Psychiatry: Breaking the ICE contains everything psychiatry trainees need in order feel confident and competent in general adult inpatient and community placements. * A practical and reassuring guide to life as a psychiatrist, structured around the tasks expected both in day-to-day practice and in out-of-hours work * Key themes running throughout the book include ethical and legal issues, risk assessment and management, patient experience and safe prescribing * The authors are closely involved in the training, mentoring and supervision of core trainees, and know the real-world challenges faced by junior psychiatrists

Autism Spectrum Disorders from Theory to Practice Apply the latest ASD theory to assessment and intervention in real-world clinical environments In Autism Spectrum Disorders from Theory to Practice, a team of experienced interventionists deliver a practical application of modern theory regarding autism spectrum disorders (ASDs) to common, real-world clinical situations. Hands-on guidance is paired with advice on culturally appropriate and responsive practices informed by professionals who collectively have over 40 years of combined speech pathology experience. The work of special contributors like Dr. Pamela Wiley, who is the Founder and President of the Los Angeles Speech and Language Therapy Center, appears alongside evidence-based ASD intervention instruction that draws from the latest studies and from the authors' assessments and interventions with clients from a diverse range of backgrounds. When combined with the reader's own professional competence, clinical experiences, and continuing education, this book is a powerful resource that will improve patient outcomes. Autism Spectrum Disorders readers will also find: Personal anecdotes from the authors' clinical practices to help illustrate the application of the concepts discussed within Active Learning Tasks that educators can use to promote learning activities that encourage direct engagement with the material Helpful and illustrative diagrams included throughout the text to help elucidate points and clarify information in each chapter Goal Spotlights that provide sample intervention goals practitioners can use with actual clients with autism Reflection Letters in which individuals from various perspectives and backgrounds--from autism researchers to developmental psychologists, advocates such as Holly Robinson Peete, and adults thriving with autism--describe their experiences Autism Spectrum Disorders from Theory to Practice is a useful reference for new and experienced practitioners in the field of autism research, speech-language pathologists, developmental psychologists, adapted physical education teachers, professors, and those affected by ASD in their everyday life.

Mapping BRICS Media is the first comprehensive and comparative study of the emerging media landscape in the world's most dynamic and fastest growing markets. This pioneering collection focuses on one of the key topics in contemporary international relations - the emergence of BRICS (Brazil, Russia, India, China and South Africa) - a grouping that includes some of the world's largest populations and fastest growing economies. The volume brings together leading scholars, mainly from the BRICS nations, to examine how the emergence of the BRICS media will impact on global media and communication. Contextualizing the rise of the BRICS nations within the broader shifts in global power relations, the chapters investigate the unprecedented growth of the BRICS media within a 'multi-polar' world, evaluating the media landscapes in the individual BRICS countries, their histories, and their journalism practices, as well as analyzing emerging inter-BRICS media relationships. Accessible and comprehensive, the book provides a critical guide to the complex debates about the impact of the 'rise of the rest' on the media globe and how far this poses a challenge to the Western-dominated world order and its media systems.

This groundbreaking book unleashes a brilliant new plan for permanently curing heartburn by relieving the root cause of the problem: low stomach acid. The fact is that heartburn is caused by too little stomach acid -- not too much, as many doctors profess. As explained in this book, the current practice of reducing stomach acid may be a temporary fix, but this fix comes at a cost to our long-term health that is being ignored by the pharmaceutical companies, the FDA, and the thousands of physicians that prescribe anti-acid drugs like Prilosec, Tagamet, Zantac, Pepcid, and others.

The Annual Update compiles reviews of the most recent developments in experimental and clinical intensive care and emergency medicine research and practice in one comprehensive reference book. The chapters are written by well recognized experts in these fields. The book is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Knowledge Translation in Health Care is a practical introduction to knowledge translation for everyone working and learning within health policy and funding agencies, and as researchers, clinicians and trainees. Using everyday examples, it explains how to use research findings to improve health care in real life. This new second edition defines the principles and practice of knowledge translation and outlines strategies for successful knowledge translation in practice and policy making. It includes relevant real world examples and cases of knowledge translation in action that are accessible and relevant for all stakeholders including clinicians, health policy makers, administrators, managers, researchers, clinicians and trainees. From an international expert editor and contributor team, and fully revised to reflect current practice and latest developments within the field, Knowledge Translation in Health Care is the practical guide for all health policy makers and researchers, clinicians, trainee clinicians, medical students and other healthcare professionals seeking to improve healthcare practice.

