Rodents are the predominant experimental animals found in life-sciences research laboratories. The body temperature of a rodent is markedly affected by surgical, chemical or environmental manipulation. Because temperature regulation is controlled essentially by a 'holistic' regulatory system, meaning that its responses affect the activities of all other psychological and behavioural processes, it is clear that researchers working with rodents must be familiar with thermoregulatory physiology. With the help of extensive data tables and figures, this book explains the key facets of rodent thermal physiology, including neurological control and gender and intraspecies variations. There is a novel chapter on the effects of trauma, toxic chemicals and other factors. The book should therefore find use in government, academic or industrial laboratories whose researchers are working with rodents.

In this unique book, Sir Donald Harrison draws on his wide-ranging experience as a surgeon and comparative anatomist to produce an authoritative and detailed account of the anatomy and physiology of the mammalian larynx. His investigation of the larynx has involved the study of over 1400 specimens of mammalian larynges from around the world, as well as using data from his own clinical experiences. The comparative morphology of the larynx is discussed from a developmental and functional perspective and the involvement of the larynx in respiration, locomotion and vocalisation is highlighted. Throughout the book the relationship of structure to function is drawn out and the clinical relevance of features of the human larynx is emphasised. This book will be an invaluable reference for all researchers and clinicians involved in laryngology as well as for anatomists, zoologists and anaesthesiologists.

The analysis of the circulation of the blood is one of the most important areas of fluid mechanics research, with far-reaching medical and physiological implications.

This book provides a comprehensive account of the proteins involved in blood coagulation, fibrinolysis and the complement system. A major section of the book is devoted to each of these three systems, with separate chapters dealing in detail with structural aspects and different functional processes. Topics covered in the blood coagulation section include the activation of factors IX and X and prothrombin, and the formation and stabilisation of fibrin. The fibrinolysis section includes the activation of plasminogen, the degradation of fibrin and the regulation of fibrinolysis. The complement system itself is covered in chapters dealing with classical activation, alternative activation, the lytic complex and the regulatory processes involved. In addition, one section deals with special topics, including the kinin system, signal peptides, haemostasis, and the evolution of protein structure. This volume will be of use to researchers and advanced students in the fields of haematology, immunology and clinical chemistry.

The Flagellates presents a multidisciplinary view of the flagellates exploring both their unity, in terms of their structure, mechanisms and processes, and their diversity in terms of biogeography, niche colonisation, and adaptations to their environment. In addition, evolutionary relationships amongst flagellates are explored. This is the only book published on this subject and features the most up to date information available making it an essential read for any one interested in or working in this field.

Aquatic organisms swim in a variety of ways, from jet propulsion to ciliary action: they swim at a wide range of speeds and span a vast size range, from bacteria to protists, to the largest whales. One of the most fascinating aspects of aquatic locomotion is the remarkable sets of adaptations that have been evolved for different purposes. This volume brings together research on a wide range of swimming organisms, with an emphasis on the biomechanics, physiology and hydrodynamics of swimming in or on water. Several chapters deal with different aspects of fish swimming, from the use of different 'gaits' to the operation of the locomotor muscles. All chapters are by recognized authorities in their different fields, and all are accessible to biologists interested in aquatic locomotion.

This book gives a concise account of the physiology and form of the fish circulatory system. The emphasis is primarily on function, but details of structure have been included. Following a revision of ideas on hemodynamics, attention is focused on the heart as the primary pump in the fish circulatory system. The fine structure and the electrical and ionic events of cardiac myocytes are described and the major events of the cardiac cycle are outlined. The structure of the peripheral vessels then follow and attention is devoted to the circulation in certain special areas such as the gills, the renal portal system, and the secondary blood system. There are also chapters devoted to the blood and the hemopoetic tissues and an account is given of the different types of retial systems that concentrate oxygen or heat in various parts of the body. Following a description of the autonomic nervous system, the circulatory responses to exercise and hypoxia are described. The book concludes with a discussion on the circulation of hagfish and how it illuminates our understanding of the functional and structural evolution of the circulatory system.

