Admixture Dynamics, Natural Selection and Diseases in Admixed Populations (Paperback, Softcover reprint of the original 1st ed. 2015)

In this thesis, Dr. Jin presents the distribution of ancestral chromosomal segments in the admixed genome, which could provide the information needed to explore population admixture dynamics. The author derives accurate population histories of African Americans and Mexicans using genome-wide single nucleotide polymorphisms (SNPs) data. Mapping the genetic background facilitates the study of natural selection in the admixed population, and the author identifies the signals of selection in African Americans since their African ancestors left for America. He further demonstrates that many of the selection signals were associated with African American-specific high-risk diseases such as prostate cancer and hypertension, suggesting an important role these disease-related genes might have played in adapting to their new environment. Lastly, the author reveals the complexity of natural selection in shaping human susceptibility to disease. The thesis significantly advances our understanding of the recent population admixture, adaptation to local environment and its health implications.

General

Imprint:	Springer
Country of origin:	Netherlands
Series:	Springer Theses
Release date:	August 2016
First published:	2015
Authors:	Wenfei Jin
Dimensions:	235 x 155mm (L x W)
Format:	Paperback
Pages:	114
Edition:	Softcover reprint of the original 1st ed. 2015
ISBN-13:	978-9402404302
Categories:	Books > Medicine > Pre-clinical medicine: basic sciences > Medical genetics Books > Science & Mathematics > Biology, life sciences > Molecular biology Books > Science & Mathematics > Mathematics > Applied mathematics > General Promotions
LSN:	9402404309
Barcode:	9789402404302

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