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Basic Biostatistics for Medical and Biomedical Practitioners, Second Edition makes it easier to plan experiments, with an emphasis on sample size. It also shows what choices are available when simple tests are unsuitable and offers investigators an overview of how the kinds of complex tests that they won't do on their own work. The second edition presents a new, revised and enhanced version of the chapters, taking into consideration new developments and tools available, discussing topics, such as the basic aspects of statistics, continuous distributions, hypothesis testing, discrete distributions, probability in epidemiology and medical diagnosis, comparing means, regression and correlation. This book is a valuable source for students and researchers looking to expand or refresh their understanding of statistics as it applies to the biomedical and research fields. Based on the author's 40+ years of teaching statistics to medical fellows and biomedical researchers across a wide range of fields, it is a valuable source for researchers who need to understand more about biostatistics to apply it to their work.
The purpose of this book is to summarize key strategies and recent accomplishments in the area of developing cell/biomaterial constructs for regenerative medicine. The first section is a review of the state-of-the-art of biomaterial carriers and is divided into synthetic and natural materials. A subset of the latter are decellularized organs which retain the structure and some of the biological activities of the target organ. The bulk of the book is devoted to unique problems associated with key tissue and organ targets. Key selling features: Describes developing cell/biomaterial constructs for regenerative medicine Reviews state-of-the-art of biomaterial carriers Summarizes the unique problems associated with key tissue and organ targets Discusses issues associated with clinical translation including quality control, manufacturing practices, nondestructive imaging, and animal models
This authored monograph presents key aspects of signal processing analysis in the biomedical arena. Unlike wireless communication systems, biological entities produce signals with underlying nonlinear, chaotic nature that elude classification using the standard signal processing techniques, which have been developed over the past several decades for dealing primarily with standard communication systems. This book separates what is random from that which appears to be random and yet is truly deterministic with random appearance. At its core, this work gives the reader a perspective on biomedical signals and the means to classify and process such signals. In particular, a review of random processes along with means to assess the behavior of random signals is also provided. The book also includes a general discussion of biological signals in order to demonstrate the inefficacy of the well-known techniques to correctly extract meaningful information from such signals. Finally, a thorough discussion of recently proposed signal processing tools and methods for addressing biological signals is included. The target audience primarily comprises researchers and expert practitioners but the book may also be beneficial for graduate students.
This volume presents the proceedings of the first European Biomedical Engineering Conference for Young Investigators ENCY2015. It was in Budapest, from 28th to 30th May, 2015. The papers were assembled under the motto "Understanding complex living systems" and cover the topics sensors, image processing, bioinformatics, biomechanics, and modeling.
This book offers examples of how data science, big data, analytics, and cloud technology can be used in healthcare to significantly improve a hospital's IT Energy Efficiency along with information on the best ways to improve energy efficiency for healthcare in a cost effective manner. The book builds on the work done in other sectors (mainly data centers) in effectively measuring and improving IT energy efficiency and includes case studies illustrating power and cooling requirements within Green Healthcare. Making Healthcare Green will appeal to professionals and researchers working in the areas of analytics and energy efficiency within the healthcare fields.
At the cross-roads of biology, microfluidics and photonics the field of optofluidics allows for quick and compact solutions for medical and biochemical sensing and manipulation. This book is concerned with the ingredients for a polymer-based platform which is able to culture and pattern life cells for a sufficient period of time, enables the integration of photonic devices, and provides means to integrate electronic readout. Thus - in its cross-discipline approach - it touches on aspects of photonics, nanofabrication, and biological methods alike.
The book set develops a bridge between physiologic mechanisms and diagnostic human engineering. While the first volume is focused on the interface between physiologic mechanisms and the resultant biosignals, this second volume is devoted to the interface between biosignals and biomedical sensors. That is, in the first volume, the physiologic mechanisms determining biosignals are described from the basic cellular level up to their advanced mutual coordination level. This second volume, considers the genesis of acoustic and optic biosignals and the associated sensing technology from a strategic point of view. As a novelty, this book discusses heterogeneous biosignals within a common frame. This frame comprises both the biosignal formation path from the biosignal source at the physiological level to biosignal propagation in the body, and the biosignal sensing path from the biosignal transmission in the sensor applied on the body up to its conversion to a, usually electric, signal. Some biosignals arise in the course of the body's vital functions while others map these functions that convey physiological data to an observer. It is highly instructive how sound and light beams interact with biological tissues, yielding acoustic and optic biosignals, respectively. Discussed phenomena teach a lot about the physics of sound and physics of light (as engineering sciences), and, on the other hand, biology and physiology (as live sciences). The highly interdisciplinary nature of biosignals and biomedical sensors is obviously a challenge. However, it is a rewarding challenge after it has been coped with in a strategic way, as offered here. The book is intended to have the presence to answer intriguing "Aha!" questions.
