Insects are the most ecologically important multicellular heterotrophs in terrestrial systems. They play critical roles in ecological food webs, remain devastating agricultural and medical pests, and represent the most diverse group of eukaryotes in terms of species numbers. Their dominant role among terrestrial heterotrophs arises from a number of key physiological traits, and in particular by the developmental and evolutionary plasticity of these traits. Ecological and Environmental Physiology of Insects presents a current and comprehensive overview of how the key physiological traits of insects respond to environmental variation. It forges conceptual links from molecular biology through organismal function to population and community ecology. As with other books in the Series, the emphasis is on the unique physiological characteristics of the insects, but with applications to questions of broad relevance in physiological ecology. As an aid to new researchers on insects, it also includes introductory chapters on the basics and techniques of insect physiology ecology.

This manual provides an easy guide to pain management for the veterinary practitioner. Beginning with pain terminology, it goes on to describe to physiology of pain, management strategies, various drugs and techniques, and the management of specific conditions and procedures. Strategies for the treatment of pain are comprehensively reviewed, with an overview of the mechanisms by which pain is perceived and the principles of pain management. The drugs currently used in the treatment of acute and chronic pain are discussed as well as the specific techniques that can be used to control intra- and post operative pain in dogs and cats. The book covers a broad range of information on specific aspects of pain management from analgesic techniques to management of chronic pain to pain perception. Published by Teton New Media USA and distributed by CRC Press outside of North America.

Principles of Animal Physiology, Second Edition continues to set a new standard for animal physiology textbooks with its focus on animal diversity, its modern approach and clear foundation in molecular and cell biology, its concrete examples throughout, and its fully integrated coverage of the endocrine system. Carefully designed, full-color artwork guides students through complex systems and processes while in-text pedagogical tools help them learn and remember the material. The book includes the most up-to-date research on animal genetics and genomics, methods and models, and offers a diverse range of vertebrate and invertebrate examples, with a student-friendly writing style that is consistently clear and engaging. Christopher Moyes and Patricia Schulte present animal physiology in a current, balanced, and accessible way that emphasizes the integration of physiological systems, an overarching evolutionary theme, and thorough coverage of the cellular and molecular basis of animal physiology. Principles of Animal Physiology comes with a comprehensive supplements package for students and instructors that includes a new Media Manager CD-ROM, a new Print and Computerized Test Bank, and a powerful Companion Website. The InterActive Physiology(R) 10-System Suite CD-ROM and PhysioEx(TM) V7.0 laboratory simulations can be packaged with the text at a discounted price.

Living organisms exhibit specific responses when confronted with sudden changes in their environmental conditions. The ability of the cells to acclimate to their new environment is the integral driving force for adaptive modification of the cells. Such adaptation involves a number of cellular and biochemical alteration including metabolic homeostasis and reprogramming of gene expression. Changes in metabolic pathways are generally short-lived and reversible, while the consequences of gene expression are a long-term process and may lead to permanent alternation in the pattern of adaptive responses.
The heart possesses remarkable ability to adapt itself against any stressful situation by increasing resistance to the adverse consequences. Stress composes the foundation of many degenerative heart diseases including atherosclerosis, spasm, thrombosis, cardiomyopathy, and congestive heart failure. Based on the concept that excessive stress may play a crucial role in the pathogenesis of ischemic heart disease, attempts were made to design methods for preventing of myocardial injury. Creation of stress reactions by repeated ischemia and reperfusion or subjecting the hearts to heat or oxidative stress enables them to meet the future stress challenge. Repeated stress exposures adapt the heart to withstand more severe stress reactions probably by upregulating the cellular defense and direct accumulation of intracellular mediators, which presumably constitute the material basis of increased adaptation to stress. Thus, the powerful cardioprotective effect of adaptation is likely to originate at the cellular and molecular levels that compose fundamental processes in the prophylaxis of such diseases.
Volume six of the Advances in Organ Biology series contains state-of-the-art reviews on myocardial preservation and cellular adaptation from the leading authorities in this subject.

Evolutionary biomechanics is the study of evolution through the analysis of biomechanical systems. Its unique advantage is the precision with which physical constraints and performance can be predicted from first principles. Instead of reviewing the entire breadth of the biomechanical literature, a few key examples are explored in depth as vehicles for discussing fundamental concepts, analytical techniques, and evolutionary theory. Each chapter develops a conceptual theme, developing the underlying theory and techniques required for analyses in evolutionary biomechanics. Examples from terrestrial biomechanics, metabolic scaling, and bird flight are used to analyse how physics constrains the design space that natural selection is free to explore, and how adaptive evolution finds solutions to the trade-offs between multiple complex conflicting performance objectives. Evolutionary Biomechanics is suitable for graduate level students and professional researchers in the fields of biomechanics, physiology, evolutionary biology and palaeontology. It will also be of relevance and use to researchers in the physical sciences and engineering.

