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Books > Medicine > Clinical & internal medicine > Renal medicine
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Physiology of Membrane Disorders (Paperback, Softcover reprint of the original 1st ed. 1978)
Loot Price: R1,874
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Physiology of Membrane Disorders (Paperback, Softcover reprint of the original 1st ed. 1978)
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The purpose of this book is to provide the reader with a rational
frame of reference for assessing the pathophysiology of those
disorders in which derangements of membrane transport processes are
a major factor responsible for the clinical manifestations of
disease. In the present context, we use the term "membrane
transport processes" in a catholic sense, to refer to those
molecular processes whose cardinal function, broadly speaking, is
the vectorial transfer of molecules- either individually or as
ensembles-across biological interfaces, the latter includ- ing
those interfaces which separate different intracellular
compartments, the cellu- lar and extracellular compartments, and
secreted fluids-such as glomerular fil- trate-and extracellular
fluids. Evidently, consideration of these processes, and of the
pathophysiology of membrane disorders, requires an understanding of
the composition and structure of biomembranes, of the physical
rules governing mem- brane transport processes, of the way in which
chemical regulators-either physio- logic or pharmacologic-regulate
or modify membrane transport processes, and of the ways in which
these events are interpreted into specialized phenomena such as
cell volume regulation, signal transmission in excitable tissues,
cell-to-cell commu- nication, and secretory processes in epithelia.
Accordingly, Physiology of Membrane Disorders is divided into five
major sections. Part 1, The Nature of Biological Membranes,
provides an overview ofthe physical structure and composition of
plasma membranes, and of the dynamic relations between structure
and function.
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