Teledentistry is of growing interest to the healthcare world. Over the last few years, momentum is growing in research and service in Teledentistry - mostly carried out by tertiary medical institutes across the world. While Teledentistry is advanced in some sub-specialties, it has high potential to receive more attention from general communities, dentists, dental hygienists, physicians, nurses, researchers and students. For the first time, this book will present essential knowledge from experts in this field. They will discuss the current status of technology and service in various Telledentistry sub specialties and its future implications. Written by experts from around the globe, (i.e., from USA, Europe, Australia and Asia), this book presents technical issues and clinical applications. It includes collective experiences from dental service providers in different parts of the world practicing a wide range of Teledentistry applications. This book lays the foundations for the globalization of Teledentistry procedures, making it possible for dental service to be delivered anywhere in the world.
This Brief highlights Informatics and related techniques to Computer Science Professionals, Engineers, Medical Doctors, Bioinformatics researchers and other interdisciplinary researchers. Chapters include the Bioinformatics of Diabetes and several computational algorithms and statistical analysis approach to effectively study the disorders and possible causes along with medical applications.
Most current applications of biomaterials involve structural functions, even in those organs and systems that are not primarily structural in their nature, or very simple chemical or electrical functions. Complex chemical functions, such as those of the liver, and complex electrical or electrochemical functions, such as those of the brain and sense organs, cannot be carried out by biomaterials at this time. With these basic concepts in mind, Biomaterials: Principles and Practices focuses on biomaterials consisting of different materials such as metallic, ceramic, polymeric, and composite. It highlights the impact of recent advances in the area of nano- and microtechnology on biomaterial design. Discusses the biocompatibility of metallic implants and corrosion in an in vivo environment Provides a general overview of the relatively bioinert, bioactive or surface-reactive ceramics, and biodegradable or resorbable bioceramics Reviews the basic chemical and physical properties of synthetic polymers, the sterilization of the polymeric biomaterials, the importance of the surface treatment for improving biocompatibility, and the application of the chemogradient surface for the study on cell-to-polymer interactions Covers the fundamentals of composite materials and their applications in biomaterials Highlights commercially significant and successful biomedical biodegradable polymers Examines failure modes of different types of implants based on material, location, and function in the body The book discusses the role of biomaterials as governed by the interaction between the material and the body, specifically, the effect of the body environment on the material and the effect of the material on the body.
Rapid progress in health research has led to generation of new knowledge and innovative practices in management of illness. This has resulted in a significant challenge for health professionals: if today we discovered a new therapy through research, when will this discovery be regularly prescribed or utilized to treat all patients suffering from this condition? Knowledge translation is the non-linear and often complicated process of translating knowledge into routine health practices. Technology enabled knowledge translation (TEKT) is the use of information and communication technologies (ICT) to accelerate knowledge translation. With the ubiquity of the internet, the proliferation of different approaches in communication and social networking, and the continuously improving technologies from netbooks to smartphones, there are rich opportunities for TEKT in health education, service delivery, and research.
This book provides a broad overview of the topic Bioinformatics with focus on data, information and knowledge. From data acquisition and storage to visualization, ranging through privacy, regulatory and other practical and theoretical topics, the author touches several fundamental aspects of the innovative interface between Medical and Technology domains that is Biomedical Informatics. Each chapter starts by providing a useful inventory of definitions and commonly used acronyms for each topic and throughout the text, the reader finds several real-world examples, methodologies and ideas that complement the technical and theoretical background. This new edition includes new sections at the end of each chapter, called "future outlook and research avenues," providing pointers to future challenges. At the beginning of each chapter a new section called "key problems", has been added, where the author discusses possible traps and unsolvable or major problems.
New computerized approaches to various problems have become critically important in healthcare. Computer assisted diagnosis has been extended towards a support of the clinical treatment. Mathematical information analysis, computer applications have become standard tools underpinning the current rapid progress with developing Computational Intelligence. A computerized support in the analysis of patient information and implementation of a computer aided diagnosis and treatment systems, increases the objectivity of the analysis and speeds up the response to pathological changes.
This book presents a variety of state-of-the-art information technology and its applications to the networked environment to allow robust computerized approaches to be introduced throughout the healthcare enterprise. Image analysis and its application is the traditional part that deals with the problem of data processing, recognition and classification. Bioinformatics has become a dynamically developed field of computer assisted biological data analysis.
This book is a great reference tool for scientists who deal with problems of designing and implementing processing tools employed in systems that assist the radiologists and biologists in patient data analysis.
Monitoring cardiovascular function is a fundamental check on the
patient's wellbeing in the conscious or unconscious state. Time
honoured methods such as the ECG and blood pressure monitoring have
been joined by recent advanced technological methods that require a
sound understanding on the part of the user. This book is a
comprehensive and authoritative guide to all the methods currently
available. It discusses both basic technology and practical
implementation in the clinical situation. Chapters include:
Each chapter contains an extensive literature search, and the
final chapter covers the general rationale behind medical alarms
and discusses their advantages and disadvantages.
The demand today is for non-invasive monitoring methods wherever possible, for patient comfort and to minimize risk and possible litigation. These non-invasive procedures are therefore becoming the most widely used by hospital doctors, general practitioners, hospital and community nurses and midwives, and by all those working in anaesthesia, intensive care and emergency care. The up-to-date information in this book, amply illustrated with explanatory line diagrams, will provide all required to perform these procedures with a reassuringly complete and clearly described reference.
