Isoenzymes were 'discovered' 20 years ago and were at first regarded as interesting but rare occurrences. Since then a wealth of information on enzyme heterogeneity has accrued and it now seems likely that at least half of all enzymes exist as isoenzymes. This is important in many areas of biological and medical science. Thus isoenzyme studies have provided the main experimental substance for the neutral drift controversy in genetics and evolution; they have greatly extended our understanding of metabolic regulation not only in animals but also in bacteria and plants; their existence has made available a multitude of highly sensitive markers for the study of differentiation and development, as well as providing indices of aberrant gene expression in carcinogenesis and other pathological processes. Iso enzymes are also being used increasingly in diagnostic clinical bio chemistry. It is surprising that this phenomenon which affects such a high pro portion of enzymes and is clearly important in biochemistry should receive such scant attention in the standard textbooks of that subject, the formal treatment of isoenzymology in these rarely exceeding one or two pages. This may be because the 'pure biochemist' has tended to regard variation in enzyme properties between tissues more as an unwanted complication than as a potential source of insight into diversity of biological function."

In this book we present a largely biochemical look at the metals of life and their functions, which we hope will be of interest to chemists and biologists as well as biochemists. The field of 'inorganic bio chemistry' is one of rapid change. Recent developments in our know ledge of the activity of calcium, and of the iron-sulphur proteins, are two examples, and increasing attention is being paid to non-metals as well 3]. For reasons of space, we shall restrict ourselves to the normal biological activities of metals. We must ignore, on the one hand, the gross physiological effects of metal deficiency or toxicity, and on the other, the many model studies which have been stimulated by the unusual properties of metals in biological systems. Usually the synthesis of model metal compounds follows rather than anticipates the dis covery of novel biological configurations. However, such studies give us a firm basis for an understanding of the biological systems, and sometimes answer questions that cannot be tackled any other way (for instance, what is the net charge on an iron-sulphur cluster?). As a result, we can refer to new and interesting information on the metals oflife at a chemical level. We gratefully acknowledge the help of Professor P. Banks and Dr D. Fenton who have read and criticized the manuscript, though any errors or misconceptions remain our own responsibility. We thank Mr P. Elliot for preparing Fig. 5.2."

With the current interest in the environmental and economic sustainability of dairy farming, grass forage crops have emerged as a potential solution to some of the nutrient management problems now encountered on intensively managed dairy farms. The expansion and reintegration of grass-based systems into the mainstream of dairying systems will require a major paradigm shift involving economic, social and ecological, as well as biological factors. This book examines the role of grass in milk production in sustainable agricultural ecosystems. It provides a current summary of the role of grass in dairy cattle systems, including the breeding, management, storage, feeding and economics of grass for both lactating and dry dairy cows. Written by leading specialists from Australia, Europe, New Zealand, North and South America, this is an essential reference source for researchers, dairy industry professionals and advanced students of forage and dairy cattle nutrition.

The Proceedings of the 14th Symposium on Energy Metabolism of Farm Animals, held in Northern Ireland in September 1997, comprises 85 original contributions by leading scientists from over 20 countries around the world. In keeping with previous Symposia in the series, held under the auspices of the European Association for Animal Production, this book contains papers which provide the latest research on the energy metabolism and other aspects of the physiology of a wide variety of farmed animals. Highlights include a comprehensive review of the current state of research on leptins and their potential applications in animal production, and a large section relating to organ and tissue metabolism, with major contributions from the USA, UK, France, Germany and Denmark. An important strength of the book is the diversity of species covered. For example, the sections on modelling and feed evaluation relate to pigs, sows, broiler chickens, laying hens, turkeys, lambs, beef and dairy cattle and fish. There are also substantial contributions on lactation and reproduction, growth, environmental aspects and maintenance. This book is essential reading for research workers in animal science, particularly those concerned with nutrition and feed evaluation.

