This book discusses glycobiology and various forms of human diseases. Topics covered include immunoglobulins, inflammation and glycosylation, the role and therapeutic significance of natural anti-glycan antibodies in malignancies and in normal and aberrant pregnancy, identifying urinary glycans as a possible method for the diagnosis of lysosomal storage diseases, glycobiology of human milk (biological roles and diseases) and pectins as biological modulators of human physiological reactions. The book includes analysis of comprehensive data and some productive conclusions and perspectives.

This book advocates a new approach to the clinical management of the musculoskeletal system in children with cerebral palsy based on the concept of intervention to a complex adaptive system with the aim of improving the lived experience of the child with cerebral palsy. Provides a critical review of the current understanding and management of musculoskeletal deformity in children with CP, in the context of the available evidence base and models of clinical practice. Transfers current understanding of muscle and bone physiology and impairment, from the realms of research into mainstream clinical thinking Discusses an alternative clinical model of assessment and intervention, focusing on impairment of muscle growth and function Considers the musculoskeletal system in a child with cerebral palsy as a linked system of interactive processes and subsystems, extending from individual molecules to the child and their environment. The concepts discussed regarding clinical knowledge, evidence, causation, and complex adaptive systems are relevant to the clinician, child, and family, and the possibility of new models and new therapeutic approaches offer exciting future opportunities to improve the child's interaction with, and experience of, the world of which they are a part.

Single Best Answer (SBA) examinations are an increasingly popular means of testing medical students and those undertaking postgraduate qualifications in a number of subject areas. Written by a final year medical student, junior doctors and experienced clinicians, 450 Single Best Answers in the Clinical Specialties provides invaluable guidance from authors who understand from personal experience that detailed and accurate explanations are the key to successful revision. The presentation of questions arranged by specialty area as well as the inclusion of a practice exam of random questions, coupled with the clear discussion of how to correct answer was reached and other options ruled out for every question, make this book an excellent learning aid during all stages of clinical studies, and particularly while preparing for medical finals.

A groundbreaking, evidence-based text to the growing field of evolutionary medicine Evidence-Based Evolutionary Medicine offers a comprehensive review of the burgeoning field of evolutionary medicine and explores vital topics such as evolution, ecology, and aging as they relate to mainstream medicine. The text integrates Darwinian principles and evidence-based medicine in order to offer a clear picture of the underlying principles that reflect how and why organisms have evolved on a cellular level. The authors--noted authorities in their respective fields--address evolutionary medicine from a developmental cell-molecular perspective. They explore the first principles of physiology that explain the generation of existing tissues, organs, and organ systems. The text offers an understanding of the overall biology as a vertically integrated whole, from unicellular to multicellular organisms. In addition, it addresses clinical diagnostic and therapeutic approaches, both traditional and cell-homeostatic. This groundbreaking text: - Offers a much-needed, logical, and fundamental approach to biology and medicine - Provides a clear explanation of complex physiology and pathophysiology - Integrates topics like evolution, ecology and aging into mainstream medicine, making them more relevant - Contains the first evidence-based text on evolutionary medicine Written for medical and graduate students in biology, physiology, anatomy, endocrinology, reproductive biology, medicine, pathology, systems biology, this vital resource offers a unique text of both biology as an integrated whole with universal properties; and of medicine seeing the individual as a whole, not an inventory of parts and diseases.

The MRCP examination is constantly changing, reflecting the changing pressures on doctors in training. Whilst the MRCP PACES examination has evolved with the times, the core ethos of it, to act as a benchmark for sound clinical examination, logical diagnostic ability, common sense and most importantly, the development of compassionate and ethical physicians has remained unchanged.Whilst this exam has often struck fear into the hearts of junior doctors, we believe it is an assessment of progression during a physician's training that should be relished as an opportunity to demonstrate these ageless qualities that caring practitioners should possess.This book was born out of the philosophy that all doctors sitting their MRCP PACES already have the knowledge and skill to pass the exam, but just require guidance in the correct logical approach that the Royal College is looking for.The book has, therefore, quite unlike other MRCP PACES books, avoided any attempts at being a definitive text. Rather, it has focused on the key aspects that the authors believe are required to pass the examination, in particular focus on presentation style. Whilst medicine is indeed an ocean, the most commonly examined topics have been selected to reflect the likely scenarios a candidate will face - as the old adage goes - 'common things occur commonly'.In producing this book, extensive feedback was sought from candidates revising for the examination to reflect their needs. The layout therefore involves a methodical approach with a short introduction, similar to that presented in the exam, followed by clinical findings expected to be found. An example of presentation style has then been produced to allow the candidate to rehearse and practice this essential component of the exam.Doctors preparing for the exam have limited time due to busy work schedules. Therefore, summary books are key for candidates sitting the MRP PACES examination.Most PACES candidates fail the exam based on history and communication stations.Therefore, attention has been paid to:

Kleinians is a compelling account of the extraordinary revolution in psychology pioneered by the psychoanalyst Melanie Klein and nine of her colleagues and followers, including Susan Isaacs, Joan Riviere, Wilfred Bion, Frances Tustin and Hanna Segal.

