This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue. Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroid plexus is not only important for the readers' understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia. Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.

Johannes G. de Vries: Pd-catalyzed coupling reactions.- Gregory T. Whiteker and Christopher J. Cobley: Applications of Rhodium-Catalyzed Hydroformylation in the Pharmaceutical, Agrochemical and Fragrance Industries.- Philippe Dupau: Ruthenium-catalyzed Selective Hydrogenation for Flavor and Fragrance Applications.- Hans-Ulrich Blaser, Benoit Pugin and Felix Spindler: Asymmetric Hydrogenation.- Ioannis Houpis: Case Study: Sequential Pd-catalyzed Cross-Coupling Reactions; Challenges on Scale-up.- Adriano F. Indolese: Pilot Plant Scale Synthesis of an Aryl-Indole - Scale up of a Suzuki Coupling.- Per Ryberg: Development of a Mild and Robust Method for Palladium Catalysed Cyanation on Large Scale.- Cheng-yi Chen: Application of Ring Closing Metathesis Strategy to the Synthesis of Vaniprevir (MK-7009), a 20-Membered Macrocyclic HCV Protease Inhibitor.

This volume is the fourth in a series designed to facilitate inter-disciplinary communication between scientists concerned with the description of societal phenomena and those investigating adult development. As such, it contains a compilation of papers presented at an annual conference held at the Pennsylvania State University. These essays by sociologists and epidemiologists deal with the impact of disease and health outcomes with advancing age and are critiqued by members of related disciplines. In addition, there are overviews as well as specific discussions about the impact of cancer, depression, and cardiovascular diseases upon psychosocial functions.

Contemporary Surgical Management of Liver, Biliary Tract, and Pancreatic Diseases presents an excellent resource for surgical residents, hepatobiliary fellows and practicing surgeons interested in hepatobiliary surgery. This textbook offers a readable, concise and practical alternative. It is divided into three sections: liver, biliary tract, and pancreatic diseases. Each section covers the spectrum of benign and malignant disease. In addition, several chapters in each section are devoted to surgical techniques. This textbook should ultimately serve as an essential source for the rapidly evolving field of hepatobiliary surgery and its practitioners.

This issue of Clinics in Geriatric Medicine, edited by Drs. Dan Blazer and Susan Schultz, will cover a number of important aspects of Geriatric Psychiatry. Topics in this issue include, but are not limited to: Delirium in the elderly; Depression and cardiac disease in later life; Schizophrenia in later life; Anxiety Disorders in later life; Neurological changes and depression; Behavioral Changes with Alzheimer's Disease and Vascular Dementia; Palliative Care in Dementia and Chronic Mental Illness; Collaborative Care for the elderly with psychiatric disorders; and Post Traumatic Stress Disorders in the elderly.

Indigenous peoples today are enmeshed in the expanding modern economy, subject to the pressures of both market and government. This book takes indigenous peoples as actors, not victims, as its starting point in analysing this interaction. It assembles a rich diversity of statements, case studies and wider thematic explorations, primarily from North America, and particularly the Cree, the Haudenausaunee (Iroquois) and Chippewa-Ojibwe peoples who straddle the US/Canadian border, but also from South America and the former Soviet Union. It explores the complex relationships between indigenous peoples, civil society, and the environment. It shows how the boundaries between indigenous peoples' organizations, civil society, the state, markets, development and the environment are ambiguous and constantly changing. These complexities create both opportunities and threats for local agency. People resist or react to the pressures of market and state, while sustaining 'life projects' of their own, embodying their own local history, visions and strategies.

This issue of Psychiatric Clinics, edited by Drs. Dan Blazer and Susan Schultz, will cover a number of important aspects of Geriatric Psychiatry. Topics in this issue include, but are not limited to: Delirium in the elderly; Depression and cardiac disease in later life; Schizophrenia in later life; Anxiety Disorders in later life; Neurological changes and depression; Behavioral Changes with Alzheimer's Disease and Vascular Dementia; Palliative Care in Dementia and Chronic Mental Illness; Collaborative Care for the elderly with psychiatric disorders; and Post Traumatic Stress Disorders in the elderly.

