This unique selection of reviews summarizes current knowledge in all major fields of crustacean neurobiology and all levels of their CNS organization, using lobster and crayfish. It not only imparts theoretical knowledge but also describes all available contemporary and advanced techniques, such as patch clamp recordings, microelectrode techniques, immunocytochemistry, and all methods of molecular genetics to identify cellular pathways of protein synthesis and peptidergic control. In summary, it is a comprehensive account of the research achievements in one of the major nervous systems besides the mammalian CNS.

The Development of the Vascular System: Embryonic Development of Blood Vessels; F. Dieterlen-Lievre, L. Pardanaud. Regulation of Embryonic Blood Vessel; H. Drexler et al.. Biology of Endothelial Cells and Angiogenesis: Basic Fibroblast Growth Factor and Endothelial Cells; M. Presta, et al. Role of Integrinss in Endothelial Cell Function; E. Dejana, et al. Angiogenesis in Disease States: Angiogenesis and Neoplastic Transformation; P.M. Gullino. Tumor Induced Angiogenesis; J.L. Ambrus, et al. Promoters and Inhibitors of Angiogenesis: Brain Tumor Angiogenesis; C. Guerin, et al. Therapeutic Potential of Promoters and Inhibitors of Angiogenesis: On Promoter of Angiogenesis and Therapeutic Potential; P.M. Gullino. Methodology: Assays for Angiogenic Factors; J.B. Weiss. 23 additional articles. Index.

This detailed new edition aims to provide a range of methods and protocols for studying vascular morphogenesis in vivo and in vitro to reflect up-to-date advances in the field. Of note, the book explores endothelial cell signaling is currently understood to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation, and postnatal tissue remodeling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and timely, Vascular Morphogenesis: Methods and Protocols, Second Edition will serve as an ideal guide to this area of study for a broad audience amongst cell biologists, anatomists, pathologists, and physiologists.

The second edition of the book has sold over 3850 copies, making this our bestselling veterinary textbook. Day passed away in 2020 and Professor Brian Catchpole and Harm HogenEsch are the ideal authors to update this in his stead, actively teaching and researching in this field at the RVC, the UK's biggest veterinary college, and Purdue, a huge vet school in the US. The two new authors give this greater international coverage. The most accessible book on this topic for veterinary students: chapters are concise and informative, focused on the main message. It stands out among the competitor 'tomes' which are expensive and inaccessible, or are geared towards human (or mouse) immunology. In a nutshell, this book provides the essential immunological information specifically for vet students, but remains light and easy to read. Colour illustrations are effective, clear, simple and straight to the point, with nearly one illustration/schematic for each important section/paragraph. The clinical cases bring the material to life, while a short animation adds new practical application via the Support Materials tab on the Routledge website.

This book is actually a product of efforts of many people, not only of the authors. W ide investigations of marine mammals began in Russia (that time, in the former Soviet Union) in the 1960s when a few teams of enthusiasts founded in captivity experimental stations intended for keeping dolphins and seals and for performing experimental studies of these fascinating animals. It was a time when attention of many people throughout the world was attracted to dolphins and other marine mammals due to appearance of oceanariums and dolphinariums, which demonstrated unique capabilities of these animals. So scientists in many countries concentrated on studies of them. There was much to learn about the morphology, physiology, and psychology of marine mammals, and investigators spending their time and efforts on studies in this field were rewarded by a number of surprising findings. The authors of this book represent one of such research teams focused on the neuro- and sensory physiology of marine mammals. A few decades of studies naturally resulted in the idea to summarize in a book both the results of these studies and a large body of data in adjacent fields. Our goal was to synthesize the many research findings and the present knowledge on sensory capabilities and mechanisms of sensory systems of aquatic mammals. We realize, however, that the appearance of this book was made possible due to the help and assistance of many colleagues.