Over the last few decades, cardiac resynchronization therapy (CRT) has been introduced as a choice treatment for heart failure (HF) patients, refractory to maximal drug therapy and left bundle branch block. Advanced heart failure is related to cardiac fibrosis, hypertrophy and apoptosis, and CRT in 30% of patients is not able to ameliorate cardiac performance and mechanical efficiency. This clear loss of effect (CRT failure) is frustrating and leaves HF patients in a steady and/or advanced, uncontrolled worsening state of clinical symptoms and NYHA class. Several hypotheses have been conducted to explain this loss of effect: investigating epigenetic (microRNAs activation pattern), echocardiography (mechanical cardiac dyssynchrony assessment), arrhythmias (atrial fibrillating patients), left ventricle lead positioning (target wall and vessel) and pacing modalities (bipolar vs multipolar), and epicardial approaches (cardiac surgery) to reach the target ventricular wall. The selection criteria, the implant technique and CRT monitoring are relevant aspects of the CRT world in all its complexity. The necessity to follow and characterize CRT recipients (responders vs non responders), and the routine follow up with recent advancements in technology (telemonitoring) may be an instrument to improve CRT response entity and clinical outcomes. The creation of a social platform (social networks) may represent a necessary and evolutionary step to share individual experiences and to exchange ideas about CRT recipients and experienced operators. The opportunity to improve CRT responders percentage may represent a gold standard and an attractive prospective in failing heart patients CRT recipients. In this book, we have investigated these aspects, hoping to provide to the reader the right reading tools in the CRT world. Our message remains: To help people suffering from cardiovascular diseases and to live better with their disease.
Red blood cells in humans-and most other mammals-have a tendency to form aggregates with a characteristic face-to-face morphology, similar to a stack of coins. Known as rouleaux, these aggregates are a normally occurring phenomenon and have a major impact on blood rheology. What is the underlying mechanism that produces this pattern? Does this really happen in blood circulation? And do these rouleaux formations have a useful function? The first book to offer a comprehensive review of the subject, Red Blood Cell Aggregation tackles these and other questions related to red blood cell (RBC) aggregates. The book covers basic, clinical, and physiological aspects of this important biophysical phenomenon and integrates these areas with concepts in bioengineering. It brings together state-of-the-art research on the determinants, mechanisms, and measurement and effects of RBC aggregation as well as on variations and comparative aspects. After an introductory overview, the book outlines factors and conditions that affect RBC aggregation. It presents the two hypotheses-the bridging model and the depletion model-that provide potential mechanisms for the adhesive forces that lead to the regular packing of the cells in rouleaux formations. The book also reviews the methods used to quantify RBC aggregation in vitro, focusing on their importance in clinical practice. Chapters discuss the effect of RBC aggregation on the in vitro rheology of blood as well as on tube flow. The book also looks at what happens in the circulation when red blood cells aggregate and examines variations due to physiological and pathophysiological challenges. The concluding chapter explores the formation of red blood cell aggregates in other mammals. Written by leading researchers in the field, this is an invaluable resource for basic science, medical, and clinical researchers; graduate students; and clinicians interested in mammalian red blood cells.
The second edition of a bestseller, Design Controls for the Medical Device Industry provides a comprehensive review of the latest design control requirements, as well as proven tools and techniques to ensure your company's design control program evolves in accordance with current industry practice. The text assists in the development of an effective design control program that not only satisfies the US FDA Quality System Regulation (QSR) and ISO 9001 and 13485 standards, but also meets today's third-party auditor/investigator expectations and saves you valuable time and money. The author's continual participation in FDA QSR inspections and Notified Body ISO audits is reflected in updates to all chapters and appendices of the book, now bursting at the seams with: New coverage of ISO 9001 and 13485 design control requirements More real-world examples from the medical device industry Additional detail for greater understanding and clarity Fresh templates for practical implementation Extensive references for further study The book addresses design control elements such as design planning, input, output, review, verification, validation, change, transfer, and history, as well as risk management inclusive of human factors and usability, biocompatibility, the FDA Quality System Inspection Technique (QSIT) for design controls, and medical device regulations and classes in the US, Canada, and Europe.
The three-volume set LNCS 8149, 8150, and 8151 constitutes the refereed proceedings of the 16th International Conference on Medical Image Computing and Computer-Assisted Intervention, MICCAI 2013, held in Nagoya, Japan, in September 2013. Based on rigorous peer reviews, the program committee carefully selected 262 revised papers from 789 submissions for presentation in three volumes. The 81 papers included in the third volume have been organized in the following topical sections: image reconstruction and motion modeling; machine learning in medical image computing; imaging, reconstruction, and enhancement; segmentation; physiological modeling, simulation, and planning; intraoperative guidance and robotics; microscope, optical imaging, and histology; diffusion MRI; brain segmentation and atlases; and functional MRI and neuroscience applications.
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