General Modes of Pattern Formation; J.D. Murray. Process and Outcome; P. Alberch, M.J. Blanco. Retinoic Acid Cannot be the Morphogen in Reaction Diffusion Models for the Formation of the Chick Wing Bud; Y. Almirantis, S. Papageorgiou. Pattern Formation in Heterogeneous Domains; D.L. Benson, et al. A Field Model of Symmetry Reversals in the Pattern Regulation of a Cell; W.A.M. Brandts. Patterning in Limbs; S.V. Bryant, et al. The Development of a Spatial Pattern in a Model for Cancer Growth; M.A.J. Chaplain. Sequential and Synchronous Skin Pattern Formation; G.C. Cruywagen, et al. Control of Gap Junction Permeability Can Control Pattern Formation in Limb Development; R. Dillon, H.G. Othmer. Mapping Gene Activities into Morphological Patterns in Drosophila; B. Goodwin, S. Kauffman. Trajectories of Swimming Microorganisms and Continuum Models of Bioconvection; N.A. Hill. The Chicken and the Egg; T.J. Horder. 20 additional articles. Index.

This is the first book entirely dedicated to Intravital Microscopy. It provides the reader with a broad overview of the main applications of Intravital Microscopy in various areas of the biomedical field. The book contains accurate descriptions of the state of the art methodologies used to image various organs at different level of resolution, ranging from whole tissue down to sub-cellular structures. Moreover, it is an extremely valuable guide to scientists that want to adopt this powerful technique and do not have experience with animal models and microscopy.

Divided into two volumes, the book begins with a pedagogical presentation of some of the basic theory, with chapters on biochemical reactions, diffusion, excitability, wave propagation and cellular homeostasis. The second, more extensive part discusses particular physiological systems, with chapters on calcium dynamics, bursting oscillations and secretion, cardiac cells, muscles, intercellular communication, the circulatory system, the immune system, wound healing, the respiratory system, the visual system, hormone physiology, renal physiology, digestion, the visual system and hearing.

New chapters on Calcium Dynamics, Neuroendocrine Cells and Regulation of Cell Function have been included.

This book discusses oxidative stress and hormesis from the perspective of an evolutionary ecologist or physiologist. In the first of ten chapters, general historical information, definitions, and background of research on oxidative stress physiology, hormesis, and life history are provided. Chapters 2-10 highlight the different solutions that organisms have evolved to cope with the oxidative threats posed by their environments and lifestyles. The author illustrates how oxidative stress and hormesis have shaped diversity in organism life-histories, behavioral profiles, morphological phenotypes, and aging mechanisms. The book offers fascinating insights into how organisms work and how they evolve to sustain their physiological functions under a vast array of environmental conditions.

Methods for Obtaining X-Ray Diffraction Patterns from Drosophila 198 Diffraction Patterns from Drosophila IFM 203 Concluding Remarks 211 Note Added in Proof 211 17. Functional and Ecological Effects of Isoform Variation in Insect Flight Muscle 214 James H. Marden Abstract 214 Introduction 215 Nature's Versatile Engine 215 The Underlying Genetics: An Underinflated Genome and a Hyperinflated Transcriptome and Proteome 216 Functional Effects of Isoform Variation 219 Alternative Splicing and the Generation of Combinatorial Complexity 220 Functional Consequences of Naturally Occurring Isoform Variation 220 18. Muscle Systems Design and Integration 230 Fritz- OlafLehmann Abstract 230 Power Requirements for Flight 230 Power Reduction 233 Power Constraints on Steering Capacity 234 Balancing Power and Control 236 Changes in Muscle Efficiency in Vivo 238 Concluding Remarks 239 From the Inside Out 19. Molecular Assays for Acto-Myosin Interactions 242 John C. Sparrow and Michael A. Geeves Abstract 242 Introduction 242 Myosin Purification and Preparation of the SI Fragment 243 Purification of Flight Muscle Actin 244 Assays of Myosin and Acto-Myosin 244 Major Conclusions Relating to the Enzymatic Properties of Insect Flight Muscle Acto-Myosin 247 Major Questions about Insect Flight Muscle Acto-Myosin Kinetics That Remain 249 20.

The Laboratory Animal Pocket Reference Series discusses procedures that ensure laboratory animals receive the best, most humane, and most responsible care possible. The 17 volumes are compact. The contents of each includes important biological features, husbandry, management, veterinary care, regulatory concerns, and commonly used and new procedures, as well as an invaluable list of suppliers. Each book in the series can be purchased individually or as part of the set.