The fifth Oxford Conference was held on September 17th-19th, 1991, at the Fuji Institute of Training in Japan -the first time that the meeting has taken place in the Asian area. The facts that only a relatively few Japanese had attended previous Oxford Conferences and that Japan is far from other regions with possible participants made the organizers anticipate a small attendance at the meeting. However, contrary to our expectations, 198 active members (72 foreign and 126 domestic participants) submitted 146 papers from 15 countries. This was far beyond our preliminary estimate and could have caused problems in providing accommodation for the participants and in programming their scientific presentations. These difficulties, however, were successfully overcome by using nearby hotels, by telecasting presentations into a second lecture room and by displaying a substantial number of poster presentations during the whole period of the meeting. The meeting had two types of sessions: regular and current topics. The first paper in each session represented a shon overview or introduction so as to make it easier for the audience to comprehend the problems at issue. Because of the large number of papers submitted, carefully selected speakers (mostly well-known scholars) made excellent presentations that were followed by lively discussions. In this way, the conference laid a foundation on which to base its continued scientific success.

This volume provides the reader with an overview of an intriguing and interdisciplinary field of research. For the first time the mammalian pineal gland, its mode of action and its physiological effects are discussed in a comprehensive, single-authored work.

From an evolutionary perspective, understanding chimpanzees offers a way of understanding the basis of human nature. This book on cognitive development in chimpanzees is the first of its kind to focus on infants reared by their own mothers within a natural setting, illustrating various aspects of chimpanzee cognition and the developmental changes accompanying them. The subjects are chimpanzees of three generations inhabiting an enriched environment, as well as a wild community in West Africa. There is a foreword by Jane Goodall and 26 color photos of chimpanzees in the laboratory and in the field in West Africa are included.

A number of remarkable recent breakthroughs have made the study of nitric oxide one of the most exciting fields in physiology and pathophysiology. This authoritative edited volume reviews the progress to date and opens perspectives to novel diagnostic and therapeutic strategies. The contributors are leading authorites, in most cases the investigators who have pioneered the ideas explored in the book.

Extremely diverse and complicated bacterial and protozoan populations inhabit the rumen and intestinal tract of animals, and there is a delicate balance among the individual populations within this complex microbial community. This authoritative edited volume, the first in a two-volume set, reviews the gut environment and the fermentations taking place in animal digestive tracts. It is an essential source of reference for microbial ecologists and physiologists, medical microbiologists and gastroenterologists, biochemists, nutritionists, veterinarians and animal scientists, and wildlife ecologists.

How to Raise a Puppy moves away from the traditional approach to raising puppies, focused on obedience and control, and instead takes an holistic, dog-centred approach. Drawing on research into how dogs naturally rear their young, and how dogs have evolved to behave and spend their time, it supports a new way of sharing our lives with our dogs. It also offers advice on dealing with some of the common challenges people experience with puppies, and tips for managing adolescence. A much-needed resource for dog trainers, veterinarians and behaviourists to recommend to clients, this conveys a powerful message to help overcome all too common issues so many people have with their puppies. Packed with practical advice, it offers an overdue "puppy perspective", with respect for a dog as a sentient being at its core.

Functional and Structural Constituents of Neuronal Ca2+ Channel Modulation by Neurotransmitters; E. Carbone, et al. Target Striatal Cells Regulate Development of Midbrain Dopaminergic Neurones; C. Perrone-Capano, et al. Facts and Fantasies about Hair Cells; J.F. Ashmore. The Vomeronasal Organ; A. Cavaggioni, et al. Potassium Currents of Hair Cells in Thin Slices of Vestibular Epithelium; I. Prigioni, et al. A Compartment Model for Vertegrate Phototransduction Predicts Sensitivity and Adaptation; J.P. Raynauld. Modeling Odor Intensity and Odor Quality Coding in Olfactory Systems; J.P. Rospars, et al. Functional Connections between the Architecture of the Dendritic Arborization and the Microarchitecture of the Dendritic Membrane; P. Gogan, et al. The Functional Significance of Cerebellar Anatomy; D. Heck. Architecture for a Replicative Memory; J. D' Ninio. Measuring Information from Neuronal Activity; S. Panzeri, et al. Visual Processing in the Temporal Lobe for Invariant Object Recognition; E.T. Rolls. Biophysical Aspects of Cortical Networks; S. Rotter. On the Time Required for Recurrent Processing in the Brain; A. Treves, et al. 16 additional articles. Index.

