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Books > Science & Mathematics > Biology, life sciences > Biochemistry > Proteins
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New Methods for the Study of Biomolecular Complexes (Hardcover, 1998 ed.)
Loot Price: R4,643
Discovery Miles 46 430
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New Methods for the Study of Biomolecular Complexes (Hardcover, 1998 ed.)
Series: NATO Science Series C, 510
Expected to ship within 10 - 15 working days
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A NATO Advanced Research Workshop entitled New Methods for the
Study of Molecular Aggregates was held at Tbe Lodge at Kananaskis
Village, Alberta, Canada from 16 -20 June 1996. In fact the meeting
was entirely concerned with the problem of analyzing biomolecular
complexes, so the title of these proceedings has been altered to
give a more precise description of the content. Tbe workshop was
hosted by the time-of-flight group of the Department of Physics at
the University of Manitoba, and was attended by 64 participants
from around the world. '!\venty-one invited talks were given and 27
papers were presented as posters. Of the 48 contributions, 22
papers (12 orals, 10 posters) are included in these proceedings.
Tbe subject of the conference was the investigation of noncovalent
biomolecular complexes, with particular focus on the application of
mass spectrometry to their characterization. '!\vo new ionization
techniques introduced in the late 1980s, electrospray ionization
(ES I) and matrix-assisted laser desorptionlionization (MALDI),
resulted in a breakthrough in mass spectrometry, enabling its use
in molecular weight and primary structure determination of
biopolymers larger than 100 kDa. Recently it has been discovered
that ESI mass spectrometry mayaiso be used to characterize
complexes containing noncovalent interactions, thus opening new
perspectives for supramolecular chemistry. ESI mass spectrometry
has the advantage that the sampie is introduced from a homogenous
solution which can be maintained at near physiological conditions
of pR, concentration, and temperature.
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