Adopting a multidisciplinary approach with input from physicists, researchers and medical professionals, this is the first book to introduce many different technical approaches for the visualization of microcirculation, including laser Doppler and laser speckle, optical coherence tomography and photo-acoustic tomography. It covers everything from basic research to medical applications, providing the technical details while also outlining the respective strengths and weaknesses of each imaging technique.
Edited by an international team of top experts, this is the ultimate handbook for every clinician and researcher relying on microcirculation imaging.

Birds have colonized almost every terrestrial habitat on the planet - from the poles to the tropics, and from deserts to high mountain tops. Ecological and Environmental Physiology of Birds focuses on our current understanding of the unique physiological characteristics of birds that are of particular interest to ornithologists, but also have a wider biological relevance.
An introductory chapter covers the basic avian body plan and their still-enigmatic evolutionary history. The focus then shifts to a consideration of the essential components of that most fundamental of avian attributes: the ability to fly. The emphasis here is on feather evolution and development, flight energetics and aerodynamics, migration, and as a counterpoint, the curious secondary evolution of flightlessness that has occurred in several lineages. This sets the stage for subsequent chapters, which present specific physiological topics within a strongly ecological and environmental framework. These include gas exchange, thermal and osmotic balance, 'classical' life history parameters (male and female reproductive costs, parental care and investment in offspring, and fecundity versus longevity tradeoffs), feeding and digestive physiology, adaptations to challenging environments (high altitude, deserts, marine habitats, cold), and neural specializations (notably those important in foraging, long-distance navigation, and song production).
Throughout the book classical studies are integrated with the latest research findings. Numerous important and intriguing questions await further work, and the book concludes with a discussion of methods (emphasizing cutting-edge technology), approaches, and future research directions.

Historically the field of endocrine research has always been at the forefront of scientific endeavors. The investigators of these important breakthroughs in research have been rewarded by numerous Nobel awards. In the field of diabetes alone, Nobel prizes have been awarded to researchers who discovered insulin, characterized the protein and invented radioimmunoassays using insulin as a paradigm. Not surprisingly, biomedical researchers have always been attracted by the endocrine system and other similar systems of intercellular communication.
Over the past two decades, endocrine research has developed rapidly and adapted modern molecular and cellular biology techniques for its specific use. These changes have allowed researchers in the field to maintain their edge. Thus, endocrine disease-related genes have been characterized and mutations in these genes have helped explain common and
less common endocrine disorders. Our understanding of the regulation of gene expression has been greatly enhanced by molecular techniques.
In an attempt to bring investigators up to date with the recent advances in this exploding field we have decided to publish a series entitled Advances in Molecular and Cellular Endocrinology. Internationally famous investigators have agreed to participate and their contributions are appreciated.
Volume 1 has focused on aspects of the hypothalamic-pituitary axis including GnRH and GH gene regulation, molecular aspects of insulin, insulin-like growth factors and glucagon. In addition, reviews on the recently cloned calcium receptor and steroid receptor interactions with DNA are presented.

The Laboratory Animal Pocket Reference Series discusses procedures that ensure laboratory animals receive the best, most humane, and most responsible care possible. The 17 volumes are compact. The contents of each includes important biological features, husbandry, management, veterinary care, regulatory concerns, and commonly used and new procedures, as well as an invaluable list of suppliers. Each book in the series can be purchased individually or as part of the set.

Spanning biological, mathematical, computational, and engineering sciences, computational biofluiddynamics addresses a diverse family of problems involving fluid flow inside and around living organisms, organs, tissue, biological cells, and other biological materials. Computational Hydrodynamics of Capsules and Biological Cells provides a comprehensive, rigorous, and current introduction to the fundamental concepts, mathematical formulation, alternative approaches, and predictions of this evolving field. In the first several chapters on boundary-element, boundary-integral, and immersed-boundary methods, the book covers the flow-induced deformation of idealized two-dimensional red blood cells in Stokes flow, capsules with spherical unstressed shapes based on direct and variational formulations, and cellular flow in domains with complex geometry. It also presents simulations of microscopic hemodynamics and hemorheology as well as results on the deformation of capsules and cells in dilute and dense suspensions. The book then describes a discrete membrane model where a surface network of viscoelastic links emulates the spectrin network of the cytoskeleton, before presenting a novel two-dimensional model of red and white blood cell motion. The final chapter discusses the numerical simulation of platelet motion near a wall representing injured tissue. This volume provides a roadmap to the current state of the art in computational cellular mechanics and biofluiddynamics. It also indicates areas for further work on mathematical formulation and numerical implementation and identifies physiological problems that need to be addressed in future research. MATLAB (R) code and other data are available at http://dehesa.freeshell.org/CC2