With at least 40% new or updated content since the last edition, "Clinical Decision Support," 2nd Edition explores the crucial new motivating factors poised to accelerate Clinical Decision Support (CDS) adoption. This book is mostly focused on the US perspective because of initiatives driving EHR adoption, the articulation of 'meaningful use', and new policy attention in process including the Office of the National Coordinator for Health Information Technology (ONC) and the Center for Medicare and Medicaid Services (CMS). A few chapters focus on the broader international perspective. "Clinical Decision Support," 2nd Edition explores the technology, sources of knowledge, evolution of successful forms of CDS, and organizational and policy perspectives surrounding CDS.

Exploring a roadmap for CDS, with all its efficacy benefits including reduced errors, improved quality, and cost savings, as well as the still substantial roadblocks needed to be overcome by policy-makers, clinicians, and clinical informatics experts, the field is poised anew on the brink of broad adoption. "Clinical Decision Support," 2nd Edition provides an updated and pragmatic view of the methodological processes and implementation considerations. This book also considers advanced technologies and architectures, standards, and cooperative activities needed on a societal basis for truly large-scale adoption.
At least 40% updated, and seven new chapters since the previous edition, with the new and revised content focused on new opportunities and challenges for clinical decision support at point of care, given changes in science, technology, regulatory policy, and healthcare financeInforms healthcare leaders and planners, health IT system developers, healthcare IT organization leaders and staff, clinical informatics professionals and researchers, and clinicians with an interest in the role of technology in shaping healthcare of the future

Now for the first time, a new diagnosis and treatment guide with even more focus on the most commonly encountered disorders than ever before. All major internal medicine diseases and disorders are covered in this new succinct evidence-based guide to treatment and diagnosis in internal medicine. Organized by body system, and focused on critical core topics, the Mayo Clinic Internal Medicine Concise Textbook is replete with summary tables, algorithms, and summary points. Easy-access to tables of current medications, indications and side-effects saves time and improves treatment outcomes. In addition, special sections provide expert guidance on preparation for the USMLE Step 2 Clinical Knowledge and Clinical Skills examinations.

The critically acclaimed laboratory standard for almost 50 years, "Methods in Enzymology" is one of the most highly respected publications in the field of biochemistry. Each volume is eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with more than 530 volumes and 40,000 chapters in the collection, this is an essential publication for researchers in all fields of life sciences, including microbiology, biochemistry, cancer research, and genetics, just to name a few.

This volume brings together a number of core protocols concentrating on protein, carefully written and edited by experts, including: Pulse-chase analysis to measure protein degradationLabeling a protein with fluorophores using NHS ester derivitizationImmunoaffinity purification of proteinsProteolytic affinity tag cleavagePurification of GST-tagged proteins
Indispensable tool for the researcher Carefully written and edited by experts to contain step-by-step protocolsThis volume focuses on core protocols involving protein

In this issue of Foot and Ankle Clinics, guest editor Fabian Krause brings considerable expertise to the topic of the diabetic foot. Provides in-depth reviews on the latest updates in the diabetic foot, providing actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field; Authors synthesize and distill the latest research and practice guidelines to create these timely topic-based reviews.

Following the issuance of new radiological protection recommendations in Publication 103 (ICRP, 2007), the Commission released, in Publication 110 (ICRP, 2009), the adult male and female voxel-type reference computational phantoms to be used for the calculation of the reference dose coefficients for both external and internal exposures. While providing more anatomically realistic representations of internal anatomy than the older stylised phantoms, the voxel phantoms have their limitations, mainly due to voxel resolution, especially with respect to small tissue structures (e.g. lens of the eye) and very thin tissue layers (e.g. stem cell layers in the stomach wall mucosa and intestinal epithelium). This report describes the construction of the adult mesh-type reference computational phantoms (MRCPs) that are the modelling counterparts of the Publication 110 voxel-type reference computational phantoms. The MRCPs include all source and target regions needed for estimating effective dose, even the m-thick target regions in the respiratory and alimentary tract, skin, and urinary bladder, assimilating the supplemental stylised models. The MRCPs can be directly implemented into Monte Carlo particle transport codes for dose calculations, i.e. without voxelisation, fully maintaining the advantages of the mesh geometry.