Drawing on her experience as a professor, writer and therapist, Janet Sayers tells the story of this revolution through an account of the personal and public lives of its main architects, their families and patients. The result is a lively mixture of biography, psychoanalytic theory and individual case studies. The author begins with Klein's pioneering extension of Freud's theories to the analysis of very young children. This led to her claim that from birth onwards children internalize figures from their outer world, resulting in an interaction of inner and outer factors which then govern our psychology. Sayers shows how, sometimes with bitter controversy, this radical insight was variously developed, and is still being developed by Klein's followers, thereby enormously enhancing our understanding of the creative and destructive factors shaping our everyday lives.

Kleinians continues the engaging biographical approach of Sayers's previous successful collections, Mothering Psychoanalysis and Freudian Tales, and will be appealing and informative to all those interested in psychology -- to students and specialists (in psychiatry, psychotherapy, counselling and social work), and to general readers alike.

"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings's College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Chirurgische Sofortmassnahmen" by G. H. Willital an established classic in a new edition provides valuable orientation for every surgically active physician. The book covers all diseases and accidents which might make emergency surgical intervention necessary. The surgical procedures for each case are systematically structured and presented in a clear and concise manner for rapid consultation."

The process of discovery of medicinal compounds has evolved over millennia, from Neanderthal man's use of medicinal herbs to the highly-evolved techniques of biotechnology and high-throughput screening used by today's medicinal chemists. "Drug Discovery - A History" reviews the full panoply of discovery of therapeutic compounds in use today.

The book is divided into three parts. The first, the Legacy of the Past, gives an overview of medicinal compounds in society, ranging from the earliest use of medicinal herbs through the ancient civilisations in Mesopotamia, Egypt, Greece, and Rome, concluding with an overview of development of life-saving organic compounds in the 20th century. The second part examines the commonest source of the drug - the natural world. Prototypes from vegetable, animal, and microbial sources are described in separate chapters, as are the medicinal compounds prepared from them. The problem of relying on nature as a source of drug prototypes is confronted. Part Three considers synthetic compounds that have served as drug prototypes, the role of serendipity in providing these synthetic prototypes, and a review of compounds derived from them.

"Drug Discovery - A History" is essential reading for medicinal chemists, pharmacologists, organic chemists, physicians, researchers and anyone with an interest in the development of therapeutic drugs.

Ntoumanis and Myers have done sport and exercise science researchers and students a tremendous service in producing An Introduction to Intermediate and Advanced Statistical Analyses for Sport and Exercise Scientists. This book has an outstanding compilation of comprehensible chapters dealing with the important concepts and technical minutia of the statistical analyses that sport and exercise science scholars use (or should be using!) in their efforts to conduct meaningful research in the field. It is a resource that all sport and exercise scientists and their students should have on their book shelves. Robert Eklund, School of Sport, University of Stirling, UK Motivating, to have a statistics text devoted to enabling researchers studying sport and exercise science to apply the most sophisticated analytical techniques to their data. Authors hit the mark between using technical language as necessary and user-friendly terms or translations to keep users encouraged. Text covers traditional and well-used tools but also less common and more complex tools, but always with familiar examples to make their explanations come alive. As a dynamic systems theorist and developmentalist, I would love to see more researchers in my area create study designs that would enable the use of tools outlined here, such as multilevel structural equation modeling (MSEM) or mediation & moderation analyses, to uncover cascades of relations among subsystems contributing to motor performance, over time. This text can facilitate that outcome. Beverly D. Ulrich, School of Kinesiology, University of Michigan, USA The domain of quantitative methods is constantly evolving and expanding. This means that there is tremendous pressure on researchers to stay current, both in terms of best practices and improvements in more traditional methods as well as increasingly complex new methods. With this volume Ntoumanis and Myers present a nice cross-section of both, helping sport and exercise science researchers to address old questions in better ways, and, even more excitingly, to address new questions entirely. I have no doubt that this volume will quickly become a lovingly dog-eared companion for students and researchers, helping them to continue to move the field forward. Gregory R. Hancock, University of Maryland and Center for Integrated Latent Variable Research (CILVR), USA