Much has happened in the 19 years since the publication of the first edition of Reptiles and Amphibians: Self-Assessment Color Review. Many more scientists and clinicians have taken an interest in reptiles and amphibians, novel radiographic techniques have been developed, and veterinary surgeons have devised operative solutions to numerous serious conditions in both reptiles and amphibians. The time is right for an expanded second edition that covers these developments and more. See What's in the Second Edition: More than 230 new and revised reptile and amphibian cases, illustrated in color Case studies with answers that fully explore the disease or disorder in question Case selection based on common reptilian and amphibian species kept as pets or study animals Written by a foremost authority, this book presents more than 230 cases and questions at different levels of expertise, with detailed explanatory answers. The cases appear in random order, just as they would in real life, and enable you-by solving the clinical puzzle-to make differential diagnoses, treatment plans, and prognoses. The color review includes a wealth of problem-oriented information of value-and enjoyment-for formal and informal training and continuing education.

The Australian Zebra Finch is widely used by researchers and teachers in many scientific disciplines where it is the preferred subject for investigations ranging from anatomy and physiology to behavioural development and evolutionary ecology. This monograph is the first to synthesize the information on this colourful species that has accumulated during the past thirty years. It summarizes and integrates much of the laboratory work and places it in the context of the biology of the animals in the wild, with an emphasis on behaviour and ecology. This leads to a detailed understanding of Zebra Finch adaptations and life history that will further enhance the value of the species for researchers and students in behaviour, ecology, and other fields. Aviculturists who keep these attractive birds will also find much of interest in this book.

Continues to be clear, concise and very easy to understand Remains an important resource for uncommon conditions The differential diagnosis segment is a big selling point Content is now thoroughly up to date, including for instance - significant scientific advances in diagnostic procedures, new classification of microbes. The color images are exceptional quality and now presented in a larger format. This second edition includes five additonal section on pythiosis, equine encephalosis, Acinetobacter baumanii, enteric coronavirus-induced disease, and viral hepatitis. These emerging diseases in equine medicine are duly elaborated upon in this second edition. The most dynamic changes in veterinary medicine concern the development of new molecular diagnostic techniques and therapies, and these have been updated with most recent references throughout this second edition. The practicality of the book for clinicians remains warranted by means of the included appendices containing a list of differential diagnoses based on clinical signs to support clinical decision-making, and a list of zoonoses and reportable diseases, and an elaborate illustrated appendix on clinical pathology and hematology. Equally dynamic is the field of emerging infectious diseases especially in the human-animal interface. The new edition emphasises the important role of the clinical and research veterinarian at forefront in recognizing and diagnosing new emerging infectious diseases.

The first book on zoo/captive animal behavior and how this applies to welfare. Despite growing evidence of the need to implement more suitable, naturalistic practices into zoo animal welfare, it still seems to be somewhat overlooked - this book will address this oversight. Includes specific detail and examples focusing on taxa, a huge factor in managing animals in zoos that has not previously been addressed in this way. Covers invertebrates as well as vertebrate species. Would be a recommended or core text on Zoo Biology courses, BScs in Animal Science, and Animal Welfare MScs, as well as an invaluable practitioner reference. A lot of students interested in animal behaviour are interested in zoos. Each chapter covers species-specific content include the following information: Ecology and natural history as relevant to the zoo, behaviour and welfare measures based on ecological knowledge, feeding ecology and nutritional management, mating systems and reproductive characteristics, enrichment and behavioural diversity. The chapters are consistently formatted for ease of information, with end of chapter summaries, boxes with selected enrichment devices or welfare assessment methods for assessing welfare state, and directed reading of peer reviewed and other reputable sources that help advance care. A final Part explores welfare assessment tools, quality of life, veterinary interventions and evidence-based approaches. It looks at ways to increase the value of zoo and aquarium animals by enhancing visitor interest and visitor behaviour change. Also, research needs for keepers and how to build evidence into a daily routine, as well as management of native species programmes and the future of zoo research.

