This book is primarily a monograph of the reproductive diversity among animals, including protozoans. This diversity is listed for each group in Chapter 6; it is cross-listed by process in chapter 7.

This book presents a comprehensive and coherent picture of how molecules diffuse across a liquid that is, on average, only two molecules thick. It begins by characterizing bilayers structurally, using X-ray diffraction, and then mechanically by measuring elastic moduli and mechanisms of failure. Emphasis is placed on the stability and mechanical properties of plant membranes that are subject to very large osmotic and thermal stresses. Using this information, the transport of molecules of increasing complexity across bilayers is analyzed.

Molt is an important avian life history event in which feathers are shed and replaced. The timing, duration, seasonality, extent and pattern of molt follows certain strategies and this book reviews and describes these strategies for nearly 190 species based on information gathered from a 30-year study of Central Amazonian birds. Most species accounts are illustrated with several color photos focusing on wing and tail feather molt, molt limits, and how to use these patterns to accurately age birds. Published in collaboration with and on behalf of the American Ornithological Society, this volume in the highly-regarded Studies in Avian Biology series is a rich source of life history information for ornithologists working on tropical birds.

Handbook of Comparative Pharmacokinetics and Residues of Veterinary Therapeutic Drugs is a unique compilation of comparative pharmacokinetic data for veterinary therapeutic drugs. The book features an excellent introductory chapter on basic veterinary pharmacokinetics and includes pharmacological data taken from hundreds of primary research references. These data are presented in standardized units and are arranged in conveniently organized tables so that comparisons between data can be made easily. Much of the data is new and was taken from articles in which data was not subjected to pharmacokinetic analysis.

This updated monograph deals with methanogenic endosymbionts of anaerobic protists, in particular ciliates and termite flagellates, and with methanogens in the gastrointestinal tracts of vertebrates and arthropods. Further chapters discuss the genomic consequences of living together in symbiotic associations, the role of methanogens in syntrophic degradation, and the function and evolution of hydrogenosomes, hydrogen-producing organelles of certain anaerobic protists. Methanogens are prokaryotic microorganisms that produce methane as an end-product of a complex biochemical pathway. They are strictly anaerobic archaea and occupy a wide variety of anoxic environments. Methanogens also thrive in the cytoplasm of anaerobic unicellular eukaryotes and in the gastrointestinal tracts of animals and humans. The symbiotic methanogens in the gastrointestinal tracts of ruminants and other "methanogenic" mammals contribute significantly to the global methane budget; especially the rumen hosts an impressive diversity of methanogens. This makes this updated volume an interesting read for scientists and students in Microbiology and Physiology.

Mechanisms of Taste Transduction introduces a number of topics essential to a complete understanding of taste. These topics range from the control of food intake to the biophysical mechanisms of transduction and the design of food flavors in the food industry. The responses and organization of special sensory pathways are described in regard to their development, morphology, composition, electrophysiological and biochemical responses. Details are presented at several levels to appeal to researchers in molecular biology, membrane biophysics, human psychophysics, neuroanatomy, and chemistry. Current research is described in the context of what preceding studies have revealed, and the chapter authors are among today's most active and highly respected researchers in the field of chemical senses.

The objective of this multi-authored compendium is, therefore, to bring together the state of arts reported in one place. Written by specialists by specialists in various fields of rondentology, and to suggest future lines of research. It is also felt that this work on rodent pest management will trigger more research effort for the benefit of mankind and help certain countries and organizations in revitalizing serious work in this field which, it appears, has dampened during the last few years.

This timely publication updates and standardizes currently used diagnostic procedures for this widespread, economically costly livestock disease. It includes state-of-the-art technology, now in limited use, which will replace the conventional methodology in the near future. The volume covers research done on improved diagnostic techniques, vaccines, taxonomy, epidemiology, pathology, and basic immunology. It is an important literature review for those more established in this field and serves as a guide to researchers or diagnosticians becoming involved with this disease.

