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Reproductive and Developmental Toxicity of Metals (Paperback, Softcover reprint of the original 1st ed. 1983)
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Reproductive and Developmental Toxicity of Metals (Paperback, Softcover reprint of the original 1st ed. 1983)
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The Permanent Commission and International Association on
Occupational Health (PCIAOH) established in 1969 a Subcommittee on
the Toxicology of Metals under the chairmanship of Lars Friberg.
This committee, which later was named the Scientific Committee on
the Toxicology of Metals, has organized a number of previous
meetings that have led to publications in three major areas of
metal toxicology: a preliminary meeting in Slanchev Bryag, Bulgaria
in- 1971, followed by a meeting in 1972 in Buenos Aires, Argentina
which produced two reports (Dukes and Friberg, 1971; Task Group on
Metal Accumulation, 1973), that discussed the metabolism of metals
with special reference to absorption, excretion and biological
half-times. The effects and dose-response relationships of toxic
metals, including a discussion of general principles, was the
second major topic addressed by the Scientific Committee at a
meeting in Tokyo in 1974 (Nordberg, 1976). The philosophy of this
conference, as well as the previous one in Buenos Aires, was based
on the concept of a "threshold dose" for the occurrence of adverse
effects. In a conference held in Atlanta, USA in 1980, the scope of
discussion on metal effects was broadened to include the role of
metals in carcinogenesis. Thus, for the first time, the Scientific
Committee took under consideration the possibility of non-threshold
relationships (Belman and Nordberg, 1981). In addition, the
Scientific Committee on the Toxicology of Metals organized a
workshop on metal interactions in Stockholm 1977 (Nordberg et al.
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