Specialist Periodical Reports provide systematic and detailed review coverage of progress in the major areas of chemical research. Written by experts in their specialist fields the series creates a unique service for the active research chemist, supplying regular critical in-depth accounts of progress in particular areas of chemistry. For over 80 years the Royal Society of Chemistry and its predecessor, the Chemical Society, have been publishing reports charting developments in chemistry, which originally took the form of Annual Reports. However, by 1967 the whole spectrum of chemistry could no longer be contained within one volume and the series Specialist Periodical Reports was born. The Annual Reports themselves still existed but were divided into two, and subsequently three, volumes covering Inorganic, Organic and Physical Chemistry. For more general coverage of the highlights in chemistry they remain a 'must'. Since that time the SPR series has altered according to the fluctuating degree of activity in various fields of chemistry. Some titles have remained unchanged, while others have altered their emphasis along with their titles; some have been combined under a new name whereas others have had to be discontinued. The current list of Specialist Periodical Reports can be seen on the inside flap of this volume.

Conditioned taste aversion (CTA) is a robust defence device protecting animals against repeated consumption of toxic food. It is characterised by the ability of many animals to learn to avoid certain substances by their sight, smell, or taste after experiencing an unpleasant or harmful reaction to them. CTA is encountered at all levels of evolution, with similar forms of food aversion learning found in vertebrate and invertebrate species whose ancestral lines diverged more than 500 million years ago. CTA has a number of unusual properties contrasting sharply with the basic assumptions of traditional learning theories, which has brought it increasingly to the attention of neurobiologists interested in neural plasticity. In CTA, the usual time parameters between stimulus and aversion are relaxed considerably, frequently with delays of hours rather than seconds. Moreover, the critical stage of CTA acquisition may proceed under deep anaesthesia incompatible with other forms of learning. In the past decade several pivotal discoveries have considerably avanced our understanding of the neural processes underlying CTA, and opened new possibilities for their analysis at the molecular and cellular levels. This book, written by three of the world's leading researchers in the subject, comprehensively reviews the current state of research into conditioned taste aversion. The first book of its kind to provide an up-to-date summary of research into the neuroanatomy, pharmacology, electrophysiology, and functional morphology of CTA, it will be welcomed by all researchers and graduate students in the field.

Multimodal Management of Canine Osteoarthritis, Second Edition takes an evidence-based approach to the canine patient with osteoarthritis, pursuing the objective of the best available medicine by a variety of means: multiple drugs, agents, adjuncts and delivery methods. Appreciating that surgical intervention may initially be required, particularly for stabilizing a joint, the major focus in this work is the conservative management of osteoarthritis. A clear and visual approach is taken with the overlapping of two three-pointed triangles of management: medical and non-medical. The completely updated new edition offers a major new chapter on Regenerative Medicine in collaboration with Drs Sherman Canapp and Brittany Jean Carr. It is recommended for any small animal veterinary practitioner, as well as researchers and students of the RCVS CertAVP.

Radicals for Life: the Various Forms of Nitric Oxide provides an up-to-date overview of the role of nitrosocompounds and nitrosyl-iron complexes in physiology. Nitrosocompounds can be considered as stabilised forms of nitric oxide, one of the most important regulatory molecules in physiology today. Many nitrosocompounds share some of the physiological functions of nitric oxide, and may be formed inside living organisms. This is the first book to be published that is dedicated to the role of such nitrosocompounds in physiology, with particular emphasis on the nitrosocompounds that are endogenously formed in higher organisms and humans.
Points of discussion include: physical and chemical properties of the compounds, the main chemical pathways in vivo, as well as the physiological effects that have been recognised to date. Each of the nineteen chapters is written by distinguished specialists in the field, well known for their original and important contributions to the subject. Also included are results from a wide range of studies in vitro, in cell cultures, animal models and human volunteers.
Examples of alternative forms of nitric oxide, with special emphasis on their protective role against widespread human diseases like atherosclerosis, Alzheimer's disease, diabetes, sexual dysfunction, and renal insufficiency to stroke and ischemia are also included.
* First monograph to consider and provide an overview of endogenous nitrosocompounds and nitrosyl-iron complexes
* Extensive bibliographic references, written by specialists of human physiology
* Providing high scientific quality with a focus on implications for human diseases

This comprehensive text is suitable for researchers and graduate students of a 'hot' new topic in medical physics.

