Nanoparticles have gained much attention as a promising drug
delivery system due to their unique properties. Rosiglitazone
maleate, an antidiabetic agent, acts as a highly selective and
potent agonist for PPAR receptors in target tissues for insulin
action. In spite of its high efficiency, side effects limit the
clinical use. To reduce the side effects of conventional dosage
form, rosiglitazone loaded nanoparticles have been formulated.
Nanoparticles were formulated by gelatin and chitosan via double
desolvation and ionotropic gelation technique respectively, &
subjected to photon correlation spectroscopy, transmission electron
microscopy & encapsulation efficiency studies. These studies
favorably revealed that the mean particle diameter of optimized
formulation was 49 nm (gelatin) and 86 nm (chitosan) with spherical
morphology. The optimized formulation demonstrated favorable in
vitro prolonged release characteristics with zero order, diffusion
and erosion mechanisms. Nanoparticles also showed excellent
stability. Hence, the designed delivery system can be fine tuned on
the depending clinical applications.
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