The first comprehensive edition and translation of Old English writings on health and healing in more than 150 years. Unlike elsewhere in Europe, vernacular writings on health and healing had a major place in early medieval England. These texts—unique local remedies and translations of late antique Latin treatises—offer insights into the history of science and medicine, social history, scribal practices, and culture. Some cures resemble ones still used today; others are linguistically extravagant, prescribing ambitious healing practices. Alongside recipes for everyday ailments such as headaches are unparalleled procedures for preventing infant mortality, restoring lost cattle, warding off elf-shot, or remedying the effects of flying venom. Medical Writings from Early Medieval England presents the first comprehensive edition and translation from Old English of these works in more than 150 years. Volume I includes The Old English Herbal, Remedies from Animals, Lacnunga, the Peri Didaxeon, and a compendium of miscellaneous texts.

BURNT HUMAN REMAINS An all-encompassing reference and guide designed for professionals involved in the forensic analysis of burnt remains Burnt Human Remains: Recovery, Analysis and Interpretation presents an in-depth multidisciplinary approach to the detection, recovery, analysis, and identification of thermally altered remains. Bridging the gap between research and practice, this invaluable one-stop reference provides detailed coverage of analytical techniques in forensic medicine and pathology, forensic anthropology, forensic odontology, and forensic chemistry and forensic biology. Contributions from a panel of expert authors review the newest findings in forensics research and discuss their applicability to forensic case work. Opening with a historical overview of the discipline, the book covers the search and recovery aspects of burnt human remains, medico-legal investigations, determination of the post mortem interval of burnt remains, structural changes of burnt bone and teeth, DNA extraction from burnt remains, and much more. Throughout the text, the authors emphasize the importance of understanding the changes undergone by bodies when subjected to fire for establishing identity, reconstructing the events leading up to incineration, and determining the cause and manner of death. Provides a systemic framework that integrates established forensic methods and state-of-the-art analytical approaches Describes different forensic analyses from the macroscopical, microscopical, biochemical, and molecular level Features international case studies of challenging individual cases as well as natural or man-made mass fatalities requiring the identification of incinerated remains Demonstrates how changes to the macro- and microstructure of burnt remains can reveal information about incineration conditions Discusses organizations and programs focused on developing standards and best practice for the recovery and analysis burnt remains Burnt Human Remains: Recovery, Analysis and Interpretation is an indispensable resource for all practitioners engaged in the interpretation of burned human tissue, including pathologists, forensic chemists, forensic biologists, forensic anthropologists, forensic odontologists, and archaeologists.

This book advocates a new approach to the clinical management of the musculoskeletal system in children with cerebral palsy based on the concept of intervention to a complex adaptive system with the aim of improving the lived experience of the child with cerebral palsy. Provides a critical review of the current understanding and management of musculoskeletal deformity in children with CP, in the context of the available evidence base and models of clinical practice. Transfers current understanding of muscle and bone physiology and impairment, from the realms of research into mainstream clinical thinking Discusses an alternative clinical model of assessment and intervention, focusing on impairment of muscle growth and function Considers the musculoskeletal system in a child with cerebral palsy as a linked system of interactive processes and subsystems, extending from individual molecules to the child and their environment. The concepts discussed regarding clinical knowledge, evidence, causation, and complex adaptive systems are relevant to the clinician, child, and family, and the possibility of new models and new therapeutic approaches offer exciting future opportunities to improve the child's interaction with, and experience of, the world of which they are a part.

Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences A practical guide to the use of basic principles of experimental design and statistical analysis in pharmacology Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences provides clear instructions on applying statistical analysis techniques to pharmacological data. Written by an experimental pharmacologist with decades of experience teaching statistics and designing preclinical experiments, this reader-friendly volume explains the variety of statistical tests that researchers require to analyze data and draw correct conclusions. Detailed, yet accessible, chapters explain how to determine the appropriate statistical tool for a particular type of data, run the statistical test, and analyze and interpret the results. By first introducing basic principles of experimental design and statistical analysis, the author then guides readers through descriptive and inferential statistics, analysis of variance, correlation and regression analysis, general linear modelling, and more. Lastly, throughout the textbook are numerous examples from molecular, cellular, in vitro, and in vivo pharmacology which highlight the importance of rigorous statistical analysis in real-world pharmacological and biomedical research. This textbook also: Describes the rigorous statistical approach needed for publication in scientific journals Covers a wide range of statistical concepts and methods, such as standard normal distribution, data confidence intervals, and post hoc and a priori analysis Discusses practical aspects of data collection, identification, and presentation Features images of the output from common statistical packages, including GraphPad Prism, Invivo Stat, MiniTab and SPSS Experimental Design and Statistical Analysis for Pharmacology and the Biomedical Sciences is an invaluable reference and guide for undergraduate and graduate students, post-doctoral researchers, and lecturers in pharmacology and allied subjects in the life sciences.

This book contains 300 multiple choice questions and is equivalent to five full MRCGP examinations. However, the layout is not as five examinations, but in the 15 subjects which have been chosen as relevant to general practice by the MCQ group of the Royal College of General Practitioners Examiners. I hope that using this format of individual sections will enable the book to have a wider use than just as a crammer for the exam: it should also serve as an aid to trainers and course organisers in assessing trainees during their vocational training. The questions themselves are in the usual multiple choice style with a stem followed by five responses, which can be answered true, false or don't know. The usual scoring method for examinations is ] 1 for a true, -1 for a false and 0 for a don't know. In keeping with the current thinking of the College MCQ group, the stems have been kept as short as possible and an attempt has been made to adhere to standard nomenclature.

The cervical spine is always examined initially using standard radiographs, which often provide a sufficient basis for diagno- sis. Malformations, tumours, more frequently trauma, rheuma- tism, and even plain neck pain require a radiological exam- ination. The interpretation of radiological images is often difficult because of overlapping pieces of bone, the summation phe- nomena and the diversity of projections. In this book, two- or three-dimensional CTscans accompany the standard radiographs, serving as an excellent aid for com- prehension. It is almost as if the reader actually had the bones shown in the radiographs in his hands. From then on, everything becomes easy, superimpositions vanish, traps come to light, anatomy triumphs, and the images takes on life. Besanl$on, 1990 J .-F. BONNEVILLE, F. CATTIN v Contents Introduction 1 Iconography and Text with Corresponding Schemes 2 Subject Index ...123 VII Normal cervical spine: 3-D imaging 1 1 2 Case 1 1 Our starting point is a normal lateral radiograph of the cervical spine. It will serve as a guide and point of reference in our task of comprehending the interrelationships between the structures of the cervical spine. This radiograph correctly includes the entire area from the base of the skull to the cervicothora- cic junction. The soft tissues are clearly visible anteriorly, as are the extremities of the spinous processes posteriorly. In this case, with the subject looking straight ahead, is a slight, regular, physiological lordosis ofthe cervical column.

"More MRCP Part 1" provides five further mock MRCP type examination papers for quick self-assessment. It contains another collection of multiple choice questions used in the Bloomsbury MRCP Part 1 course and supplements the previously published volume: "Johnson/Pozniak, MRCP Part 1." Any candidate preparing for such examinations will find valuable guidelines as to the strengths and weaknesses of his knowledge.

A comprehensive resource on the recent developments of stem cell use in wound healing With contributions from experts in the field, Wound Healing offers a thorough review of the most recent findings on the use of stem cells to heal wounds. This important resource covers both the basic and translational aspects of the field. The contributors reveal the great progress that has been made in recent years and explore a wide range of topics from an overview of the stem cell process in wound repair to inflammation and cancer. They offer a better understanding of the identities of skin stem cells as well as the signals that govern their behavior that contributes to the development of improved therapies for scarring and poorly healing wounds. Comprehensive in scope, this authoritative resource covers a wealth of topics such as: an overview of stem cell regeneration and repair, wound healing and cutaneous wound healing, the role of bone marrow derived stems cells, inflammation in wound repair, role and function of inflammation in wound repair, and much more. This vital resource: Provides a comprehensive overview of stem cell use in wound healing, including both the basic and translational aspects of the field Covers recent developments and emerging subtopics within the field Offers an invaluable resource to clinical and basic researchers who are interested in wound healing, stem cells, and regenerative medicine Contains contributions from leading experts in the field of wound healing and care Wound Healing offers clinical researchers and academics a much-needed resource written by noted experts in the field that explores the role of stem cells in the repair and restoration of healing wounds.