It is known that the medial geniculate body (MGB) is the last relay center in the audi- tory system. Its projections to the auditory cortex have been studied extensively in the cat using retrograde cell degeneration and the Marchi technique. The auditory cortex has also been defined electrophysiologically and cytoarchitecturally by many authors (Fig. 1). Woolsey and Walzl (1942) first defined the primary (AI) and secondary (All) auditory areas by electrical stimulation of cochlear nerve fibers. Later studies have dem- onstrated other cortical areas responsive to auditory stimulation: the posterior ecto- sylvian area (Ep), the suprasylvian fringe (SF), the third auditory'area (AlII) in the sec- ond somatic sensory area (SII), the insular area (Ins) or the fourth auditory area (AIV), and the temporal area (Temp). Classic anatomic methods, such as the Marchi and retrograde cell degeneration methods, were not suitable for studying the precise organization of the cortical pro- jections of MGB, however, the Nauta method has been useful in the study of these pro- jections (Wilson and Cragg, 1969; Niimi and Naito, 1972, 1974; Sousa-Pinto, 1973). These studies indicated that parts of MGB send differential projections to individual auditory areas, although considerable overlap of the projections is seen. Furthermore, some authors showed that the pulvinar nuclear group also projects to the auditory cor- tex (Graybiel, 1973; Niimi et aI. , 1974a; Rosenquist et aI. , 1974).

Updating recommendations last made by the National Research Council in the mid-1980s, this report provides nutrient recommendations based on physical activity and stage in life, major factors that influence nutrient needs. It looks at how nutrients are metabolized in the bodies of dogs and cats, indications of nutrient deficiency, and diseases related to poor nutrition. The report provides a valuable resource for industry professionals formulating diets, scientists setting research agendas, government officials developing regulations for pet food labeling, and as a university textbook for dog and cat nutrition. It can also guide pet owners feeding decisions for their pets with information on specific nutrient needs, characteristics of different types of pet foods, and factors to consider when feeding cats and dogs. Table of Contents Front Matter Summary

The standard electrocardiogram (ECG) is an indispensable, safe, and inexpensive test to assess dogs and cats with heart disease. This bestselling user-friendly book discusses the principles of electrocardiography, then systematically explores the evaluation of the ECG, including determination of heart rate, measurement of intervals, derivation of mean electrical axis, and criteria for atrial/ventricular enlargement or hypertrophy. At the core of this book is an extensive series of ECG cases for the reader to work through: practice makes perfect. New to this edition: Instructions on how to obtain an ECG A new chapter on the treatment of the most common clinically important ECG arrhythmias A second new chapter on 24-hour ECG (Holter) monitoring A handy one-page reference guide of important ECG values and diagrams, which can be downloaded from the book's webpage for easy reference 15 new ECG cases have been added to the original 46 cases, with a selection of advanced cases geared toward readers craving more challenging topics such as electrical cardioversion and pacemaker function. This updated edition will further aid veterinarians in their quest to better interpret the ECG. It provides information in an appealing, accessible, and easy to use format that fits with the busy lives of veterinary practitioners.

How are sights and sounds and smells converted into electrical signals in a form that can be interpreted by the nervous system? Although this process, called sensory transduction, began to be understood only relatively recently, so much progress has been made that it is now possible to say at least in outline (but in most cases in remarkable detail) how transduction occurs for all of the major sense organs of the body. Since the first edition was published in 2003, many new experiments have radically changed some of our previously-held views.This new edition fulfils the book's original aims, both as an accessible textbook and a general introduction to the senses, by bringing the contents fully up to date with the new information acquired over the last 15 years. In so doing, it continues to provide a comprehensive survey of one of the greatest achievements of modern biology and neuroscience - the unravelling of the mechanism of sensation. Sensory Transduction is written for advanced undergraduates, graduate students, and researchers in neurophysiology and sensory neuroscience. It is also of relevance and use to a broader audience of neuro, evolutionary, integrative, and comparative biologists.

