Truly international, this extensive text combines the efforts of eight laboratories from seven countries in investigating the study of problems of manipulation, orienting, and navigating in humans and animals. The novel, multidisciplinary approach places the study of multisensory control of movement in a three-dimensional frame, with reference to computer models and neuronal mechanisms. Of interest to researchers, clinicians, and advanced students in neuroscience, psychology, and neurology, the text also has important implications for researchers in biomedical engineering and robotics.

This text is a graduate-level introduction to neural networks, focusing on current theoretical models, examining what these models can reveal about how the brain functions, and discussing the ramifications for psychology, artificial intelligence, and the construction of a new generation of intelligent computers. The book is divided into four parts. The first part gives an account of the anatomy of the central nervous system, followed by a brief introduction to neurophysiology. The second part is devoted to the dynamics of neuronal states, and demonstrates how very simple models may stimulate associative memory. The third part of the book discusses models of learning, including detailed discussions on the limits of memory storage, methods of learning and their associated models, associativity, and error correction. The final section of the book reviews possible applications of neural networks in artificial intelligence, expert systems, optimization problems, and the construction of actual neuronal supercomputers, with the potential for one-hundred fold increase in speed over contemporary serial machines.

The ordered growth and functioning of animal cells requires the transfer of information from one part of the cell to another. This information comes from a bewildering variety of sources, both within and outside the cell. Hormones, neurotransmitters, growth factors and extracellular metabolites interact with specific receptors on the plasma membrane or in the cytoplasm. Inside the cell, information is relayed by intracellular messengers, including cyclic nucleotides, inositol polyphosphates, diacylglycerol and calcium, and by GTP-binding proteins, protein kinases, and DNA-binding proteins. Finely balanced interactions between these different signalling pathways ensure that the required response occurs, and abnormalities in any of the components of the system can lead to a variety of diseases, including cancer. This textbook brings together and puts into perspective a large body of knowledge about intracellular signalling systems. Written in a clear and authoritative style, with many illustrations, it will be invaluable to students on advanced undergraduate and graduate courses. It also provides a detailed introduction to and review of this central topic for researchers in cell biology and related disciplines.

Although most often considered in terms of the generation of action potentials, there are several other electrical, metabolic and ionic correlates of neuronal activity. This book draws together in a single volume, ten different facets of the activity of nerve cells. There are chapters on the monitoring of extracellular unit activity, intracellular voltage and current clamping, patch clamping, video imaging, in vivo voltammetry, intracerebral dialysis, antibody micro- and ion-selective electrodes. The techniques described range from the well-established to the experimental. In each case the chapters include up-to-date information, methodological tips and detailed protocols allowing the reader to follow each method in a stepwise fashion. The wide range of techniques in the book should be of interest to neuroscientists, whether concerned with traditional or novel indices on neuronal function.

The axolotl, or Mexican salamander, is used in a wide range of biological research, from the study of the regulation of gene expression to pattern formation, neurobiology, and regeneration. This volume offers a short yet comprehensive survey of basic developmental research utilizing the animal, along with practical information for rearing and maintaining the axolotl in a laboratory environment. The book will serve as a useful reference for developmental biologists.

Domestic and wild large mammalian herbivores occur on every continent except Antarctica. Through their browsing and grazing, they affect the structure and distribution not only of vegetation, but also of associated fauna. Consequently, the interactions between management practices and herbivore populations influence the biodiversity, structure and dynamics of ecosystems across vast expanses around the globe: signs of human activity that will be detectable for epochs to come. As a follow-up work to The Ecology of Browsing and Grazing, published in 2008, this new volume presents cutting-edge research on the behaviour, distribution, movement, and direct and indirect impacts of domestic and wild herbivores on terrestrial ecosystems. The respective chapters highlight strategic and applied research on cross-cutting issues in palaeontology and ecology, and provide concrete recommendations on the management of large herbivores to integrate production and conservation in terrestrial systems. Given its scope, the book will appeal to students, researchers and anyone interested in understanding these fascinating wild animals and how they shape the natural world.