This volume provides an interdisciplinary approach to this central research topic. Firstly, the hippocampus is presented generally as a model for experiments on neurotransmission in the central nervous system; secondly, special features of synaptic organisation and synaptic transmission in this area of the brain are introduced. Of particular note is the wide-ranging methodological approach which includes light and electron microscopy, immunocytochemistry, Golgi/EM techniques, intracellular differentiation and intracellular colorings, histochemistry of transmitter enzymes and receptoraudiography. The reader thereby gains insight into the broad scope of methodological possibilities for the examination of such a complex problem as neurotransmission in the hippocampus.

The Fifth International Symposium on Human Purine and Pyrimidine Metabolism was held in San Diego, California (U. S. A. ) in July and August of 1985. Previous meetings in this series were held in Tel Aviv (Israel), Baden (Austria), Madrid (Spain) and Maastricht (The Netherlands). The proceedings of each of these meetings were published by Plenum. The next meeting will be in Japan. This Symposium differed from those that went before in that it per mitted us to honor Dr. J. E. Seegmiller, Professor of Medicine at the University of California San Diego, for his many contributions to our understanding of purine metabolism in man. This publication is dedicated as a Festschrift to Jay. Dr. Richard W. E. Watts delivered the keynote address outlining in scholarly fashion the history of Dr. Seegmiller's accomplishments in research on purine metabolism and the great number of currently active scientists in this field who have worked with him. This address is published as the first contribution to Volume I. Dr. Dewitt Stetten, Jr., was scheduled to be the speaker at our banquet. Unfortunate ly, he could not be with us. Dr. Seegmiller has written an appreciation of Dr. Stetten and his contributions to our field, and this has been pub lished following Dr. Watts' paper. The growth of knowledge in purine and pyrimidine metabolism continues to be exponential. The variety of subjects included in these volumes is impressive."

Among the more frequently quoted epidemiological facts in current public health discussions are: (a) the elderly today represent about 10% of the population of the industrialized world; (b) the third world nations are moving in the same direction; (c) the trend toward a growing proportion of the aged in the world population will continue over the next few decades; (d) people over 80 now represent the fa. stest growing sector in North America; (e) in the elderly, general morbidity - and particularly morbidity of the central nervous syste- is many times that in the younger popUlation; (f) 5% of those over 65 years of age and 20% of those over 80 suffer from some degree of dementia. A global tidal wave of patients suf fering from Alzheimer's disease (or senile dementia) is threat ening to engulf us by the year 2000. This disease, which is, at our present state of knowledge, ir reversible, and other age-related dementias are perhaps the most sinister forms of any disability. They deprive their vic tims not only of their physical capacities but also of their autonomy and their ability to think and to make decisions for themselves. The future cost of psychogeriatric diseases in terms of suffering for individuals, stress for families, demand for manpower, and budgetary requirements for governments could become astronomical."

Point of care ultrasound is a critical tool required for assessing all patients, providing rapid answers to clinical questions and facilitating high quality care for patients. This essential guide caters for all generalist clinicians beginning their ultrasound journey and extends to more advanced assessments for those with established ultrasound experience wishing to advance their knowledge and skills. It covers a wide range of ultrasound topics from echocardiography, thoracic and COVID-19 to emerging areas such as palliative care, hospital at home and remote and austere medicine. An extensive collection of colour images, videos and examples of clinical applications will inspire readers to acquire the skills of point of care ultrasound quickly, safely and systematically. The printed code on the inside of the cover provides access to an online version on Cambridge Core. An essential aid for acute clinicians, paramedics, general practitioners as well as remote medical providers, medical educators and students.

