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Enzymatic Transformation (Hardcover, 2013 ed.)
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Enzymatic Transformation (Hardcover, 2013 ed.)
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Transformations using enzymes have been extensively investigated in
the last two decades and the results promise great potential for
this growing field, especially in the area of synthetic organic
chemistry mainly due to of its many advantages. Accordingly, this
book has attempted to bring out the advantages of using enzymes
involving complex underivatized and unprotected substrates in
non-polar media under homogenous and heterogeneous reaction
conditions. Merits and demerits of using enzymes in terms of yields
and selectivity/specificity are presented without any prejudice.
Almost all the reactions dealt with are from the author's
laboratory comprising diverse substrates, and the catalysis
involves two important hydrolyzing enzymes, extensively examined
for the reverse reactions. Thus, esterification involving lipses
and glycosylation involving glycosidases were investigated with
respect to various strategies like optimization of reaction
conditions, response surface methodology and kinetics, carrying out
reactions under solvent, non-solvent and super critical carbon
dioxide conditions. In short, the work presented is to ensure the
comprehension of the problems faced by the researchers in this area
so as to work out further efficient strategies for carrying out
enzymatic transformations in the laboratory successfully with
better yields and specificity.
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