Handbook of Mammalian Metabolism of Plant Compounds provides an extensive survey of how mammals metabolize compounds found in higher plants. Information about these compounds is important to researchers in pharmacology, toxicology, medical and natural products chemistry, and food sciences. Although there is plenty of literature about mammalian metabolism of plant compounds, it is scattered, and summaries of specific plant compounds are often difficult to obtain. This book contains 11 chapters discussing the metabolic fate of individual plant compounds grouped according to chemical class. It also features structural formulas of the compounds and their metabolites, including probable pathways of metabolism. This book provides a convenient single-volume reference source that will benefit all researchers requiring this type of information.

First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. The Series provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic. A volume can focus on a single molecule or on a disease that is related to vitamins or hormones. A hormone is interpreted broadly so that related substances, such as transmitters, cytokines, growth factors and others can be reviewed. This volume focuses on hormone and transport systems.

Mechanisms of Taste Transduction introduces a number of topics essential to a complete understanding of taste. These topics range from the control of food intake to the biophysical mechanisms of transduction and the design of food flavors in the food industry. The responses and organization of special sensory pathways are described in regard to their development, morphology, composition, electrophysiological and biochemical responses. Details are presented at several levels to appeal to researchers in molecular biology, membrane biophysics, human psychophysics, neuroanatomy, and chemistry. Current research is described in the context of what preceding studies have revealed, and the chapter authors are among today's most active and highly respected researchers in the field of chemical senses.

Laboratory animals are becoming increasingly important for biomedical research. It is said that approximately 70% of biomedical research is associated with the use of experimental animals. Laboratory animal research not only expands our knowledge of science, but also greatly improves human and animal health. The field of laboratory animal science is ever-growing and changing as new experimental techniques are developed and new animal models are created. It is essential to know not only the biological features of each laboratory animal but also how to use and care for them responsibly in order to perform high-quality experiments. Courses in beginning Laboratory Animal Science are starting to be offered in many universities throughout the world. However, a practical introductory textbook that contains state-of-the-art techniques is still lacking. Fundamentals of Laboratory Animal Science provides comprehensive information on the principles and practices of using laboratory animals for biomedical research. Each individual chapter focuses on a key sub-discipline of laboratory animal science: animal welfare and best humane care practices in the laboratory; the quality control of laboratory animals; the anatomy, physiology, and husbandry of commonly used species; the principles of creating and using animal models for studying human diseases; practical techniques used for laboratory animal experiments; experimental design; and animal experimentation management. Knowledge of this broad spectrum of concepts and skills will ensure research goes smoothly while greatly reducing animal pain and distress. Well-illustrated and thoroughly referenced, this book will serve not only as a standard textbook but also as a handy guide for veterinarians, researchers, animal care staff, administrators, and other professionals who are involved in laboratory animal science.

Structure and Function of Domestic Animals provides a solid introduction to the functional anatomy of domestic animals. The author covers general principles, phenomena, and mechanisms and then supports this information by providing concrete examples, giving you a working understanding of the biology of animals. Line drawings, tables, and text boxes provide supplemental information. The author examines the functions of animals from the basic to the complex. The pragmatic application of these principles allows for the raising and caring for animals with the appropriate regard for their welfare. He covers morphology, myology, electrophysiology, endocrinology, comparative anatomy, metabolism, cell growth and development, and reproductive mechanisms. The mechanism and phenomena described in this book will introduce you to the flexibility or plasticity of normal animal function. The author's pedagogical writing style clearly delineates normal function and abnormal function. Structure and Function of Domestic Animals explores many of the seemingly endless examples of the ways in which animals apply the fundamental principles of chemistry and physics to preserve their integrity. It gives you an insightful overview to a very broad subject.

This new volume gives a concise overview covering the most basic and exciting chapters of comparative medicine with regards to physiology and function in healthy individuals. The book includes core concepts in anatomy and physiology in human and model animals which one needs to understand to make independent contributions inthe research area of comparative medicine. During the writing process of the book the authors were in constant interdisciplinary dialogue. Theyaim to contribute to the improvement of quality of life for human and animal patients.

