A cross-disciplinary approach to the complex problems of obesity.

This issue of the Medical Clinics of North America, edited by Douglas Paauw, is devoted to Common Symptoms in the Ambulatory Setting.? Articles in this issue include: Evaluation and treatment of chronic cough; Evaluation and treatment of lower back pain; Lower extremity symptoms; Common dermatologic problems; Evaluation and treatment of shoulder pain; Headache; Evaluation and treatment of colonic symptoms; Dyspepsia; Insomnia; Dizziness; Fatigue; Common anal problems; Involuntary Weight Loss; Evaluation and treatment of neck pain; and Multiple unexplained symptoms.

To ensure the best outcomes, cardiologist must have a deep understanding of the design, manufacturing, and malfunctions of implantable devices. This issue of Cardiac Electrophysiology thoroughly examines implantable devices, providing the most reliable and updated information. Topics include MRI conditionally safe pacemakers, complications in lead extraction, troubleshooting malfunctioning pacemakers and ICDs.

This issue of Medical Clinics will focus on the common foot and ankle problems that internal medicine doctors often face in the outpatient setting. The articles in this issue will review best practices for managing and treating patients who present with such common injuries hammertoes, ankle sprains, plantar fasciitis, and achilles tendon strains.

The Year Book of Medicine brings you abstracts of the articles that reported the year's breakthrough developments in medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed Sections are included on Rheumatology, Infectious Disease, Hematology and Oncology, Kidney, Water, and Electrolytes, Pulmonary Disease, Heart and Cardiovascular Disease, The Digestive System, and Endocrinology, Diabetes, and Metabolism.

This issue of Physical Medicine and Rehabilitation Clinics devoted to Multiple Sclerosis is Guest Edited by Drs. George Kraft and Shana Johnson. Articles in this issue include: Gait Impairment and Optimizing Mobility in MS; Spasticity management; Exercise; ADLs and Adaptive Equipment; Movement Disorders; Fatigue Management; Cognitive Impairment and Management; Neurogenic Bladder and Bowel; Visual Issues; Depression and Pain; Adaptive Technology and Vocational Issues; Aging; Evoked Potentials; and Research.

This volume complies a set of Data Mining techniques and new applications in real biomedical scenarios. Chapters focus on innovative data mining techniques, biomedical datasets and streams analysis, and real applications. Written in the highly successful Methods in Molecular Biology series format, chapters are thought to show to Medical Doctors and Engineers the new trends and techniques that are being applied to Clinical Medicine with the arrival of new Information and Communication technologies Authoritative and practical, Data Mining in Clinical Medicine seeks to aid scientists with new approaches and trends in the field.

Lymphedema is swelling caused by the abnormal accumulation of lymphatic fluid in the skin. Lymphedema can be caused by burns, injury, surgery, radiation therapy, obesity, or circulatory problems. Many breast- and prostate-cancer survivors have, or risk developing, lymphedema. There is also an inherited form. If not treated, lymphedema can be painful and lead to life-threatening infections. This book will help you live well with lymphedema through treatment, self-management, and helpful tips for daily living. It will also help you understand how the lymphatic system works, how lymphedema is diagnosed, how to cope with the emotional challenges of lymphedema, how to find treatment, and deal with insurance issues. Living Well is for those with, or at risk for, lymphedema as well as healthcare professionals, caregivers, and friends and family.

This special volume of "Progress in Molecular Biology and Translational Science "focuses on the molecular biology of arrestins, with contributions from leaders in the field. Arrestins have emerged as central players in the regulation of many facets of G protein-coupled receptor signaling. This volume covers a variety of topics with reviews written by experts in the field.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

"Animal Models for the Study of Human Disease" identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. Thefirst section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse.
Organized by disease orientation for ease of searchabilityProvides information on locating resources, animal alternatives and animal ethicsCovers a broad range of animal models used in research for human disease"

This issue examines PET-MRI with evolving but potentially competing technologies. The guest editors have put together an extremely timely issue as practicing radiologists are increasingly curious about the role of diffusion weighted imaging with MRI as a competing or a complementary technique to PET.

