This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This is the first of two volumes covering protein kinase inhibitors in research and medicine, and includes chapters on such topics as fragment-based screening, broad kinome profiling of kinase inhibitors, and designing drug-resistant kinase alleles.
First of two volumes focusing on protein kinase inhibitors in research and medicinePart of the Methods in Enzymology serial with authors who are experts in their disciplines

Are we satisfied with the rate of drug development? Are we happy with the drugs that come to market? Are we getting our money's worth in spending for basic biomedical research? In Translational Systems Biology, Drs. Yoram Vodovotz and Gary An address these questions by providing a foundational description the barriers facing biomedical research today and the immediate future, and how these barriers could be overcome through the adoption of a robust and scalable approach that will form the underpinning of biomedical research for the future. By using a combination of essays providing the intellectual basis of the Translational Dilemma and reports of examples in the study of inflammation, the content of Translational Systems Biology will remain relevant as technology and knowledge advances bring broad translational applicability to other diseases. Translational systems biology is an integrated, multi-scale, evidence-based approach that combines laboratory, clinical and computational methods with an explicit goal of developing effective means of control of biological processes for improving human health and rapid clinical application. This comprehensive approach to date has been utilized for in silico studies of sepsis, trauma, hemorrhage, and traumatic brain injury, acute liver failure, wound healing, and inflammation.

A historical review of the evolution of concepts, postulates and guidelines concerning disease causation from early germ theory to current work in the area of chronic noncontagious diseases. Students and researchers in epidemiology, clinical medicine, microbiology and related fields will value discussion of changing criteria as these apply to speci

This issue of the Atlas of the Oral and Maxillofacial Surgery Clinics of North America serves as an aid to identification of 70 of the more important head and neck syndromes, and organized using the same nosology as in the landmark text of Robert Gorlin. As such, it should be useful to a varied audience, including not only the oral and maxillofacial surgeon but also the oral pathologist, the practitioner of oral medicine, and members of the craniofacial team--the orthodontist, pediatric dentist, speech and language specialist, geneticist, plastic surgeon, ENT specialist, pediatrician, nurse coordinator, and others. Areas covered include: Craniosynostosis Syndromes; Syndromes Affecting Bone; Metabolic and Autoimmune Syndromes; Syndromes Affecting Skin and Mucosa; Hamartoneoplastic Syndromes; Branchial Arch Syndromes; Clefting Syndromes; Syndromes Affecting the Central Nervous System; Chromosomal Syndromes; Syndromes with Unusual Facies; and Syndromes with Unusual Dental Findings or Gingival Components.

This issue begins with an overview that distinguishes evidence-based practice (EBP) and translation science, followed by a description of Hawaii's statewide EBP program that uses active and multifaceted translation science strategies to facilitate the rate and extent of adoption of EBP changes. With one exception, the remaining articles describe individual EBP projects from five different health care facilities that used the Iowa Model to guide their work. Each article includes an evidence summary, a description of implementation strategies, an evaluation of the innovation, and lessons learned. These completed projects were initiated between 2009 and 2012, address a variety of topical nursing issues, and, for the most part, focus on preventing complications (ie, blood sugar elevations, increased lengths of stay, extubation failures, noise-related injury, pain, surgical site infections, pneumonia, restraint use, delirium, and fever). An additional article describes the use of evidence to inform simulation-based learning, a possible strategy for ensuring competencies in and compliance with EBP interventions. Nursing leaders will come away with solid information about utilizing EBP to improve patient outcomes. The Hawaii program demonstrates that health care quality can be realized by employing the best available evidence and empowering the nursing workforce. It also offers a glimpse of the care that the future nursing workforce could provide to create a health system that provides accessible, affordable and quality care to everyone in the United States.

Regulated Cell Death Part A & Part B of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches.
Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization scienceRegulated Cell Death Part A & Part B contains sections on such topics as apoptosis focusing on the important areas of intrinsic pathway, extrinsic pathway, caspases, cellular assays and post-apoptotic effects and model organisms; as well as topics on necroptosis and screening approaches

This issue of the Medical Clinics of North America, edited by Douglas Paauw, is devoted to Common Symptoms in the Ambulatory Setting.? Articles in this issue include: Evaluation and treatment of chronic cough; Evaluation and treatment of lower back pain; Lower extremity symptoms; Common dermatologic problems; Evaluation and treatment of shoulder pain; Headache; Evaluation and treatment of colonic symptoms; Dyspepsia; Insomnia; Dizziness; Fatigue; Common anal problems; Involuntary Weight Loss; Evaluation and treatment of neck pain; and Multiple unexplained symptoms.

To ensure the best outcomes, cardiologist must have a deep understanding of the design, manufacturing, and malfunctions of implantable devices. This issue of Cardiac Electrophysiology thoroughly examines implantable devices, providing the most reliable and updated information. Topics include MRI conditionally safe pacemakers, complications in lead extraction, troubleshooting malfunctioning pacemakers and ICDs.

A cross-disciplinary approach to the complex problems of obesity.

