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Flow Cytometry in Neoplastic Hematology - Morphologic-Immunophenotypic-Genetic Correlation (Hardcover, 4th edition)
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Flow Cytometry in Neoplastic Hematology - Morphologic-Immunophenotypic-Genetic Correlation (Hardcover, 4th edition)
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This fourth edition presents an updated and expanded text and
illustrations to reflect continued morphologic, immunophenotypic,
and especially molecular advances in the field of neoplastic
hematology, mostly due to the rapidly expanding application of
next-generation sequencing. Those advances not only allow a more
reliable diagnosis of the majority of tumors and identification of
early changes such as monoclonal B-cell lymphocytosis or clonal
hematopoiesis of indeterminate potential (CHIP), but also in many
cases identify mutations or phenotypic changes in tumors that can
be targeted by mutation-specific or antigen-specific drugs. This
edition incorporates the updated WHO classification of
hematopoietic tumors and new immunophenotypic and molecular markers
to provide a thorough pathologic overview of hematologic neoplasms
while focusing on flow cytometric features. Special emphasis has
been put on hematological neoplasms with crucial clinical
significance such as acute promyelocytic leukemia, other acute
leukemias, and difficult areas in flow cytometry. Flow cytometric
features in AML, MDS, CMML, CLL and measurable residual disease
were significantly expanded. There are many new comparative tables,
illustrations, and diagrams of algorithmic approaches.
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