"The Elderly" is the third monograph in a series on management and treatment in major patient groups and subspecialties. Each book is complete in its own right. The whole series, however, has fill a gap between standard text-books of medicine been prepared to and therapeutics and research reviews, symposia and original arti cles in specialist fields. The aim of the series is to present up-to-date authoritative advice on patient management with particular refer ence to drug treatment. The first two volumes in the series, on gastrointestinal diseases and rheumatic diseases, were addressed to major therapeutic areas or subspecialties. The present volume, "The Elderly," is intended to provide overall guidance on the manage ment of a range of medical problems in elderly patients. The elderly make up an increasing proportion of the population and require a substantial proportion of health care resources. The management of elderly patients falls not only upon specialist geriatricians but also upon a range of others, including general practitioners, general physicians and almost all other medical specialists with the excep tion of paediatricians. It has become apparent in recent years that the management of disease in the elderly in general and drug treatment in particular presents new problems and challenges. Some of these relate to the wide spectrum of disease in elderly patients, in whom there is often multiple pathology, while others concern age-induced changes in drug handling or drug effect."

This issue of Medical Clinics, guest edited by Drs. Jeffrey H. Samet, Patrick G. O'Connor, and Michael D. Stein, is devoted to Substance Use and Addiction Medicine. Articles in this outstanding issue include: Making Unhealthy Substance Use a Part of Behavioral Health Integration in Primary Care; The Inpatient Addiction Consult Medical Service: Expertise for Hospitalized Patients with Complex Addiction Problems; The Addiction Physician Workforce: Addiction Psychiatry and Addiction Medicine Collaboration in a New Age; Preventing Opioid Overdose in the Clinic and Hospital: Analgesia and Opioid Antagonists; The Role of Non-Traditional Maintenance Treatments: Injectable Opioid Agonist Therapies and Managed Alcohol Programs; Office-Based Addiction Treatment (OBAT) in Primary Care: Models that Work; Alcohol Use Disorder Pharmacotherapy: the Use of FDA and non-FDA Approved Medications; When and How to Treat Possible Cannabis Use Disorder; Clinical Presentations of New Drugs with Abuse Potential; Use of Technology in Addiction Therapy; Sleep Management Among Patients with Substance Use Disorders; Pain Management Among Patients with Substance Use Disorders; E-Cigarettes: A Path to Recovery or a Road to Hell?; Are Adolescent and Young Adults Different When Addressing Substance Use Disorders?; and Smoking Cessation for Those in Recovery from Substance Use Disorders.

Remarkable developments in the field of transplantation have created opportunities to address the formidable challenges of transplantation across histocompatibility barriers, stem cell expansion, and prevention of complications and generation of graft-vs-tumor activity to eradicate residual disease. Stem Cell Transplantation for Hematologic and Other Disorders, Second Edition provides a glimpse into potential future applications of bone marrow derived stem cells in the field of cardiac repair. The updated chapters introduce the biologic underpinnings of hematopoietic cell transplantation, basic stem cell biology, immunobiology, and histocompatibility, with emphasis on indications and results of transplantation for specific diseases. Written by experts in the field, Stem Cell Transplantation for Hematologic Disorders, Second Edition provides seasoned professionals with a complete understanding of the current state of transplantation biology as well as a clear vision into the future.

Drugs may cause disease, or they may aggravate the morbidity of the condition for which they are prescribed, and certain patients may for one or other reason be particularly liable to drug injury. The inextricable relationships between the toxic profiles of drugs, the natural history of the diseases for which they are given, and the adverse drug effects that may develop in the course of such diseases are of considerable interest. It is the study of these rather neglected aspects of pharmacology and therapeutics which has formed the basis of this book. An explanation is required of the approach and the style which have been followed. The monograph does not purport to be comprehensive. Only important drug groups which are commonly used in practice are considered. Emphasis has been placed on achieving maximum benefit and safety of the appropriate drugs in the management of common illnesses. When treatment fails, either ab initio or subsequent to an initial response, the risk-benefit relationship of drugs inevitably alters. For this reason the main factors responsible for treatment failure have been considered, with special attention to the possible contribution of or implications for drug therapy in such a situation. Finally, proposals have been put forward for improving the diagnosis and reporting of adverse drug effects. In order to be practical and, as far as possible, constructive it has been necessary for me to "take a position" on numerous issues.