The use of small animal models in basic and preclinical sciences constitutes an integral part of testing new pharmaceutical agents prior to their application in clinical practice. New imaging and therapeutic approaches need to be tested and validated first in animals before application to humans. Handbook of Small Animal Imaging: Preclinical Imaging, Therapy, and Applications collects the latest information about various imaging and therapeutic technologies used in preclinical research into a single source. Useful to established researchers as well as newcomers to the field, this handbook shows readers how to exploit and integrate these imaging and treatment modalities and techniques into their own research. The book first presents introductory material on small animal imaging, therapy, and research ethics. It next covers ionizing radiation and nonionizing radiation methods in small animal imaging, hybrid imaging, and imaging agents. The book then addresses therapeutic research platforms and image quantification, explaining how to ensure accurate measurements of high-quality data. It concludes with an overview of many small animal imaging and therapy applications that demonstrate the strength of the techniques in biomedical fields.

Health and welfare issues of brachycephalic (flat-faced) animals are one of the most pressing problems facing companion animals right now. Dogs, in particular, are suffering from a 'brachycephalic crisis' resulting from a perfect storm where predispositions to an array of health issues are amplified by a population boom for certain brachycephalic breeds such as the French Bulldog and Pug. But yet, for many owners, these dogs represent the perfect companion: endearing personas and cute looks in a socially desirable package. So where is the truth in all of this? This book will equip veterinary professionals, animal welfare scientists, breeders and owners with the fuller story about brachycephalic health and welfare. The first half of the book provides the context of how and why we are in this crisis, offering in-depth historical, social, ethical, communication, nursing, welfare, epidemiological, genetics and international perspectives. The second half shifts towards the clinical arena, with chapters that cover the background, diagnosis, treatment and prevention of the many unique healthcare needs of brachycephalic animals. Cutting-edge knowledge is shared on a range of disciplines including respiratory disease, ophthalmology, dermatology, dentistry, neurology, obesity, reproduction and anesthesia. With twenty chapters written by world-leading experts, lifetimes of experience and knowledge are condensed into the first book dedicated exclusively to brachycephaly in companion animals. This essential reference resource will inform, challenge and stimulate; it will open your mind to new opportunities for you to improve the welfare of brachycephalic animals by your personal and collective choices and actions. But prepare to be surprised: you may just find that your views on brachycephaly in companion animals will be changed forever.

Erythrocytes of the Rhesus and Cynomolgus Monkeys addresses the morphologic, quantitative, and generative aspects of the erythrocytes of the rhesus monkey Macaca mulatta and the cynomolgus monkey Macaca fascicularis (long-tailed macaque, crab-eating monkey). These two species are the most commonly selected nonhuman primates for basic science and clinical medical investigations. The hemopoietic cells of man and the rhesus monkey display an intimate homogeneity. Their functional activities are close and at times identical. The cynomolgus monkey was enlisted in biomedical studies at a time when rhesus monkeys were not available in sufficient quantities. It has gained increased use in the Far East and in the Western world. It is, for example, employed in the current development of a vaccine against the deadly Ebola virus. The authors of the book discuss the erythropoietic profiles of normal and abnormal macaques of both sexes and of all age groups as investigated with contemporary electronic methodologies. They cover the role of stress as it is perceived by the monkey and how it impacts erythrocellular values, and how to train the monkey to be a cooperative, unperturbed subject for hematologic study. Additional topics include the role of medication in deriving normal physiologic erythrocellular data, the development of the precursors of the erythrocyte (normoblasts), the morphologic analysis of the megaloblastic series of abnormal erythroid cells, the analysis of erythropoiesis in bone marrow, the relationship of the simian immunodeficiency virus and erythropoiesis, erythrocyte life span, and parasitic invasion of the red cell.

Originally published in 1972, Homo Sapiens examines how humans emerged from among the millions of other species and achieved our unique position within the animal kingdom. The book examines what direction future evolution will take and what may be regarded as the 'meaning' of human existence. It stipulates that these are the questions for which no real basis of discussion existed before the 20th century, and at the time of publication, some were still without a definite answer. The book sets out analyse these questions and the continuing debate that has arisen from their study. This is an account of the uniqueness of man in the animal kingdom, how this uniqueness arose during evolution, and what traces of it can be detected in animals other than man. The book describes the mental and physical evolution of man, from his earliest ancestors to the present day. He also gives an account of man's cultural development seeking to establish that there is an underlying principal of cultural evolution, a principle that has been denied by many historians. Later chapters deal with the future and with possible forecasts of mankind's further physical, intellectual and cultural evolution.