This issue of Critical Care Nursing Clinics, Guest Edited by Stephen D. Krau, PhD, RN, CNE, from Vanderbilt University, will focus on Summer Trauma. Article topics will include Tick bites, Rabies, Snake bites, West Nile Virus, Spider bites, Allergic Reactions to Bee and Wasp Stings, Heat Exhaustation and Stroke, Near Drowning, and Musculoskeletal Injuries.

Alles Wissenswerte uber das kardiovaskulare System auf einen Blick! The Cardiovascular System at a Glance ist das Referenzwerk des Fachgebiets. Die neueste Auflage prasentiert einen integrierten pragnanten UEberblick, von den Grundlagen bis zur Anwendung mit einer Vielzahl von Abbildungen. Neue Inhalte zu Schlaganfall, Untersuchungsmethoden und Bildgebung, Herzblock und EKG, Myopathien und Kanalopathien. Das Fachbuch geht noch einen Schritt weiter und bietet neue und aktualisierte Fallstudien sowie Multiple-Choice-Fragen auf einer begleitenden Website. - Verbindet Grundlagen und klinische Themen. - Kurze Kapitel, deren Inhalte sich leicht aneignen lassen. - Beschreibt Anatomie und Histologie, Blut und Blutstillung, Zellphysiologie, Form und Funktion, Regulierung und Integration der kardiovaskularen Funktion, Anamnese, Untersuchung und Nachforschungen, Pathologie und Therapieansatze. - Mit einer Fulle ansprechender, farbiger Illustrationen als Erganzung und Erlauterung des Textes. In der 5. Auflage ist The Cardiovascular System at a Glance das ideale Lehrbuch fur Studenten der Medizin, Assistenzarzte, Studenten anderer Fachgebiete im Gesundheitswesen und Pflegepersonal in der Kardiologie.

This book provides an overview of multiple facets of ageing and its evolving dynamics in various Indian states. It elaborates on key dimensions like health, dependence and disability, as well as living arrangements for the elderly. Drawing on information from National Sample Surveys to offer readers a broader and richer understanding of the evolving demographic reality in India, the book addresses a range of detailed policies and programmes for the elderly in India. Given its scope, the book is essential reading for students and researchers in the fields of sociology, demography, economics and development studies. It also offers a valuable reference guide for anyone engaged in planning and policy formulation for social security, welfare of the aged or mainstreaming ageing concerns.

Kidney stones affect nearly 3 million people every year and the management of these stones can often be complicated. This issue of the Urologic Clinics covers all of the current treatments for kidney stones from medicine to surgery. There are also articles on pathology, imaging, and diet and alternative therapies.

This issue of Medical Clinics covers the current best practices surrounding the management of patients with acute and chronic headache pain. Guest edited by Steven Waldman, MD, JD, the topics covered will include concerning factors in the diagnosis of headache pain, imaging techniques, tension headaches, migraine headaches, cluster headaches, postdural puncture headaches and more.

In October of 2011, CLSI published a new guideline EP23A on "Laboratory Quality Control Based on Risk Management.? In March, 2012, CMS announced its intention to incorporate key concepts from EP23A into its Interpretative Guidelines and QC policy for "Individualized Quality Control Plans.? Thus begins a new era of Quality Control in the Age of Risk Management. This issue is intended to help laboratories with the transition between traditional QC practices and the new risk management approach. Laboratories face a steep learning curve to apply risk analysis for identifying and prioritizing failure-modes, developing and implementing control mechanisms to detect those failure-modes, and assessing the acceptability of the residual risks that exist after implementation of a QC Plan. One of the main benefits of the new risk analysis based QC Plans should be an integration of all the control mechanisms that are needed to monitor the total testing process, including pre-analytic, analytic, and post-analytic controls.? One of the main risks of the new approach is an expectation that Statistical QC is no longer important, even though SQC still remains the most useful and flexible approach for monitoring the quality of the analytic process. The key to the future is the successful integration of all these control mechanisms to provide a cost-effective quality system that monitors all phases of the total testing process. This issue should help laboratories understand the evolution of QC practices to include risk management, but also to recognize the need to maintain traditional techniques such as Statistical QC, especially during the transition to well-designed and carefully-validated QC Plans. Risk analysis may be risky business unless laboratories proceed carefully and cautiously.

