1 Introduction 1. 1 General Remarks The connective and supportive tissues constitute a considerable amount of the biomass in human and animal organisms. Characteristically, the osseous, car- laginous, and ?brous tissues each connect a vital part (cells) with a non-vital part, i. e. , extracellular matrix (ECM). The composition of the ECM constitutes the mechanical qualities of the respective tissue. The functional role of the bone and cartilage tissues is exhaustively discussed in the relevant literature. Whereas bone tissue provides the static and dynamic stability of the system as a whole, cartilage tissue accounts for the power transfer between bones. The articular cartilage insures a fairly friction free mobility of skeletal elements; likewise, cartilage interposed between skeletal elements allows mobility due to its reversible deformability. Under both static and dynamic con- tions, the powers transferred are remarkably large, while the ensuing mechanical force on various tissue zones varies. Tight connective tissue, especially muscle tendons and ligaments, are also part of the skeletal power transfer system. facilitating the transfer of tensile forces. The tendons of the locomotor system serve the purpose of transferring muscular - ergy to those skeletal elements to which they are attached. In this function, they are referred to as tensile tendons ("Zugsehnen"). Inseveral body parts, however, tendons appear in a peculiar mechanical situation: they pass around so-called - pomochlia, i. e. , bony pulleys. Hence, these tendons are referred to as wrap-around tendons ("Gleitsehnen").

The book discusses the controversial issue of whether animals are designed according to the same rules that engineers use in building machines, namely that materials and energy are used economically while attempting to achieve a high level of performance. There is considerable scientific controversy surrounding this question because, although there is much evidence suggesting that animals are indeed well designed, evolutionary biology tells us that animals are not 'engineered' but result from evolution by natural selection. This book collates this evidence which is discussed by a group of eminent biologists from many different biological disciplines."

This book provides an up-to-date review of our understanding of smooth muscle and integrates molecular, cellular and physiological information with tissue and anatomical studies. Well-known researchers have written chapters giving detailed reviews of our current knowledge of the biochemistry, pharmacology, physiology, and anatomy of smooth muscle. In particular, they cover the seven most important areas of smooth muscle function including morphology, electrophysiology, mechanisms of electromechanical and pharmacomechanical coupling, calcium homeostasis, signal transduction, mechanics of contraction, and the contractile proteins.

Environmental temperature varies in time and space on timescales ranging from a few hours to long-term climate change. Organisms are therefore continually challenged to regulate and maintain functional capacities as their thermal environment changes. This volume brings together many of the leading workers in thermal biology, with backgrounds spanning the disciplines of molecular biology, cell biology, physiology, zoology, ecology and evolutionary biology, to discuss the responses of a wide range of species to temperature change at all scales of organization, ranging through the molecular, cellular, organismal, population and ecosystem levels. The volume provides an important and comprehensive contribution to the study of temperature adaptation, which, given the concern about global climate change, will provide much to interest a wide range of biologists.

How do hormones and growth factors regulate animal growth in the developing embryo and after injury? What processes at the molecular level determine the growth patterns of different tissues? In this diverse synthesis of recent research the regulation of growth in response to environmental and genetic stimuli is discussed at the level of the animal, tissues and cells. Contrasts are drawn between regulation in foetal and adult tissues, and in different tissues such as the CNS, bone and muscle. Functional chapters focus on the molecular links between mechanical tension and muscle growth, for example, while other chapters review the roles of specific molecules such as growth hormone. This state-of-the-art review will be of significant interest to graduate students and research scientists in the fields of animal growth, endocrinology and cell biology.

Ion channels are crucial components of living cells. Situated in the cell membrane, they allow ions to pass from one side of the membrane to the other. This book provides an overview of ion channel study, including up-to-date coverage of the permeability and selectivity of channels, their gating and modulation, their response to drugs and toxins, and the human diseases that result from channel malfunction. Students of molecular biology, biochemistry, physiology, and neurobiology will benefit from this modern, concise text.

Bioenergetics is the name given to the collection of disciplines within biochemistry and physiology that aims at a description and understanding of the function of living systems. These functions include the exchange, metabolism and accumulation of matter, as well as their related energy transformations. The authors present an accessible textbook, providing the reader with the fundamental principles of the subject and how these can then be applied to practical problems. This textbook is ideal for graduate students and researchers in biochemistry, physiology and chemistry. The book should also be of interest to workers in the applied life sciences.

Mit diesem Nachschlagewerk wird eine systematische Katalogisierung der Losungen angeboten, die dem Designer oder Konstrukteur einen grossen Fundus zur kreativen Umsetzung in der Technik liefert."