Mammalian oocytes occupy a critical nexus in reproduction as they not only contribute half the genetic makeup of the embryo but also provide virtually all of the cytoplasmic building blocks required for sustaining embryogenesis. The journey that transforms a primordial germ cell into a mature oocyte (or egg) capable of fertilisation and embryonic development is of unrivalled complexity. The end-product of this remarkable developmental process is the "mature" egg, now replete with macromolecules and organelles, and poised to support embryonic development if fertilisation should occur. Given the importance of the oocyte for embryonic development, it is of no surprise that the oocyte holds centre stage in fertility clinics and greatly influences the outcome of assisted reproductive treatments (ARTs). Mammalian Oocyte Regulation: Methods and Protocols provides a highly diverse compendium of detailed methodologies - primarily focusing on the murine model but also including chapters on human oocytes - for enabling researchers to interrogate every aspect of mammalian oocyte development including recombination, meiotic maturation, oocyte substrate uptake, chromosomal segregation and fertilisation. Written in the highly successful Methods in Molecular Biology (TM) series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Mammalian Oocyte Regulation: Methods and Protocols serves as an ideal guide to novice oocyte researchers, experts who wish to add another dimension to their established portfolio, as well as the wider research community.

Handbook of Mammalian Metabolism of Plant Compounds provides an extensive survey of how mammals metabolize compounds found in higher plants. Information about these compounds is important to researchers in pharmacology, toxicology, medical and natural products chemistry, and food sciences. Although there is plenty of literature about mammalian metabolism of plant compounds, it is scattered, and summaries of specific plant compounds are often difficult to obtain. This book contains 11 chapters discussing the metabolic fate of individual plant compounds grouped according to chemical class. It also features structural formulas of the compounds and their metabolites, including probable pathways of metabolism. This book provides a convenient single-volume reference source that will benefit all researchers requiring this type of information.

Gives an account of the morphologies of vertebrate respiratory organs and attempts to explicate the basis of the common and different structural and functional designs and stratagems that have evolved for acquisition of molecular oxygen. The book has been written with a broad readership in mind: students of biology as well as experts in the disciplines of zoology, physiology, morphology, biological microscopy, biomedical engineering, and ecology and those that work or may contemplate working on materials and aspects concerning respiration in whole organisms will find it useful. Scientists in earth sciences with particular interest on the outcomes of past interactions between environmental factors (the physical domain) and evolution and adaptation (the biological domain), mechanisms that have set the composition, patterning, and anatomies of extant animal life, will find the book of interest.

Neuroplasticity, Development, and Steroid Hormone Action explores the effects of steroid hormones on brain development, function, and aging and is a compilation of cutting-edge research of concern to the disciplines of neurobiology, neuroendocrinology, endocrinology, and developmental biology. The experimental approaches covered range from molecular to behavioral and endocrine to neurobiological. The authors are noted neurobiologists and active researchers from the United States, Japan, and the United Kingdom.

Divided into five sections and containing scientific photographs, line drawings, tables, color illustrations, and graphs, this interesting and timely text covers the neuroplastic effects of steroid hormones throughout the lifetime of various animal models, such as bees, fish, lizards, turtles, birds, mice, rats, and primates. These sections focus on:
Ÿ The development and differentiation of neuroendocrine systems
Ÿ Steroid dependent brain differentiation
Ÿ The central regulation of hormone secretion
Ÿ Steroid hormones and neuroplasticity in the mature brain
Ÿ Steroid mediated mechanisms of cell growth and survival

Ecologists have always believed, at least to a certain extent, that physiological mechanisms serve to underpin ecological patterns. However, their importance has traditionally been at best underestimated and at worst ignored, with physiological variation being dismissed as either an irrelevance or as random noise/error. Spicer and Gaston make a convincing argument that the precise physiology does matter

In contrast to previous works which have attempted to integrate ecology and physiology, Physiological Diversity adopts a completely different and more controversial approach in tackling the physiology first before moving on to consider the implications for ecology. This is timely given the recent and considerable interest in the mechanisms underlying ecological patterns. Indeed, many of these mechanisms are physiological.

