During the period August 5-9, 1992, and immediately preceding the 1992 Gordon Research Conference on Motile and Contractile Systems, the "Third International Conference on the Structure and Function of Ubiquitous Cellular Protein Actin" was held at the Emma Willard School in Troy, New York, under the title "ACTIN '92". This conference focused on the fundamental properties and cellular functions of actin and actin based microfilament systems. The first conference in this series was held in 1982, in Sydney, Australia, and hosted by Dr. Cristobal G. dos Remedios and Dr. Julian A. Barden, both from the University of Sydney (New South Wales, Austrailia). The second conference convened in Monza, Italy in June 1987, and was organized by Dr. Roberto Colombo, University of Milan (Italy). This third gathering of researchers devoted to the study of actin and actin-associated proteins was organized by Dr. James E. Estes, Albany Stratton V A Medical Center and Dr. Paul 1. Higgins, Albany Medical College, who were assisted by an Organizing Committee consisting of Dr. Edward D. Korn (National Heart, Lung and Blood Institute, NIH), Dr. Thomas P. Stossel (Massachusetts General Hospital), Dr. Fumio Matsumura (Rutgers University), and Dr. Stephen Farmer (Boston University). This meeting was dedicated to the many pioneering contributions of Professor Fumio Oosawa to the field of actin research.

Two techniques were used to estimate the L/M cone ratio, best-fit linear sum of the L- and M-cone spectral sensitivities to heterochromatic flicker photometric spectral sensitivity and psychometric function shape for point source detection of lights of varying wavelength. Data from five color-normal observers run on both paradigms all are consistent with a preponderance of L-cones relative to M-cones though there are individual differences in the estimates of L/M cone ratio. The observers showed congruence in their individual results across technique. In a separate study, the perceptual consequences of individual variation in L/M cone populations were evaluated by looking for a relation between flicker photometric spectral sensitivity and the spectral locus of equilibrium yellow. No significant relation was found, suggesting that receptor populations do not play a major role in the normalization of the perceptual red/green opponent channel. ACKNOWLEDGEMENT Supported in part by USPH NEI grant EY00901. REFERENCES Adam, A. (1969) Foveal red-green ra. C10S c:,f normals, colorblinds and heterozygotes. Proceedings Tel-Hasrcomer Hospital (Tel-Aviv). 8: 2-6. Ahnelt, P. , H. Kolb and R. Pflug. (1987). Identification of a subtype of cone photoreceptor, likely to be blue sensitive, in the human retina. Journal of Compa:cative Neurology. 255: 18-34. Alpern, M. and E. Pugh. (1977). variation in the action spectrum of erythrolabe among deuteranopes. Journal of Physiology (London). 266: 613-646. Boynton, R. (1979). Human Color Vision. New York, Holt, Rinehart and Winston. Brindley, G. (1954) The summation areas of human colour-receptive mechanisms at increment threshold.

Acute lung injury, respiratory failure, and acute respiratorydistresssyndrome associ- ated with sepsis and multiorgan dysfunction isbecoming more common in hospitals through- out the world. Although new classesofantimicrobial medications have been introduced and aggressive intensive life support systems are in use in many hospitals, mortality remains in the range of35 to 65 percent in even the best equipped medical facilities. However, with new technologies inphysiology and cellularand molecularbiology, wonderful opportunities now exist for scientists to explore more effective approaches to identificationofpatients at risk, to develop better insights to pathogenic mechanisms, to use new tools to follow the progression and natural history ofdisease, and to develop better modes oftherapies. The NATOAdvanced Study Institute on Acute RespiratoryDistress Syndrome: Cel- lularandMolecularMechanisms and ClinicalManagement was an outstanding opportunity for laboratory scientists and clinical investigators to discuss their own research approaches, explore opportunities for bringing newdimensions to their laboratories, and work together to identify possible clinical applications. The conference brought together investigators who have worked with patients ofall ages, including those who have so successfully treated in- fants with respiratory distress syndrome. There is no doubt that this stimulating conference will bring new dimensions, new technologies, and new investigators into the scientific labo- ratoriesofeach participant. This provides hope that new therapeutic approaches will eventu- ally be available.