Good nutrition is fundamental to the success and sustainability of the aquaculture industry in terms of economics, fish health, high quality product production and minimizing environmental pollution. This book provides a unique, complete coverage of current information on nutrient requirements, feed formulations and feeding practices of commercially important aquaculture species cultured around the world. Each chapter contains detailed feeding information on specific species and is written by an expert nutritionist on that species. The book is of interest to those working professionally in the industry, graduate level students and researchers.

This volume is a self-contained companion piece to Studying Vibrational Communication, published in 2014 within the same series. The field has expanded considerably since then, and has even acquired a name of its own: biotremology. In this context, the book reports on new concepts in this fascinating discipline, and features chapters on state-of-the art methods for studying behavior tied to substrate-borne vibrations, as well as an entire section on applied biotremology. Also included are a historical contribution by pioneers in the field and several chapters reviewing the advances that have been made regarding specific animal taxa. Other new topics covered are vibrational communication in vertebrates, multimodal communication, and biotremology in the classroom, as well as in art and music. Given its scope, the book will appeal to all those interested in communication and vibrational behavior, but also to those seeking to learn about an ancient mode of communication.

Animal Models in Toxicology is a single-source reference for the use of animal models in toxicology. Chapters cover nine species used in toxicology and experimental biology. With contributions from experts in toxicology, toxicological pathology, and species-specific metabolism, each of these chapters provides an excellent introductory "course" along with guidance to the literature for a more detailed understanding. This edition includes five new chapters. The first of these provides specific and detailed guidance on the humane, efficient, and effective performance of necropsies for laboratory animals. Other new chapters discuss new technologies available for laboratory animal research-imaging technologies, use of telemetry in animal studies, transgenic animal models, and immunology endpoint for assessment. Also provided is an overview of the increasingly complex laws and regulations that govern how laboratory animals are obtained, maintained, and utilized. A helpful appendix provides a quick guide to commercial sources of laboratory animals.

An essential introduction to microbiome science, a new cutting-edge discipline that is transforming the life sciences This book provides an accessible and authoritative guide to the fundamental principles of microbiome science, an exciting and fast-emerging new discipline that is reshaping many aspects of the life sciences. Resident microbes in healthy animals--including humans-can dictate many traits of the animal host. This animal microbiome is a second immune system conferring protection against pathogens; it can structure host metabolism in animals as diverse as reef corals and hibernating mammals; and it may influence animal behavior, from social recognition to emotional states. These microbial partners can also drive ecologically important traits, from thermal tolerance to diet, and have contributed to animal diversification over long evolutionary timescales. Drawing on concepts and data across a broad range of disciplines and systems, Angela Douglas provides a conceptual framework for understanding these animal-microbe interactions while shedding critical light on the scientific challenges that lie ahead. Douglas explains why microbiome science demands creative and interdisciplinary thinking-the capacity to combine microbiology with animal physiology, ecological theory with immunology, and evolutionary perspectives with metabolic science. An essential introduction to a cutting-edge field that is revolutionizing the life sciences, this book explains why microbiome science presents a more complete picture of the biology of humans and other animals, and how it can deliver novel therapies for many medical conditions and new strategies for pest control.

This book addresses how skeletons can inform us about behavior by describing skeletal lesions in the Gombe chimpanzees, relating them to known life histories whenever possible, and analyzing demographic patterns in the sample. This is of particular interest to both primatologists and skeletal analysts who have benefited from published data on a smaller, earlier skeletal sample from Gombe. The Gombe skeletal collection is the largest collection of wild chimpanzees with known life histories in existence, and this work significantly expands the skeletal sample from this long-term research site (49 chimpanzees). The book explores topics of general interest to skeletal analysts such as demographic patterns, which injuries leave signs on the skeleton, and rates of healing, and discusses both qualitative and quantitative analysis of the patterning of lesions. The book presents the data in a narrative style similar to that employed in Dr. Goodall's seminal work The Chimpanzees of Gombe. Readers already familiar with the Gombe chimpanzees are likely to appreciate summaries of life events correlated to observable skeletal features. The book is especially relevant at this time to remind primate conservationists of the importance of the isolated chimpanzee population at Gombe National Park as well as the availability of the skeletons for study, both within the park itself as well as at the University of Minnesota.

