This book examines how an Ethics Review Committee using today's
ethical standards as articulated in The Nuremburg Code, and the
WHO/CIOMS International Ethical Guidelines for Biomedical Research
Involving Human Subjects, might assess the scientific and ethical
design of Edward Jenner's first experimental vaccine experiment. It
explores the potential risks and benefits to young James, the
adequacy of the preliminary evidence that Jenner used to justify
performing his experiment, and how he might have complied with
requirements for informed consent. In addition to its historical
interest for 18th century England and for the origins of today's
biomedical research ethics standards, the book is significant as a
case study in the ethics of basic vaccine research. It thus raises
relevant questions about today's vaccine research, particularly
relating to HIV.
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