This volume is the fourth in a series designed to facilitate inter-disciplinary communication between scientists concerned with the description of societal phenomena and those investigating adult development. As such, it contains a compilation of papers presented at an annual conference held at the Pennsylvania State University. These essays by sociologists and epidemiologists deal with the impact of disease and health outcomes with advancing age and are critiqued by members of related disciplines. In addition, there are overviews as well as specific discussions about the impact of cancer, depression, and cardiovascular diseases upon psychosocial functions.

Depression has become the most frequently diagnosed chronic mental illness, and is a disability encountered almost daily by mental health professionals of all trades. "Major Depression" is a medical disease, which some would argue has reached epidemic proportions in contemporary society, and it affects our bodies and brains just like any other disease. Why, this book asks, has the incidence of depression been on such an increase in the last 50 years, if our basic biology hasn't changed as rapidly? To find answers, Dr. Blazer looks at the social forces, cultural and environmental upheavals, and other external, group factors that have undergone significant change. In so doing, the author revives the tenets of social psychiatry, the process of looking at social trends, environmental factors, and correlations among groups in efforts to understand psychiatric disorders.

Faith Development in Early Childhood is a collection of key essays which have grown out of the experience of the December 1987 Kanuga National Symposium on Faith Development in Early Childhood. Essays contained herein explore many aspects of faith development in the early, formative years of life. Throughout, they show reverence for the integrity of each growing child, as well as for the vital task of faith development.

Depression has become the most frequently diagnosed chronic mental illness, and is a disability encountered almost daily by mental health professionals of all trades. Major depression is a medical disease, which some would argue has reached epidemic proportions in contemporary society, and it affects our bodies and brains just like any other disease. The Age of Melancholy asks why the incidence of depression has been on such an increase in the last 50 years, if our basic biology hasn't changed as rapidly. To find answers, Dr. Blazer looks at the social forces, cultural and environmental upheavals, and other external, group factors that have undergone significant change. In so doing, the author revives the tenets of social psychiatry, the process of looking at social trends, environmental factors, and correlations among groups in efforts to understand psychiatric disorders. The biomedical model of psychiatry that has dominated the field for the past half-century has faced minimal scrutiny, due in part to the apparent advances made in the treatment of mental health issues during that time. But, Dr. to complement and complete the model, and he points to two concurrent trends for support: during the same 50-year period that saw the death of social psychiatry, the rate of occurrence and increasing medicalization of depression as a secluded individual's issue have brought us to the Prozac era. In making the case for the connection of these two trends (both the products themselves of larger social and cultural movements), the author proposes a return of a new, more mature social psychiatry, to complete - not replace - the biomedical and clinical research models in place today. This book is eminently readable, and should appeal to a broader audience than the psychiatrists, clinicians, and researchers who will make up the primary audience. While replete with the standard mental health references, sound research, and authored by a recognized and respected professional, the ease of language and range of examples make this text accessible to a lay reader. This book should have cross-over appeal in sociology as well as social work and psychology.

This book highlights the importance of the choroid plexus, which forms the blood-cerebrospinal fluid barrier and is the site of the major production of the cerebrospinal fluid (CSF). The authors show that this barrier is crucial for maintaining important compositional differences between the blood plasma and the CSF. The choroid plexus epithelial cells also prevent the spread of infectious agents and other blood-borne entities to the brain tissue. Chapter topics range from the production of CSF by electrolyte regulation in the choroid plexus, to details on the selectively transporting nature of this barrier. Further, the authors elaborate on the important roles of CSF in sustaining brain health by providing hydration, solutes, and nutrients to the brain tissue. Readers will also learn how CSF circulates signaling molecules within the compartments of the brain and removes waste products from the brain tissue. Elucidating the regulation of these processes in the choroid plexus is not only important for the readers' understanding of normal brain development and function, but is also crucial for resolving a variety of cerebral challenges that lead to brain edema, as well as developing treatments for diseases. The book discusses disease models like hydrocephalus, sleep disorders, and age-related dementia. Its comprehensive coverage makes this volume a valuable resource for researchers in cell and neurophysiology, as well as graduate students of the neurosciences.

