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Drugs and Aging (Paperback, Softcover reprint of the original 1st ed. 1986)
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Drugs and Aging (Paperback, Softcover reprint of the original 1st ed. 1986)
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Experimental gerontological research is necessary to obtain optimal
information and thus ensure proper drug therapy for the elderly.
Most older persons acquire multiple diseases, first of all chronic
diseases. They involve complex problems of a physical, social, and
psychological nature. The multimorbidity of the elderly raises many
questions in drug therapy. By contrast with our extensive knowledge
of pharmacokinetics and pharmacodynamics in younger age groups, few
facts are available in respect of the elderly. A variety of factors
may influence drug therapy. Physiological and pathological
age-related changes of molecules, cells, organs, and the total
organism may interact to enhance or inhibit drug therapy in higher
age groups. It is well known that elderly patients are
overmedicated and therefore the incidence of adverse drug reactions
increases with age. Elderly patients with multimorbidity often have
a diminished body clearance of drugs; age-related changes of the
kidney seems to be one of the most important factors in this
regard. Far less important than the elimination of drugs through
the kidney is their excretion in the bile. So far results have
disclosed that oxidative steps in drug clearance are more likely to
be disturbed than phase II reactions. Furthermore; changes in
distribution volume and age-related alterations in receptor
sensitivity also influence the clearance of drugs in the elderly.
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