Environmental temperature varies in time and space on timescales ranging from a few hours to long-term climate change. Organisms are therefore continually challenged to regulate and maintain functional capacities as their thermal environment changes. This volume brings together many of the leading workers in thermal biology, with backgrounds spanning the disciplines of molecular biology, cell biology, physiology, zoology, ecology and evolutionary biology, to discuss the responses of a wide range of species to temperature change at all scales of organization, ranging through the molecular, cellular, organismal, population and ecosystem levels. The volume provides an important and comprehensive contribution to the study of temperature adaptation, which, given the concern about global climate change, will provide much to interest a wide range of biologists.

The maintenance of a stable acid-base status within biological tissue is a fundamental homeostatic process in all organisms, necessary to preserve the metabolic function of proteins and other macromolecules. The study of acid-base regulation has advanced enormously over recent decades due to the development of increasingly accurate and sensitive techniques for measuring acid-base variables. This volume brings together contributions from leading comparative physiologists working on factors affecting the acid-base status of the internal fluids of animals and plants. The result is a broad-ranging, authoritative and accessible review of the most recent and exciting discoveries in this area, together with a critical look at current techniques and tools.

From a human viewpoint, the cold waters of deep sea and polar marine regions present an inhospitable and harsh environment for life. The study of organisms which have exploited this seemingly hostile ecological niche has revealed intriguing physiological adaptations. This volume summarizes the information on the adaptations exhibited by representatives of the main groups of polar animals, including marine invertebrates, fish, mammals and birds, at scales ranging from the whole organism through to the underlying molecular adaptational mechanisms. Unique in its breadth of coverage, this volume will provide an important resource for all those concerned specifically with how animals have adapted to life in extreme conditions, as well as being of general interest to all marine biologists.

The cestodes, or tapeworms, are a group of parasitic worms many species of which cause serious, often fatal, diseases in man and domestic animals throughout the world. This book is an updated and expanded version of Professor Smyth's The Physiology of Cestodes (1969). The text has now been entirely rewritten, taking into account advances in investigative techniques such as immunocytochemistry, in vitro culture and scanning electron microscopy, which have immensely increased our understanding of these organisms. The biochemical coverage now includes the spectacular advances in molecular biology that have occured. The book also shows how cestodes are increasingly being recognized as valuable models for investigating fundamental biological phenomena such as membrane transport and asexual/sexual differentiation. Students of medicine, veterinary medicine, parasitology and zoology will find this book invaluable. Its high research content and extensive references also make it an essential reference book for researchers in these fields.

This book accompanies Infectious Diseases and Pathology of Reptiles, Second Edition to cover noninfectious diseases of reptiles, meeting the need for a similar, authoritative single-source reference. The volume features color photos of normal anatomy and histology, as well as gross, light, and electron microscopic imagery of diseases. Subjects range from neoplasia, nutrition, and metabolic disease, and deposition disorders to developmental anomalies, trauma, and physical diseases, and the unique contribution of paleopathology and diseases of bone. Each chapter is supported by numerous figures, many of which are unique and cannot be found in the published literature. Readers will note that some of the chapters are based on organ system, a trend that will continue into the next edition to encompass all of the basic organ systems. This book holds the most information ever accrued into one publication on noninfectious diseases and pathology of this class of animals, providing information on every aspect of the anatomy, pathophysiology, and differential diagnosis. With up-to-the-minute data, a never-before-seen collection of images, and a stellar panel of contributors, Noninfectious Diseases and Pathology of Reptiles is the definitive resource for veterinarians, biologists, and researchers involved in the study of reptile diseases.

Primate dentitions vary widely both between genera and between species within a genus. This book is a comparative dental anatomy of the teeth of living non-human primates that brings together information from many disciplines to present the most useful and comprehensive database possible in one consolidated text. The core of the book consists of comparative morphological and metrical descriptions with analyses, reference tables and illustrations of the permanent dentitions of 85 living primate species to establish a baseline for future investigations. The book also includes information on dental microstructure and its importance in understanding taxonomic relationships between species, data on deciduous dentitions, prenatal dental development and ontogenetic processes, and material to aid age estimation and life history studies. Primate Dentition will be an important reference work for researchers in primatology, dental and physical anthropology, comparative anatomy and dentistry as well as vertebrate paleontology and veterinary science.