This detailed new edition aims to provide a range of methods and protocols for studying vascular morphogenesis in vivo and in vitro to reflect up-to-date advances in the field. Of note, the book explores endothelial cell signaling is currently understood to promote fundamental cues for cell fate specification, embryo patterning, organ differentiation, and postnatal tissue remodeling. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and timely, Vascular Morphogenesis: Methods and Protocols, Second Edition will serve as an ideal guide to this area of study for a broad audience amongst cell biologists, anatomists, pathologists, and physiologists.

This is the Second Edition of a well-received book that reflects a fresh, integrated coverage of the concepts and scientific measurement of stress and welfare of animals including humans. This book explains the basic biological principles of coping with many forms of adversity. The major part of this work is devoted to explaining scientifically usable concepts in stress and welfare. A wide range of welfare indicators are highlighted in detail with examples being drawn from man and other species. The necessity for combining information from disciplines is emphasized with a one-health, one-welfare approach. This information forms the basis for a synthesis of new ideas. Among the issues covered are: - How brain and body systems regulate using feelings, physiological responses, behaviour and responses to pathology - Limits to adaptation - Assessing positive and negative welfare during both short-term and long-term situations - Ethical problems and suggested solutions A proper assessment of animal welfare is essential to take informed decisions about what is morally acceptable in terms of practice and in the development of a more effective legislation. This work encapsulates a very wide body of literature on scientific aspects of animal welfare and will thus prove a valuable asset for animal welfare scientists, psychologists, students and teachers of all forms of biology, behaviour, medicine, veterinary medicine and animal usage.

This authoritative volume reviews the subject in a style which is comprehensible to the non-specialist. Contributions by leading authorities review avian meat science from basic meat structure and function, color, texture and flavor, through to practical aspects of production, harvesting and slaughter factors affecting meat quality. The book is the result of the 25th Poultry Science Symposium held at the University of Bristol in September 1997.

Recognizing the significant advances made in the field of animal genetics in the ten years since the first edition of Genetics of the Dog, this new edition of the successful 2001 book provides a comprehensive update on the subject, along with new material on topics of current and growing interest. Existing chapters on essential topics such as immunogenetics, genetics of diseases, developmental genetics and the genetics of behaviour have been fully updated, while new authors report on the latest advances in areas such as genetic diversity of dog breeds, canine genomics, olfactory genetics and cancer genetics.

During the last two decades, major advances have been made in mammalian genetics. New methods in molecular and cytogenetics, and in biotechnology have been developed. Many of these have been applied to investigating the genetics of sheep and to improving the production of wool, meat and milk. This book is a comprehensive reference work on sheep genetics. All relevant topics have been included, from fundamental genetic structure to the genetics of various production and other traits, to transgenic sheep and genetic conservation. Chapters have been specially commissioned for the volume and written by internationally recognized experts from Europe, USA, Australia and New Zealand. The book will be invaluable to advanced students and research workers in animal genetics, breeding and biotechnology.

Ecological morphology examines the relation between an animal's anatomy and physiology--its form and function--and how the animal has evolved in and can inhabit a particular environment. Within the past few years, research in this relatively new area has exploded. "Ecological Morphology" is a synthesis of major concepts and a demonstration of the ways in which this integrative approach can yield rich and surprising results.
Through this interdisciplinary study, scientists have been able to understand, for instance, how bat wing design affects habitat use and bat diet; how the size of a predator affects its ability to capture and eat certain prey; and how certain mosquitoes have evolved physiologically and morphologically to tolerate salt-water habitats. "Ecological Morphology" also covers the history of the field, the role of the comparative method in studying adaptation, and the use of data from modern organisms for understanding the ecology of fossil communities.
This book provides an overview of the achievements and potential of ecological morphology for all biologists and students interested in the way animal design, ecology, and evolution interact.

