, readers will discover how to assess, conceptualize, and treat children suffering from the effects of exposure to various forms of trauma and adversity and to provide their clients' parents with the tools neccessary to facilitate further healing in the home and beyond. TIPs also Provides: A thorough introduction to trauma that describes the historical roots and prevalence of trauma as well as the impact of adverse childhood experiences on child development and emotion regulation A comrehensive exploration of case conceptualization and the creation of clinical formulations that identify, define, and integrate the primary problems facing the client A fulsome discussion of treatment planning, including goal development, objective construction, intervention creation, and diagnosis determination An indespensible resource for clinicians dealing with trauma-impacted children, Trauma-Informed Parenting Program will earn a plce in the libraries of mental health counselors, social works, psychologists, psychiatrists, and all the practitioners who seek to make the parents of their clients an integral and usefual part of the treatment process.

This book provides an overview of multiple facets of ageing and its evolving dynamics in various Indian states. It elaborates on key dimensions like health, dependence and disability, as well as living arrangements for the elderly. Drawing on information from National Sample Surveys to offer readers a broader and richer understanding of the evolving demographic reality in India, the book addresses a range of detailed policies and programmes for the elderly in India. Given its scope, the book is essential reading for students and researchers in the fields of sociology, demography, economics and development studies. It also offers a valuable reference guide for anyone engaged in planning and policy formulation for social security, welfare of the aged or mainstreaming ageing concerns.

Alcohol, Drugs, Genes and the Clinical Laboratory provides an overview and quick reference to genetic relationships and clinical laboratory information related to the serious public health issue of alcohol and drug abuse. Written in a clear and concise manner, this book discusses the necessary information for health and safety professionals working in public health to learn about complex issues quickly to better help their patients, employees, and others affected by alcohol and drug abuse. Alcohol, Drugs, Genes and the Clinical Laboratory covers the important aspects of drugs and alcohol abuse including genetic aspects along with laboratory methods for analysis of alcohol and abused drugs with emphasis on false positive test results. The book is helpful to healthcare professionals, such as pathologists who oversee alcohol and drug testing, emergency room physicians, family practice physicians who are first healthcare professionals who identify patients susceptible to drug and alcohol abuse, and psychiatrists involved with drug and alcohol rehabilitation programs. It will also be useful to safety professionals who have to assess individuals for workplace responsibilities, ranging from police and recruitment to occupational safety and occupational medicine and public health officials.

Metabolomics and Microbiomics: Personalized Medicine from the Fetus to the Adult encompasses the most recent advances on the usage of metabolomics and microbiome research to improve disease diagnosis and healthcare. Medicine is changing from epidemiologic, descriptive, reductionist, and reactive approaches to individualized, predictive, and holistic ones by applying microbiomics to understand the functionality of the human body. The book discusses topics such as systems biology approaches, omics technologies, perinatal programming, and personalized medicine. It also discusses the ethical implications of microbiomics research and new pathways of research, such as renal regenerative medicine, gender medicine in perinatology, and animals and the science of healing. The book is a valuable resource for medical professionals and researchers in metabolomics, nutrition, microbiology, and personalized-predictive medicine. The book also will appeal to non-specialized professionals who may take advantage of its captivating and simple language.

Did you know that plants and plant products can be used to improve people's cognitive, physical, psychological, and social functioning? Well, they can, and Horticulture as Therapy is the book to show you how If you are already familiar with the healing potential of horticultural therapy, or even practice horticultural therapy, this book will help you enrich your knowledge and skills and revitalize your practice. You will learn how horticultural therapy can be used with different populations in a variety of settings, what resources are available, effective treatment strategies, and the concepts behind horticultural treatment.The first comprehensive text on the practice of horticulture as therapy, this one-of-a-kind book will enable the profession to educate future horticultural therapists with fundamental knowledge and skills as they embark on careers as practitioners, researchers, and educators. You come to understand the relationship between people and plants more deeply as you learn about: vocational, social, and therapeutic programs in horticulture special populations including children, older adults, those who exhibit criminal behavior, and those with developmental disabilities, physical disabilities, mental health disorders, or traumatic brain injury use of horticultural therapy in botanical gardening and community settings adaptive gardening techniques applied research documentation and assessment in horticultural practiceHorticulture as Therapy establishes, integrates, and communicates a foundation of knowledge for horticultural therapists, other therapists, horticulturists, students, research scientists, gardeners, and others interested in this special and unique kind of therapy. By reading Horticulture as Therapy, you will see how you can make a difference in the health and well-being of so many people, today and tomorrow.