Making speedy and appropriate clinical decisions and then choosing the best course of action is an essential skill for doctors. Exploring initial medical assessment, 100 Cases in Clinical Medicine presents 100 scenarios commonly seen by medical students and junior doctors in the emergency or outpatient department, on the ward, or in the community setting. Each case begins with a succinct summary of the patient's history, examination, and initial investigation. The text includes photographs where relevant and questions on the diagnosis and management of each case. The answers provide a detailed discussion on each topic, with further illustration where appropriate. Most of the cases included are common problems but the book also includes more unusual cases to illustrate specific points and to emphasize that rare things do present. The first 20 cases are arranged by systems; the next 80 are in random order because symptoms such as breathlessness and pain may relate to many different clinical problems in various systems. These true-to-life cases will teach students and junior doctors to recognize important clinical symptoms and signs and to develop the diagnostic and management skills needed for the cases they will encounter on the job.

This book assumes that it is no longer tenable to work in healthcare without considering the person as a whole being constituted by a rich weaving of mind, body, culture, family, spirit and ecology. The MindBody approach embraces this "whole." But how does it transform clinical practice and training for the clinician and treatment for the patient/client? The book collects together the experiences from a diverse range of clinical practitioners (including psychotherapy, specialist medicine, general practice, physiotherapy, occupational therapy, dietetics, nursing, and complementary and alternative medicine practitioners) who have deliberately chosen to integrate a MindBody philosophy and skill set in their clinical practices. All reflect deeply on their unique journeys in transforming their clinical encounters. Most have been trained in the dominant Western framework and have inherited the classical dualistic approach which typically keeps mind and body apart. This dualistic clinical ethos values clinician expertise, labeling, diagnosis, measurement, and grouped phenomena. The MindBody approach retains the best of the classical model as well as valuing personal experience, patient/client story, the unique patterning of the individual s illness and disease, and the healing elements of the relationship between the clinician and the patient/client. The MindBody transformation of the clinician is a challenging journey, and each clinician experiences this uniquely. From these stories the reader can see vividly the ways in which conventional healthcare can break out of its current restrictive paradigm creating new satisfaction for the clinicians and much wider treatment outcomes for patients and clients."

This book brings together a range of academic, industry and practitioner perspectives on translational medicine (TM). It enhances conceptual and practical understanding of the emergence and progress of the field and its potential impact on basic research, therapeutic development, and institutional infrastructure. In recognition of the various implications TM has for public health policy and commercial innovation, the book addresses the major systemic aspects of the field. The contributors explore the dynamic interactions and key challenges in translating new science into viable therapies for the clinic, which includes recognizing the importance of social, commercial, and regulatory environments in addition to good science.

Das TNM-Klassifizierungssystem der Union for International Cancer Controls (UICC) ist das weltweit am meisten eingesetzte Klassifizierungs- und Staging-System. Es beschreibt das anatomische Ausmass der Krankheit und ist fur die Patientenversorgung, die Forschung und Krebskontrolle massgebend. Die 5. Auflage von TNM Supplement: A Commentary of Uniform Use bietet Medizinern eine Fulle von Informationen als Erganzung im Klinikalltag. - Aktualisierte Definitionen zu Begriffen aus dem Krebs-Staging. - Neue Abschnitte zu Karzinomen der Thymusdruse, Sarkomen der Wirbelsaule und des Beckens, Weichteil-Sarkomen von Kopf und Nacken, umfassende UEberarbeitungen der Inhalte zu Kopf- und Nackenkarzinomen, Lungenkarzinomen und neuroendokrinen Turmoren. - FAQ aus der Hotline der UICC. Die Erganzung kann durchaus als Begleitpublikation zur neuen 8. Auflage von TNM Classification of Malignant Tumours (978-1-119-26357-9) dienen, die die korrekte und einheitliche Anwendung des TNM-Klassifizierungssystem unterstutzt. Weiterhin lasst es sich als eigenstandiges Referenzwerk nutzen mit Erlauterungen und Beispielen zu vielen Fragestellungen, die beim taglichen Einsatz des TNM-Krebsklassifizierungssystem sowie des Staging-Systems auftauchen, insbesondere bei nicht alltaglichen Fallen.