Egg transfer was first performed in 1890, but for half a century it received scant attention. However, since 1950 the technique has become increasingly widely used - in the laboratory for fundamental studies and more recently in practice, both veterinary and medical, to boost reproductive potential of genetically superior cattle and to overcome sterility due to impaired rubal function in women. As a result, a considerable body of literature has accumulated, totaling well in excess of a thousand references. But till now there has not been a single comprehensive text devoted solely to this subject. The present work was designed to meet that need at a time when the field is fast expanding with new techniques and approaches constantly being evolved. One need only cite the tremendous rate of progress in human egg transfer in the last three years. The work embraces laboratory and farm animals and primates, including man, altogether representing a total of 16 species.

Accumulation into one source of what is known regarding the feeding value of these materials and systems which have been developed for improving their digestibility, palatability or methods of handling was the motivation for organising this book. These has been an effort to include the major categories of unconventional materials which can potentially be upgraded to provide the ruminant with needed nutrients, but certainly some have been missed. It is hoped that this treatise will prove to be a valuable tool for workers involved in improving the utilization of residues and waste products for animals.

Most consumable products of animal origin, such as eggs and milk, are obtained through exploitation of the reproductive processes of livestock, making efficiency extremely important in intensive production units. Critical evaluation of each technological innovation in this field is necessary before widespread introduction, and this requires an extensive knowledge of reproductive biology.
This volume presents comprehensive, current discussions of the individual aspects comprising the complete reproductive process in domesticated animals, covering various technological procedures for regulation and manipulation of particular events. It provides extensive coverage of reproductive anatomy and includes avian reproduction, supplying original and often innovative figures. This book will be of great value to agriculturalists and veterinarians as well as to food and environmental scientists.

Structure and Function of Domestic Animals provides a solid introduction to the functional anatomy of domestic animals. The author covers general principles, phenomena, and mechanisms and then supports this information by providing concrete examples, giving you a working understanding of the biology of animals. Line drawings, tables, and text boxes provide supplemental information. The author examines the functions of animals from the basic to the complex. The pragmatic application of these principles allows for the raising and caring for animals with the appropriate regard for their welfare. He covers morphology, myology, electrophysiology, endocrinology, comparative anatomy, metabolism, cell growth and development, and reproductive mechanisms. The mechanism and phenomena described in this book will introduce you to the flexibility or plasticity of normal animal function. The author's pedagogical writing style clearly delineates normal function and abnormal function. Structure and Function of Domestic Animals explores many of the seemingly endless examples of the ways in which animals apply the fundamental principles of chemistry and physics to preserve their integrity. It gives you an insightful overview to a very broad subject.

These volumes provide information which will be helpful to comparative pathologists, veterinarians, and all marine scientists and other individuals who are interested in the study of marine mammals, and the diseases they develop in both their feral and captive environment.This publication is a reflection of the observations of the various authors, some of whom have pioneered in this field, and is an attempt to update the available information concerning the natural diseases, and the corresponding pathologic changes in marine mammals.

* Classifies and describes different orders and families of rumen ciliate protozoa* Describes morphological features and how they are used to identify protozoa* Features line drawings, created by the author, of various rumen protozoa with all morphological features and size measurements

A major problem with vampire bats is that whatever information exists is scattered throughout the literature or is not recorded. There are some excellent books on the ecology and biology of bats with very little on vampire bats. This volume fills that gap to provide an in-depth presentation of these unique animals.

Bioenergetics is an emerging discipline which offers a more profound understanding of the ecology, behaviour, and evolution of wild herbivores. Increasingly, bioenergetic principles have been applied in management since they provide insight into population dynamics and are relevant to manipulation of habitats and assessment of the impacts of resource development. Growing interest in the agricultural potential of wild herbivores has provided further impetus. In spite of this promise, there are few comprehensive syntheses of the concept and its application to wild herbivores. This volume attempts to fill this need. This book provides a great amount of detail but its expressive aim is to lead us to the whole animal, to a herd, to population as integral parts of an ecological entity which in turn is the result of evolutionary forces.The concept of this book promises the realization of an overdue change in the approach to bioenergetics, to nutrition and husbandry, and thus to the management of wild herbivores: the final emancipation from rules and views based primarily on domesticated herbivores or on experimental animals held under unnatural conditions, necessarily impending them behaviourally, physically, and psychically.

