Androgens and androgen receptors (AR) play critical roles in the
development and progression of prostate cancer, the most frequently
diagnosed cancer and second leading cause of cancer death in US
males. AR is an androgen-dependent DNA-binding transcription factor
that regulates the expression of androgen-responsive genes.
Identification and characterization of androgen-responsive genes
provide insights into the cellular mechanisms of androgen action
and may lead to new approaches in diagnosis, prognosis, prevention
and/or treatment of prostate cancer. This volume provides critical
information from well respected experts in the field. Some of the
exciting topics include the new understanding of mechanisms
underlining the regulation of androgen-responsive gene expression,
and functions of various androgen-responsive genes in biological
processes essential in carcinogenesis including cell growth,
angiogenesis, and epithelial-to-mesenchyme transition (EMT). Other
important aspects addressed are the current and potential clinic
applications of knowledge on androgen-responsive gene regulation
and function. This book is intended for researchers, scientists,
faculty, and advanced graduate students with an interest in
androgen action and prostate cancer.
General
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