When sports ministry first emerged in the 1950s and 1960s, its founders imagined male celebrity athletes as powerful salespeople who could deliver a message of Christian strength: "If athletes can endorse shaving cream, razor blades, and cigarettes, surely they can endorse the Lord, too," reasoned Fellowship of Christian Athletes founder Don McClanen. But combining evangelicalism and sport did much more than serve as an advertisement for religion: it gave athletes the opportunity to think about the embodied experiences of sport as a way to experience intimate connection with the divine. As sports ministry developed, it focused on individual religious experiences and downplayed celebrity sales power, opening the door for female Christian athletes to join and eventually dominate sports ministry. Today, women are the majority of participants in sports ministry in the United States. In Playing for God, Annie Blazer offers an exploration of the history and religious lives of Christian athletes, showing that evangelical engagement with popular culture can carry unintended consequences. When sport became an avenue for embodied worship, it forced a reckoning with evangelical teachings about the body. Female Christian athletes increasingly turned to their own bodies to understand their religious identity, and in so doing, came to question evangelical mainstays on gender and sexuality. What was once a male-dominated masculinist project of sports engagement became a female-dominated movement that challenged evangelical ideas on femininity, marriage hierarchy, and the sinfulness of homosexuality. Though evangelicalism has not changed sporting culture, for those involved in sports ministry, sport has changed evangelicalism.

Johannes G. de Vries: Pd-catalyzed coupling reactions.- Gregory T. Whiteker and Christopher J. Cobley: Applications of Rhodium-Catalyzed Hydroformylation in the Pharmaceutical, Agrochemical and Fragrance Industries.- Philippe Dupau: Ruthenium-catalyzed Selective Hydrogenation for Flavor and Fragrance Applications.- Hans-Ulrich Blaser, Benoit Pugin and Felix Spindler: Asymmetric Hydrogenation.- Ioannis Houpis: Case Study: Sequential Pd-catalyzed Cross-Coupling Reactions; Challenges on Scale-up.- Adriano F. Indolese: Pilot Plant Scale Synthesis of an Aryl-Indole - Scale up of a Suzuki Coupling.- Per Ryberg: Development of a Mild and Robust Method for Palladium Catalysed Cyanation on Large Scale.- Cheng-yi Chen: Application of Ring Closing Metathesis Strategy to the Synthesis of Vaniprevir (MK-7009), a 20-Membered Macrocyclic HCV Protease Inhibitor.

The Romanistische Arbeitshefte (Romance Studies Workbooks), edited by Georgia Veldre-Gerner and Volker Noll since 2004, have been constant and reliable companions for students of Romance Studies for fifty years. In their conception, they are designed as a reflection of the present state of research with an orientation towards application and the specific needs and difficulties of students. Thus they provide a reliable instrument for getting to grips with various areas of Romance linguistic studies and encourage students to utilise their newly-acquired knowledge with integrated exercises.

A clarion call to save humanity's most essential fellow creatures - and our health Far beneath our skin exists an unfathomable, ancient universe - an internal ecosystem that is critical to our health. Dr Martin Blaser invites us into the wilds of the human 'microbiome', unfurling its inner workings and evolution. For thousands of years, bacteria and human cells have co-existed in a relationship that has ensured the health and equilibrium of our body. But now, much like the natural world outside of us, our internal environment is being irrevocably destroyed. The culprit: some of our most revered medical advances - antibiotics - which appear to be linked to the epidemics of asthma, eczema, obesity, certain forms of cancer, and other diseases plaguing modern society. In a book that stands as the Silent Spring of its day, Blaser sounds a provocative alarm that we ignore at our peril.