This book highlights the nano-antioxidants and their potential therapeutic applications. The chapters start with basic information on free radicals and antioxidants, through natural antioxidants, mechanisms of their action, ending with the use of nano-antioxidants particularly its potential therapeutic applications. Nano-antioxidant therapy has a promising future that has to be explored. It is a bridge topic to connect the already existing literature with potential therapeutic highlights. This book is designated for students and researchers interested in Biochemistry, Chemistry, Physics, Food Science and nutrition, Pharmaceutical Science and Medicine. It would also be interesting to global audiences from human and animal nutrition to food preservation and packaging.

How do electrical activity and calcium signals in neurons influence the secretion of peptide hormones? This volume presents the current state of knowledge regarding the electrical, calcium signaling and synaptic properties of neuroendocrine systems from both vertebrate and invertebrate systems. The contributions span in vivo and in vitro studies that address: state-dependent plasticity, relevance of firing patterns, membrane properties, calcium flux (including dynamic imaging and homeostasis), and molecular mechanisms of exocytosis, including from non-neuronal secretory cells. The chapters focus not only on research results but also on how experiments are conducted using state-of-the-art techniques, and how the resulting data are interpreted. While there are many books on the secretory properties of neurons, this is the first to focus on the distinctive secretory properties of neuroendocrine neurons. Accordingly, it offers an important text for undergraduate and graduate neuroscience students, and will also appeal to established scientists and postdoctoral fellows. This is the eighth volume in the Masterclass in Neuroendocrinology series* - now a co-publication between Springer Nature and the INF (International Neuroendocrine Federation). *Volumes 1-7 published by Wiley

This unique book presents a wealth of information on common presentations and illnesses, presented as medical case studies. It is useful for exam preparation, as a quick reference guide for working doctors, and as an interesting read for all those interested in medicine. 250 Clinical Cases covers a wide variety of conditions, providing in-depth insights into the most relevant topics, classified by system. Cases are accompanied by common viva voce examination questions as well as more advanced level questions that will help the reader develop a deeper understanding. Now in its sixth edition, the book has been fully updated to reflect current evidence and relevance for working doctors. It will help everyone, from medical students to consultants, to find the hidden clinical gems and historical background they need to achieve true clinical excellence. 250 clinical cases in print - provides a comprehensive overview of all relevant topics Conversational and accessible style - suitable for medical students Based on the latest evidence - provides an ideal quick reference guide 'Ward round' type question and answer section - ideal for exam preparation Cases alphabetised by system for easy navigation Easily portable size - fits into any medical bag An enhanced eBook version is included with purchase. The eBook allows you to access all the text, figures and references, with the ability to search, customize your content, make notes and highlights, and have content read aloud Self-assessment by system Interesting medical emergency presentations Procedures for the core medical curriculum Topics updated for clinical relevance Multiple choice questions replaced with open answer questions

This book is dedicated to those who died of malignant hyperthermia and to their families. It contains cases studies that would be helpful for anesthesiologists, surgeons, physiologists, molecular biologists, biophysicists, biochemists, pathologists, students, and post doctoral fellows.

Wilson Disease: Pathogenesis, Molecular Mechanisms, Diagnosis, Treatment and Monitoring translates both clinical and experimental findings into a comprehensive approach for anyone involved in research and patient care. While the clinical variability of Wilson Disease poses a challenge from a diagnostic approach, the book uses the translational impact of new research findings to relate to new treatment concepts. Comprehensive chapters include common knowledge, guideline consensus statements, and discussions of clinical evidence. This is a must-have reference for researchers and clinicians in translational research.

