Voltage-gated calcium channels are critical regulators of
cytoplasmic levels of calcium, the universal signaling ion. As
such, calcium channels trigger a wide range of cellular functions,
from muscle contraction to neurotransmitter secretion, and are
important players in human disease. Prominent in the nervous,
cardiovascular, and endocrine systems, members of the calcium
channel family are targets for existing antihypertensive and
anticonvulsant drugs. In addition, they are emerging targets for
drugs to treat an extraordinarily diverse group of disorders,
including pain, cerebral ischemia, cardiac arrhythmia, and
migraine. This book reviews the compounds that target individual
calcium channel subtypes and the cellular and behavioral functions
governed by each different channel. It contains information for
basic scientists using calcium channel antagonists as experimental
tools, for behavioralists studying animal models of human disease,
and for pharmaceutical scientists interested in creating the next
generation of calcium channel-targeted drugs. Several factors make
an entire book on calcium channel pharmacology timely.
General
Imprint: |
Kluwer Academic / Plenum Publishers
|
Country of origin: |
United States |
Release date: |
November 2003 |
First published: |
November 2003 |
Editors: |
Stefan I. McDonough
|
Dimensions: |
254 x 178 x 32mm (L x W x T) |
Format: |
Hardcover
|
Pages: |
418 |
Edition: |
2004 ed. |
ISBN-13: |
978-0-306-47878-9 |
Categories: |
Books >
Professional & Technical >
Veterinary science >
General
|
LSN: |
0-306-47878-1 |
Barcode: |
9780306478789 |
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