Laboratory animals are becoming increasingly important for biomedical research. It is said that approximately 70% of biomedical research is associated with the use of experimental animals. Laboratory animal research not only expands our knowledge of science, but also greatly improves human and animal health. The field of laboratory animal science is ever-growing and changing as new experimental techniques are developed and new animal models are created. It is essential to know not only the biological features of each laboratory animal but also how to use and care for them responsibly in order to perform high-quality experiments. Courses in beginning Laboratory Animal Science are starting to be offered in many universities throughout the world. However, a practical introductory textbook that contains state-of-the-art techniques is still lacking. Fundamentals of Laboratory Animal Science provides comprehensive information on the principles and practices of using laboratory animals for biomedical research. Each individual chapter focuses on a key sub-discipline of laboratory animal science: animal welfare and best humane care practices in the laboratory; the quality control of laboratory animals; the anatomy, physiology, and husbandry of commonly used species; the principles of creating and using animal models for studying human diseases; practical techniques used for laboratory animal experiments; experimental design; and animal experimentation management. Knowledge of this broad spectrum of concepts and skills will ensure research goes smoothly while greatly reducing animal pain and distress. Well-illustrated and thoroughly referenced, this book will serve not only as a standard textbook but also as a handy guide for veterinarians, researchers, animal care staff, administrators, and other professionals who are involved in laboratory animal science.

Handbook of Mammalian Metabolism of Plant Compounds provides an extensive survey of how mammals metabolize compounds found in higher plants. Information about these compounds is important to researchers in pharmacology, toxicology, medical and natural products chemistry, and food sciences. Although there is plenty of literature about mammalian metabolism of plant compounds, it is scattered, and summaries of specific plant compounds are often difficult to obtain. This book contains 11 chapters discussing the metabolic fate of individual plant compounds grouped according to chemical class. It also features structural formulas of the compounds and their metabolites, including probable pathways of metabolism. This book provides a convenient single-volume reference source that will benefit all researchers requiring this type of information.

Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

The popularity of germ-free animal models, particularly mice, for investigation of human physiology and disease has recently exploded. Gnotobiotic Mouse Technology: An Illustrated Guide provides the first manual for the maintenance, husbandry, and experimental manipulation of germ-free and gnotobiotic mice. It includes information on all aspects of establishing and operating a germ-free mouse research facility, from basic principles and equipment to detailed instructions for assembling and maintaining isolators, sterilizing supplies, handling animals, and monitoring sterility. The book breaks down techniques and procedures into modules, each of which contains a step-by-step practical and visual guide to a set of related procedures. Each description consists of a materials list, introduction, and general overview, followed by a thoroughly illustrated walkthrough of the steps for each procedure. The descriptions end with troubleshooting tips. Technical chapters are heavily illustrated and include notations of potential pitfalls and alternatives. Other chapters discuss management procedures and practices such as the hiring and training of personnel, setting fee schedules, and record keeping. This book is a landmark resource for establishing and maintaining a facility for germ-free mouse research. Useful to both technicians and investigators, it presents every step necessary to establish a successful facility. It also gives direction in expanding multi-user facilities and applying new technologies to your current practices.

