Thin layer chromatography (TLC) is well suited for performing
enantioseparations for research as well as larger-scale
applications. A fast, inexpensive, and versatile separation
technique, there are many practical considerations that contribute
to its effectiveness. Thin Layer Chromatography in Chiral
Separations and Analysis is the first book to focus solely on the
theory, capabilities, and applications of TLC for direct and
indirect enantioseparations.
The first part of the book examines the fundamental principles
of chirality and TLC. It describes the necessary materials,
laboratory equipment, procedures, and strategies for the
separation, quantification, isolation, and analysis of chiral
compounds. The second part evaluates the real-world
enantioseparations and densitometric analyses. Emphasizing
pharmaceutical applications, the book discusses chiral separation
mechanisms and methods for analyzing the chiral purity of
diastereoisomers, amino acids, beta-blockers, and NSAIDS. Topics
alsoinclude commercial stationary phases and chiral modifiers of
mobile phases.
Thin Layer Chromatography in Chiral Separations and Analysis
presents a unified perspective of theory and experimental details
underlying the collective developments in the field. The book
offers scientists in a variety of disciplines and levels of
expertise a complete guide to understanding the current and
potential applications of chiral TLC.
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