3* Doody's Star Rating (R) CHOICE Magazine 'Recommended' (May 2020) As of 2018, pet obesity in the US affects an estimated 55.8 percent of dogs and 59.5 percent of cats, resulting in secondary conditions such as arthritis, diabetes mellitus, kidney disease, and certain forms of cancer. A complete and balanced diet accompanied by regular exercise is fundamental to optimize health and longevity in companion animals, meaning overweight pets have reduced quality of life and shorter life expectancy. Seeking to address this major modern-day problem, this book provides a comprehensive review of obesity in small animal medicine. Reviews epidemiology and how animal- and human-specific factors contribute to excess weight gain. Discusses the metabolic effects and inflammatory mediators associated with adiposity. Looks at various disease states and how they relate or develop as a result of obesity. Reviews different modalities to determine body composition to diagnose obesity. Offers a clinical approach to managing obesity with diet including discussion on the nutrients of concern for therapeutic weight loss diets. Veterinarians seeking to provide weight management services in practice will find clinically-applicable information from expert authors from both academic and practice backgrounds. Chapters cover topics ranging from epidemiology and pathophysiology of obesity to evaluation of body composition, and nutritional and behavioral management. The book also explores the role of exercise in managing obesity and looks at the management of co-morbidities. Finally, the authors present a range of case studies to demonstrate these topics in real-life practice.

The aim of this study was to investigate the development and diffferentiation of the adrenal glands in the grass snake during early stages of ontogenesis. After light microscopy and ultrastructural investigation, six developmental phases were distinguished in the grass snake adrenal glands. Similar developmental phases were described in pig embryos but they slightly differ from those presented above. In reptile and mammal embryos a similar direction of changes is observed in primaordia of both tissues forming adrenal glands.

In most animals, from bees to bulls, mice to men, it is possible to see at a glance whether an individual is male or female. How and why these differences in appearance and behavior developed and the nature and extent of the differences between males and females is a complex subject. This book reviews the latest molecular, genetic, hormonal, anatomical, and behavioral data in a wide range of species in a series of lively and highly readable articles from the world's leading experts in this field. Unashamedly Darwinian, this book brings sexual selection up to date and discusses not only a dazzling array of differences between the sexes, but probes the mechanisms by which they are produced and the adaptive significance of the differences themselves. It should have a wide appeal, especially to undergraduates and graduates in the biological and medical sciences, and should help to bridge the gap between those who study genes and molecules in the laboratory and those who study the behavior of animals in the wild.

In most animals, from bees to bulls, mice to men, it is possible to see at a glance whether an individual is male or female. How and why these differences in appearance and behavior developed and the nature and extent of the differences between males and females is a complex subject. This book reviews the latest molecular, genetic, hormonal, anatomical, and behavioral data in a wide range of species in a series of lively and highly readable articles from the world's leading experts in this field. Unashamedly Darwinian, this book brings sexual selection up to date and discusses not only a dazzling array of differences between the sexes, but probes the mechanisms by which they are produced and the adaptive significance of the differences themselves. It should have a wide appeal, especially to undergraduates and graduates in the biological and medical sciences, and should help to bridge the gap between those who study genes and molecules in the laboratory and those who study the behavior of animals in the wild.

The main objective of this book is to present some of the fundamental structural aspects in the design of respiratory organs while debating and speculating on when, how and why these states were founded. The author's main thesis is that the modern gas exchangers are products of protracted processes that have entailed adaptation to specific environments and lifestyles. Only those feasible designs that have proven adequately compentent in meeting demands for molecular oxygen have been preserved. The author's approach has been to look into the limiting functional properties as regards the respiratory capacities of gas exchangers while finding out the specific structural adaptations that have evolved to meet the metabolic needs or to look into form and discern how it limits function.

This book is a concise summary of the present knowledge about skeletal muscle fibres. The fibre types aare characterized from different points of view. The difficulties and possibilities of classifying muscle fibres in distinct non-overlapping types are shown. A main emphasis is put on metabolic fibre typing by cytophotometry as well as the adaptability of a given fibre type to altered physiological and pathological conditions. Extensive analyses of several rat hindlimb muscles revealed regional differences of fibre properties within the muscles and showed the influence of ageing, myopathy, hypoxia, diabetes and Ginkgo biloba-treatment on the different fibre tyypes.