Volume II features a variety of animal and human prion diseases, including the newly-identified atypical forms of bovine spongiform encephalopathy and scrapie in animals, and variably protease-sensitive prionopathy in humans, prions in the environment, Tau pathology in human prion disease, transmission of the disease by blood transfusion, mammalian and non-mammalian models, conventional and advanced diagnoses, prion-specific antibodies, as well as decontamination of prions and development of therapeutics of prion diseases, such as the application of immunomodulation. This volume provides up-to-date knowledge about the etiology, pathogenesis, classification, histopathological, and clinical aspects of the highly publicized animal and human prion diseases.

This book is a practical guide for researchers and advanced graduate students in biology and biophysics who need a quantitative understanding of acoustical systems such as hearing, sound production, and vibration detection in animals at the physiological level. It begins with an introduction to physical acoustics, covering the fundamental concepts and showing how they can be applied quantitatively to understand auditory and sound-producing systems in animals. Only after the relatively simple mechanical part of the system is explained does the author focus his attention on the underlying physiological processes. The book is written on three levels. For those wanting a brief survey of the field, each chapter begins with a nonmathematical synopsis which summarizes the content and refers to the figures, all of which are designed to be understood apart from the main text. At the next level, the reader can follow the main text, but need not give close attention to anything but the general concepts and techniques involved. At the third level, the reader should follow the mathematical arguments in detail and attempt the discussion of questions at the end of each chapter. The author has provided detailed solutions which serve to expand the discussions of particular cases.

The popularity of germ-free animal models, particularly mice, for investigation of human physiology and disease has recently exploded. Gnotobiotic Mouse Technology: An Illustrated Guide provides the first manual for the maintenance, husbandry, and experimental manipulation of germ-free and gnotobiotic mice. It includes information on all aspects of establishing and operating a germ-free mouse research facility, from basic principles and equipment to detailed instructions for assembling and maintaining isolators, sterilizing supplies, handling animals, and monitoring sterility. The book breaks down techniques and procedures into modules, each of which contains a step-by-step practical and visual guide to a set of related procedures. Each description consists of a materials list, introduction, and general overview, followed by a thoroughly illustrated walkthrough of the steps for each procedure. The descriptions end with troubleshooting tips. Technical chapters are heavily illustrated and include notations of potential pitfalls and alternatives. Other chapters discuss management procedures and practices such as the hiring and training of personnel, setting fee schedules, and record keeping. This book is a landmark resource for establishing and maintaining a facility for germ-free mouse research. Useful to both technicians and investigators, it presents every step necessary to establish a successful facility. It also gives direction in expanding multi-user facilities and applying new technologies to your current practices.

This is the first guide to Veterinary Narrative Medicine, a cutting-edge approach in human medicine with multiple applications in veterinary medicine. The text combines the latest research with numerous real-world examples and practical techniques to improve client communication, patient care, and veterinary well-being. Narrative Medicine maintains that a patient should be viewed as an individual rather than an example of a disease process, and that this can be accomplished by using narrative. This book explores methods and theories from leaders in the human Narrative Medicine field while addressing topics unique to veterinary medicine. Readers will gain tools to help navigate difficult conversations and situations in clinical practice, including those involving the end of life. Narrative Medicine in Veterinary Practice also addresses the important issue of veterinary wellness. The ability to view the veterinarian's own stories and those of clients and patients as narratives may help practitioners maintain both emotional and work-place boundaries as well as decrease burnout and compassion fatigue. The book describes basic techniques to promote self-reflection and mindfulness, skills often overlooked in the veterinary profession which can improve resilience and increase the enjoyment of veterinary practice. This is important reading for veterinary practitioners, students, veterinary nurses, technicians, social workers, and all veterinary clinic staff.

The first book to highlight research done by women of color in the field of shark science. A special emphasis is placed on amplifying the voices of Black, Indigenous, People of Color as well as artisanal fishers and economically disadvantaged coastal communities. Accessible to younger readers too, encouraging school children to get into marine science. Covers a broad range of topics including biology, ecology and evolution as well as some less talked about topics like outreach and stakeholder engagement. Interdisciplinary approach to shark science and conservation Easily digestible content for non-experts Focuses on a charismatic group of animals, sharks Offers diverse perspectives and cutting-edge research while diving into issues regarding the decolonization of shark science and changing public perception of sharks. This is an opportunity to challenge the notion that there is only one type of scientist or that scientists look and think a certain way.

