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Development of the Rat Spinal Cord: Immuno- and Enzyme Histochemical Approaches (Paperback)
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Development of the Rat Spinal Cord: Immuno- and Enzyme Histochemical Approaches (Paperback)
Series: Advances in Anatomy, Embryology and Cell Biology, 129
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The studies described here were carried out in the Neuroregul ation
Group, Department of Physiology, University of Leiden, the
Netherlands. Over the last decade, this group, in close
collaboration with the Department of Neurosurgery of the Academic
Hospital of Leiden, has studied the development of the central
nervous system from a neuroanatomical as well as a clinical
perspective. During this period, the expression of several morphore
gulators in the developing rat spinal cord was extensively
investigated. Parallel studies focused on the development of the
spinal cord fiber systems, which was studied by means of the
intrauterine use of neuronal tracers. The main goal of these
studies was to extend our knowledge about the (normal) generation
of the spinal cord and to contribute to the under standing of
clinical problems related to regeneration and degeneration in the
mammalian central nervous system. The studies on morphoregulators,
in particular, appeared to benefit two different scientific areas.
Firstly, the correlation between morphoregulator expression
patterns and known anatomy contributed to our knowledge about
spinal cord development. Secondly, the correlation between morpho
regulator expression patterns and known developmental processes may
help to understand their precise function(s). This volume of
Advances in Anatomy, Embryology and Cell Biology presents these
particular studies on the development of the rat spinal cord
performed over the last decade. As well as integrating the results
of the tracer studies, this volume also provides an update on the
development of the rat spinal cord.
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