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Principles for the Assessment of Risks to Human Health from Exposure to Chemicals (Paperback)
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Principles for the Assessment of Risks to Human Health from Exposure to Chemicals (Paperback)
Series: Environmental Health Criteria Series, No. 210
Expected to ship within 10 - 15 working days
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A state-of-the-art review of methods and procedures for assessing
the risks to human health posed by environmental chemicals.
Addressed to regulatory authorities, risk managers and other
decision-makers, the book aims to demystify the principles of risk
assessment and thus encourage wider use of this powerful tool for
protecting populations. Since the detection of chemical hazards may
have socioeconomic and political consequences, the book gives
particular attention to methods for the accurate identification of
risks and determination of their severity. The book has four
chapters covering each logical step in the process of risk
assessment. The first, on hazard identification, explains how data
on a chemical's toxicity and mode of action can be used to
determine whether the chemical will cause adverse effects on
health. The strengths and limitations of different types of data
are discussed together with criteria commonly used to establish
causality. Methods for assessing dose-response relationships are
reviewed in chapter two, which explains how to characterize the
relationship between the dose administered or received and the
incidence of an adverse effect. Exposure assessment is covered in
the next chapter, which describes methods for determining the
nature and extent of contact with chemical substances and discusses
the characteristics of exposure in the general environment, in the
workplace, and from consumer products. The final chapter explains
the procedure of risk characterization as a decision-making tool
that brings together estimates of exposure levels and risks and
summarizes sources of uncertainty in the scientific data. Practical
options for risk management are presented asa range of regulatory,
non-regulatory, economic, and technological measures.
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