The third edition of this innovative work again provides a unique perspective on the clinical discovery process by providing input from experts within the NIH on the principles and practice of clinical research. Molecular medicine, genomics, and proteomics have opened vast opportunities for translation of basic science observations to the bedside through clinical research. As an introductory reference it gives clinical investigators in all fields an awareness of the tools required to ensure research protocols are well designed and comply with the rigorous regulatory requirements necessary to maximize the safety of research subjects. Complete with sections on the history of clinical research and ethics, copious figures and charts, and sample documents it serves as an excellent companion text for any course on clinical research and as a must-have reference for seasoned researchers.
Incorporates new chapters on Managing Conflicts of Interest in Human Subjects Research, Clinical Research from the Patient's Perspective, The Clinical Researcher and the Media, Data Management in Clinical Research, Evaluation of a Protocol Budget, Clinical Research from the Industry Perspective, and Genetics in Clinical ResearchAddresses the vast opportunities for translation of basic science observations to the bedside through clinical researchDelves into data management and addresses how to collect data and use it for discoveryContains valuable, up-to-date information on how to obtain funding from the federal government

Single Best Answer (SBA) examinations are an increasingly popular means of testing medical students and those undertaking postgraduate qualifications in a number of subject areas. Written by a final year medical student, junior doctors and experienced clinicians, 450 Single Best Answers in the Clinical Specialties provides invaluable guidance from authors who understand from personal experience that detailed and accurate explanations are the key to successful revision. The presentation of questions arranged by specialty area as well as the inclusion of a practice exam of random questions, coupled with the clear discussion of how to correct answer was reached and other options ruled out for every question, make this book an excellent learning aid during all stages of clinical studies, and particularly while preparing for medical finals.

Dental defects may be the physical expression of genetic defects, and so they can often be seen in a variety of syndromes associated with malformations of organs. However, dental defects are often not recognized, identified, nor characterised despite representing a possible diagnostic sign for an undiagnosed condition. This book addresses this gap by providing an understanding of dental genetics and its developmental biology counterpart. With approximately seventy well-illustrated examples, the authors present the clinical oro-facial manifestations accompanying various syndromes, providing the necessary knowledge for diagnostic purposes, as well as giving insight into recent development for each specific condition. The clarity and format of this book make it an ideal support guide both in the clinic and while conducting research.

This updated edition of Painless Evidence-Based Medicine presents basic concepts and application of research statistics in simple and practical manner creating an introductory approach to the complex and technical subject of evidence-based medicine from experienced teachers. * A simplified introductory approach to the complex and technical subject of evidence-based medicine from experienced teachers * Approaches learning from the vantage point of clinical questions on therapy, diagnosis, prognosis or harm rather than the framework of study designs * Provides tables and boxed case studies throughout highlighting key topics, or difficult issues, in an easy to read manner * Emphasizes applicability of EBM, encouraging readers to dissect the evidence and how results can be applied to individual patients with different circumstances, varying values and preferences * New to the Second Edition are chapters on health screening, clinical practice guidelines, and major updates incorporating recommended trial criteria

Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences A practical guide to the use of basic principles of experimental design and statistical analysis in pharmacology Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences provides clear instructions on applying statistical analysis techniques to pharmacological data. Written by an experimental pharmacologist with decades of experience teaching statistics and designing preclinical experiments, this reader-friendly volume explains the variety of statistical tests that researchers require to analyze data and draw correct conclusions. Detailed, yet accessible, chapters explain how to determine the appropriate statistical tool for a particular type of data, run the statistical test, and analyze and interpret the results. By first introducing basic principles of experimental design and statistical analysis, the author then guides readers through descriptive and inferential statistics, analysis of variance, correlation and regression analysis, general linear modelling, and more. Lastly, throughout the textbook are numerous examples from molecular, cellular, in vitro, and in vivo pharmacology which highlight the importance of rigorous statistical analysis in real-world pharmacological and biomedical research. This textbook also: Describes the rigorous statistical approach needed for publication in scientific journals Covers a wide range of statistical concepts and methods, such as standard normal distribution, data confidence intervals, and post hoc and a priori analysis Discusses practical aspects of data collection, identification, and presentation Features images of the output from common statistical packages, including GraphPad Prism, Invivo Stat, MiniTab and SPSS Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences is an invaluable reference and guide for undergraduate and graduate students, post-doctoral researchers, and lecturers in pharmacology and allied subjects in the life sciences.