This book includes articles relating to presentations given in a variety of forms (lectures, posters, contributions to round tables, software presentations) at the 5th International Biothermokinetics Meeting held in Bordeaux-Bombannes, September 23-26, 1992. The fact that not just lectures were considered for these proceedings reflects the aims of BTK meetings to instigate discussion, promote scientific cooperation and confront as many different ideas as possible with each other (at best heretical ones). BTK conferences have expanded more and more; 130 participants came to the 1992 meeting from 20 countries. It was therefore necessary to hold the round tables in parallel sessions. It is difficult to have an unbiased feeling of what should be selected as the salient features of the meeting. As the name suggests, Biothermokinetics embraces thermodynamic and kinetic approaches to experimental and theoretical investigations of biological processes, in particular at the cellular level. This "classical" point of view is mainly represented in the chapter "Thermodynamics and Kinetics of Transport Processes and Biological Energy Transduction."

A decade ago, for most scientists investigating various issues in life sciences the word "NO" was used in a negative context. It is astounding to observe how recently researchers are addressing the issue of NO, namely, nitric oxide, in over fifty publications weekly. Science journal, while naming nitric oxide: "Molecule of the Year" (December 1992), said it all: "NO news is good news. " For a long period of time NO was considered as a pollutant and every ecology minded person tried to eliminate it. It was the discovery of NO involvement in the process of host killing by macrophages and several years later the finding that EDRF is none else but NO, that promoted this field. Nitric oxide's major role in the control of blood pressure is merely one factor of an extensive list of effects and functions attributed to it. NO is implicated in long-term potentiation (LPT), a principal process involved in memory consolidation and it is considered as the main biochemical substance responsible for penile erection. It should be noted that additional roles for NO are discovered continuously as many laboratories join the quest for the mystery of this small molecule. The observation that NO is involved in various biological processes is not unique, as other second messengers (i. e., cyclic AMP), participate in a diverse set of functions."

Similarities in structure and function between pigs and human beings include size, feeding patterns, digestive physiology, dietary habits, kidney structure and function, pulmo nary vascular bed structure, coronary artery distribution, propensity to obesity, respiratory rates, tidal volumes and social behaviors. Since the pig is an omnivore, it provides an adaptable model to evaluate chronic and acute exposures to xenobiotics such as alcohoL caffeine, tobacco, food additives and environmental pollutants. Swine have been used successfully as models to evaluate alcoholism, diabetes, absorption, digestion, total paren teral nutrition, organ transplantation, atherosclerosis, exercise, hypertension. hemorrhagic hypotension, melanoma, gingivitis, obstructive and reflux nephropathy. osteochondrosis. dermal healing and septic shock. A severe and worsening shortage of organs and tissues for transplantation in patients with severe organ failure has encouraged the consideration of inter species or xenotransplan tation. In developing programs toward this end, the pig generally is viewed as the preferred donor because of its size, physiology and availability. The pig harbors relatively few diseases which could be transmitted inadvertently to human patients. The ability to genetically modify swine to ameliorate the consequences of the human immune response offers a further significant advantage. Another important consideration for an animal model is that basic biologic back ground information be available for investigators to design future prospective studies."

Photobiology - the science of light and life - begins with basic principles and the physics of light and continues with general photobiological research methods, such as generation of light, measurement of light, and action spectroscopy. In an interdisciplinary way, it then treats how organisms tune their pigments and structures to the wavelength components of light, and how light is registered by organisms. Then follow various examples of photobiological phenomena: the design of the compound eye in relation to the properties of light, phototoxicity, photobiology of the human skin and of vitamin D, photomorphogenesis, photoperiodism, the setting of the biological clock by light, and bioluminescence. A final chapter is devoted to teaching experiments and demonstrations in photobiology.
This book encompasses topics from a diverse array of traditional disciplines: physics, biochemistry, medicine, zoology, botany, microbiology, etc., and makes different aspects of photobiology accessible to experts in all these areas as well as to the novice. It is intended primarily for graduate students and for researchers who wish to look outside their speciality, but can also act as a source of information for undergraduate students.