Love, one of the most profound of human emotions, love that accompanies us from puberty to old age, love that follows us from ancient times to modern, from ancient writings, through the Bible and the texts of medieval scribes to modern day books and movies. Through the millennia love has lost none of its secrecy, charm, attractiveness, craziness, even in this digital age, when we are overwhelmed by information. But what is love? Where does this emotion originate? Are we humans the only living beings feeling this emotion? Can love be explained by some chemical reactions in our brains? Is love just a trick of nature or is love some kind of higher feeling? We do not have definite answers to any of these questions, nevertheless, neuroscience, behavioral science and others have provided us with some, at least partial answers. We know today a great deal more than ever before about what is happening in the brain when we are madly in love. We understand why our hearts beat faster when we see the person we love, we know why we sweat and why we feel anxious when the loved one is away from us, and we have some ideas about how feelings of attachment form in the brain. This book guides you through the complicated labyrinth of genes, molecules and brain cells that are involved in the feelings of love, attachment, affection, and also simple sexual reproduction.

How to Raise a Puppy moves away from the traditional approach to raising puppies, focused on obedience and control, and instead takes an holistic, dog-centred approach. Drawing on research into how dogs naturally rear their young, and how dogs have evolved to behave and spend their time, it supports a new way of sharing our lives with our dogs. It also offers advice on dealing with some of the common challenges people experience with puppies, and tips for managing adolescence. A much-needed resource for dog trainers, veterinarians and behaviourists to recommend to clients, this conveys a powerful message to help overcome all too common issues so many people have with their puppies. Packed with practical advice, it offers an overdue "puppy perspective", with respect for a dog as a sentient being at its core.

Originally published in 1976, this volume contains new and original contributions of the time addressed to a related set of ideas concerning processes of memory in animals. The theme is that animals remember and that theories of animal learning must take this into account as well as the coding processes that have been assumed to be specific to human beings. The focus of the book is on processes, and some progress is reported in differentiating types of memory. The emphasis in applying animal work to studies of human memory is made not in terms of paradigms but in terms of processes implicated via performance in a variety of tasks. Also, many of the chapters reflect the usefulness of applying a memory framework to a variety of "nonmemory" paradigms. This work will be essential reading for all those interested in animal as well as human memory, and provided the most up to date and broadest examination of animal memory processes at the time, from both a theoretical and conceptual framework.

Unstable angina, myocardial infarction and stroke, precipitated by thrombosis, are the leading causes of death in the western world. In response to such vascular trauma, platelets rapidly adhere to the exposed subendothelial matrix. Platelet activation through agonist and adhesion receptors leads to a cascade of intracellular events including cytoskeletal reorganization and secretion of platelet dense bodies, ultimately resulting in platelet aggregation.;This text aims to highlight the key areas of platelet function in the regulation of haemostasis and thrombosis. The volume covers areas such as platelet production, interaction of platelets with leukocytes, and mechanisms of cross-talk between platelets, leukocytes, and endothelium. The two major clinical causes of thrombosis, anti-phospholipid antibodies and genetic predisposition, are also addressed.

--- EMS (extra-mural studies) are an essential element of undergraduate veterinary education. Students must complete a minimum of 38 weeks EMS during their course, which should normally consist of 12 weeks pre-clinical and 26 weeks of clinical placements, a large portion of which takes place on farms. -- The highly illustrated approach allows readers to see the highlighted differences rather than try to imagine what cases look like and differentiate them from written descriptions. -- A repository of over 1000 10-second video clips accompanies the book, accessible to students on the farm with a smart phone. Each clip uniqeuly shows the animal's clinical presentation, internal disease/imaging and then healthy recovery -- There are a limited number of common conditions seen by vets in farm animal practice and an exhaustive list of all known diseases is not needed: textbooks often include such diseases for the benefit of an academic reviewer rather than student and general practitioner readers. -- This concise guide offers a breath of fresh air among the existing hefty expensive large animal medicine tomes on the market. --- Some comments from veterinary students on the proposal: "I firmly believe that this would be a very useful book and only wish that it existed already for my clinical EMS"; "There are currently several 'pocket books' for small animal medicine such as the Mini Vet guide but nothing for farm animals"; "Using a small animal 'quick', ring-bound, reference guide on EMS has been extremely useful, and it would be very beneficial to have a large animal alternative"; "The author's suggested use of high quality illustrations is what a student desperately needs. At the end of the day we need to be able to work out many diseases with similar symptoms - this book would provide that where may other current textbooks do not. I would support this new book, and hope it is released before I go into exams in the future - as it is what I currently need help within revision like so many other students. It is what the veterinary student dreams of having, and yet no one has produced it!"