This issue of Medical Clinics will focus on the common foot and ankle problems that internal medicine doctors often face in the outpatient setting. The articles in this issue will review best practices for managing and treating patients who present with such common injuries hammertoes, ankle sprains, plantar fasciitis, and achilles tendon strains.

ABC of Equality, Diversity and Inclusion in Healthcare Improve inclusion, for both patients and staff, in your healthcare environment Fulfilment in personal and professional life is facilitated by feeling able to bring one’s complete self to work. The promotion of Equality, Diversity & Inclusion (EDI) and its support in the workplace is crucial to achieving this. Diverse and inclusive teams are characterised by good people management, leading to better decision-making and improved performance which staff wellbeing and patient safety depend on. Though issues including racism, sexism and homophobia have roots in wider society, they also exist across healthcare systems worldwide. They contribute to problems with recruitment and retention of staff and can make patients reluctant to access the care they need and deserve. The ABC of Equality, Diversity and Inclusion in Health summarises the key issues and the impacts on both patients and staff of excluding people from good healthcare solely on the basis of who they are. As well as considering impacts on individuals and teams, we consider also how inclusion can be improved for the benefit of everyone—all patients and all staff. Topics include: Racism in healthcare Women in healthcare Sexual orientation and gender identity Disability, disparities and ableism in medicine Teaching equality, diversity, and inclusion in healthcare The authors are distinguished healthcare practitioners whose personal and professional lives have been enriched by the diversity of all they meet through their work and who are passionate about ensuring positive change for colleagues and patients. This book aims to contribute to important discussions about how to ensure systemic change that will enable an inclusive culture by recognising and celebrating diversity. ABC of Equality, Diversity and Include (EDI) in Healthcare is essential reading for students and professionals who want to champion inclusivity and fulfilment in a workplace environment. About the ABC series The ABC series has been designed to help you access information quickly and deliver the best patient care, and remains an essential reference tool for GPs, junior doctors, medical students and healthcare professionals. Now offering over 80 titles, this extensive series provides you with a quick and dependable reference on a range of topics in all the major specialties. The ABC series is the essential and dependable source of up-to-date information for all practitioners and students in primary healthcare. To receive automatic updates on books and journals in your specialty, join our email list. Sign up today at www.wiley.com/email

The Year Book of Medicine brings you abstracts of the articles that reported the year's breakthrough developments in medicine, carefully selected from more than 500 journals worldwide. Expert commentaries evaluate the clinical importance of each article and discuss its application to your practice. There's no faster or easier way to stay informed Sections are included on Rheumatology, Infectious Disease, Hematology and Oncology, Kidney, Water, and Electrolytes, Pulmonary Disease, Heart and Cardiovascular Disease, The Digestive System, and Endocrinology, Diabetes, and Metabolism.

This issue of Physical Medicine and Rehabilitation Clinics devoted to Multiple Sclerosis is Guest Edited by Drs. George Kraft and Shana Johnson. Articles in this issue include: Gait Impairment and Optimizing Mobility in MS; Spasticity management; Exercise; ADLs and Adaptive Equipment; Movement Disorders; Fatigue Management; Cognitive Impairment and Management; Neurogenic Bladder and Bowel; Visual Issues; Depression and Pain; Adaptive Technology and Vocational Issues; Aging; Evoked Potentials; and Research.

This volume complies a set of Data Mining techniques and new applications in real biomedical scenarios. Chapters focus on innovative data mining techniques, biomedical datasets and streams analysis, and real applications. Written in the highly successful Methods in Molecular Biology series format, chapters are thought to show to Medical Doctors and Engineers the new trends and techniques that are being applied to Clinical Medicine with the arrival of new Information and Communication technologies Authoritative and practical, Data Mining in Clinical Medicine seeks to aid scientists with new approaches and trends in the field.

Lymphedema is swelling caused by the abnormal accumulation of lymphatic fluid in the skin. Lymphedema can be caused by burns, injury, surgery, radiation therapy, obesity, or circulatory problems. Many breast- and prostate-cancer survivors have, or risk developing, lymphedema. There is also an inherited form. If not treated, lymphedema can be painful and lead to life-threatening infections. This book will help you live well with lymphedema through treatment, self-management, and helpful tips for daily living. It will also help you understand how the lymphatic system works, how lymphedema is diagnosed, how to cope with the emotional challenges of lymphedema, how to find treatment, and deal with insurance issues. Living Well is for those with, or at risk for, lymphedema as well as healthcare professionals, caregivers, and friends and family.

This special volume of "Progress in Molecular Biology and Translational Science "focuses on the molecular biology of arrestins, with contributions from leaders in the field. Arrestins have emerged as central players in the regulation of many facets of G protein-coupled receptor signaling. This volume covers a variety of topics with reviews written by experts in the field.

Key features:

* Contributions from leading authorities * Informs and updates on all the latest developments in the field

"Animal Models for the Study of Human Disease" identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. Thefirst section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, cancer, hypertension, genetic diseases, and diseases of abuse.
Organized by disease orientation for ease of searchabilityProvides information on locating resources, animal alternatives and animal ethicsCovers a broad range of animal models used in research for human disease"

This issue examines PET-MRI with evolving but potentially competing technologies. The guest editors have put together an extremely timely issue as practicing radiologists are increasingly curious about the role of diffusion weighted imaging with MRI as a competing or a complementary technique to PET.