Cell to Organ: Electromechanical Activation.- 1 Regulation of Intracellular Calcium in Cardiac Muscle.- 2 Neuromodulation of Calcium Current by Extracellular ATP in Isolated Ventricular Myocytes.- 3 Intracellular Calcium and Myocardial Function during Ischemia.- 4 Intracellular Signaling in Vascular Smooth Muscle.- 5 Myocardial Energetics.- 6 Mechanisms of Endocardial Endothelium Modulation of Myocardial Performance.- 7 Calcium Kinetic and Mechanical Regulation of the Cardiac Muscle.- 8 Cellular Responses to Electrical Stimulation: A Study Using a Model of the Ventricular Cardiac Action Potential.- 9 Excitation-Contraction Coupling and Contractile Protein Function in Failing and Nonfailing Human Myocardium.- Mechanics and Microcirculation.- 10 Estimation of Myocardial Mechanical Properties with Dynamic Transverse Stiffness.- 11 Intramyocardial Mechanical States: Vessel-Interstitium-Muscle Interface.- 12 Myocardial Mechanics and Coronary Flow Dynamics.- 13 Modeling of Coronary Capillary Flow.- Microstructure: Mechanics and Microcirculation.- 14 Models for Coronary Pressure-Flow Relationships.- 15In VivoMyocardial Microcirculation: Evaluation with a Whole-Body X-Ray CT Method.- 16 Endocardial Coronary Microcirculation of the Beating Heart.- 17 Distribution and Control of Coronary Microvascular Resistance.- 18 Theoretical Analysis of Coronary Blood Flow and Tissue Oxygen Pressure-Control.- Microcirculation and Metabolic Transport.- 19 Adenosine Coronary Vasodilation during Hypoxia Depends on Adrenergic Receptor Activation.- 20 Chaos in Cardiac Signals.- 21 Intramyocardial Fluid Transport Effects on Coronary Flow and Left Ventricular Mechanics.- 22 Metabolic Protection of Post-Ischemic Phosphorylation Potential and Ventricular Performance.- 23 Metabolic and Mechanical Control of the Microcirculation.- Remodeling of Muscle and Vessels.- 24 Asymmetrical Changes in Ventricular Wall Mass by Asynchronous Electrical Activation of the Heart.- 25 Ventricular Remodeling after Myocardial Infarction.- 26 Arterial Remodelling after Percutaneous Transluminal Balloon Angioplasty.- 27 Structural and Functional Remodeling of Poststenotic Arteries in the Rat.- 28 Myocardial Collagen and Its Functional Role.- Cardiac Function and Circulation.- 29 Ventricular-Arterial Interaction: Cardiac Effects of Mean versus Pulsatile Arterial Load.- 30 The Veins and Ventricular Preload.- 31 Why Smaller Animals Have Higher Heart Rates.- 32 Feedback Effects in Heart-Arterial System Interaction.- Integrated Analysis.- 33 The Relationship between Altered Load and Impaired Diastolic Function in Conscious Dogs with Pacing Induced Heart Failure.- 34 Interactions: The Integrated Functioning of Heart and Lungs.- 35 Carotid-Cardiac Interaction: Heart Rate Variability during the Unblocking of the Carotid Artery.- 36 Right and Left Ventricle Interaction and Remodeling in Congenital Heart Disease.- 37 Macroscopic Three-Dimensional Motion Patterns of the Left Ventricle.- 38 Cardiovascular Flow Velocity Measurements by 2D Doppler Imaging for Assessment of Vascular Function.- The Editors.- Contributors.

Recent advances in fish cytogenetics have enhanced the interest in chromosome analysis in both fundamental (systematics and comparative genomics among fishes and other vertebrate groups) and applied (aquaculture, conservation and response to pollutants, whole genome sequencing of model fish species) research. Although the genomic material, the chromosomes, is basically the same in the various organisms, experience has clearly shown that fish chromosomes have to be handled with specific protocols. In laboratories around the world, traditional cytogenetic techniques and molecular cytogenetics have seen a vast improvement but the technical details and protocols are often not published in scientific journals because of constraints in format and size and therefore they are not accessible to the whole scientific community. These shortcomings are very well known to fish cytogeneticists and the idea to prepare a specific manual was first discussed during the first "Workshop of Fish Cytogenetics" held in Concarneau (France), in 1992. Resulting from the above workshop, a draft compilation of the techniques and protocols in fish cytogenetics available at that time had been produced and distributed privately, but never published. There does not exist, at present, any published handbook or manual specifically dealing with fish cytogenetics. This book fills this void by bringing together and updating the main techniques so that the traditional methods can be standardized. Moreover, this book includes novel developments or improvements; some of the protocols provided here are practically unknown to the scientific community and even now unpublished.

Mechanical stress is vital to the functioning of the body, especially for tissues such as bone, muscle, heart, and vessels. It is well known that astronauts and bedridden patients suffer muscle and bone loss from lack of use. Even the heart, in pumping blood, causes mechanical stress to itself and to vascular tissue. With the loss of mechanical stress, homeostasis becomes impaired and leads to pathological conditions such as osteopenia, muscle atrophy, and vascular tissue dysfunction. In elderly populations, such mechanical pathophysiology, as well as the mechanical activities of locomotor and cardiovascular systems, is important because skeletal and heart functions decline and cause diseases in other organs. In this monograph, mechanical stress is discussed by experts in the field with respect to molecular, cellular, and tissue aspects in relation to medicine. Covering topics such as gravity and tissues and disuse osteoporosis, the book provides the most up-to-date information on cutting-edge advancements in the field of mechanobiology and is a timely contribution to research into locomotor and circulatory diseases that are major problems in contemporary society.