DIRECTLY APPLIES TO LIFE ON LAND SDG and CLIMATE CHANGE SDG. International organizations such as the Intergovernmental Panel on Climate Change (IPPC), World Health Organization, Food and Agriculture Organization and World Organization for Animal Health have all reminded us that health impacts of climate change will become some of societies' greatest challenges. How we respond or adapt to climate change will have profound implications for people, animals, biodiversity, economies and ecosystems today as well as in the future. The book provides, in one easy reference, all of the information Animal Health practitioners need from defining the climate change concept, providing science-based evidence of climate change degradation of animal (ecosystem) health and successful mitigation and reversal strategies. Despite being arguably the most important challenges of the 21st century, engagement, and leadership from the animal health sector on climate change remains hard to find. This book attempts to support animal health professionals by providing information, knowledge, and experiences they can use to remedy this situation. There is no other book that covers anything like the proposed subject matter to this level of completeness and detail. The publishing of a text of this nature could help erode the power of the climate denialism lobby, shifting the debate and allowing mitigation efforts to gain higher priority. The tone of the book has an understated sense of urgency, leaning slightly toward presenting as a 'Manual for the apocalypse'. This has potential to be a benchmark publication. The text not only defines climate change but takes a proactive approach with intervention and corrective action examples: each chapter ends with suggestions on teachable and actionable ideas that could be used to mobilize concepts and information provided into education or advocacy. In this way, the book not only brings key ideas, principles and information to understand the implications for climate change for animal health, but will help translate the book's offerings into education and intervention. Teachers and researchers could use this one-of-a-kind book to frame a course or seminar series heightening student career engagement and stewardship of a more sustainable and healthier planet.

This book on ancient fishes unites the work of many specialists coming from different areas of biology. Hagfishes, lungfishes, Chondrosteans, and Holosteans constitute the main subject of study. Fossil records and extant species are compared to establish the conservation or the degeneration of specific characters. However, phylogenetic relationships have mostly been revisited in the light of new molecular and developmental data. The morphology of several organs is also revisited. This volume includes a phylogenetic account of the cardiac outflow tract, and the particulars of the heart and circulation in lungfishes. The control of breathing and the lung-swim bladder issue is discussed. The developmental anatomy of the sturgeon gut and accounts of the gut structure in lungfishes and garfishes are also included. Biochemical and physiological aspects of the behavior of lungfishes and gars are presented. Reports on the fish olfactory system, and on the amazing slime glands of hagfishes, are also covered.

Recent advances in fish cytogenetics have enhanced the interest in chromosome analysis in both fundamental (systematics and comparative genomics among fishes and other vertebrate groups) and applied (aquaculture, conservation and response to pollutants, whole genome sequencing of model fish species) research. Although the genomic material, the chromosomes, is basically the same in the various organisms, experience has clearly shown that fish chromosomes have to be handled with specific protocols. In laboratories around the world, traditional cytogenetic techniques and molecular cytogenetics have seen a vast improvement but the technical details and protocols are often not published in scientific journals because of constraints in format and size and therefore they are not accessible to the whole scientific community. These shortcomings are very well known to fish cytogeneticists and the idea to prepare a specific manual was first discussed during the first "Workshop of Fish Cytogenetics" held in Concarneau (France), in 1992. Resulting from the above workshop, a draft compilation of the techniques and protocols in fish cytogenetics available at that time had been produced and distributed privately, but never published. There does not exist, at present, any published handbook or manual specifically dealing with fish cytogenetics. This book fills this void by bringing together and updating the main techniques so that the traditional methods can be standardized. Moreover, this book includes novel developments or improvements; some of the protocols provided here are practically unknown to the scientific community and even now unpublished.

