Eupatorium adenophorum is considered to be a serious weed in
agriculture, especially in rangelands where it often replaces
either the more-desirable vegetation or native species, but also in
forests. Grazing animals get accidentally exposed to the plant
under scarcity conditions. A considerable variation between the
animal species exists in terms of susceptibility to toxicity due to
E. adenophorum. It is generally unpalatable to grazing animals, but
goats graze on this plant infrequently. It is fatally toxic to
horses and causes the "blowing disease" in Hawaii and "Numinbah
disease" or "Tollebudgera horse disease" in Australia.
Toxicopathological studies were taken up in Swiss albino mice, as a
model and the effects of the plant extract on hematological,
biochemical, gross pathological and histopathological parameters
were recorded. The plant extract was found to be highly hepatotoxic
in mice as evidenced by the changes in blood-biochemical, liver
enzyme activities, gross and histopathology of liver. The results
of the study suggest that the consumption of the extract of E.
adenophorum as medicinal purposes without proper dosing may produce
hepatotoxicity in humans.
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