This book attempts to explore the contribution that biochemistry
has made, thus far, to our understanding of the endocrine pancreas
and its relationship to diabetes mellitus. It was written with the
aim of using an important clinical problem to illustrate, to
medical students, that there are many aspects of the biochemistry
taught in the early years which have direct relevance to clinical
medicine. Furthermore, it is hoped that such information might
provide biochemistry students with a frame work on which to base
further studies. To this end a selection of recent references has
been placed at the end of each chapter. In spite of considerable
advances in our understanding of diabetes mellitus, it is still a
disease which many physicians do not seem to com prehend. This is
in part related to their lack of understanding of the molecular
biology of the disease. Advances in this area have been dramatic in
recent years and we are now able to offer a molecular basis for a
rational approach to therapy. It may be therefore that this book
will provide some physicians with the information they require to
help them gain a deeper understanding of the disease. I hope that
everyone who reads this book is able to capture some of the
fascination that the islets of Langerhans hold for myself and the
many other workers actively engaged in trying to unravel their mys
teries."
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