This issue of Medical Clinics covers the important advances and current best practices surrounding the management of patients with diabetic chronic kidney disease. Guest edited by Mark Williams of the Joslin Diabetes Clinic, the topics covered will include proteonomics, diabetes and hypertension, obesity, genetic predispositions, pancreas transplantation, fibrotic therapies, and more.

With increasing urgency, decisions about the digitalized future of healthcare and implementations of new assistive technologies are becoming focal points of societal and scientific debates and addresses large audiences. Decisions require a careful weighing of risks and benefits and contextualizing in-depth ethical analysis with robust empirical data. However, up to now, research on social assistive technologies is mostly dispersed over different academic fields and disciplines. A comprehensive overview on discussions regarding values at stake and ethical assessment of recent developments especially in healthcare is largely missing. This publication initiates an interdisciplinary discourse on ethical, legal and social implications of socially assistive technologies in healthcare. Contributions include perspectives from nursing science, social sciences, philosophy, medical ethics, economics and law to present an - to our knowledge - first and comprehensive overview on different aspects of the use and implementation of socially assistive technologies from an ethical perspective. It combines practically relevant insights and examples from current research and development with ethical analysis to uncover exemplary moral tipping points between promotion of participation or well-being and risks and damages to these values. Healthcare professionals involved in implementation of smart technologies as well as scholars from the field of humanities, nursing and medicine, interested in the discussions on ethics and technology in healthcare, will benefit from this new contribution. The publication is part of the international DigitAs conference "Aging between Participation and Simulation - Ethical Dimensions of Socially Assistive Technologies" held at the Institute of Medical Ethics and History of Medicine (Ruhr University Bochum) from 4 February to 8 February 2019. Within this framework, twelve young scholars were invited to discuss their contributions with renowned experts in the field. The Institute of Medical Ethics and History of Medicine is one of the leading institutes in empirically informed ethical analysis in healthcare and medicine and is a member of the European Association of Centres of Medical Ethics (EACME).

This new volume of "Methods in Enzymology" continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. The volumecovers ghrelin, andhas chapters on such topics as orphan gpcrs and methods for identifying their ligands, ghrelin o-acyltransferase assays and inhibition, and thermogenic characterization of ghrelin receptor null mice.
Contains quality chapters authored by leaders in the field Has chapters on such topics as orphan gpcrs and methods for identifying their ligands, ghrelin o-acyltransferase assays and inhibition, and thermogenic characterization of ghrelin receptor null mice"