The International Society for Arterial Chemoreception (ISAC) was founded in August 1988 during the 9th International Symposium on Arterial Chemoreception which was held at Park City, Utah, USA. ISAC was established with the aim of providing a framework to support the increasing number of investigators from a wide variety of disciplines (anatomists, pathologists, respiratory physiologists and clinicians, high altitude physiologists, biochemists, biophysicists, physiologists and pharmacologists) who share a common interest in arterial chemoreception. ISAC took over the co-ordination of the international chemoreceptor meetings, with the membership deciding the venue for forthcoming meetings. During the Park City symposium Dublin was selected to host the 1993 meeting, under the Presidency of Professor Ronan O'Regan. The 12th International Meeting on Arterial Chemoreception, which was held in Dublin in August 1993, was acclaimed as a great success by all those present. The delegates not only shared in a wide-ranging feast of chemoreceptor based science, they had plenty of opportunity during the meeting for renewing acquaintances and establishing new friendships. The location for the meeting at University College Dublin's modem Belfield campus helped to promote such interaction, and the social programme was outstanding.

A review of our understanding of this area of the brain, showing how it fits into the general picture of those areas concerned with modulating mammalian behavior. The chapters, all written by leading figures in behavioral neuroscience, discuss the anatomy, neurochemistry, physiology, and behavioral relations in the septal area. Due to the great deal of current research shown in the related areas of hippocampus and the amygdala, this book will be of great interest to all those who research the hippocampus and the amygdala in addition to the septum itself.

The aimoftheHypospadiasand Genital Symposium, held at theUniversityof California,SanFrancisco,wastoprovideaforumforauthoritativeinvestigatorswhoare activelyinvolvedinthevariousdisciplineswhichdefinetheleadingedgesofhypospadias and genital research. It is important for such investigators to continue to meet for the purpose of discussing the latest developments in their individual fields, to analyze the significanceofcurrent research, to discuss new tactics for unresolved problems and to develop new theories andapproaches asneeded. The two day conference on hypospadiasandgenitaldevelopment research was organizedintothreesections: 1)HumanStudies;2)MechanismofGenitalDevelopment; and 3) Endocrine Disruptors and Sexual Dimorphism in the Animal Kingdom. Each sessionwasintroducedbyanexpertmoderatorfollowedtheinvitedspeakerswithtimefor extensiveinteractionbetweeninvestigators. Thisbookdocumentstheproceedingsofthe HypospadiasandGenitalDevelopmentSymposium. Iwould especially like to thank Kari Gaudette for editorial assistants, Cynthia Ashe, Selcuk Yucel, Antonio Souza and the administrative staffinthe Departmentof Urology. Ihopeyoufindthisresourceuseful. Laurence S. Baskin,M. D. ProgramChair ChiefPediatricUrology UCSF vii ACKNOWLEDGEMENTS Supportforthissymposiumisgratefullyacknowledged TheNationalInstituteofHealthGrant#R13DK*HDS997 UCSFDepartmentofUrology AmericanUrologicAssociation CONTENTS Introduction...1 SECTIONI. HUMANSTUDIES EpidemiologyofHypospadias...*...*...25 J. DavidErickson EndocrineEvaluationofHypospadias...31 G. HyunandT. Kolon EndocrineAbnormalitiesinBoyswithHypospadias...45 R. I. Silver GeneticandClinicalStudiesonHypospadias...***...**...*...73 A. Nordenskjold SECTIONII. MECHANISMOFGENITALDEVELOPMENT DevelopmentofthePenileUrethra. . 87 G. CunhaandL. Baskin AnatomicalStudiesoftheMouseGenitalTubercle...103 L. Baskin,W. Liu,J. Bastacky,andS. Yucel AnatomicalStudiesoftheFibroblastGrowthFactor-l0Mutant,Sonic HedgeHogMutant,andAndrogenReceptorMutantMouseGenital Tubercle...*. **. . 123 S. Yllcel,W. Liu,DCordero,A. Donjacour,G. Cunha,andL. Baskin DevelopmentalGeneticsofHypospadias...149 M. Cohn xiii xiv Contents DevelopmentoftheMouseExternalGenitalia: UniqueModelof Organogenesis...159 K. Suzuki, K. Shiota,Y. Zhang,L. Lei,andG. Yamada NewConceptsontheDevelopmentoCtheVagina...173 E. Shapiro. H. Huang,andX. R. Wu SECTIONIII. ENDOCRINEDISRUPTORSANDSEXUAL DIMORPHISMINTHEANIMALKINGDOM EndocrineDisruptionOverview: AreMalesatRisk? 189 T. Colburn EndocrineDisruptionandHypospadias...203 G. Steinhardt Toxicant-InducedHypospadiasintheMaleRat * 217 L. E. Gray. . I. Ostby,J. Fun,C. Wolf,C. Lambright,V. Wilson, and N. Noreiga MasculinizationofFemaleMammals: LessonsfromNature...243 N. J. PI:H'candS. Glickman Index...255 SectionI Introduction HYPOSPADIAS LaurenceS. Baskin* M. D. ,FAAP 1.