Reviews: Methods and Technology in Fish Biology and Fisheries published by Kluwer Academic Publishers is a book series dedicated to the publication of information on advanced, forward-looking methodologies, technologies, or perspectives in fish and is especially dedicated to relevant topics addressing global, fisheries. This series international concern in fish and fisheries. Humans continue to challenge our environments with new technologies and technological applications. The dynamic creativity of our own species often tends to place the greatest burden on our supporting ecosystems. This is especially true for aquatic networks of creeks, lakes, rivers and ocean environments. We also frequently use our conceptual powers to balance conflicting requirements and demands on nature and continue to develop new approaches and tools to provide sustainable resources as well as conserve what we hold most dear on local and global scales. This book series will provide a window into the developing dynamic among humans, aquatic ecosystems (both freshwater and marine), and the organisms that inhabit aquatic environments. There are many reasons to doubt the increasing social and economic value technology has gained over the last two centuries. Science and technology represent stages in human development. I agree with Ernst Mayer when he said in Toward a New Philosophy of Biology (1988) that "endeavors to solve all scientific problems by pure logic and refined measurements are unproductive, if not totally irrelevant.

As a student in Cambridge, Alan Hodgkin first became interested in the basis of nerve conduction, using single nerve fibers from a shore crab in his experiments. In 1963, he won the Nobel prize for his work on nerve conduction, and in 1970 became President of the Royal Society. Chance and Design is a fascinating chronicle of Hodgkin's life, providing a glimpse into the world of Cambridge undergraduates in the thirties, the motivation behind his research into nerve conduction, his work on centimeter radar during World War II, and his life as a Cambridge academic after the war. The book concludes with an account of the Nobel prize ceremony in 1963. This highly readable autobiography gives an insight into the working patterns and private life of an eminent scientist, and will appeal not only to scientists, but also to those interested in gaining an understanding of what inspires scientific research.

This is an extensive collection of essays on all aspects of vision, approached from the perspective of coding and efficiency. It examines the broad spectrum of vision research from one particular, unifying viewpoint, namely the way that visual systems efficiently encode and represent the outside world. This approach, both rigorous and general, was championed by H.B. Barlow in the fifties and has been followed in many areas of vision research. The approach has recently acquired new significance due to the growing interest of computer science and artificial intelligence in the processes of vision, which attempts to describe visual processes in algorithmic terms, equally relevant to a robotic visual system, the eye of a fly or the complex visual pathways in the human brain.

This text is a graduate-level introduction to neural networks, focusing on current theoretical models, examining what these models can reveal about how the brain functions, and discussing the ramifications for psychology, artificial intelligence, and the construction of a new generation of intelligent computers. The book is divided into four parts. The first part gives an account of the anatomy of the central nervous system, followed by a brief introduction to neurophysiology. The second part is devoted to the dynamics of neuronal states, and demonstrates how very simple models may stimulate associative memory. The third part of the book discusses models of learning, including detailed discussions on the limits of memory storage, methods of learning and their associated models, associativity, and error correction. The final section of the book reviews possible applications of neural networks in artificial intelligence, expert systems, optimization problems, and the construction of actual neuronal supercomputers, with the potential for one-hundred fold increase in speed over contemporary serial machines.

The rapid development of molecular biology and genetics has led to renewed interest in embryology, comparative embryology, and studies of the relations between ontogeny and phylogeny. In fact, genes have been identified which are involved in the formation of shapes and structures, and it is becoming apparent that their primary morphological expressions are conspicuously similar in different species. The primarily identical shapes do not become diversified until advanced individualization of embryos, and it is here that it is possible to employ the knowledge of comparative embryology, the branch of science engaged in the study of the development and differentiation of tridimensional structures in different animal groups. However, comparative embryology has been neglected during the past decades, as its development has appeared to have been completed. In our opinion, the decreased interest in comparative embryology has been caused by the fact that often the time factor was not or could not be respected. In fact, in the case of embryos of wild animals even their ontogenetic age and sometimes the duration of intrauterine development are unknown.

Sex differences are observed in various physiological, behavioral, and psychic functions, including reproductive behavior, aggres sion, emotions, and cognition. Such differences are expressed even in early childhood with preferences to definite activities. It has been generally accepted that differences between genders are formed under the influence of biological as well as environmental factors. The existence of sex differences in functions of the central nervous system has suggested that there are also morphological sex differences. In recent years several reports on sexual dimorphism in the brain of vertebrates have been published. However, the mecha nisms of sexual differentiation of the central nervous system remain unclear in most cases. It is often difficult to correlate morphological sex differences to differences in definite function or behavior. We set out to explore the sexual dimorphism of the limbic system and especially the bed nucleus of the stria terminalis and the amygdala, which are considered generally to be occupied with the control of reproductive behavior and autonomic and compli cated psychic functions. Several reports on sexual dimorphism of these structures have been published. Some of them have been directed to the total neuronal number and the volume of the nuclei, while others have concentrated on definite subpopula tions of neurons. In many cases the mechanisms of sexual differ entiation were tested, but sometimes they could not be estab lished."