Assembles a collection of experts to provide a current account of different approaches (e.g., traditional, comparative and experimental) being applied to study mobility. Moreover, the book aims to stimulate new theoretical perspectives that adopt a holistic view of the interaction among intrinsic (i.e. skeletal) and extrinsic (i.e. environmental) factors that influence differential expression of mobility. Since the environment undoubtedly impacts mobility of a wide variety of animals, insights into human mobility, as a concept, can be improved by extending approaches to investigating comparable environmental influences on mobility in animals in general. The book teases apart environmental effects that transcend typical categories (e.g., coastal versus inland, mountainous versus level, arboreal versus terrestrial). Such an approach, when coupled with a new emphasis on mobility as types of activities rather than activity levels, offers a fresh, insightful perspective on mobility and how it might affect the musculoskeletal system.

Advances in Insect Physiology publishes eclectic volumes containing important, comprehensive and in-depth reviews on all aspects of insect physiology. It is an essential reference source for invertebrate physiologists and neurobiologists, entomologists, zoologists and insect biochemists. First published in 1963, the serial is now edited by Steve Simpson (Oxford University, UK).
* More than 300 pages with contributions from the leading researchers in entomology
* Over 40 figures and illustrations combined
* Includes an in-depth review of the genetics of the honey bee
* Discusses the physiological diversity in insects

Conservation Physiology for the Anthropocene: A Systems Approach, Volume 39A in the Fish Physiology series, is a comprehensive synthesis on the physiology of fish in the Anthropocene. This volume closes the knowledge gap by considering the many ways in which different physiological systems (e.g., sensory physiology, endocrine, cardio-respiratory, bioenergetics, water and ionic balance and homeostasis, locomotion/biomechanics, gene function) and physiological diversity are relevant to management and conservation. As the world is changing, with a dire need to identify solutions to the many environmental problems facing wild fish populations, this book comprehensively covers conservation physiology and its future techniques. Conservation physiology reveals the many ways in which environmental change and human activities can negatively influence wild fish populations. These tactics inform new management and conservation activities and help create the necessary conditions for fish to thrive.

This book offers a new explanation for the development of flight in mammals and offers detailed morphological descriptions of mammals with flapping flight. The skeletomuscular apparatus of the shoulder girdle and forelimbs of tree shrews, flying lemurs and bats is described in detail. Special attention is paid to the recognition of peculiar features of the skeleton and joints. For the basic locomotor patterns of flying lemurs and bats, the kinematic models of the shoulder girdle elements are developed. The most important locomotor postures of these animals are analyzed by means of statics. The key structural characters of the shoulder girdle and forelimbs of flying lemurs and bats, the formation of which provided transition of mammals from terrestrial locomotion to gliding and then, to flapping flight, are recognized. The concept is proposed that preadaptations preceding the acquisition of flapping flight could have come from widely sprawled forelimb posture while gliding from tree to tree and running up the thick trunks. It is shown that flying lemur is an adequate morphofunctional model for an ancestral stage of bats. The evolutionary ecomorphological scenario describing probable transformational stages of typical parasagittal limbs of chiropteran ancestors into wings is developed.

Primate Craniofacial Function and Biology is an integrative volume with broad coverage of current research on primate craniofacial biology and function. Topic headings include: the mammalian perspective on primate craniofacial form and function, allometric and comparative morphological studies of primate heads, in vivo research on primate mastication, modeling of the primate masticatory apparatus, primate dental form and function, and palaeoanthropologic studies of primate skulls. Additionally, the volume includes introductory chapters discussing how primatologists study adaptations in primates and a discussion of in vivo approaches for studying primate performance. At present, there are no texts with a similar focus on primate craniofacial biology and no sources that approach this topic from such a wide range of research perspectives. This breadth of research covered by leaders in their respective fields make this volume a unique and innovative contribution to biological anthropology.

In biology, few organs have been as elusive as the lung-air sac system of birds. Considerable progress has recently been made to fill the gaps in the knowledge. While summarizing and building on earlier observations and ideas, this book provides cutting-edge details on the development, structure, function, and the evolutionary design of the avian respiratory system. Outlining the mechanisms and principles through which biological complexity and functional novelty have been crafted in a unique gas exchanger, this account will provoke further inquiries on the many still uncertain issues. The specific goal here was to highlight the uniqueness of the design of the avian respiratory system and the factors that obligated it.

Physiological Systems in Insects, Fourth Edition explores why insects have become the dominant animals on the planet. Sections describe the historical investigations that have led us to our current understanding of insect systems. Integrated within a basic physiological framework are modern molecular approaches that provide a glimpse of the genetic and evolutionary frameworks that testify to the unity of life on earth. This updated edition describes advances that have occurred in our understanding of hormone action, metamorphosis, and reproduction, along with new sections on the role of microbiomes, insecticide action and its metabolism, and a chapter on genetics, genomics and epigenetic systems. The book represents a collaborative effort by two internationally known insect physiologists who have instructed graduate courses in insect physiology. As such, it is the ideal resource for entomologists and those in other fields who may require knowledge of insect systems.