This book describes cases in medical and pediatrics field in which physicians may encounter in daily practice. Case reports in our book were conducted in a broad range of medical field (medical acupuncture, internal medicine, pediatrics, sports medicine, physical, and rehabilitation, infectious disease, dermatology, and venereology, pulmonology, psychiatry, emergency, and critical care). We combined common and unusual but unique cases in daily practice, which readers will find very interesting. Chapters are divided by nine specific fields including medical acupuncture, internal medicine, sports medicine, physical, and rehabilitation, infectious disease, dermatology and venereology, pulmonology, psychiatry, emergency and critical care, and pediatrics. Our cases are original and might have unexpected presentations of a new and emerging disease. This book will expand knowledge in the field of medicine that is written by our best practitioners and specialists. This valuable bundle of 61 case reports provides access to the case (history, physical examination, and diagnostic tests including laboratory, imaging, and histopathological examination), differential diagnosis, treatment, and educational messages for suggested case solutions. Approach to the cases is explained step-by-step with clear explanations of theory and practice. Essential key learning points and references are included in every case to aid the physician to understand better about the disease and to improve the patient outcomes.

Interprofessional education (IPE) and collaborative practice (IPCP) are the keys to improving health, safety, satisfaction and cost in the modern healthcare system. This IPE Toolkit provides healthcare educators, administrators, and clinicians with a practical, evidence-based manual for leading change. With these keys, we invite you to unlock meaningful collaboration for the next generation of health professionals, supported by an interprofessional collaboration of authors with more than 50 years of combined experience in education, practice, and scholarship in medicine, nursing, pharmacy, physical therapy, speech-language pathology, instructional design, simulation and online education. Following a step-by-step approach with supporting resources and examples, this guide offers a structured method for successful interprofessional program design, implementation, and assessment. Readers will explore IPE through the context of accreditation standards, administrative leadership, stakeholder buy-in, faculty and professional development, scholarship, teaching and learning, and curriculum development. Ten toolkits give professionals and educators the resources they need to quickly start new IPE learning experiences. This book is the go-to manual to fully explore, successfully launch, and advance quality IPE that creates results. Key Features: * Presents active learning strategies including team-based learning, case-based learning, simulation, and dilemma discussions. * Highlights best practices for virtual and online IPE that help educators overcome major IPE barriers, especially accessibility, scalability and cost. * Offers an abstract, key definitions, and concepts at the beginning of each chapter to set the reader's expectations. * Utilizes illustrations and tables to help clarify and expand on key concepts, enabling readers to more easily understand and apply material. * Includes comprehensive appendices on available resources for IPE and IPCP. * Provides step-by-step checklists, tables and figures on how to build IPE using didactic, simulation, online, and experiential learning andragogies. * Explores techniques to identify and reduce interdisciplinary biases, stereotypes, and prejudices, all barriers to dual professional identity and successful teaming.

In The Esophagus werden die Anatomie, die Physiologie und die Pathologie der Speiseroehre betrachtet. Diese sechste, umfassend uberarbeitete und aktualisierte Auflage enthalt zudem Informationen uber die Diagnose und Behandlung verschiedener Erkrankungen der Speiseroehre. Das Werk umfasst Behandlungsrichtlinien, die mit den beiden groessten Gesellschaften fur Gastroenterologie in den USA, der ACG und der AGA, abgestimmt sind. Schliesslich gehoeren zwei ehemalige Vorsitzende dieser Organisationen zu den Mitherausgebern. Fortschritte in der Diagnostik werden ebenso vorgestellt wie Entwicklungen in der chirurgischen und medikamentoesen Therapie. Ein einmaliges Team von Herausgebern und Autoren hat an der sechsten Auflage von The Esophagus mitgewirkt, das in Farbe gedruckt ist und uberall dort zum Einsatz kommt, wo die Anatomie, Physiologie und Pathologie der Speiseroehre Thema und Lehrstoff sind. Auf einer begleitenden Website sind alle Abbildungen aus dem Buch im PowerPoint-Format zu finden. www.wiley.com/go/richter/esophagus6e

Widely recognized as one of the most important signaling mechanisms in development and disease, Wnt signaling pathways are networks of proteins that play significant roles in embryogenesis or cancer development. Wnt Signaling in Development and Disease addresses the fundamentals of Wnt signaling and delves into molecular pathway mechanisms, its role in embryogenesis, adult tissue homeostasis, and chronic disease. This comprehensive resource details current knowledge of Wnt signaling while looking ahead to future progress.