The effects of the bone morphogenetic proteins (BMPs) family on bone formation are well documented, but the transforming growth factor (TGF)-beta ( ) isoforms are much less studied. The product of 20 years of study, Induction of Bone Formation in Primates: The Transforming Growth Factor- 3 sums up editor Ugo Ripamonti's research into the osteogenic activity of the three mammalian TGF- isoforms, particularly in primates. It explores how the mammalian TGF- isoforms have the potential to shed light on the apparent redundancy of bone induction signaling. The book unearths the profound and important bone inductive activity of the TGF- 3 isoform. It includes accounts of extensive research in non-human primates from craniofacial tissue regeneration, heterotopic tissue induction, and chapters on periodontal tissue regeneration and synergistic induction of bone formation. It also discusses the future clinical role of the TGF- isoform, including in human studies. This book contributes to the fascinating history of BMP and TGF- research at the intersection of molecular biology, tissue induction, bone regeneration, and craniofacial surgery. It provides a revolutionary awakening to new possibilities in skeletal reconstruction, tissue engineering, and molecular and cellular biology.

In dem Forschungsgebiet "Insektenflug" treffen Fragestellungen der Biologie und der StrAmungsmechanik vielseitig zusammen. Der Bogen reicht von der Konstruktionsmorphologie A1/4ber die Flugbiophysik bis zur Energetik und zum Flugverhalten. Der Autor ist einer der international angesehensten Grundlagenforscher in diesem Forschungsgebiet. Das Buch stellt nicht nur einen Bericht A1/4ber die vielseitigen ForschungsansAtze von ihm und seiner Arbeitsgruppe dar; es bringt auch die allgemeinen Grundlagen und fA1/4hrt mit einer FA1/4lle von Beispielen an die Grenzen des derzeitigen Kenntnisstandes.

3* Doody's Star Rating (R) CHOICE Magazine 'Recommended' (May 2020) As of 2018, pet obesity in the US affects an estimated 55.8 percent of dogs and 59.5 percent of cats, resulting in secondary conditions such as arthritis, diabetes mellitus, kidney disease, and certain forms of cancer. A complete and balanced diet accompanied by regular exercise is fundamental to optimize health and longevity in companion animals, meaning overweight pets have reduced quality of life and shorter life expectancy. Seeking to address this major modern-day problem, this book provides a comprehensive review of obesity in small animal medicine. Reviews epidemiology and how animal- and human-specific factors contribute to excess weight gain. Discusses the metabolic effects and inflammatory mediators associated with adiposity. Looks at various disease states and how they relate or develop as a result of obesity. Reviews different modalities to determine body composition to diagnose obesity. Offers a clinical approach to managing obesity with diet including discussion on the nutrients of concern for therapeutic weight loss diets. Veterinarians seeking to provide weight management services in practice will find clinically-applicable information from expert authors from both academic and practice backgrounds. Chapters cover topics ranging from epidemiology and pathophysiology of obesity to evaluation of body composition, and nutritional and behavioral management. The book also explores the role of exercise in managing obesity and looks at the management of co-morbidities. Finally, the authors present a range of case studies to demonstrate these topics in real-life practice.

Erythrocytes of the Rhesus and Cynomolgus Monkeys addresses the morphologic, quantitative, and generative aspects of the erythrocytes of the rhesus monkey Macaca mulatta and the cynomolgus monkey Macaca fascicularis (long-tailed macaque, crab-eating monkey). These two species are the most commonly selected nonhuman primates for basic science and clinical medical investigations. The hemopoietic cells of man and the rhesus monkey display an intimate homogeneity. Their functional activities are close and at times identical. The cynomolgus monkey was enlisted in biomedical studies at a time when rhesus monkeys were not available in sufficient quantities. It has gained increased use in the Far East and in the Western world. It is, for example, employed in the current development of a vaccine against the deadly Ebola virus. The authors of the book discuss the erythropoietic profiles of normal and abnormal macaques of both sexes and of all age groups as investigated with contemporary electronic methodologies. They cover the role of stress as it is perceived by the monkey and how it impacts erythrocellular values, and how to train the monkey to be a cooperative, unperturbed subject for hematologic study. Additional topics include the role of medication in deriving normal physiologic erythrocellular data, the development of the precursors of the erythrocyte (normoblasts), the morphologic analysis of the megaloblastic series of abnormal erythroid cells, the analysis of erythropoiesis in bone marrow, the relationship of the simian immunodeficiency virus and erythropoiesis, erythrocyte life span, and parasitic invasion of the red cell.