Simulated Patient Methodology is a timely book, aimed at health professional educators and Simulated Patient (SP) practitioners. It connects theory and evidence with practice to ensure maximum benefit for those involved in SP programmes, in order to inform practice and promote innovation. The book provides a unique, contemporary, global overview of SP practice, for all health sciences educators. Simulated Patient Methodology: Provides a cross-disciplinary overview of the field Considers practical issues such as recruiting and training simulated patients, and the financial planning of SP programmes Features case studies, illustrating theory in practice, drawn from across health professions and countries, to ensure relevance to localised contexts Written by world leaders in the field, this invaluable resource summarises the theoretical and practical basis of all human-based simulation methodologies.

Biological safety is a critical requirement when working with or around infectious disease agents. To prevent exposures and keep staff and patients safe, laboratories and health care facilities rely on personal protective equipment, standard operating procedures (SOPs), and engineering controls. In an instant, however, a single inappropriate human behavior can negate any of these safeguards. This reference provides an important call to action for anyone who relies on safety plans to consider carefully the humans who must follow those plans. Written by an expert in behavioral biosafety training, Prepare and Protect offers a common-sense program for addressing and reducing the risk factors of human behavior. Learn how to Examine the safety culture of your organization and its approach to risk Motivate the compliance, adherence to rules, and community thinking that keep everyone safe Evaluate, validate, and verify SOPs and staff competence Create safety plans and safety training programs that connect outcomes to behaviors Provide leadership that translates the containment philosophy from words to actions The critical message of this book is illustrated and enriched by personal accounts from infectious disease pioneers, from lab safety directors and trainers to the researchers and health care workers directly affected by infectious hazards. If your work involves pathogenic microbes-whether treating patients in a hospital emergency department or conducting research in a biosafety level 2 or higher laboratory-or overseeing those who do these jobs, this resource will teach you how to develop a culture of biosafety through behavior.

Now in its fifth edition, this classic introduction to the practice and teaching of evidence-based medicine is written for busy clinicians at any stage of their career who want to learn how to practise and teach evidence-based medicine (EBM). It is short and practical, emphasizing direct clinical application of EBM and tactics to practise and teach EBM in real-time. The online toolkit includes Critical appraisal worksheets, Educational prescription, Pocket Cards, EBM calculators, Educational Prescriptions, Clinical Questions log, Self evaluations. Thoroughly updated with examples from latest evidence/studies. Revised electronic ancillaries, now available online Expanded coverage of audit and measuring quality improvement. Teaching moments now indexed for easy reference. New contributing authors Reena Pattani and Areti Angeliki Veroniki

Step by Step to Proficiency in Diagnostic Ultrasound This workbook is divided into lessons that guide you—like an instructor in an ultrasound course—systematically through the individual organ systems and body regions. Key features of the fourth edition: Special multiple-exposure photos demonstrate the dynamics of handling the transducer Triplet-image units vividly illustrate transducer positioning, the ultrasound image, and relevant anatomy Reference numbers on the accompanying diagrams help you to both actively develop your knowledge and to test it at any time. The legend located on the back cover flap is the key to the reference numbers that are used consistently in each diagram. Quiz images at the end of each chapter are the perfect tool for rigorous self-evaluation Physical fundamentals are presented in vibrant, illustrative diagrams Numerous practical tips and tricks make it easy to familiarize yourself with ultrasound A primer on ultrasound interpretation explains specialized terminology concisely and clearly Precise descriptions of algorithms for transducer positioning facilitate real-time examinations Videos (online access) showing relevant ultrasound anatomy, optimal transducer positioning, and the images you will see on the monitor during examination let you experience the content live—a perfect complement to the book that will greatly improve your retention of the material. This book includes complimentary access to a digital copy on https://medone.thieme.com.

Across all cultures parenting is the foundation of family life. It is the domain where adult mental health meets infant development. Beginning in pregnancy, parenting involves many conscious and unconscious processes which have recently been shown to affect a child's development significantly. This book focuses on pregnancy and the first year of life, providing a thorough account of the points of encounter between adult and infant psychiatry. In a fresh and comprehensive way, it summarises knowledge about early parenting, including a critical analysis of parenting, what it means to be a "good enough parent," and its relationship to infant, parent and family outcomes. In addition to the psychiatric dimension, the book emphasises the biological aspects of parenting, parental psychopathology and normal and abnormal infant development.