Molecular Detection of Animal Viral Pathogens presents expert summaries on state-of-the-art diagnostic approaches for major animal viral pathogens, with a particular emphasis on identification and differentiation at the molecular level. Written by specialists in related research areas, each chapter provides a concise overview of an individual virus or group concerning its Classification Morphology Genome organization Epidemiology Clinical features Diagnosis Sample collection and preparation procedures Molecular detection protocols Each chapter also discusses future prospects or further research requirements for streamlining the identification and epidemiological tracking of the virus concerned. With broad coverage presented in a concise format, Molecular Detection of Animal Viral Pathogens is an essential reference for both beginning and experienced laboratory scientists as well as students of virology. It also offers an indispensable guide applicable to medical, veterinary, and industrial settings that are dependent on speedy turnarounds, extreme sensitivity, and exquisite specificity of virological testing for decision making and disease prevention.

This is the fifth volume of the series, highlighting research in the field of animal cell technology. Recent data on cell growth and productivity in various cell culture systems are provided, including systems for recombinant animal gene expression and production of monoclonal antibodies, extending the investigations in the previous volumes. In addition, application of cell culture systems in new areas are presented: biosafety testing, removal of microorganisms, and the assessment of physiologically functional substances in food and natural sources. Also, a special section deals with applications of human monoclonal antibodies. All those involved in animal cell culture should find this volume a useful source on current research.