This issue of Critical Care Nursing Clinics, Guest Edited by Stephen D. Krau, PhD, RN, CNE, from Vanderbilt University, will focus on Summer Trauma. Article topics will include Tick bites, Rabies, Snake bites, West Nile Virus, Spider bites, Allergic Reactions to Bee and Wasp Stings, Heat Exhaustation and Stroke, Near Drowning, and Musculoskeletal Injuries.

This book provides an overview of multiple facets of ageing and its evolving dynamics in various Indian states. It elaborates on key dimensions like health, dependence and disability, as well as living arrangements for the elderly. Drawing on information from National Sample Surveys to offer readers a broader and richer understanding of the evolving demographic reality in India, the book addresses a range of detailed policies and programmes for the elderly in India. Given its scope, the book is essential reading for students and researchers in the fields of sociology, demography, economics and development studies. It also offers a valuable reference guide for anyone engaged in planning and policy formulation for social security, welfare of the aged or mainstreaming ageing concerns.

Kidney stones affect nearly 3 million people every year and the management of these stones can often be complicated. This issue of the Urologic Clinics covers all of the current treatments for kidney stones from medicine to surgery. There are also articles on pathology, imaging, and diet and alternative therapies.

This issue of Medical Clinics covers the current best practices surrounding the management of patients with acute and chronic headache pain. Guest edited by Steven Waldman, MD, JD, the topics covered will include concerning factors in the diagnosis of headache pain, imaging techniques, tension headaches, migraine headaches, cluster headaches, postdural puncture headaches and more.

In October of 2011, CLSI published a new guideline EP23A on "Laboratory Quality Control Based on Risk Management.? In March, 2012, CMS announced its intention to incorporate key concepts from EP23A into its Interpretative Guidelines and QC policy for "Individualized Quality Control Plans.? Thus begins a new era of Quality Control in the Age of Risk Management. This issue is intended to help laboratories with the transition between traditional QC practices and the new risk management approach. Laboratories face a steep learning curve to apply risk analysis for identifying and prioritizing failure-modes, developing and implementing control mechanisms to detect those failure-modes, and assessing the acceptability of the residual risks that exist after implementation of a QC Plan. One of the main benefits of the new risk analysis based QC Plans should be an integration of all the control mechanisms that are needed to monitor the total testing process, including pre-analytic, analytic, and post-analytic controls.? One of the main risks of the new approach is an expectation that Statistical QC is no longer important, even though SQC still remains the most useful and flexible approach for monitoring the quality of the analytic process. The key to the future is the successful integration of all these control mechanisms to provide a cost-effective quality system that monitors all phases of the total testing process. This issue should help laboratories understand the evolution of QC practices to include risk management, but also to recognize the need to maintain traditional techniques such as Statistical QC, especially during the transition to well-designed and carefully-validated QC Plans. Risk analysis may be risky business unless laboratories proceed carefully and cautiously.

This issue of Medical Clinics covers the important advances and current best practices surrounding the management of patients with diabetic chronic kidney disease. Guest edited by Mark Williams of the Joslin Diabetes Clinic, the topics covered will include proteonomics, diabetes and hypertension, obesity, genetic predispositions, pancreas transplantation, fibrotic therapies, and more.

With increasing urgency, decisions about the digitalized future of healthcare and implementations of new assistive technologies are becoming focal points of societal and scientific debates and addresses large audiences. Decisions require a careful weighing of risks and benefits and contextualizing in-depth ethical analysis with robust empirical data. However, up to now, research on social assistive technologies is mostly dispersed over different academic fields and disciplines. A comprehensive overview on discussions regarding values at stake and ethical assessment of recent developments especially in healthcare is largely missing. This publication initiates an interdisciplinary discourse on ethical, legal and social implications of socially assistive technologies in healthcare. Contributions include perspectives from nursing science, social sciences, philosophy, medical ethics, economics and law to present an - to our knowledge - first and comprehensive overview on different aspects of the use and implementation of socially assistive technologies from an ethical perspective. It combines practically relevant insights and examples from current research and development with ethical analysis to uncover exemplary moral tipping points between promotion of participation or well-being and risks and damages to these values. Healthcare professionals involved in implementation of smart technologies as well as scholars from the field of humanities, nursing and medicine, interested in the discussions on ethics and technology in healthcare, will benefit from this new contribution. The publication is part of the international DigitAs conference "Aging between Participation and Simulation - Ethical Dimensions of Socially Assistive Technologies" held at the Institute of Medical Ethics and History of Medicine (Ruhr University Bochum) from 4 February to 8 February 2019. Within this framework, twelve young scholars were invited to discuss their contributions with renowned experts in the field. The Institute of Medical Ethics and History of Medicine is one of the leading institutes in empirically informed ethical analysis in healthcare and medicine and is a member of the European Association of Centres of Medical Ethics (EACME).