In this issue of Medical Clinics of North America, guest editors Drs. Anand V. Kulkarni and K. Rajender Reddy bring their considerable expertise to the topic of Hepatology: An Update. Top experts in the field cover key topics such as NAFLD; hepatic manifestations of a systemic illness; cirrhosis and portal hypertension; hepatic encephalopathy; ICU care of the patient with cirrhosis; hepatocellular carcinoma; liver transplantation for the non-hepatologist; and more. Contains 15 relevant, practice-oriented topics including the global burden of chronic liver disease; the rising epidemic of alcoholic hepatitis; inpatient hepatology consultation; frailty and sarcopenia; and more. Provides in-depth clinical reviews on hepatology, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.

Produced by microbes on a large scale, methane is an important alternative fuel as well as a potent greenhouse gas. This volume focuses on microbial methane metabolism, which is central to the global carbon cycle. Both methanotrophy and methanogenesis are covered in detail. Topics include isolation and classification of microorganisms, metagenomics approaches, biochemistry of key metabolic enzymes, gene regulation and genetic systems, and field measurements. The state-of-the-art techniques described here will both guide researchers in specific pursuits and educate the wider scientific community about this exciting and rapidly developing field.

Topics include isolation and classification of microorganisms, metagenomics approaches, biochemistry of key metabolic enzymes, gene regulation and genetic systems, and field measurements The state-of-the-art techniques described here will both guide researchers in specific pursuits and educate the wider scientific community about this exciting and rapidly developing field

The third edition of the Gross Motor Function Measure (GMFM-66 & GMFM-88) User's Manual has retained the information contained in the original 2002 and 2013 publications which included the conceptual background to the development of the GMFM, and the administration and scoring guidelines for people to be able to administer this clinical and research assessment tool appropriately. This includes information on the development and validation of two abbreviated methods of estimating GMFM-66 scores using the GMFM-66- Item sets (GMFM-66- IS) and the GMFM-66- B&C (Basal & Ceiling) and a chapter providing a longitudinal case illustration of how the measure and the short forms of the GMFM can be applied and interpreted in clinical practice. The new edition includes information and an Appendix on the updated version of the Gross Motor Ability Estimator scoring program (GMAE-3), which is available through the GMFM App+ (see the CanChild website at (https: //www.canchild.ca/en/shop/38-the-gross-motor-function-measure-app).

Oxidative stress and inflammation are among the most important factors of disease. Chronic infections, obesity, alcohol and tobacco usage, radiation, environmental pollutants, and high-calorie diets have been recognized as major risk factors for a variety of chronic diseases from cancer to metabolic diseases. All these risk factors are linked to chronic diseases through inflammation. While short-term, acute inflammation generated by the immune system serves a therapeutic role, chronic low-level inflammation that may persist "silently" for decades is responsible for chronic diseases. Inflammation, Lifestyle, and Chronic Diseases: The Silent Link describes the role of dysregulated inflammation in persistent and recurring diseases. It investigates links to lifestyle and presents research on how the suppression of proinflammatory pathways may provide opportunities for both prevention and treatment of chronic diseases. The book covers neurodegenerative diseases, pulmonary diseases, asthma, rheumatic and arthritic diseases, skin disease, heart disease, chronic wounds, infectious disease, neuropsychiatric disorders such as depression, gastrointestinal diseases, insulin resistance, and cancer, many of which are also diseases of old age. For each chronic disease, contributors review the clinical and scientific literature and examine current and potential therapies, including conventional pharmacotherapies as well as natural products. Noting that the long-term use of steroids and nonsteroidal anti-inflammatory drugs (NSAIDs) can cause adverse side effects, many of the chapters address the role of dietary agents such as fruits, vegetables, legumes, pulses, nuts, and spices as ideal anti-inflammatory agents that can be consumed regularly. The book also suggests directions for further research. Clinical and science researchers, students, and health professionals interested in the link between inflammation, lifestyle, and chronic diseases will find this an informative resource.

In this issue of Medical Clinics of North America, guest editor Dr. Heather Hofmann brings her considerable expertise to the topic of Communication Skills and Challenges in Medical Practice. Communication is a core part of medical practice, and just as physicians increase their knowledge and hone clinical reasoning skills, so too must communication skills be refined. This issue provides an evidence-based review of patient-centered communication for the general practitioner, covering key communications skills commonly used in patient encounters, including challenges posed by modern medicine to effective communication. Contains 15 relevant, practice-oriented topics including addressing the challenges of cross-cultural communication; gender and health communication; eliciting the patient narrative; motivating behavioral change; breaking bad news; using technology to enhance communication; and more. Provides in-depth clinical reviews on communication skills and challenges in medical practice, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.