1 Vascular Analysis of the Carotid Body in the Spontaneously Hypertensive Rat.- 2 Role of the Carotid Sinus Nerve and of Dopamine in the Biochemical Response of Sympathetic Tissues to Long-Term Hypoxia.- 3 The Effects of Almitrine on [3H]5HT and [125I] Endothelin Binding to Central and Peripheral Receptors: An In Vitro Autoradiographic Study in the Cat.- 4 Immunocytochemical and Neurochemical Aspects of Sympathetic Ganglion Chemosensitivity.- 5 Neuronal and Neuroendocrine Markers in the Human Carotid Body in Health and Disease.- 6 The Effects of Chronic Hypoxaemia upon the Structure of the Human Carotid Body.- 7 Dopaminergic and Peptidergic Sensory Innervation of the Rat Carotid Body: Organization and Development.- 8 Effects of Cell-Free Perfusion and Almitrine Bismesylate on the Ultrastructure of Type-1 Cell Mitochondria in the Cat Carotid Body.- 9 Multi-Unit Compartmentation of the Carotid Body Chemoreceptor by Perineurial Cell Sheaths: Immunohistochemistry and Freeze-Fracture Study.- 10 Light and Electronmicroscopical Immunohistochemical Investigation of the Innervation of the Human Carotid Body.- 11 Serotonin (5-Hydroxytryptamine) Expression in Pulmonary Neuro-Endocrine Cells (NE) and a Netumor Cell Line.- 12 Effects of Hypoxia on Cultured Chemoreceptors of the Rat Carotid Body: DNA Synthesis and Mitotic Activity in Glomus Cells.- 13 Localization of Dopamine D2 Receptor mRNA in the Rabbit Carotid Body and Petrosal Ganglion by in situ Hybridization.- 14 Noradrenergic Glomus Cells in the Carotid Body: An Autoradiographic and Immunocytochemical Study in the Rabbit and Rat.- 15 The Modulation of Intracellular pH in Carotid Body Glomus Cells by Extracellular pH and pCO2.- 16 Evidence for Glucose Uptake in the Rabbit Carotid Body.- 17 Effects of Inorganic Calcium Channel Blockers on Carotid Chemosensory Responses in the Cat.- 18 Those Strange Glomus Cells.- 19 Carotid Body Neurotransmission.- 20 Carbonic Anhydrase and the Carotid Body.- 21 Ca2+ Dynamics in Chemoreceptor Cells: An Overview.- 22 Spectrophotometric Analysis of Heme Proteins in Oxygen Sensing Cell Systems.- 23 Neurochemical and Molecular Biological Aspects on the Resetting of the Arterial Chemoreceptors in the Newborn Rat.- 24 Carbonic Anhydrase and Carotid Body Chemoreception in the Presence and Absence of CO2-HCO3-.- 25 Role of Ion-Exchangers in the Cat Carotid Body Chemotransduction.- 26 Dopamine Metabolism in the Rabbit Carotid Body in vitro: Effect of Hypoxia and Hypercapnia.- 27 PO2-Dependence of Phospholipase C in the Cat Carotid Body.- 28 Optical Measurements of Micro-Vascular Oxygen Pressure and Intracellular pH in the Cat Carotid Body: Testing Hypotheses of Oxygen Chemoreception.- 29 Elevation of Cytosolic Calcium Induced by pH Changes in Cultured Carotid Body Glomus Cells.- 30 Role of Carbon Dioxide for Hypoxic Chemotransduction of the Cat Carotid Body.- 31 Metabolic Substrate Dependence of Carotid Chemosensory Responses to Stop-Flow Evoked Hypoxia and to Nicotine.- 32 Effects of Chemosensory Stimulation Membrane Currents Recorded with the Perforated-Patch Method from Cultured Rat Glomus Cells.- 33 Carbonic Anhydrase Near Central Chemoreceptors.- 34 Update on the Bicarbonate Hypothesis.- 35 Regulation of Intracellular pH in Type I Cells of the Neonatal Rat Carotid Body.- 36 Noradrenergic Inhibition of the Goat Carotid Body.- 37 Role of Substance P in Rat Carotid Body Responses to Hypoxia and Capsaicin.- 38 Carotid Sinus Nerve Inhibition Mediated by Atrial Natriuretic Peptide.- 39 Neurotransmitters and Second Messenger Systems in the Carotid Body.- 40 Does Adenosine Stimulate Rat Carotid Body Chemoreceptors?.- 41 Effects of Haloperidol on Cat Carotid Body Chemoreceptionin Vitro.- 42 Effect of Arterial Chemoreceptor Stimulation: Role of Norepinephrine in Hypoxic Chemotransmission.- 43 Carotid Body Denervation and Pulmonary Vascular Resistance in the Rat.- 44 Effects of Chemoreceptor Stimulation by Almitrine Bismesylate on Renal Function in Conscious Rats...

Biology of Sharks and Their Relatives is an award-winning and groundbreaking exploration of the fundamental elements of the taxonomy, systematics, physiology, and ecology of sharks, skates, rays, and chimera. This edition presents current research as well as traditional models, to provide future researchers with solid historical foundations in shark research as well as presenting current trends from which to develop new frontiers in their own work. Traditional areas of study such as age and growth, reproduction, taxonomy and systematics, sensory biology, and ecology are updated with contemporary research that incorporates emerging techniques including molecular genetics, exploratory techniques in artificial insemination, and the rapidly expanding fields of satellite tracking, remote sensing, accelerometry, and imaging. With two new editors and 90 contributors from the US, UK, South Africa, Portugal, France, Canada, New Zealand, Australia, India, Palau, United Arab Emirates, Micronesia, Sweden, Argentina, Indonesia, Cameroon, and the Netherlands, this third edition is the most global and comprehensive yet. It adds six new chapters representing extensive studies of health, stress, disease and pathology, and social structure, and continues to explore elasmobranch ecological roles and interactions with their habitats. The book concludes with a comprehensive review of conservation policies, management, and strategies, as well as consideration of the potential effects of impending climate change. Presenting cohesive and integrated coverage of key topics and discussing technological advances used in modern shark research, this revised edition offers a well-rounded picture for students and researchers.