Animation is a limitless medium for telling stories. Artists can create worlds, defy gravity, flip from factual to fantasy, and transport audiences to places they never imagined. The challenge is having the discipline to reel it in and be intentional about your storytelling choices. This book shows you how. In Animated Storytelling, learn how to create memorable stories using animation and motion graphics by following 10 simple guidelines that take you through the stages of concept development, pre-production, storyboarding, and design. Explore traditional linear storytelling and learn different processes for creating successful nonlinear animated stories, and also discover the wonders of experimental filmmaking. Award-winning filmmaker, educator, and motivator Liz Blazer uses clear examples and easy-to-follow exercises to provide you with the instruction, encouragement, and tools you need to get your designs moving. Whether your goal is to create exciting shorts for film festivals, effective messaging for broadcast or online, or simply to gain a deeper understanding of the medium, Animated Storytelling simplifies the process of creating clear and engaging stories for animation and motion graphics so you can get started easily. Animated Storytelling teaches you how to: * Write a creative brief for your project * Find and communicate your story's Big Idea * Create tight stories with linear and nonlinear structures * Explore experimental filmmaking techniques * Use storyboards to communicate your visual story * Use color to clarify and enrich your story * Define the rules for your animated world * Ease into the challenging task of animation * Make the work you want to be hired to do * Share your work with the world! "Equal parts inspiring and practical, Animated Storytelling is a step-by-step guide that takes aspiring storytellers from raw idea to final render to distribution. -Justin Cone, Co-founder, Motionographer "This book is the instruction manual for navigating the complex world of animated storytelling. It's informative, inspirational, and extremely entertaining to read. Anyone working (or hoping to work) in the field of animation needs to read this. -Joey Korenman, CEO & Founder, School of Motion

This volume contains 14 survey articles by reputed database researchers. They give an account of the state of the art, present research highlights and offer an outlook into the '90s regarding the most likely evolution of database technology-research, ad-tech, products and applications. The volume is structured into the following parts: - The evolution of database technology and its impact on enterprise information systems (keynote paper); - Demands on database systems in the '90s (office, engineering, science, multimedia, standardization); - User aspects (application programmers, ad hoc query users); - Database system and architecture concepts for novel applications (data models, object orientation, deductive DBMS, extensibility, data replication); - System and implementation aspects (performance and reliability, distributed and cooperative DBMS, hardware impact). The volume may serve as an orientation for all those who are interested in database systems and their impact on computer applications.

Derzeit verfugbare "universelle" Datenbanksysteme sind historisch fur betriebswirt- schaftliche Anwendungen entst&lden. In Anwendungsgebieten wie der Unterstutzung von Burotatigkeiten oder der rechnergestutzten Konstruktion und Fertigung (CAD/CAM - CIM) stossen sie daher vielfach Rn die Grenzen ihrer Fahigkeiten. Diese Tatsache spiegelt sich wider in dem angelsachsis,;hen Schlagwort "non-standard date base applications", was sich vielleicht mit "nicht-konventionelle Datenbank-Anwendungen" wiedergeben lasst. Fur derartige Anwendungen werden immer haufiger neuartige DB-Systeme gefordert. Die Datenbank-Forschung griff diese Problematik schon vor einigen Jahren verstarkt auf. Das lasst sich belegen durch das Fachgesprach Datenbanken der GI -Jahrestagung 1983, aber auch durch so renommierte internationale Konferenzen wie SIGMOD '84 oder VLDB84 , bei denen sich etwa 50 % der Beitrage mit Datenbank-Problemen beschaftigten, die sich durch Anwendungen in Buro, Technik und Wissenschaft stellen. Unter diesen Umstanden hielt es der Fachausschuss 2.5 "Rechnergestutzte Informations- systeme" der Gesellschaft fur Informatik fur angebracht, eine Fachtagung eigens uber Datenbanksysteme fur die Unterstutzung von Burotatigkeiten und fur technisch-wissen- schaftliche Anwendungen auszurichten. Die erfreulich grosse Resonanz, die der Aufruf zu Tagungsbeitragen fand, hat diese Einschatzung bestatigt. Es ist den Veranstaltern ein Bedurfnis, an dieser Stelle den vielen Autoren zu danken, die durch ihre einge~ reichten Beitrage die Bedeutung der Thematik unterstrichen haben, und zwar ausdrucklich auch denen, deren Beitrage nicht im Tagungsprogramm erscheinen. In den meisten Fallen ist der Grund dafur nicht die mangelnde Qualitat, sondern der Zwang zur zeitlichen und thematischen Konzentration, der die Organisatoren vor die Qual der Wahl stellte.