This textbook provides a contemporary summary of physiological diversity as it occurs at different hierarchical levels (individual, population, species etc.), and the implications of such diversity for ecology and, by implication, evolution. It reviews what is known of physiological diversity and in doing so exposes the reader to all the key works in the field. It also portrays many of these studies in a completely new light, thereby serving as an agenda for, and impetus to, the future study of physiological variation.

"Physiological Diversity" will be of relevance to senior undergraduates, postgraduates and professional researchers in the fields of ecology, ecological physiology, ecotoxicology, environmental biology and conservation. The book spans both terrestrial and marine systems.

This title offers an approach to the subject area by fully integrating the field of animal behaviour and biomechanics. It demonstrates how the study of biomechanics is useful in understanding, evaluating and making predictions about animal behaviour. The book examines how the mechanical limits of movement constrain and determine animal behaviour, for example swimming strategy of aquatic vertebrates, walking energetics in invertebrates, light mechanics and migration performance in birds.

Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. With contributions from an international selection of authors who are leaders in commercial infusion technology, Non-Clinical Vascular Infusion Technology, Volume II: The Techniques provides a current account of the techniques involved in all the major laboratory animal species for conducting successful vascular infusion studies with xenobiotics. Following in the footsteps of the highly praised Handbook of Pre-Clinical Continuous Intravenous Infusion, this new volume covers both up-to-date procedures and equipment. It is organized by species, including all those commonly used in pre-clinical studies: rat, mouse, dog, minipig, large primate, and marmoset. There are also chapters on juvenile studies and reproductive toxicity studies. Each section addresses the selection of the best model, surgical and non-surgical best practices, practical techniques, equipment selection, and commonly encountered background pathologies. Using a fresh approach, the authors identify best practices to be shared across the industry, and provide guidance on choices for the most acceptable methodologies from an animal welfare perspective. This volume, along with Volume I: The Science, provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery. Features: Emphasizes best practices in accordance with the 3Rs-reduction, refinement, and replacement of animal usage in laboratories Presents step-by-step procedures and practical tips covering a wide range of common animal models, augmented by the liberal use of illustrations Covers modern practices and procedures in accordance with up-to-date equipment development

Intravenous infusion is a necessary mode of delivery for many pharmaceuticals currently on the market or undergoing clinical trials. The technique of prolonged intravenous delivery in conscious, free-moving animal models has broadened the opportunity to study and evaluate the safety and efficacy of these therapeutic products. For the first time, the collective sciences involved in the understanding of this mode of drug delivery are brought together in one publication. Non-Clinical Vascular Infusion Technology, Volume I: The Science covers the scientific principles behind the delivery systems, from both physical and physiological standpoints. The book addresses body fluid dynamics, describes the scientific processes necessary to understand the various aspects of the physico-chemical issues relating to vascular infusion delivery, and discusses vascular infusion dynamics. It also considers all the essential elements of the preparation of a formulation intended for vascular delivery as well as assessment of compatibility of the formulation with the dosing apparatus. This volume, along with Volume II: The Techniques, provides a foundation of knowledge on infusion technology and its importance for safe clinical use of substances via this route of delivery. Features Identifies and shares best practices for non-clinical vascular infusion Presents modern practices and procedures in line with up-to-date equipment development Offers recommendations for in-life assessments in order to monitor the success or problems with the vascular infusion delivery Makes comparisons with human data in many areas

Ear, Nose and Throat Diseases of the Dog and Cat is the ultimate reference for veterinarians and other professionals trying to diagnose and treat both common and less frequently diagnosed diseases and conditions of the ear, nose and throat. The book is divided into four sections: The Ear, The Nose, The Throat and Surgery of the Ear, Nose and Throat. Each of the first three sections begins by discussing anatomy and physiology and then reviews a wide variety of diagnostic procedures including video-endoscopic examination of the external ear canal, nose and throat, radiography and advanced imaging, and histopathological examination of biopsy samples. Chapters in each of the three sections then provide a detailed and extensive review of the diseases of the pinna, external ear canal, middle ear and inner ear - nasal planum, nasal cavities and sinuses and nasopharynx - pharynx and larynx. The final section opens with a chapter on perioperative management with subsequent chapters that cover surgery of the ear, nose and throat. Extensively referenced, and including nearly 500 color illustrations to assist in diagnosis and treatment, the book is an invaluable resource for both veterinarians in training and in practice for the accurate diagnosis and management of diseases of the ear, nose and throat.