A new, comprehensively updated edition of the acclaimed textbook by F.H. Attix (Introduction to Radiological Physics and Radiation Dosimetry) taking into account the substantial developments in dosimetry since its first edition. This monograph covers charged and uncharged particle interactions at a level consistent with the advanced use of the Monte Carlo method in dosimetry; radiation quantities, macroscopic behaviour and the characterization of radiation fields and beams are covered in detail. A number of chapters include addenda presenting derivations and discussions that offer new insight into established dosimetric principles and concepts. The theoretical aspects of dosimetry are given in the comprehensive chapter on cavity theory, followed by the description of primary measurement standards, ionization chambers, chemical dosimeters and solid state detectors. Chapters on applications include reference dosimetry for standard and small fields in radiotherapy, diagnostic radiology and interventional procedures, dosimetry of unsealed and sealed radionuclide sources, and neutron beam dosimetry. The topics are presented in a logical, easy-to-follow sequence and the text is supplemented by numerous illustrative diagrams, tables and appendices. For senior undergraduate- or graduate-level students and professionals.

This book presents recent outcomes of the collaborative "Tricorder" project, which brings together partners from industry, research institutes and hospitals to deliver an easy contactless alternative for electrocardiograms (ECG). Featuring contributions investigating the possible applications of laser Doppler vibrometry (LDV) signals for the remote measurement of vital parameters of the heart, the book provides insights into the vision and the history of the "Tricorder" project and the basic differences between the vibrocardiograms and electrocardiograms. It also discusses topics such as signal processing, heartbeat measurement techniques, respiration frequency and oxygen saturation determination, with a particular focus on the diagnostic value of the method presented, e.g., diagnosis of atrial fibrillation and estimation of the oxygen saturation in premature infants. Further, the authors review the advantages and drawbacks of the new method and the specific fields of application. This book will appeal to researchers and industry leaders interested in laser remote sensing for medical applications as well as medical professionals curious about new healthcare technologies.

An Updated Reference on Human Exposure to Environmental Toxicants and A Study of Their Impact on Public Health With the 4th edition of Environmental Toxicants: Human Exposures and Their Health Effects, readers have access to up-to-date information on the study and science of environmental toxicology and public health worldwide. Practitioners and professionals can use this resource to understand newly discovered information on the adverse health effects of toxins and pollutants in air, water, and occupational and environmental environments on large human populations. The 4th edition of this book is updated to reflect new knowledge and research on: Performing risk assessments on exposed individuals Assessing the effects of toxicants and substances on large populations for health and medical professionals Patterns of human exposure to select chemical toxicants World Trade Center dust, agents for chemical terrorism, and nanoparticles For health professionals, including health authorities, public health officials, physicians, and industrial managers, who are seeking new research and techniques for managing environmental substances, this invaluable reference will guide you through in a thorough, easy- to-read manner.

The book of 50 clinical cases covers a large part of the internal medicine curriculum. It fills the gap between theoretical knowledge and clinical practice and allows students to practice their clinical diagnostic skills and the development of management plans. Each of the cases is discussed using logical and scientific approaches and provides model answers to questions. Take-home messages throughout outline key points for examination revision. The book will stimulate self-directed learning and a deeper understanding of internal medicine. Readers will be able to test their understanding and the ability to answer short answer questions and multiple-choice questions. More than 50 clinical cases, covering the core undergraduate medicine curriculum Case discussions using a logical and scientific approach to help students achieve their own diagnoses Model answers for comparison, to improve learning outcomes Summary of fundamental points for examination revision Useful up-to-date resources Short-answer and multiple-choice questions to test knowledge Diagrams and tables to deepen understanding and consolidate essential concepts Includes an Enhanced eBook version with purchase. The enhanced eBook allows the end user to access all of the text, figures, and references from the book on a variety of devices

The largest high-level encyclopedia on molecular medicine is now publishing a topical volume on Nanomedicine. The long awaited volume gives a comprehensive overview on nanomaterials in drug delivery, imaging and as therapeutics.