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Tricesyl Phosphate (Paperback, No. 110 ed.)
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Tricesyl Phosphate (Paperback, No. 110 ed.)
Series: Environmental Health Criteria, No 110
Expected to ship within 10 - 15 working days
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Evaluates risks to human health and the environment posed by the
production and use of tricresyl phosphate. Tricresyl phosphate is
used in industry as a plasticizer in vinyl plastic manufacture, as
a flame-retardant, as a solvent for nitrocellulose, in cellulosic
molding compositions, and in the manufacture of fire-resistant
hydraulic fluids and lubricants. Because of the physico-chemical
properties of tricresyl phosphate and its rapid biodegradation, the
report concludes that use of the compound does not threaten the
environment, though there is some evidence that crop plants can be
affected by tri-o-cresyl phosphate released from plastic coverings.
A section devoted to kinetics and metabolism concentrates on
mechanisms of absorption, distribution, metabolism, and elimination
that can help explain the well-documented neuropathic actions of
tricresyl phosphate and, most notably, its highly toxic isomer,
tri-o-cresyl phosphate. The most extensive section assesses
findings from toxicity studies, emphasizing the large number of
studies documenting neurotoxic effects, often at very low doses.
These effects are further characterized through a review of the
numerous reported cases of large-scale human poisoning following
the ingestion of accidentally or deliberately contaminated
medicines and foodstuffs. Readers are given detailed information on
the clinical symptoms of poisoning, the characteristics of delayed
neuropathy, long-term prognosis, and advice on the first-aid
treatment of victims. While the concluding section notes that use
of tricresyl phosphate poses very little risk to either the
environment or the general population, the report underscores the
severity and long-duration of the neuropathology caused by
accidental poisoning, noting that some victims never recover.
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