This book is composed of a set of chapters contributed by past and present collaborators of the Nobel laureate Sir Andrew Huxley, covering the areas of muscle research to which he has made major contributions. The purpose of the book is to discuss the way that muscle works, asking questions at a fundamental level about the molecular basis of muscle tone production and muscle contraction. The majority of the chapters are concerned with muscle physiology and the relation between structure and function. The process of activation of muscle is dealt with, together with the mechanism of contraction itself. Although most of the book concerns itself with vertebrate skeletal muscle, several of the chapters deal with cardiac muscle. The book also features two introductory chapters discussing Sir Andrew's achievements in both nerve and muscle physiology. All those interested in the structure and function of muscle, or cell motility in general, will wish to read this book.

Preparatory work for this monograph started in 1988 and 1989. The motive was provided by certain incongruities in the illustra- tion of descensus testis for the chapter "Entwicklung der Genital- organe" in the book Humanembryologie. The evoked discussion was reason enough for our own re- search on the phenomenon and uncertainties of testicular des- cent in human. The basis ofthese investigations was the collection of human embryos founded by Prof. Hinrichsen in 1970 at the Department of Anatomy and Embryology, Ruhr-University Bo- chum. The preparation of the material used in this paper has been done with the help of many staff members of our department to whom we feel obliged. We are especially indebted to Prof. Hin- richsen who prepared the foetuses and took the first steps of this project. We wish also to acknowledge Dr. Heinz Jiirgen Jacob for careful fixation and microdissection of specimens intended for scanning electron microscopy. Weare also grateful to Mrs. Vera Mannheim for her involvement and her sensitivity in making scanning electron micrographs, and Mrs. Antje Jaeger for provid- ing an expert and skilful photographic technique especially in the setting up of micrographs. Our thanks are also due to Mrs. Marion Kohn for skilful technical assistance and to all those technical assistants who worked in our department during the past 25 years and who were engaged in providing the serial sec- tions. The English text has been thoroughly revised by Prof. Dr.

There is often confusion over the meaning and usage of terms such as efficiency, economy, effectiveness, optimization, and perfection in biology. This book defines and discusses these concepts within a broad evolutionary perspective and considers how evolutionary pressures can affect the economy and efficiency of animals. Chapters consider biomaterials, skeletal systems, muscular function, aquatic and terrestrial locomotion, and cardiovascular systems. The result is a book of interest to all biologists, particularly those working in the field of comparative physiology and evolutionary biology.

The value of the canine nose is well-documented, and working dogs are being utilized for their olfactory skills in an increasing number of fields. Not only are dogs used by police, security, and the military, but they are also now used in forensic science, in medical detection of disease, in calculating population trends of endangered species and eradicating invasive species in protected environments, and in identifying infestations and chemical contaminants. Edited and contributed to by eminent scholars, Canine Olfaction Science and Law: Advances in Forensic Science, Medicine, Conservation, and Environmental Remediation takes a systematic scientific approach to canine olfaction. It includes work from scientists working in pure and applied disciplines, trainers and handlers who have trained and deployed detection dogs, and lawyers who have evaluated evidence produced with the aid of detection and scent identification dogs. The book is divided into six sections covering The anatomy, genetics, neurology, and evolution of canine olfaction as well as diseases affecting it The chemistry and aerodynamics of odors Behavior, learning, and training Uses of canine olfaction in forensics and law Uses in conservation and remediation Uses in detection of diseases and medical conditions The various contributors describe cutting edge research, some conclusions of which are the subject of vigorous debates between various laboratories and researchers. The editors have added cross-references so that readers can consider the different perspectives that are currently being advanced and understand where consensus is being built and where more research needs to be done. A useful practical reference, Canine Olfaction Science and Law provides a wealth of information beneficial to a wide range of disciplines. It aids trainers and handlers of detection dogs as well as various professionals in healthcare, law enforcement, forensic science, and environmental conservation to gain a better understanding of the remarkable power of the canine nose while encouraging further advances in applications.

In this treatise, current knowledge on the neurogenesis, axonal outgrowth, synaptogenesis, and regenerative capacity of descending supraspinal pathways in tetrapods is discussed. Although emphasis is on the clawed toad, Xenopus laevis, chicken embryos, opossums and rodent data, also the data available for primates including man are presented. It will be shown that 1) the outgrowth of descending supraspinal pathways is the result of a coordinated program; 2) the pattern of early descending axonal tracts is similar in all vertebrate groups; 3) the formation of descending supraspinal pathways occurs according to a developmental sequence; 4) the earliest descending supraspinal fibers arrive in a rather immature spinal cord, and 5) the regenerative capacity of descending supraspinal pathways depends on the developmental stage the particular pathways arise.