Written by the world's leading experts, this book aims to present recent developments in plasma medicine, both technological and scientific, reviewed in a fashion accessible to the highly interdisciplinary audience consisting of doctors, physicists, biologists, chemists and other scientists, university students and professors, engineers and medical practitioners.

The book focuses on major topics and covers the physics required to develop novel plasma discharges relevant for medical applications, the medicine to apply the technology not only in-vitro but also in-vivo testing and the biology to understand complicated bio-chemical processes involved in plasma interaction with living tissues.

During the past two decades, fish endocrinology has witnessed exciting developments due to our increased knowledge at all levels of biological organizations, including molecular biology, cell biology, physiology and behavior. New insights into development, neurobiology, immunology and molecular genetics closely correlated with classical aspects of endocrinology and represent important contributions to our knowledge on regulatory processes of vertebrates, including fish. The purpose of this book is to overview major advances in numerous research areas of fish endocrinology. Most of the chapters not only review and discuss the state-of-the-art in the respective field, but also show perspectives of future research. The book will be of interest to scientists involved in basic fish research, comparative endocrinology, fisheries and aquaculture as well as for students of fish biology.

This manual provides an easy guide to pain management for the veterinary practitioner. Beginning with pain terminology, it goes on to describe to physiology of pain, management strategies, various drugs and techniques, and the management of specific conditions and procedures. Strategies for the treatment of pain are comprehensively reviewed, with an overview of the mechanisms by which pain is perceived and the principles of pain management. The drugs currently used in the treatment of acute and chronic pain are discussed as well as the specific techniques that can be used to control intra- and post operative pain in dogs and cats. The book covers a broad range of information on specific aspects of pain management from analgesic techniques to management of chronic pain to pain perception. Published by Teton New Media USA and distributed by CRC Press outside of North America.

This new series on The Biochemistry and Molecular Biology of Fishes grew out of the demand for state-of-the-art review articles in a rapidly expanding field of research. Up to the present, most research literature on biochemistry involved rats and humans, but new breakthroughs in the piscine setting have indicated that the field is ready for a review series of its own. Because of funding and experimental availability restrictions, most research in the field has dealt with fish and insects. Within the insect field, comparative biochemistry and comparative physiology have proceeded along independent paths as opposed to the piscine field, where the tendency has been for the latter to envelop the former.
This volume sets out to make comparative biochemistry and comparative physiology independent of each other within the piscine setting, another important rationale for this review series as well as detailing the phylogenetic evolution of fishes. The goal of the series is to provide researchers and students with an appropriate balance between experimental results and theoretical concepts.

Volume 39, devoted solely to the vital research area on molybdenum and tungsten and their role in biology, offers a comprehensive and timely account of this fascinating topic by 40 distinguished international authorities. With more than 2200 references to assist further research, Molybdenum and Tungsten: Their Roles in Biological Processes is an essential resource for scientists and students in many disciplines, including bioinorganic, inorganic, and coordination chemistry; biochemistry; biophysics; molecular biology; enzymology; pharmacology; physiology; clinical chemistry; nutrition; toxicology; and environmental sciences.

"Environment and Animal Development "is the first book to focus specifically on the interactions between the environment and developmental mechanisms with particular emphasis given to the consequences for animal populations. The underlying premise of the book is that the study of physiological mechanisms alongside the analysis of adaptive values will enable rapid advancements in our knowledge of this important field. With contributions from well-known experts, the book will be invaluable for all graduate students and researchers in this area.

Because of developments in powerful computer technology, computational techniques, advances in a wide spectrum of diverse technologies, and other advances coupled with cross disciplinary pursuits between technology and its greatly significant applied implications in human body processes, the field of biomechanics is evolving as a broadly significant area. The four volumes of Biomechanical Systems: Techniques and Applications presents the advances in widely diverse areas with significant implications for human betterment that occur continuously at a high rate. These include dynamics of musculo-skeletal systems; mechanics of hard and soft tissues; mechanics of muscle; mechanics of bone remodeling; mechanics of implant-tissue interfaces; cardiovascular and respiratory biomechanics; mechanics of blood flow, air flow, flow-prosthesis interfaces; mechanics of impact; dynamics of man machine interaction; and numerous other areas. The great breadth and depth of the field of biomechanics on the international scene requires at least four volumes for adequate treatment. These four volumes constitute a well integrated set that can be utilized as individual volumes. They provide a substantively significant and rather comprehensive, in-depth treatment of biomechanic systems and techniques that is most surely unique on the international scene.