A Practical Guide to the Histology of the Mouse provides a full-colour atlas of mouse histology. Mouse models of disease are used extensively in biomedical research with many hundreds of new models being generated each year. Complete phenotypic analysis of all of these models can benefit from histologic review of the tissues. This book is aimed at veterinary and medical pathologists who are unfamiliar with mouse tissues and scientists who wish to evaluate their own mouse models. It provides practical guidance on the collection, sampling and analysis of mouse tissue samples in order to maximize the information that can be gained from these tissues. As well as illustrating the normal microscopic anatomy of the mouse, the book also describes and explains the common anatomic variations, artefacts associated with tissue collection and background lesions to help the scientist to distinguish these changes from experimentally- induced lesions. This will be an essential bench-side companion for researchers and practitioners looking for an accessible and well-illustrated guide to mouse pathology. * Written by experienced pathologists and specifically tailored to the needs of scientists and histologists * Full colour throughout * Provides advice on sampling tissues, necropsy and recording data * Includes common anatomic variations, background lesions and artefacts which will help non-experts understand whether histologic variations seen are part of the normal background or related to their experimental manipulation

--- EMS (extra-mural studies) are an essential element of undergraduate veterinary education. Students must complete a minimum of 38 weeks EMS during their course, which should normally consist of 12 weeks pre-clinical and 26 weeks of clinical placements, a large portion of which takes place on farms. -- The highly illustrated approach allows readers to see the highlighted differences rather than try to imagine what cases look like and differentiate them from written descriptions. -- A repository of over 1000 10-second video clips accompanies the book, accessible to students on the farm with a smart phone. Each clip uniqeuly shows the animal's clinical presentation, internal disease/imaging and then healthy recovery -- There are a limited number of common conditions seen by vets in farm animal practice and an exhaustive list of all known diseases is not needed: textbooks often include such diseases for the benefit of an academic reviewer rather than student and general practitioner readers. -- This concise guide offers a breath of fresh air among the existing hefty expensive large animal medicine tomes on the market. --- Some comments from veterinary students on the proposal: "I firmly believe that this would be a very useful book and only wish that it existed already for my clinical EMS"; "There are currently several 'pocket books' for small animal medicine such as the Mini Vet guide but nothing for farm animals"; "Using a small animal 'quick', ring-bound, reference guide on EMS has been extremely useful, and it would be very beneficial to have a large animal alternative"; "The author's suggested use of high quality illustrations is what a student desperately needs. At the end of the day we need to be able to work out many diseases with similar symptoms - this book would provide that where may other current textbooks do not. I would support this new book, and hope it is released before I go into exams in the future - as it is what I currently need help within revision like so many other students. It is what the veterinary student dreams of having, and yet no one has produced it!"

The book concentrates on physiology and biochemistry and is not diluted by taxonomy/systematics - this makes it different from the competitor books and increases its worth at the postgraduate level and beyond. It makes a very good companion book to a second text that concentrates on taxonomic aspects, such as McGavin. It emphasizes the importance of a rigorous understanding of species-specific details. This is even more successful because of the depth of each chapter. The chapter on symbiosis is different, and very interesting and relevant. There is 'hidden depth', nuance and richness in many chapters, which explore a huge range of themes and relevant topics. The book puts emphasis on insect diversity and its implications for experimental design and interpretation, highlighting caveats in experimental design. It is extremely thought provoking. The writing style is easy to follow with very good descriptions of complicated topics. The edition is published in full color throughout. Ideal for upper level undergraduate and graduate students (in college course system, 300 level and above). For the first-time learners, the level of difficulty is comparable to the introductory level courses for Genetics.

The Colour Handbook deals with all aspects of urolithiasis in dogs, cats, rabbits and guinea pigs-from aetiology and pathogenesis to diagnosis, treatment and the prevention of disease recurrence. The authors introduce the reader to treatment protocols developed from their own research and experience, and incorporate international state-of-the-art knowledge of the disease. Topics covered in the Colour Handbook include epidemiology, risks in companion animal husbandry, species-specific differences, breed dispositions, genetic causes, relevant anatomical points, clinical diagnosis, stone composition, clinical pathology and treatment protocols. The Colour Handbook is a compact, wide ranging illustrated guide to dealing with urinary stones in small animals, of value to veterinarians in training and practice.