The Badgastein Lecture.- The Challenge of the 21st Century.- Neurology, Psychiatry.- First Evaluation in Humans of [123I]PE21: A Selective Radioligand for Visualization of the Striatal Dopamine Transporter Density.- Comparison of Iodine-123 labelled Nor-ss-Cit and ss-Cit as Potential Radioligands for Serotonin Transporter Imaging.- Brain Serotonin and Dopamine Transporters in Depressive Children.- Prognostic Potential of Tc-99m-ECD-SPET within 6 Hours after Onset of Stroke Symptoms.- Brain Perfusion in Patients with Severe Sleep Apnea Syndrome (SAS) before and after n-CPAP-Therapy.- Therapy.- Radioimmunotherapy of Colorectal Cancer in Small Volume Disease: Preclinical Evaluation in Comparison To Equitoxic Chemotherapy and Preliminary Results of an Ongoing Phase-I/II Clinical Trial.- Radioimmunotherapy of Glioblastoma by Using I-131 and Y-90 Labeled Anti-tenascin Monoclonal Antibodies.- I-131-Lipiodol Therapy in Liver Neoplasms.- Individualized Dose Estimation for Sr-89 with the Use of Diagnostic Tc-99m MDP Bone Scintigraphy.- Rhenium-186-HEDP and Strontium-89-Chloride in Treatment of Metastatic Bone Pain.- The Development of Chromatographic 188W/188Re Generators for Therapy.- Radiopharmacology.- Evaluation of mRNA Targeting by Labeled Oligonucleotides for Tumor-Diagnosis.- Synthesis and Evaluation of [123I]-Iodoaminoglutethimide, a Ligand for Visualization of the Aromatase Enzyme by SPECT.- Comparative Analysis of Kinetic Models to Study Glucose Metabolism of the Brain.- Bone Scintigraphy and Palliative Therapy with Multibone Kit.- Pharmaosintigraphic Study of Localization in the G.I. Tract of Controlled Release Tablets Using 153Sm as Marker.- Endocrinology, Thyroid.- On the Use of Routine Preoperative Scintigraphy in Thyroid Carcinoma Patients.- The Value of HMPAO SPECT Scanning in Patients with Congenital Hypothyreosis.- Advanced Stage Thyroid Cancer - Treatment with Isotretinoin.- Is SPECT-Technique Necessary for Preoperative Diagnosis of Parathyroid Adenoma ?.- Oncology, Haematology.- Comparison of Interlesionally and Systemically Administered Radiolabelled Monoclonal Antibodies in Implanted Tumours.- Comparison of MRI and Somatostatin Receptor Scintigraphy (SRS) in Post-surgical Follow-up of Meningioma.- Comparison of Contrast Enhanced MRI, Tc-99m Hydroxymethylene Diphosphonate and Tc-99m Tetrofosmin Scintimammography in Patients with Suspicious Breast Lesions.- Neoadjuvant Treatment of Patients with Breast Cancer under Surveillance of 99mTc-Tetrofosmin Scintigraphy.- 99Tc-Furifosmin Uptake by Melanoma Cells.- Lymphoscintigraphy in Tumors of the Head and Neck Using a Double Tracer Technique.- Clinical PET.- Clinical Application of 18FDG-PET in the Assessment of Head and Neck Tumors.- The Role of FDG-PET and MIBI Investigations in the Restaging of Treated Patients with Malignant Lymphomas.- Assessment of Pulmonary Nodules and Colorectal Cancer Recurrences by FDG Scan on an"Ordinary" Coincidence Gamma Camera (CDET).- Clinical Utility of 18FDG-PET with Molecular Coincidence Detection (MCD) and a Modified SPECT-Camera.- Deoxyglucose Uptake by Apoptosing and Proliferating Colonic Tumour Cells.- Cardiology.- Relation Between Viability, Improvement of LVEF and Heart Failure Symptoms after Revascularization.- Attenuation Corrected Tl-201 SPECT Using a Gd-153 Moving Line Source: Clinical Value and the Impact of Attenuation Correction on the Extent and Severity of Perfusion Abnormalities.- Correlation of EBCT and Tl-201-SPECT Scintigraphy in Patients with Coronary Heart Disease.- Influence of Right Ventricular Stimulation Site on Left Ventricular Function in a Trial Synchronous Pacing.- Varia.- 153Sm-EDTMP for Pain Relief in Malignant and Benign Bone and Joint Diseases.- Tc-99m-Tetrofosmin SPECT Scintigraphy in the Post-operative Follow-up of Microvascular Anastomosed Flaps in Facial Reconstruction.- Long-Term Follow-up Study of Gastric Emptying and Helicobacter Pylori Eradication among Patients with Functional Dyspepsia.- The Valu

Written by research experts, this volume of "Progress in Molecular Biology and Translational Science "focuses on current science surrounding the mechanisms of DNA repair.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field