The complex and fascinating subject of endocrinology can often seem rather daunting for non-specialists. For practising endocrinologists too, maintaining a broad overview of the subject can be a major task. Laboratory Animal Endocrinology has been written with both these audiences in mind. Focusing on the species regularly used in experimental studies (including rodents, dogs and monkeys), each chapter presents a wealth of information on hormone structure, synthesis, secretion, receptors, second messengers and their actions, and considers the various physiological and pharmacological processes which may be involved in hormonal regulation. Interspecies’ differences in hormonal structure, metabolism and interactions with drugs and other chemicals are particularly important to toxicologists and in drug safety evaluation. Laboratory Animal Endocrinology also explores these areas of research and provides much-needed support for the interpolation of endocrine data from one test species to another and to humans. The book is not intended exclusively for toxicologists however, but will prove indispensable for all those working with laboratory animals.

Since the early 1950s, work has been undertaken on the infrared sensory organs of snakes by a handful of investigators around the world. Despite progress in uncovering the morphological, physiological and behavioral functions of these organs, study was discontinued by most of these workers. Not the least of the reasons was the fact that the infrared organs are possessed either by highly venomous snakes, the pit vipers, or by equally dangerous snakes because of their size, the pythons and boas.
Only Drs Shin-ichi Terashima, MD, Ph.D. and Richard C. Goris, Ph.D. have continued to work actively on these sensory organs, their work spanning the 30 years from 1967 to the present. A first collection of their works, Infrared Sensory System, was published by the university of the Ryukyus in 1987. The present volume presents the papers by Terashima, Goris and their colleagues from 1987 to the present. Much new light is shed on the physiology and morphology of these organs, which can truly be said to be infrared 'eyes' whose input is integrated with that from the eyes. This volume will be of considerable interest to all those interested in infrared detection of any kind, whether in nature or in its multifarious industrial applications.

Since the popular first edition was published more than a decade ago, the number of swine used in toxicity studies has increased as an alternative to commonly used non-rodent species, such as dogs and primates. A volume in the Laboratory Animal Pocket Reference Series, The Laboratory Swine, Second Edition maintains the high standard set by the previous edition and is poised to continue its legacy as the premier laboratory reference on the care and use of swine in the laboratory. Emphasizes Humane Care and Use of Laboratory Swine Addressing the biology, husbandry, management, veterinary care and research applications of both large and miniature swine, this color reference is a complete source of information on the species. It is thoroughly updated and includes a major revision to the anesthetics section. It also places a heightened focus on animal welfare and addresses important considerations related to genetically modified swine. The book is divided into six parts: Important Biological Features examines everything from different breeds and behavior, to anatomical and physiological features, as well as digestive, cardiovascular, and pulmonary systems Husbandry addresses housing, nutrition, sanitation, transportation, and more Management and Quality Assurance looks at the impact of infections on animal research using swine, zoonotic diseases, legal regulations, genetic monitoring, and more Veterinary Care covers a variety of topics, such as clinical examination, diseases, pain recognition, and post-operative management Experimental Techniques addresses restraint, sampling techniques, basic surgical procedures, and other issues Resources provides extensive references for further study, including handbooks, journals, and websites

Introduction to Animal Physiology provides students with a thorough, easy-to-understand introduction to the principles of animal physiology. It uses a comparative approach, with a broad spectrum of examples chosen to illustrate physiological processes from across the animal kingdom. The book covers a wide range of topics, including neurons and nervous systems, endocrine function, ventilation and gas exchange, thermoregulation, gastrointestinal function and reproduction. It also present topics that students typically struggle with, including neuronal membrane function, in a logical, structured format, highlighting to core concepts. Simple analogies are used to clarify important facts.

Laboratory animals, including birds, play an important role in biomedical research. The humane care and management of these animals is an ongoing concern. A new addition to the acclaimed Laboratory Animal Pocket Reference series, The Laboratory Bird is the first publication dedicated to the care and use of avian species in the research setting. Covering avian species such as chickens, ducks, doves, parrots, and songbirds that are commonly used as research models, the book is divided into focused chapters that cover a broad range of topics, including: General avian biology and physiology Husbandry Regulations and regulatory compliance regarding the use of birds in research Experimental methods Veterinary care Along with discussing applicable regulations, the book also details issues of health management and quarantine approaches. The final chapter provides resources such as organizations, publications, vendors, and diagnostic laboratories. With its focus on the care of a diverse group of avian species in biomedical research settings, The Laboratory Bird is a valuable reference for animal care and veterinary technicians, laboratory animal veterinarians, trainees in laboratory animal medicine, and research staff members, as well as individuals involved in laboratory work who lack experience in working with birds.