The standard electrocardiogram (ECG) is an indispensable, safe, and inexpensive test to assess dogs and cats with heart disease. This bestselling user-friendly book discusses the principles of electrocardiography, then systematically explores the evaluation of the ECG, including determination of heart rate, measurement of intervals, derivation of mean electrical axis, and criteria for atrial/ventricular enlargement or hypertrophy. At the core of this book is an extensive series of ECG cases for the reader to work through: practice makes perfect. New to this edition: Instructions on how to obtain an ECG A new chapter on the treatment of the most common clinically important ECG arrhythmias A second new chapter on 24-hour ECG (Holter) monitoring A handy one-page reference guide of important ECG values and diagrams, which can be downloaded from the book's webpage for easy reference 15 new ECG cases have been added to the original 46 cases, with a selection of advanced cases geared toward readers craving more challenging topics such as electrical cardioversion and pacemaker function. This updated edition will further aid veterinarians in their quest to better interpret the ECG. It provides information in an appealing, accessible, and easy to use format that fits with the busy lives of veterinary practitioners.

The study of animal movement has always been a key element in ecological science, because it is inherently linked to critical processes that scale from individuals to populations and communities to ecosystems. Rapid improvements in biotelemetry data collection and processing technology have given rise to a variety of statistical methods for characterizing animal movement. The book serves as a comprehensive reference for the types of statistical models used to study individual-based animal movement. Animal Movement is an essential reference for wildlife biologists, quantitative ecologists, and statisticians who seek a deeper understanding of modern animal movement models. A wide variety of modeling approaches are reconciled in the book using a consistent notation. Models are organized into groups based on how they treat the underlying spatio-temporal process of movement. Connections among approaches are highlighted to allow the reader to form a broader view of animal movement analysis and its associations with traditional spatial and temporal statistical modeling. After an initial overview examining the role that animal movement plays in ecology, a primer on spatial and temporal statistics provides a solid foundation for the remainder of the book. Each subsequent chapter outlines a fundamental type of statistical model utilized in the contemporary analysis of telemetry data for animal movement inference. Descriptions begin with basic traditional forms and sequentially build up to general classes of models in each category. Important background and technical details for each class of model are provided, including spatial point process models, discrete-time dynamic models, and continuous-time stochastic process models. The book also covers the essential elements for how to accommodate multiple sources of uncertainty, such as location error and latent behavior states. In addition to thorough descriptions of animal movement models, differences and connections are also emphasized to provide a broader perspective of approaches.

1. First book to adapt and explain health promotion, harm reduction and health equity issues in a One Health context and in terms of animal health. 2. Action oriented, focusing on principles and lessons learned in case studies to demonstrate how to inspire actions to protect the shared health of people, animals and environments. 3. Emphasizes what we can do to keep things healthy, thus addressing the growing calls to shift from a reactive to proactive approach in One Health. 4. Examines One Health in terms of the wider threats to the world, like climate change, thus expanding its scope of practice and helping find common ground between many emerging fields that are trying to co-manage human-animal and environmental health.

The fifth edition of The Physiology of Fishes represents a compendium of knowledge across fish physiology, collecting up-to-date research into an easy-to-access single textbook. Written by the leaders in the field, it provides a comprehensive, accessible review of the core topics, integrating physiology with environmental science, ecology, evolution, and molecular cell biology. New chapters address Epigenetics, Biomechanics and Locomotion, and Behaviour and Learning. Each chapter contains an extensive bibliography, providing readers with the best sources from the primary literature. Almost three decades after the publication of the first edition, this book remains the only published single-volume work on fish physiology. The fifth edition provides an important reference for new students of fish biology, marine and freshwater biologists, ichthyologists, fisheries scientists, and comparative physiologists.