Mechanical stress is vital to the functioning of the body, especially for tissues such as bone, muscle, heart, and vessels. It is well known that astronauts and bedridden patients suffer muscle and bone loss from lack of use. Even the heart, in pumping blood, causes mechanical stress to itself and to vascular tissue. With the loss of mechanical stress, homeostasis becomes impaired and leads to pathological conditions such as osteopenia, muscle atrophy, and vascular tissue dysfunction. In elderly populations, such mechanical pathophysiology, as well as the mechanical activities of locomotor and cardiovascular systems, is important because skeletal and heart functions decline and cause diseases in other organs. In this monograph, mechanical stress is discussed by experts in the field with respect to molecular, cellular, and tissue aspects in relation to medicine. Covering topics such as gravity and tissues and disuse osteoporosis, the book provides the most up-to-date information on cutting-edge advancements in the field of mechanobiology and is a timely contribution to research into locomotor and circulatory diseases that are major problems in contemporary society.

This book presents a review of the existing literature on natural mycotoxins to create a comprehensive reference for mycotoxin levels. Each entry includes contamination, concentration rate, mostly mean mycotoxin concentration of organs (human and animal) and country of origin of the sample. Due to the serious spoilage and health issues the presence of mycotoxins can cause, it is imperative that corresponding scientists, health institutions and the food and feed industries have a more qualified understanding of mycotoxins in living things. To this end, Natural Mycotoxin Contamination in Humans and Animals provides an excellent resource. The present book complements the series of the author's previous books, Mycotoxins in Feedstuffs and Mycotoxins in Foodstuffs, in that it is a review of the literature to create a comprehensive reference for mycotoxin levels. As with Mycotoxins and their Metabolites in Humans and Animals, the focus remains the same, but the scope now covers natural mycotoxins only. Comprehensive reference of natural mycotoxin levels in humans and animals Easy-to-use database of mycotoxins Each entry is comprehensive

The Crustacea is one of the dominant invertebrate groups, displaying staggering diversity in form and function, and spanning the full spectrum of Earth's environments. Crustaceans are increasingly used as model organisms in all fields of biology, as few other taxa exhibit such a variety of body shapes and adaptations to particular habitats and environmental conditions. Physiological Regulation is the fourth volume in The Natural History of the Crustacea series, and the first book in over twenty-five years to provide an overview of the comparative physiology of crustaceans. An understanding of physiology is crucial to a comprehension of the biology of this fascinating invertebrate group. Written by a group of internationally recognized experts studying a wide range of crustacean taxa and topics, this volume synthesizes current research in a format that is accessible to a wide scientific audience.

Presenting more than 266 full color anatomic drawings arranged by organ system, this book is dedicated exclusively to feline anatomy with emphasis on those areas of anatomy that are frequently encountered in clinical practice. It includes a highly detailed chapter on special senses which collects and organizes difficult to find information for quick access. Nomenclature is from Nomina Anitomica Veterinaria so that the feline anatomy is in line with that used in other textbooks of veterinary anatomy of the domestic animals. The book accurately captures the anatomy pertinent to clinical veterinary medicine.

Chimpanzees, including common chimpanzees and bonobos, are our closest living relatives. This book, which is the first photographic and descriptive musculoskeletal atlas of the genus Pan, adopts the same format as the photographic atlases of Gorilla and Hylobates previously published by the same authors. These three books are part of a series of monographs that will set out the comparative and phylogenetic context of the gross anatomy and evolutionary history of the soft tissue morphology of modern humans and their closest relatives. The atlas, which includes detailed high-quality photographs of musculoskeletal structures from most anatomical regions of the body as well as textual information about the attachments, innervation, function and weight of the respective muscles, is based on dissections of up to 12 chimpanzees and on an extensive review of the literature. It provides an updated review of the anatomical variations within chimpanzees as well as an extensive list of the synonyms used in the literature. The book is designed for students, teachers and researchers studying primatology, comparative anatomy, functional morphology, zoology, and physical anthropology and to medical students, doctors and researchers who are curious about the origin, evolution, homology and variations of the musculoskeletal structures of modern humans.