Thinking quantitatively about physiology is something many students find difficult. However, it is fundamentally important to a proper understanding of many of the concepts involved. In this enlarged second edition of his popular textbook, Richard Burton gives the reader the opportunity to develop a feel for values such as ion concentrations, lung and fluid volumes, blood pressures etc. through the use of calculations which require little more than simple arithmetic for their solution. Much guidance is given on how to avoid errors and the usefulness of approximation and 'back-of-envelope sums'. Energy metabolism, nerve and muscle, blood and the cardiovascular system, respiration, renal function, body fluids and acid-base balance are all covered, making this book essential reading for students (and teachers) of physiology everywhere, both those who shy away from numbers and those who revel in them.

The book discusses the controversial issue of whether animals are designed according to the same rules that engineers use in building machines, namely that materials and energy are used economically while attempting to achieve a high level of performance. There is considerable scientific controversy surrounding this question because, although there is much evidence suggesting that animals are indeed well designed, evolutionary biology tells us that animals are not 'engineered' but result from evolution by natural selection. This book collates this evidence which is discussed by a group of eminent biologists from many different biological disciplines."

3* Doody's Star Rating (R) CHOICE Magazine 'Recommended' (May 2020) As of 2018, pet obesity in the US affects an estimated 55.8 percent of dogs and 59.5 percent of cats, resulting in secondary conditions such as arthritis, diabetes mellitus, kidney disease, and certain forms of cancer. A complete and balanced diet accompanied by regular exercise is fundamental to optimize health and longevity in companion animals, meaning overweight pets have reduced quality of life and shorter life expectancy. Seeking to address this major modern-day problem, this book provides a comprehensive review of obesity in small animal medicine. Reviews epidemiology and how animal- and human-specific factors contribute to excess weight gain. Discusses the metabolic effects and inflammatory mediators associated with adiposity. Looks at various disease states and how they relate or develop as a result of obesity. Reviews different modalities to determine body composition to diagnose obesity. Offers a clinical approach to managing obesity with diet including discussion on the nutrients of concern for therapeutic weight loss diets. Veterinarians seeking to provide weight management services in practice will find clinically-applicable information from expert authors from both academic and practice backgrounds. Chapters cover topics ranging from epidemiology and pathophysiology of obesity to evaluation of body composition, and nutritional and behavioral management. The book also explores the role of exercise in managing obesity and looks at the management of co-morbidities. Finally, the authors present a range of case studies to demonstrate these topics in real-life practice.

Environmental temperature varies in time and space on timescales ranging from a few hours to long-term climate change. Organisms are therefore continually challenged to regulate and maintain functional capacities as their thermal environment changes. This volume brings together many of the leading workers in thermal biology, with backgrounds spanning the disciplines of molecular biology, cell biology, physiology, zoology, ecology and evolutionary biology, to discuss the responses of a wide range of species to temperature change at all scales of organization, ranging through the molecular, cellular, organismal, population and ecosystem levels. The volume provides an important and comprehensive contribution to the study of temperature adaptation, which, given the concern about global climate change, will provide much to interest a wide range of biologists.

How do hormones and growth factors regulate animal growth in the developing embryo and after injury? What processes at the molecular level determine the growth patterns of different tissues? In this diverse synthesis of recent research the regulation of growth in response to environmental and genetic stimuli is discussed at the level of the animal, tissues and cells. Contrasts are drawn between regulation in foetal and adult tissues, and in different tissues such as the CNS, bone and muscle. Functional chapters focus on the molecular links between mechanical tension and muscle growth, for example, while other chapters review the roles of specific molecules such as growth hormone. This state-of-the-art review will be of significant interest to graduate students and research scientists in the fields of animal growth, endocrinology and cell biology.

Ion channels are crucial components of living cells. Situated in the cell membrane, they allow ions to pass from one side of the membrane to the other. This book provides an overview of ion channel study, including up-to-date coverage of the permeability and selectivity of channels, their gating and modulation, their response to drugs and toxins, and the human diseases that result from channel malfunction. Students of molecular biology, biochemistry, physiology, and neurobiology will benefit from this modern, concise text.