Three-Dimensional Structure of Lactoferrin in Various Functional States.- Characterization of Two Kinds of Lactotransferrin (Lactoferrin) Receptors on Different Target Cells.- Primary and Three-Dimensional Structure of Lactotransferrin (Lactoferrin) Glycans.- Synergism and Substitution in the Lactoferrins.- Salt Effects on the Physical Properties of the Transferrins.- Interaction of Lactoferrin with Sequestered Transition Metal Ions.- Bactericidal Activity of Different Forms of Lactoferrin.- The Effects of Lactoferrin on Gram-Negative Bacteria.- Faecal Flora in the Newborn: Effect of Lactoferrin and Related Nutrients.- The Monocytic Receptor for Lactoferrin and Its Involvement in Lactoferrin-Mediated Iron Transport.- Study on the Binding of Lactotransferrin (Lactoferrin) to Human PHA-Activated Lymphocytes and Non-Activated Platelets: Localisation and Description of the Receptor-Binding Site.- Physical Characteristics and Polymerization during Iron Saturation of Lactoferrin, a Myelopoietic Regulatory Molecule with Suppressor Activity.- Lactoferrin and the Inflammatory Response.- The Role of Lactoferrin as an Anti-inflammatory Molecule.- Interaction of Lactoferrin with Mononuclear and Colon Carcinoma Cells.- Lactoferrin Receptors in Intestinal Brush Border Membranes.- Maternal Lactoferrin in the Urine of Preterm Infants: Evidence for Retention of Structure and function.- Lactoferrin Gene Promoter in Human and Mouse: Analogous and Dissimilar Characteristics.- Lactoferrin cDNA: Expression and In Vitro Mutagenesis.- Antimicrobial Peptides of Lactoferrin.- Physicochemical and Antibacterial Properties of Lactoferrin and Its Hydrolysate Produced by Heat Treatment at Acidic pH.- A Comparison of the Three-Dimensional Structures of Human Lactoferrin in Its Iron Free and Iron Saturated Forms.- Bovine Lactoferrin: Isolation and Characterisation of Genomic Regulatory Sequences.- X-Ray Structural Analysis of Bovine Lactoferrin at 2.5 A Resolution.- Binding of Porcine Milk Lactoferrin to Piglet Intestinal Lactoferrin Receptor.- Lactoferrin-Receptor Interaction: Effect of Surface Exposed Histidine Residues.- Kinetic Parameters for the Heat Denaturation of Bovine Lactoferrin in Milk, and Its Effect on Interaction with Monocytes.- Cloning and Expression of the C-Terminal Lobe of Human Lactoferrin.- Crystallographic Studies on Metal and Anion Substituted Human Lactoferrin.- Proposed Mechanisms for the Involvement of Lactoferrin in the Hydrolysis of Nucleic Acids.- Lactoferrin Promotes Nerve Growth Factor Synthesis/Secretion in Mouse Fibroblast L-M Cells.- Summary Chapter: Lactoferrin Structure and Function: Remaining Questions, Methodological Considerations and Future Directions.

Chimpanzees, including common chimpanzees and bonobos, are our closest living relatives. This book, which is the first photographic and descriptive musculoskeletal atlas of the genus Pan, adopts the same format as the photographic atlases of Gorilla and Hylobates previously published by the same authors. These three books are part of a series of monographs that will set out the comparative and phylogenetic context of the gross anatomy and evolutionary history of the soft tissue morphology of modern humans and their closest relatives. The atlas, which includes detailed high-quality photographs of musculoskeletal structures from most anatomical regions of the body as well as textual information about the attachments, innervation, function and weight of the respective muscles, is based on dissections of up to 12 chimpanzees and on an extensive review of the literature. It provides an updated review of the anatomical variations within chimpanzees as well as an extensive list of the synonyms used in the literature. The book is designed for students, teachers and researchers studying primatology, comparative anatomy, functional morphology, zoology, and physical anthropology and to medical students, doctors and researchers who are curious about the origin, evolution, homology and variations of the musculoskeletal structures of modern humans.