The book concentrates on physiology and biochemistry and is not diluted by taxonomy/systematics - this makes it different from the competitor books and increases its worth at the postgraduate level and beyond. It makes a very good companion book to a second text that concentrates on taxonomic aspects, such as McGavin. It emphasizes the importance of a rigorous understanding of species-specific details. This is even more successful because of the depth of each chapter. The chapter on symbiosis is different, and very interesting and relevant. There is 'hidden depth', nuance and richness in many chapters, which explore a huge range of themes and relevant topics. The book puts emphasis on insect diversity and its implications for experimental design and interpretation, highlighting caveats in experimental design. It is extremely thought provoking. The writing style is easy to follow with very good descriptions of complicated topics. The edition is published in full color throughout. Ideal for upper level undergraduate and graduate students (in college course system, 300 level and above). For the first-time learners, the level of difficulty is comparable to the introductory level courses for Genetics.

Organized by body system, the new edition of this highly illustrated textbook covers the normal histological appearance of tissues in a wide range of animals, both domestic and exotic species, with relevant clinical correlates emphasizing the need to appreciate the normal in order to recognize the abnormal. In this update by two experienced veterinary pathologists and histology lecturers, new species, such as other companion mammals, aquatic species and livestock, are introduced into each chapter along with a wealth of new high-quality images. A new chapter covers epitehlial tissue and new techniques used in histology and histopathology are discussed throughout, including ISH and digital image analysis. Pathogenesis explanation is introduced in the current (and many new) cases of histopathology. The breadth of coverage-farm animals, dogs, cats, horses, birds, reptiles, amphibians, and fish-and the integration of normal and abnormal tissue provide a reference of lasting value to veterinary students as well as veterinary practitioners and pathologists needing a quick refresher.

Significant advances have been made in animal model development for biological research since the publication of the first edition of this volume, and the ramifications of the FDA s Animal Efficacy Rule have become better understood in the scientific community. With each chapter completely updated with the latest research findings, Biodefense Research Methodology and Animal Models, Second Edition spans the spectrum of coverage from basic research to advanced development of medical countermeasures.

Topics discussed in this volume include:

• A history of biological agents as weapons, from the use of corpses to contaminate water supplies to modern day anthrax attacks
• Concepts and strategies involved in biowarfare and bioterrorism
• The development, validation, and importance of animal models in biodefense research
• Infectious disease aerobiology
• Studies involving anthrax, glanders, plague, tularemia, Q fever, alphaviruses, orthopoxviruses, and a new chapter on brucellosis
• Animal models for viral hemorrhagic fevers
• Botulinum and Ricin toxins
• Staphylococcal and streptococcal superantigens

As the scientific community works diligently to protect the world s population from the misuse of infectious organisms and toxins, it is imperative that researchers stay abreast of the latest techniques for biodefense research. Exploring in vivo and in vitro assays, this volume brings researchers up to date on the latest information on bacterial and viral infectious agents and biological toxins considered to pose the greatest threats to public safety. In addition, the contributors take a step toward minimizing the use of animals in further experiments by presenting documented findings that can be built upon.

Since the last International Bile Acid Meeting in Stockholm in 2004, bile acid research has continued to flourish and therapeutic use of bile acids has attained a broader role. New insights have been gained into the mechanisms responsible for maintenance of bile acid homeostasis, and effects of bile acids on the cell signalling pathways have been further elucidated. Knowledge of the genetic basis of bile acid physiology has further increased. Therapy of chronic cholestatic liver diseases with ursodeoxycholic acid and new aspects of its chemopreventive properties continue to stimulate basic and clinical research and contribute to the understanding of underlying modes of action and to optimized treatment schedules. Chapters reflect the recent progress in bile acid metabolism and transport, nuclear receptor regulation and signaling by bile acids, as well as mechanisms of bile acid-induced cellular injury...

This is the first book to summarize the methods, conceptual issues and results of studies using the interpretation of feather growth rates as an index to nutritional condition in birds. The author has coined the term ptilochronology (literally. 'the study of feather time') to describe this technique, which relies on the fat that as a feather grows it produces visible growth bars. Both the technique and its conceptual foundations have been applied worldwide to numerous studies of avian evolution, ecology, and conservation biology. the author reviews this work, chronicles the various criticisms that have been amde, and describes how these have influenced the development of ptilochronology. He goes on to suggest experimental methodologies and analytical techniques to safeguard against invalid results. a final chapter summarises this new technique's contribution to avian biology, and suggests potential applications and a future research agenda. an appendix details specific measurements and describes the methodology associated with ptilochronology.
Ptilochronology provides a practical resource as well as a conceptual understanding of how this technique can be used to address important questions in avian biology. It will be of relevance and use to professional avian biologists and ornithologists as well as to graduate students of avian behavioural ecology, evolution and conservation.