In this unique book, Sir Donald Harrison draws on his wide-ranging experience as a surgeon and comparative anatomist to produce an authoritative and detailed account of the anatomy and physiology of the mammalian larynx. His investigation of the larynx has involved the study of over 1400 specimens of mammalian larynges from around the world, as well as using data from his own clinical experiences. The comparative morphology of the larynx is discussed from a developmental and functional perspective and the involvement of the larynx in respiration, locomotion and vocalisation is highlighted. Throughout the book the relationship of structure to function is drawn out and the clinical relevance of features of the human larynx is emphasised. This book will be an invaluable reference for all researchers and clinicians involved in laryngology as well as for anatomists, zoologists and anaesthesiologists.

Bioenergetics is the name given to the collection of disciplines within biochemistry and physiology that aims at a description and understanding of the function of living systems. These functions include the exchange, metabolism and accumulation of matter, as well as their related energy transformations. The authors present an accessible textbook, providing the reader with the fundamental principles of the subject and how these can then be applied to practical problems. This textbook is ideal for graduate students and researchers in biochemistry, physiology and chemistry. The book should also be of interest to workers in the applied life sciences.

In most animals, from bees to bulls, mice to men, it is possible to see at a glance whether an individual is male or female. How and why these differences in appearance and behavior developed and the nature and extent of the differences between males and females is a complex subject. This book reviews the latest molecular, genetic, hormonal, anatomical, and behavioral data in a wide range of species in a series of lively and highly readable articles from the world's leading experts in this field. Unashamedly Darwinian, this book brings sexual selection up to date and discusses not only a dazzling array of differences between the sexes, but probes the mechanisms by which they are produced and the adaptive significance of the differences themselves. It should have a wide appeal, especially to undergraduates and graduates in the biological and medical sciences, and should help to bridge the gap between those who study genes and molecules in the laboratory and those who study the behavior of animals in the wild.

In most animals, from bees to bulls, mice to men, it is possible to see at a glance whether an individual is male or female. How and why these differences in appearance and behavior developed and the nature and extent of the differences between males and females is a complex subject. This book reviews the latest molecular, genetic, hormonal, anatomical, and behavioral data in a wide range of species in a series of lively and highly readable articles from the world's leading experts in this field. Unashamedly Darwinian, this book brings sexual selection up to date and discusses not only a dazzling array of differences between the sexes, but probes the mechanisms by which they are produced and the adaptive significance of the differences themselves. It should have a wide appeal, especially to undergraduates and graduates in the biological and medical sciences, and should help to bridge the gap between those who study genes and molecules in the laboratory and those who study the behavior of animals in the wild.

However well the anatomy of the gastrointestinal tracts of a wide range of mammals are described and quantified, there can be no real explanation of observed patterns without consideration of the mechanical and chemical properties of the food consumed, and digestive stages involved in its processing. This book aims to integrate findings from the many different types of investigations of mammalian digestive systems into a coherent whole. Using the themes of food, form and function, researchers discuss models of digestive processes, linking this with evolutionary aspects of food utilization. Macroscopic and ultrastructural studies of the gastrointestinal tract are also presented, as are physiological, ecological and biochemical aspects of the digestion of different food types. The book ends with an integrative chapter, bringing together the themes running through the earlier sections.

As a student in Cambridge, Alan Hodgkin first became interested in the basis of nerve conduction, using single nerve fibers from a shore crab in his experiments. In 1963, he won the Nobel prize for his work on nerve conduction, and in 1970 became President of the Royal Society. Chance and Design is a fascinating chronicle of Hodgkin's life, providing a glimpse into the world of Cambridge undergraduates in the thirties, the motivation behind his research into nerve conduction, his work on centimeter radar during World War II, and his life as a Cambridge academic after the war. The book concludes with an account of the Nobel prize ceremony in 1963. This highly readable autobiography gives an insight into the working patterns and private life of an eminent scientist, and will appeal not only to scientists, but also to those interested in gaining an understanding of what inspires scientific research.