Studies have identified important families of proteins (denoted: heat shock or stress proteins, Hsps) which display an enhanced expression in response to heat shock or other physiological stresses. Besides the characterization of the genes encoding Hsp and the mechanisms of their induction, recent studies have concentrated on the function of these proteins. It was shown that the expression of Hsp protects the cell against different types of aggressions. In addition,Hsp can regulate essential biochemical processes in unstressed cells. For example, members of the Hsp60 and Hsp70 families act as ATP-binding proteins allowing the folding of nascent or denatured proteins as well as the assembly or disassembly of protein complexes. These observations have led to the discovery of the molecular chaperone concept (Ellis and Hemmingsen 1989). Amongst the proteins whose expression is up-regulated by heat shock or other types of stresses are the small stress proteins also denoted (sHsps, sHsp or sHSP). Small stress proteins encompass a large numbers of related proteins which are represented in virtually all organisms, including prokary- otes. These polypeptides share a structural domain, often referred to as the a-crystallin domain, common to the lens protein alpha-crystallin (Ingolia and Craig 1982;Wistow 1985). In addition to being increased in response to several types of stresses, the Hsp level is also upregulated during development and correlates with the differentiation and oncogenic status of the cell. In spite of the fact that sHsp can confer cellular protection against stresses,their molecular function has remained enigmatic for years.

Biological sensors are usually remarkably small, sensitive and efficient. It is highly desirable to design corresponding artificial sensors for scientific, industrial and commercial purposes.This book is designed to fill an urgent need for interdisciplinary exchange between biologists studying sensors in the natural world and engineers and physical scientists developing artificial sensors. Contributions from leading scientists in this area, whether engineers or biologists, are written to be accessible to readers from these and other disciplines. The main topics cover mechanical sensors, visual sensors and vision and chemosensors. Readers will obtain a fuller understanding of the nature and performance of natural sensors as well as enhanced appreciation for the current status and the potential applicability of artificial microsensors. Friedrich G. Barth was awarded the "Karl-Ritter-von-Frisch-Medaille at the 2003 Annual Conference of the German Zoological Society in Halle, Germany."

This volume focuses exclusively on those endocytic processes that sequester proteins by a selective, receptor-mediated mechanism. In such an endocytic process, cell surface receptors specifically bind protein ligands and localize them to specialized invaginations of the plasma membrane. These regions are coated pits, so named because they are lined on the cytoplasmic face with an ordered array of the protein, clathrin. It is this 'coat' which provides their characteristic electron microscopic image. Subsequently, these regions pinch off to form coated vesicles which rapidly lose their 'coat' and then fuse with other organelles or the plasma membrane. The hallmarks of, this process are the specific receptors, coated pits, coated vesicles and an ordered sequence of transit events leading to delivery to selected locations. Receptor recognition, specific disposition of the endocytosed ligand and the existence of recep tor-ligand complexes at highest density in coated pits define the process as selective and concentrative. This topic has received ever increasing attention during the past few years. The evolving mechanisms are especially exciting because they come at a time when the conventional views based on thermodynamic arguments suggest that proteins should not be able to cross into the cell. Receptor-mediated endocytosis, however, reconciles the view that biological membranes should be impervious to macromolecules with the evidence that certain mac romolecules do gain entrance into the cell. During the last few years this field has been stimulated by studies on the uptake and processing of low density lipoproteins (LDL) by cells."

How can industry profit from the biochemical tricks of cold-adapted organisms? This book covers a range of aspects in this fascinating field, from genetic tools to environmental biotechnology.

Electric currents and electromagnetic fields have been applied to biological systems, particularly humans, with both therapeutic and pathological results. This text discusses biological responses to electric currents and electromagnetic fields, including medical applications and shock hazards. It covers fundamental physical and engineering principles of responses to short-term electrical exposure and emphasises human reactions, although animal responses are considered as well, and the treatment covers reactions from the just-detectable to the clearly detrimental. An important new chapter discusses standards for human exposure to electromagnetic fields and electric current and demonstrates how these standards have been developed using the principles treated in earlier chapters.