A fascinating natural history of an incredibly curious substance. "Preternaturally hardened whale dung" is not the first image that comes to mind when we think of perfume, otherwise a symbol of glamour and allure. But the key ingredient that makes the sophisticated scent linger on the skin is precisely this bizarre digestive by-product-ambergris. Despite being one of the world's most expensive substances (its value is nearly that of gold and has at times in history been triple it), ambergris is also one of the world's least known. But with this unusual and highly alluring book, Christopher Kemp promises to change that by uncovering the unique history of ambergris. A rare secretion produced only by sperm whales, which have a fondness for squid but an inability to digest their beaks, ambergris is expelled at sea and floats on ocean currents for years, slowly transforming, before it sometimes washes ashore looking like a nondescript waxy pebble. It can appear almost anywhere but is found so rarely, it might as well appear nowhere. Kemp's journey begins with an encounter on a New Zealand beach with a giant lump of faux ambergris-determined after much excitement to nothing more exotic than lard-that inspires a comprehensive quest to seek out ambergris and its story. He takes us from the wild, rocky New Zealand coastline to Stewart Island, a remote, windswept island in the southern seas, to Boston and Cape Cod, and back again. Along the way, he tracks down the secretive collectors and traders who populate the clandestine modern-day ambergris trade. Floating Gold is an entertaining and lively history that covers not only these precious gray lumps and those who covet them, but presents a highly informative account of the natural history of whales, squid, ocean ecology, and even a history of the perfume industry. Kemp's obsessive curiosity is infectious, and eager readers will feel as though they have stumbled upon a precious bounty of this intriguing substance.

This book describes the major steps by which the mammalian ear transforms sound into nerve impulses. The author leads us along the pathway followed by an acoustic signal--collected by the outer ear, augmented by the middle ear, then delivered to the inner ear where the minuscule vibrations of the sound waves are transformed into nerve impulses. At each stage, the basic mechanisms are described qualitatively in terms of current theories and illustrated with experimental data. Where appropriate, related mechanisms in the ears of other vertebrates are considered. It is shown that the mammalian ear does an exquisite job of translating sound signals into a very robust nerve-pulse code. The book concludes with descriptions of some common ear impairments and a brief survey of the treatments available for them. The text is integrated with animations of mechanical and neural phenomena available through the Internet.

Nutrition spans a wide range of mechanisms from acquisition of food to digestion, absorption and retention of energy substrates, water and other nutrients. Nutritional principles have been applied to improving individual health, athletic performance and longevity of humans and of their companion animals, and to maximizing agricultural efficiency by manipulating reproduction or growth of tissues such as muscle, hair or milk in livestock. Comparative nutrition borrows from these tra- tional approaches by applying similar techniques to studies of ecology and physiology of wildlife. Comparative approaches to nutrition integrate several levels of organization because the acquisition and flow of energy and nutrients connect individuals to populations, populations to communities, and communities to ecosystems. Integrative Wildlife Nutrition connects behavioral, morphological and biochemical traits of animals to the life history of species and thus the dynamics of populations. An integrated approach to nutrition provides a practical framework for understanding the interactions between food resources and wildlife popu- tions and for managing the harvest of abundant species and the conservation of threatened populations. This book is for students and professionals in animal physiology and ecology, conservation biology and wildlife management. It is based on our lectures, dem- strations and practical classes taught in the USA, Canada and Australia over the last three decades. Instructors can use Integrative Wildlife Nutrition as a text in wildlife and conservation biology programs, and as a reference source for related courses in wildlife ecology.

The book is a step-by-step manual describing the most commonly performed diagnostic procedures in horses making it an ideal quick reference resource for general and equine practitioners. The title is a concise compilation of technical information on collection and handling body tissues for the diagnosis of equine diseases. Invasive and non-invasive diagnostic procedures along with common joint injection and aspiration techniques are thoroughly explained. The manual describes and demonstrates the collection of fluid and tissue samples from all body systems and when applicable, and discusses multiple techniques for collecting the tissue samples. This book takes a unique approach to the presentation of synoviocentesis techniques by superimposing radiographic images over the corresponding joints of the intact limbs. These images greatly assist clinicians in visualizing anatomical orientation with the described palpable landmarks. This user-friendly text includes over 150 full-color images. Published by Teton New Media in the USA and distributed by Manson Publishing outside of North America.