This updated monograph deals with methanogenic endosymbionts of anaerobic protists, in particular ciliates and termite flagellates, and with methanogens in the gastrointestinal tracts of vertebrates and arthropods. Further chapters discuss the genomic consequences of living together in symbiotic associations, the role of methanogens in syntrophic degradation, and the function and evolution of hydrogenosomes, hydrogen-producing organelles of certain anaerobic protists. Methanogens are prokaryotic microorganisms that produce methane as an end-product of a complex biochemical pathway. They are strictly anaerobic archaea and occupy a wide variety of anoxic environments. Methanogens also thrive in the cytoplasm of anaerobic unicellular eukaryotes and in the gastrointestinal tracts of animals and humans. The symbiotic methanogens in the gastrointestinal tracts of ruminants and other "methanogenic" mammals contribute significantly to the global methane budget; especially the rumen hosts an impressive diversity of methanogens. This makes this updated volume an interesting read for scientists and students in Microbiology and Physiology.

Photopigments are molecules that react to light and mediate a number of processes and behaviours in animals. Visual pigments housed within the photoreceptors of the eye, such as the rods and cones in vertebrates are the best known, however, visual pigments are increasingly being found in other tissues, including other retinal cells, the skin and the brain. Other closely related molecules from the G protein family, such as melanopsin mediate light driven processes including circadian rhythmicity and pupil constriction. This Volume examines the enormous diversity of visual pigments and traces the evolution of these G protein coupled receptors in both invertebrates and vertebrates in the context of the visual and non-visual demands dictated by a species' ecological niche.

Genetic, hormonal, neurological, and other biological factors need to be taken into account to fully understand sexual orientation. This work represents the latest research and theory on causes of variation in sexual orientation. It looks at sexual orientation as a cross-species phenomenon with numerous determining factors.

This work is a collection of chapters by some of the leading researchers in the scientific study of sexual orientation. The theory that many genetic, hormonal, neurological, and other biological factors need to be taken into account to fully understand sexual orientation is espoused in this book. It presents much of the latest research on the causes of variation in sexual orientation and related phenomena. It views sexual orientation as a cross-species phenomenon with both biological and environmental determinants.

Advances in Insect Physiology is committed to publishing eclectic volumes containing comprehensive and in-depth reviews on all aspects of insect physiology. First published in 1963, these volumes are an essential reference source for invertebrate physiologists, insect neurobiologists, entomologists, zoologists and insect biochemists. This volume is a serial index volume containing Volumes 1-29.
* Contents of Volumes 1-29
* Cumulative Subject Index
* Contributor Index

Malignant neoplasms occurring in the biliary tract and pancreas remain a therap- tic challenge. The mechanism of carcinogenesis as well as the growth and spread of these tumors is still poorly understood, making the development of rational tre- ment strategies difficult. In order to improve the clinical results achieved by sur- cal or other medical treatment of such malignant tumors, the establishment of an experimental animal model is critical. For this purpose, attempts were made to induce carcinoma experimentally in the biliary tree and finally an animal model using the hamster was established in 1994 at our laboratory. Because the tumor in this model mimicked the characteristics of human tumors, a series of experimental investigations were conducted to clarify the pathological characteristics of biliary carcinoma, the genetic alterations during biliary carcinogenesis, and the relationship between biliary inflammation and c- cinogenesis. The chemopreventive effects on the occurrence of biliary carcinoma were also successfully examined. In addition, in vitro studies led to the establi- ment of transplantable biliary cancer cell lines and biliary epithelial cell lines by utilizing the hamster model. This monograph represents the collective efforts in hepato-biliary and pancreatic disease research over the past 20 years. I hope that this monograph will be a source of useful knowledge for basic researchers as well as for clinicians involved in the care of patients with hepato-biliary and pancreatic neoplasms. Takashi Kanematsu, M.D., Ph.D.

Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. Early in the twentieth century, Fenn (1924, 1923) showed that the total energy liberated during a contraction (heat + work) was increased when the muscle was allowed to shorten and perform work. The result implied that chemical reactions during contractions were load-dependent. The observation underlying the "Fenn effect" was taken to a greater extent when Hill (1938) published a pivotal study showing in details the relation between heat production and the amount of muscle shortening, providing investigators with the force-velocity relation for skeletal muscles. Subsequently, two papers paved the way for the current paradigm in the field of muscle contraction. Huxley and Niedergerke (1954), and Huxley and Hanson (1954) showed that the width of the A-bands did not change during muscle stretch or activation. Contraction, previously believed to be caused by shortening of muscle filaments, was associated with sliding of the thick and thin filaments. These studies were followed by the classic paper by Huxley (1957), in which he conceptualized for the first time the cross-bridge theory; filament sliding was driven by the cyclical interactions of myosin heads (cross-bridges) with actin. The original cross-bridge theory has been revised over the years but the basic features have remained mostly intact. It now influences studies performed with molecular motors responsible for tasks as diverse as muscle contraction, cell division and vesicle transport.

This volume examines fish sounds that have a proven signal function, as well as sounds assumed to have evolved for communication purposes. It provides an overview of the mechanisms, evolution and neurobiology behind sound production in fishes, and discusses the role of fish sounds in behavior with a special focus on choice of mate, sex-specific and age-specific signaling. Furthermore, it highlights the ontogenetic development of sound communication and ecoacoustical conditions in fish habitats and the influence of hormones on vocal production and sound detection. Sound Communication in Fishes offers a must-have compendium for lecturers, researchers and students working in the fields of animal communication, fish biology, neurobiology and animal behavior.

The book "Parasitic Zoonoses" emphasizes a veterinary and public health perspective of zoonotic parasites. This book is suitable for higher undergraduate and graduate students of zoonoses and public health, veterinary parasitology, parasite epidemiology; public health workers; public health veterinarians; field veterinarians, medical professionals and all others interested in the subject. More than 15 protozoa and 50 other parasitic diseases are zoonotic in nature and all these diseases have been discussed in detail. The first chapter is concerned with classification of zoonotic parasites, food borne, vector borne and occupation related zoonotic parasites. The remaining chapters cover etiology, epidemiology, life cycle, transmission, clinical signs, diagnosis, prevention and control of zoonotic parasites. The text is illustrated with a large number of coloured figures. An alphabetical bibliography for every disease has also been included so that readers have access to further information.

Sunao Tawara's epoch-making work on the excitation conduction system of the mammalian heart paved the way for the advancement of modern cardiology in the 20th century. Even today, more than 90 years after the publication of the German monograph "Das Reizleitungssystem des Saugetierherzen", his precise account of the conduction system from the atrioventricular node through the His-Purkinje system to the ordinary ventricular muscle fibers retains all of its original actuality.This English edition of Tawara's monograph will serve as an invaluable reference for both basic and clinical cardiological research in the years ahead.

The marsupials are an important order of mammals that have evolved along lines parallel to eutherians. This book brings together what is known about one very important sense needed for survival - hearing. It documents various studies of the hearing capacities of marsupials and relates this information to their vocal behavior. To what sounds do marsupials respond? What are the spectra of their vocalizations? The organization of the brain auditory pathways of marsupials is compared with those of eutherian mammals and related to the structure of the auditory periphery. The fact that much of the early development of marsupial young occurs outside the mother's body enables the possibility of discoveries about the early development of brain and hearing relevant to all mammals.

Two groups of animals, bats and odontocetes (toothed whales), have independently developed the ability to orient and detect prey by biosonar (echolocation). This active mechanism of orientation allows these animals to operate under low light conditions. "Biosonar"is a conceptual overview of what is known about biosonar in bats and odontocetes. Chapters are written by bat and odontocetes experts, resulting in collaborations that not only examine data on both animals, but also compare and contrast mechanisms. This book provides a unique insight that will help improve our understanding of biosonar in both animal groups. "

Neuro-Behavioral Determinants of Interlimb Coordination: A multidisciplinary approach focuses on bimanual coordination against the broader context of the coordination between the upper and lower limbs. However, it is also broad in scope in that it reviews recent developments in the study of coordination by means of the latest technologies for the study of brain function, such as functional magnetic resonance imaging, near-infrared spectroscopy, magneto-encephalography, and transcranial magnetic stimulation. In addition, new developments in recovery of interlimb coordination following spinal cord injury and other insults of the central nervous system, such as stroke, are reviewed.
Neuro-Behavioral Determinants of Interlimb Coordination: A multidisciplinary approach is intended to be a helpful source of information for scientists in basic research as well as practioners involved in clinical settings. Those who will benefit most are neuroscientists, neurologists, neuropsychologists, cognitive neuroscientists, kinesiologists, motor and rehabilitation scientists, physical therapists etc. Special efforts have been made to make the contents accessible to graduate students by means of review chapters that contain explanatory boxes. We hope to convey our excitement and enthusiasm about the field of interlimb coordination and what it has to offer as a prototypical vehicle for a cognitive neuroscience approach to movement control.