Over the course of the past decade, there has been an enormous augmentation in the amount of information available on the lemurs of Madagascar. These advances are closely coupled with an increase in the number of national and international researchers working on these animals. As a result, Madagascar has emerged as one of the principal sites of primatological studies in the world. Furthermore, the conserva tion community has a massive interest in the preservation of the natural habitats of the island, and lemurs serve as one of the symbols of this cause. Between 10 and 14 August 1998, the XVIIth International Primatology Society (IPS) Congress was held in Antananarivo, Madagascar. For a country that about a decade ago was largely closed to foreign visitors, this Congress constituted a massive event for the Malagasy scientific community and was assisted by about 550 primatolo gists from 35 different countries. Naturally, given the venue and context of the Con gress, many of the presentations dealt with lemurs and covered a very wide breadth of subjects.

Many organisms have evolved the ability to enter into and revive from a dormant state. They can survive for long periods in this state (often even months to years), yet can become responsive again within minutes or hours. This is often, but not necessarily, associated with desiccation. Preserving one's body and reviving it in future generations is a dream of mankind. To date, however, we have failed to learn how cells, tissues or entire organisms can be made dormant or be effectively revived at ambient temperatures. In this book studies on organisms, ranging from aquatic cyanobacteria that produce akinetes to hibernating mammals, are presented, and reveal common but also divergent physiological and molecular pathways for surviving in a dormant form or for tolerating harsh environments. Attempting to learn the functions associated with dormancy and how they are regulated is one of the great future challenges. Its relevance to the preservation of cells and tissues is one of the key concerns of this book.

Animals and plants live in changing environmental conditions which require adaptation in order to cope with this. Some of these environmental changes serve as signals which have to be "sensed" and interpreted correctly by the organisms to initiate the adaptation. This signal processing is based on biochemical, molecular and neuronal processes which are discussed in this book. All examples given underline that continuous adjustment of physiological functions is an essential requirement for life and survival in complex changing environments.

Comparative Vertebrate Reproduction is the only comprehensive textbook covering major topics in the reproductive biology of vertebrates, from sexuality and gametogenesis to reproductive ecology and life history tactics. The work draws heavily on recent reviews and papers while placing topics in a historical context and conceptual framework. In addition, the author provides detailed comparative surveys of each of the major topics discussed. Comparative Vertebrate Reproduction has been written as a textbook for upper-level undergraduate and graduate-level students in biology, zoology, physiology, animal science, and veterinary medicine. The work also serves as an excellent reference for researchers in medical and veterinary schools working in reproductive medicine.

In the past few years there has been the increased recognition that the effects of oxidative stress are not limited to the damage of cellular constituents. There is now evidence that reactive oxygen species (ROS) can alter cell function by acting upon the intermediates, or second messengers, in signal transductions. Such effects on signaling mechanisms probably account for the role of oxidative stress in inflammation, aging, and cancer. This volume brings together internationally recognized researchers in both the major areas covered by the book, oxidative stress and signal transduction. The work is organized in three sections. The first deals with the immediate cellular responses to oxidative stress and the production of second messengers. The second details the connection between second messengers and the gene. The third part looks more closely at the level of the gene.

Among the fishes, a remarkably wide range of biological adaptations to diverse habitats has evolved. As well as living in the conventional habitats of lakes, ponds, rivers, rock pools and the open sea, fish have solved the problems of life in deserts, in the deep sea, in the cold Antarctic, and in warm waters of high alkalinity or of low oxygen. Along with these adaptations, we find the most impressive specializations of morphology, physiology and behaviour. For example we can marvel at the high-speed swimming of the marlins, sailfish and warm-blooded tunas, air breathing in catfish and lungfish, parental care in the mouth-brooding cichlids and viviparity in many sharks and toothcarps. Moreover, fish are ofconsiderable importance to the survival ofthe human species in the form of nutritious and delicious food of numerous kinds. Rational exploitation and management of our global stocks of fishes must rely upon a detailed and precise insight of their biology. The Chapman and Hall Fish and Fisheries Series aims to present timely volumes reviewing important aspects of fish biology. Most volumes will be of interest to research workers in biology, zoology, ecology and physiology, but an additional aim is for the books to be accessible to a wide spectrum ofnon specialist readers ranging from undergraduates and postgraduates to those with an interest in industrial and commercial aspects of fish and fisheries."