Praise for "Parenting and Mental Health"

"""Tyano, Keren, Herrman and Cox have edited a thoughtfully prepared guide on normal and abnormal parenting. They have, with enormous skill and wisdom, helped to unite the important aspects of pregnancy, infant and childhood development and parenting for adult and child and adolescent psychiatrists. World-class internationally recognized clinicians and researchers help make this book useful throughout the world. This is a masterful, culturally sensitive and important book which provides a long overdue and much needed guide on relationships among children, parents and families."
--"Michelle Riba, M.D., M.S., " Professor and Associate Chair for Integrated Medical and Psychiatric Services, Department of Psychiatry, University of Michigan, USA

"During recent decades, progress in the field of infant mental health has been revolutionary; at the same time, there has been rapid development in women's mental health. By bringing these two together, this pioneering book leads its readers to the vital new focal point around perinatal mental health. The book integrates the origins of developmental psychiatry in attachment and systemic contexts and shows concretely how relationship experiences and biology interact when new life begins.

After describing the fascinating world of early parenting, the book focuses on problems, difficulties and disorders during this phase of life and above all on how to support, intervene and treat disorders in parenting. When infants, mothers and fathers are understood in a holistic way, professionals in many fields will be able to promote the transmission of meaningful life through parenthood and parenting."
--"Tuula Tamminen," Professor of Child Psychiatry, University of Tampere, Finland; Past-President of World Association for Infant Mental Health, President of European Society for Child and Adolescent Psychiatry

Cover design by Reouth Keren

"MRCP Part 1 Self-Assessment" is the perfect revision aid. Drawn from the highly successful Medical Masterclass material from the Royal College of Physicians of London, this concise volume is specifically designed to cover the topics and format found in the Membership to the Royal College of Physicians (MRCP) Part 1 examination. The large scale, lavishly illustrated, full-colour format makes it easy to comprehend complex topics. With contributions from an extensive list of prestigious and authoritative professionals, the questions cover all areas of assessment, including the scientific background the medicine, general clinical skills, acute medicine and a range of specialties. It is ideal for examination MRCP candidates, doctors preparing for the European Diploma in internal medicine and junior doctors wanting to revise their knowledge and skills.'This collection of self-assessment questions and explanatory answers has been drawn from Medical Masterclass, which is produced and published by the Royal College of Physicians of London. The questions have been specifically written to help doctors in their first few years of training to test and revise their medical knowledge and skills; and in particular to pass postgraduate examinations, such as the MRCP(UK)' - John D Firth, in the Introduction.

Make the most of every patient encounter - from the clinical interview and history to the physical exam, both in-office and bedside. This discreet quick reference by Ilene L. Rosenberg, MD, FCCP, Todd Cassese, MD, FACP, and Dennis Barbon, RN, helps you achieve consistent and comprehensive results when collecting data and determining your next steps. Carry this thin, fully illustrated checklist in your white coat pocket for the fastest, most efficient way to access essential information you need to know and remember every day. Point-of-care reminders in the office or on the wards - immediately see what to ask, what exams to perform, what to look for, and more. Fully illustrated memory triggers throughout. Each topic is contained on one page or two facing pages for at-a-glance reference. An excellent everyday pocket reference as well as a handy review for Step 2 CS (Clinical Skills) and OSCEs (Objective Structured Clinical Exams). Written by educators who know first-hand what needs to be reviewed and remembered during the clinical patient encounter.

Jede medizinische Fachrichtung benoetigt labormedizinische Diagnostik. Neben bildgebenden Verfahren ist sie die wichtigste Hilfsdisziplin im medizinischen Alltag. Die Anzahl der Daten und Befunde steigt rapide an. Ursachen hierfur sind die Automatisierung und die Einfuhrung neuer Methoden. Anhand von Fallbeispielen werden Laborbefunde interpretiert und die Aussagekraft einzelner Werte erlautert. Raschen UEberblick ermoeglicht die Gliederung der klinischen Fragestellungen je nach Fachrichtung. Eine praktische Einfuhrung fur Studenten und AErzte in Ausbildung sowie fur Personen, die im medizinisch-diagnostischen Bereich tatig sind.

