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Books > Medicine > Clinical & internal medicine > Diseases & disorders > Infectious & contagious diseases
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Human Antibody Therapeutics For Viral Disease (Hardcover, 2008 ed.)
Loot Price: R4,562
Discovery Miles 45 620
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Human Antibody Therapeutics For Viral Disease (Hardcover, 2008 ed.)
Series: Current Topics in Microbiology and Immunology, 317
Expected to ship within 10 - 15 working days
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The articles in this volume have been selected to demonstrate the
progress in the development of human antibody therapeutics for
viral disease. Keck et al. review the nature of the immune response
to the Hepatitis C virus (HCV) and the details of viral
neutralization by antibodies, providing a conceptual model for the
clinical use of HCV-specific antibodies. Huber et al. summarize the
initial clinical experiences with antibody therapeutics for Human
Immunodeficiency Virus that can be targeted to either the HIV
virion or to host cell proteins. A discussion of the breadth immune
strategies that is required to control human rabies is provided by
Nagarajan et al., with a particular focus on India and other
countries in which rabies is endemic. The development of
pavilizumab for RSV prophylaxis is reviewed in Wu et al., in
addition to results of antibody optimization studies that provide
surprising insights and have broad general implications for
anti-viral antibody engineering. Melhop and Diamond explicate the
biology of West Nile Virus as a general model for flaviviruses,
while using their cloned antibodies as a springboard to consider
the mechanisms of WNV neutralization. The volume concludes with a
description of methods to clone human antibodies in their native
configurations, which access a class of antibodies that differ from
those obtained by recombinant DNA or transgenic mouse methods. The
articles in this volume are definitive and comprehensive reviews
written by experts who have sought to define the principles of
viral neutralization by human antibodies. They explore and
anticipate the obstacles and opportunities that will be encountered
as the power of human antibodies is harnessed to address the vast,
un-met need for effective anti-viral therapeutics.
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