To humans, cold has a distinctly positive quality. 'Frostbite', 'a nip in the air', 'biting cold', all express the concept of cold as an entity which attacks the body, numbing and damaging it in the process. Probably the richness of descriptive English in this area stems from the early experiences of a group of essentially tropical apes, making their living on a cold and windswept island group half way between the Equator and the Arctic. During a scientific education we soon learn that there is no such thing as cold, only an absence of heat. Cold does not invade us; heat simply deserts. Later still we come to appreciate that temperature is a reflection of kinetic energy, and that the quantity of kinetic energy in a system is determined by the speed of molecular movement. Despite this realization, it is difficult to abandon the sensible prejudices of palaeolithic Homo sapiens shivering in his huts and caves. For example; appreciating that a polar bear is probably as comfortable when swimming from ice floe to ice floe as we are when swimming in the summer Mediterranean is not easy; understanding the thermal sensa tions of a 'cold-blooded' earthworm virtually impossible. We must always be wary of an anthropocentric attitude when considering the effects of cold on other species."

In six parts, this book considers the extent to which computational, neural, and ecological constraints have shaped the mechanisms underlying motion vision: - Early Motion Vision - Motion Signals for Local and Global Analysis - Optical Flow Patterns - Motion Vision in Action - Neural Coding of Motion - Motion in Natural Environments Each topic is introduced by a keynote chapter which is accompanied by several companion articles. Written by an international group of experts in neurobiology, psychophysics, animal behaviour, machine vision, and robotics, the book is designed to explore as comprehensively as possible the present state of knowledge concerning the principal factors that have guided the evolution of motion vision.

Pulmonary Biology in Health and Disease was conceived as a companion to a handful of expensive, multivolume textbooks. This is part of the promising trend to publish shorter textbooks on the subjects of lung biology and remodeling. Whoever is familiar with human biology and the far-reaching consequences of the genome and postgenome revolutions is apt to concede that the centerpiece in remodeling lies in the ?eld of m- ecular cardiobiology. The ?eld of molecular cardiobiology includes the syndrome of chronic heart failure as well as ischemic cardioprotection. By analogy, the centerpiece in pulmonobiology is chronic asthma. Key topics in the present volume include s- naling mechanisms regulating the endothelium and smooth muscle cells,in?ammatory cells, mediators, airway surface liquid, and pharmacological therapy that focuses on how in?amed airways are altered. Written primarily for predoctoral and postdoctoral graduates in the basic medical sciences, the medical student and postdoctoral physician, graduates in the allied s- ences, nurses, pulmonologists, and physicians in critical care medicine, this book p- vides many of the fundamentals of contemporary pulmonology. It is divided into several parts devoted to the control of respiration, arterial chemoreceptors,muscles of ventilation, pulmonary physiology, and gas exchange in health, exercise, and disease. Special emphasis is placed on emphysema and its pathobiology, acute lung injury, asthma and inhaled toxicants. Because the ?eld is always evolving, each chapter includes recommended readings that lead the reader to sources of additional information, such as the review on remodeling of the blood gas barrier by West and Mathieu-Costello.

Various endogenous and environmental challenges of homoiostasis have resulted in the evolution of apparently quite different mechanisms for the same or similar functions in individual representatives of the animal kingdom. One of the prominent achievements of comparative physiology over the last few decades has been the description of regula- tory features common to many studied species beyond the extreme diversity of their morphological forms. Delineation offunctional princi- ples universally applicable to the physiology and biochemistry of living systems became often possible through technical advances in the devel- opment of numerous new techniques, in many cases modified and adopted from other fields of science, but also by approaching certain problems using multifactorial analysis. The advance in technology has facilitated studies of minute functional details of mechanisms, which finally lead to better understanding of generally similar functions, covered by the multiple developments of Nature as a response to an extreme variety of different conditions. Improved understanding of specific mechanisms, however, has presented new problems at the level of system integration. The importance of the integrative aspect became particularly apparent during an international symposium on 'Mecha- nisms of Systemic Regulation in Lower Vertebrates: Respiration, Circu- lation, Ion Transfer and Metabolism' (organized in 1990 by Norbert Heisler and Johannes Piiper at the Max-Planck-Institut fUr experimen- telle Medizin at Gottingen/Germany).