Winner of the Medical Journalists' Association Specialist Book of the Year Award 2006 Cynical Acumen approaches medicine in the real world, dealing with issues ignored by other books. It is a unique, 'what you really need to know' textbook designed to help medical students and senior house officers look slick and pass their exams against all odds. The book entertainingly considers the world outside medicine with anecdotes on the important things in life such as sport, literature, Thai cooking and the dissolution of the monasteries. It has been aptly described by the author as 'The Hitchhiker's Guide to Medicine'. Medical students will find this underground resource invaluable, as will medical professionals including junior hospital doctors, particularly those sitting the MRCP examination.

Cancer Prevention and Screening offers physicians and all clinical healthcare professionals a comprehensive, useful source of the latest information on cancer screening and prevention with both a global and a multidisciplinary perspective. * Includes background information on epidemiology, cancer prevention, and cancer screening, for quick reference * Offers the latest information for clinical application of the most recent techniques in prevention and screening of all major and many lesser cancer types * Emphasises the importance of multidisciplinary teamwork in cancer screening * Highlights frequent dilemmas and difficulties encountered during cancer screening * Provides clear-cut clinical strategies for optimal patient education, communication, and compliance with cancer prevention techniques

With detailed contributions from 45 renowned international authorities, this Third Edition stands alone as the most comprehensive, contemporary view of the biology, physiology, and management of acute coronary syndromes (ACS)-offering 32 chapters that span the state-of-the science in the field and provide intriguing discussions on CRP and other disease markers, microcirculation, stem cell therapy, and the development of specialized centers for ACS treatment.

Focusing on the essential information you need to know for the most commonly encountered problems in outpatient internal medicine, this practical volume in the Washington Manual® series provides concise, high-yield content that reflects today’s advances in patient evaluation and management. In one convenient, portable resource, you’ll find complete coverage of everything from hypertension and diabetes to sleep disorders, nutrition, and care of the cancer patient—all at your fingertips for quick review and reference. Edited by Drs. Maureen D. Lyons, Peter J. McDonnell, and Jennifer M. Schmidt, The Washington Manual® of Outpatient Internal Medicine, 3rd Edition, is an excellent companion to the Washington Manual® of Medical Therapeutics, which thoroughly covers inpatient care.   Covers common ambulatory/outpatient problems encountered in each medical subspecialty, all in the famous fast-access Washington Manual® outline format that includes easy-to-follow guidelines, diagrams, and algorithms. Thoroughly revised from cover to cover, including new content on telehealth, the trauma-informed approach, immunization reaction and allergy, functional assessment and safe prescribing for pain, breast masses, sexually transmitted infections, and more. Includes a new, full-color insert of dermatologic images to illustrate skin diagnoses and rashes. Addresses all areas of medicine and core subspecialties, including neurology and toxicology. Provides need-to-know diagnostic and therapeutic guidance from the outstanding house staff and faculty at Washington University School of Medicine in St. Louis. The Washington Manual® is a registered mark belonging to Washington University in St. Louis to which international legal protection applies. The mark is used in this publication by Wolters Kluwer Health under license from Washington University.   Enrich Your eBook Reading Experience Read directly on your preferred device(s),such as computer, tablet, or smartphone. Easily convert to audiobook,powering your content with natural language text-to-speech.

Dieses Fachbuch dient als Anleitung zur Befundung eines Thorax-Rontgenbildes und liefert zudem Informationen zum neuesten Stand der Diagnostik. Es ist das einzige Werk, in dem der Weg zur Diagnose von Thoraxerkrankungen systematisch erklart wird und die Beschreibung anhand einheitlicher Terminologie erfolgt. Behandelt werden die haufigsten rontgen-relevanten Erkrankungen der Thoraxorgane. Mit ausfuhrlichen Erklarungen, Tabellen und Abbildungen wird das exakte Procedere schrittweise erlautert. Beginnend mit den anamnestischen Daten, schliesst sich daran eine klare Beschreibung nach einheitlicher Terminologie an. Kurzkommentare erortern alle Merkmale kritisch und begrunden die mutmassliche Diagnose. Hierbei werden insbesondere auch andere Moglichkeiten und differentialdiagnostische Gesichtspunkte ausfuhrlich diskutiert.Reprasentative Rontgenbilder in einheitlichem und grosszugigem Format und klare Schilderung der wichtigsten klinischen Merkmale der Erkrankungen helfen bei der Interpretation. Insbesondere wird gezeigt, wie ein korrekter Befundbericht abfasst und eine allgemeinverstandliche Diagnose formuliert wird. Grundlage ist eine einheitliche Terminologie und standardisierte Systematik - das DDS-System(r) - mit dem die richtige Diagnose erstellt werden kann."