Their natural beauty, exceptional variety and unique biology make birds (Aves) one of the most fascinating groups of animals. They are also of great importance to humans as food and as experimental subjects that have catalyzed significant advances in many areas of biological research. Central to our ability to maintain and develop these resources is a thorough understanding of avian nutrition. This book presents, uniquely, all aspects of our current knowledge, drawn from such diverse disciplines as physiological ecology, poultry production, zoo biology and biomedical science. The physical and biochemical processes of digestion, the metabolic functions of nutrients and the diversity of evolutionary adaptations required to accommodate very different foodstuffs are examined in depth. Emphasis is placed on the quantitative nature of nutrition and the practical consequences for the dietary requirements of captive and wild avian populations throughout their life cycle. This book is key reading for advanced students of animal nutrition and poultry science and for research ornithologists. It will also be valuable for practicing nutritionists working with farmed, pet, zoo or wild birds and represents an essential purchase for libraries of animal science, veterinary medicine and ornithology.

The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

For over thirty years, rodents have been used in the study of many human and animal diseases. The rat in particular continues to serve as an experimental model for drug safety and efficacy tests for the treatment of neurological disorders, heart disease, diabetes, breast, liver and other cancers. With the more recent advent of transgenic technology, an impressive amount of new knowledge about transmissible spongiform encephalopathies has been accumulated. It is likely that the principles learned from the study of these prion diseases will be applicable to elucidating the causes of more common neurodegenerative disorders such as Alzheimer’s and Parkinson’s diseases. As a result of this and, more importantly, because of increasingly complicated legislation governing the use of animals in regulated procedures, there is a need for experimenters (both experienced and those new to the laboratory) to improve their skills continuously and to become au fait with all aspects of preparatory techniques. The Rat Nervous System provides an accessible guide to the dissection and perfusion of rats, placing particular emphasis on the preparation of nervous tissue for further study in the laboratory including biochemical analysis and microscopic study. Logically structured with highly illustrated chapters covering gross anatomy, anatomy of the nervous system, anaesthesia, biological fixation and tissue extraction, the book provides a comprehensive introduction to those techniques required to provide consistent, high-quality tissues for subsequent investigation. Animal husbandry of a high standard, together with minimisation of discomfort, is essential if the information sought by the investigator is to be valid and reproducible; an overview of these topics is therefore also incorporated in this volume.

In this authoritative three-volume reference work, leading researchers bring together current work to provide a comprehensive analysis of the comparative morphology, development, evolution, and functional biology of the skull.

This major study of animal orientation in space launches the Princeton Series in Neurobiology and Behavior. Bringing together for the first time the important work done on spatial orientation over the past twenty-five years, and reviewing research up to and including recent attempts to apply the methods of cybernetics, Hermann Schone discusses the most significant concepts in the control of position and movement in space. Originally published in 1984. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905.

An essential resource detailing information on the structure, function, and clinical application of all equine body systems The sixth edition of this highly successful book contains updates to functional anatomy which has now been totally revised. There are also new chapters on the eye, abdomen, female reproduction, ultrasonography and orthopaedics. The atlas is superbly illustrated throughout with colour drawings, photographs, and radiographs providing the reader with detailed information on the structure, function, and clinical application of all equine body systems and their interaction in the live animal. Already acknowledged by students and teachers as an essential resource for learning and revision, the sixth edition will be a valuable reference for veterinary practitioners and for those who own and work with horses.

This SpringerBrief answers the question on how birds recognize their predators using multidisciplinary approaches and outlines paths of the future research of predator recognition. A special focus is put on the role of key features to discriminate against predators and non-predators. The first part of the book provides a comprehensive review of the mechanisms of predator recognition based on classical ethological studies in untrained birds. The second part introduces a new view on the topic treating theories of cognitive ethology. This approach involves examination of conditioned domestic pigeons and highlights the actual abilities of birds to recognize and categorize.

Phoridae are probably the insect family with the greatest diversity of larval habits, but the least studied of the large families of flies due to identification difficulties. This book collates what is known about the natural history of the Phoridae world. It reviews eggs and oviposition, larval habits (including saprophages, kleptoparasites, fungus breeders, plant feeders, predator, parasitoids, parasites and enemies), pupae and their enemies, development, adult habits (including feeding, special associations, courtship, mating, phoretic mites and enemies) and ecological aspects. There follows a new user-friendly and extensively illustrated key to world genera and a review of the identification literature for each of the 229 genera recognized. A review of methods and an extensive bibliography complete the work.