The bright colour of haemoglobin has, from the very beginning, played a significant role in both the investigation of this compound as well as in the study of blood oxygen transport. Numerous optical methods have been developed for measuring haemoglobin concentration, oxygen saturation, and the principal dyshaemoglobins in vitro as well as in vivo. Modern applications include pulse oximeters, fibre optic oximeters, multiwavelength haemoglobin photometers ('co-oximeters') and instruments for near infrared spectroscopy in vivo. Knowledge of the light absorption spectra of the common haemoglobin derivatives is a prerequisite for the development and understanding of these techniques.
In the 1960s a reference method based on the absorptivity of a single derivative (haemiglobincyanide; HiCN) at a single wavelength (540 nm) was established for measuring the total haemoglobin concentration. Thus an anchor value was provided on which the absorptivity spectra of all other haemoglobin derivatives could be based.
This monograph presents absorption spectra and absorptivity data in the wavelength range of 480 to 1000 nm of the major haemoglobin derivatives for human adult and foetal haemoglobin and for haemoglobin of several animals (cow, dog, horse, pig, rat, and adult and foetal sheep). A detailed description of the methods used to acquire these data has been included to allow future investigators to reproduce and expand on the data.
The second part of the monograph includes chapters on the principles and development, in historical perspective, of the principal methods for measuring total haemoglobin concentration for two, three, and multi-component analysis of haemoglobin derivatives, and for blood oxygen saturation measurement. Accurate quantitative data pertaining to haemoglobin in human blood are presented, together with a description of methods for measuring haemoglobin oxygen capacity and oxygen affinity. These chapters have been written with a view to foster knowledge and insight concerning the principles, purposes, and limitations of the various methods of all who use these methods in research and patient care.

This title includes a number of Open Access chapters. This book looks at a range of topics covering a variety of animals, including how macaques teach their offspring, how rats transmit avoidance behavior, how supplementary feeding of tree frogs affects their breeding behavior, and more. Studies in animal behavior can have far-reaching implications for animals and humans alike, such as how humans can improve conservation efforts, how to better protect animals-both in the wild and in captivity (zoos), and what can be learned about humans from animals, such as how the human brain and behaviors might work.

Scentwork for Horses is the first practical guide on how to implement scentwork into the lives of domesticated horses, enhancing behaviour, welfare, and the human-animal bond. Scentwork is a new discipline in the field for horse and handler, and expert author Rachael Draaisma arms the reader with a palette of information to enable them to put this technique into action. As well as theoretical background information on the nose of the horse and biomechanics, Draaisma discusses how scentwork improves horses' learning abilities, development, socialisation, and their bond with the handler. Readers will learn how to have their horses explore their environment, participate in scentwork games and follow a footstep track to find a missing person or food bag. Easily accessible for anybody working with horses at any level, scentwork can be done in small areas as well as in larger spaces on various surfaces. Whether veterinarian, behaviourist, trainer, animal-assisted therapist, equine physiotherapist, osteopath, or interested horse owner, this book promises to bring both you and the horse enormous benefits, strengthening the human-animal bond. Rachael Draaisma has always lived with and had a passion for dogs and horses. In 2002, she decided to make it her profession. Achieving several diplomas, she started to work full time as a trainer and behavioural consultant, first with dogs, later with horses. Her best-selling book Language Signs and Calming Signals of Horses, published by CRC Press in 2017, has been translated into several languages. Another pillar of Draaisma's working life with horses revolves around equine mental stimulation and scentwork, and she has developed an extensive method to undertake scent tracking with horses, a new tool in enriching the human-equine relationship. Draaisma travels throughout Europe and the globe to provide workshops and lectures on calming signals of horses, equine mental stimulation, and scentwork. You can purchase scent bags to aid your scentwork practice at the author's personal website: www.scentworkforhorses.com or www.calmingsignalsofhorses.com

An integrated reference which could form the basis for advanced courses on development or become a resource for individuals teaching basic courses. Following an introduction by the volume editors, the 11 chapters represent 11 different systems, arranged phylogenetically, beginning with prokaryotic s