Sources of clinical treatment information on nonhuman primates are generally scattered across journals, textbooks, conferences, personal conversations, and more. However, when a clinician on the treatment floor is faced with a patient requiring an immediate treatment decision, time spent on making an informed decision becomes a critical factor. An alternative to conducting a literature search in time-sensitive situations, the Pocket Handbook of Nonhuman Primate Clinical Medicine supplies guidance and initial direction on diagnosis and treatment, including working doses based on past case experience. It is the frank, to-the-point nature of the writing that makes readers feel as if they had just asked a colleague how to approach a clinical problem and obtained a quick, "what you need to know" answer. The chapter authors draw on personal experience to describe commonly encountered clinical conditions and how to treat these cases including not only the "dos" but also the "don ts." This format gives readers easy access to clinical signs, diagnostic criteria, and options for treatment. The Pocket Handbook of Nonhuman Primate Clinical Medicine is a convenient, concise, case-based handbook written by and for clinicians in charge of the diagnosis and treatment of nonhuman primate patients. Available in both print and electronic formats, this handbook saves readers from having to wade through pages of data and case studies to find answers when time is a factor on the clinic floor.

This volume in the Human Molecular Genetics series is an invaluable text for endocrinologists wishing to update their knowledge. It also provides an excellent grounding in the basic genetics of molecular endocrinology and relevant analytical techniques fo

Enamel, the shiny material covering the teeth of vertebrates is the hardest tissue the vertebrate body can produce and one of the most impressive products of biomineralization. This hard tissue is closely related to feeding, the first part in the energy intake process so basic to vertebrate life. Enamel has a complex internal microstructure full of phylogenetic and biomechanic information.
Topics covered: Ontogeny; Crystallite level; Prism level; Enamel type level; Schmelzmuster level; Dentition level; Evolution; Biomechanical level; Glossary.

Pine Bark Beetles, the latest release in the Advances in Insect Physiology series, provides readers with the latest interdisciplinary reviews on the topic. It is an essential reference source for invertebrate physiologists, neurobiologists, entomologists, zoologists, and insect chemists.

The fifth edition of The Physiology of Fishes represents a compendium of knowledge across fish physiology, collecting up-to-date research into an easy-to-access single textbook. Written by the leaders in the field, it provides a comprehensive, accessible review of the core topics, integrating physiology with environmental science, ecology, evolution, and molecular cell biology. New chapters address Epigenetics, Biomechanics and Locomotion, and Behaviour and Learning. Each chapter contains an extensive bibliography, providing readers with the best sources from the primary literature. Almost three decades after the publication of the first edition, this book remains the only published single-volume work on fish physiology. The fifth edition provides an important reference for new students of fish biology, marine and freshwater biologists, ichthyologists, fisheries scientists, and comparative physiologists.

Presented in an easy-to-ready format, Small Animal Imaging: Self-Assessment Color Review offers a case-based approach to reviewing and interpreting images and developing a differential diagnosis when necessary. Each case begins with the patient's age, gender, breed, and species. The reason the patient was brought to the clinic is discussed along with preliminary examination and diagnostic test findings. The book Covers nearly 200 cases with supporting high-quality images for each case Provides detailed answers for each case, including radiographic findings and diagnosis Is written by well-respected experts in the field. A separate section presents detailed answers for each case including information on the radiographic findings. Also included are the radiographic diagnosis, comments, and notes on whether further imaging or evaluation is needed. This guide helps practitioners to develop a systematic approach to reviewing images. The easily-navigable text reminds practitioners of the basics in radiography and ultrasound interpretation and diagnosis, making it a quick and convenient reference.

Nutrient management is an important aspect of feeding livestock and poultry. Today, there is more attention directed toward this issue in animal production than ever before. The heightened awareness of the environmental impacts associated with animal production has caused animal nutritionists to refocus their thoughts, practices, and expectations regarding how nutrients are supplied to animals. In addition, the increase in the size and intensity of modern production units demands new technologies for enhancing nutrient utilization and for reducing the amount of nutrients excreted. Covering these issues and more, Nutrient Management of Food Animals to Enhance and Protect the Environment is a reference tool for agricultural industry leaders, private practitioners, government agencies, and researchers.